Metabolism and Physiology
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First-in-Human in vivo CRISPR/Cas9 Editing of the TTR Gene by NTLA-2001 in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Julian D Gillmore | University College of London, London, United Kingdom
- CRISPR-ATTR trial data summary (PPTX)
- AHA Press Release: Novel gene-editing therapy shows promise for patients with transthyretin amyloid cardiomyopathy
- ClinicalTrials ID: NCT04601051
- Original article: NEJM, 2021(link opens in new window)
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Since 1999, the BCVS Council has advanced understanding of mechanisms of basic cardiovascular regulation to support insights into cardiovascular disease and facilitate new therapies. Emphasis is on integrating molecular/cellular and physiological approaches to address problems relating to genomics, cell signaling, myocardial biology, circulatory physiology, pathophysiology, and peripheral vascular disease.
The ATVB Council focuses on arteriosclerosis, thrombosis and vascular biology. The council advances research, addresses prevention, improves diagnosis and treatment, and works actively with other organizations. It shares reliable information through its annual conference, awards and lectures, and in the AHA’s journal, Arteriosclerosis, Thrombosis, and Vascular Biology.
Gregory M. Marcus, MD, MAS explains the methodology and results of the CRAVE trial, designed to assess the acute affects of coffee consumption in ambulatory patients.
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