Basic Cardiovascular Sciences 2018 Scientific Sessions

July 30–August 2, 2018
Grand Hyatt San Antonio | San Antonio, Texas

Registration Information
Take advantage of Advance Registration through June 26

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Abstract Submission
Late-breaking Abstract Submissions are now closed.


2018 Agenda

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NEW! Print a copy of the BCVS 2018 Final Program (PDF)


Monday, July 30 - BCVS
8:00 a.m.Registration & Exhibits Open
9:45 a.m.Early Career Pre-Conference Session: Welcome Address
Nicole H. Purcell, PhD, University of California San Diego, La Jolla, California
Sean Wu Stanford, PhD, Stanford University, Stanford, California
10:00 a.m.Early Career Pre-Conference Session 1: "Next Best Thing" in Cardiovascular Research
Oral Abstract Presentations
Targeting the NAD/NADH Ratio for Heart Failure Therapy

Matthew A Walker, Univ of Washington, North Bend, WA
Cytosolic RBFox1 in Cardiac Pathological Remodeling
Chen Gao, UCLA-Los Angeles, Los Angeles, CA
A Lack in Endogenous Proteasome Regulation Provokes Exacerbated Cardiac Remodeling and Premature Heart Failure Following Catecholamine Challenge
Felix A Trogisch, Dept of Cardiovascular Physiology, Heidelberg Univ, Heidelberg, Germany
Evaluation of Patient Specific MTERF4 Variants in Gene Edited Human iPSC-derived Cardiomyocytes
Maribel Marquez, Medical Coll of Wisconsin, Milwaukee, WI
A Microrna-hippo Pathway Functions in Cardiac Conduction System Homeostasis and Regeneration
Jun Wang, Baylor Coll of Med, Houston, TX
11:20 a.m.Early Career Pre-Conference Session 2
Common Career Hurdles and How to Clear Them
Sakthivel Sadayappan, PhD, MBA, University of Cincinnati College of Medicine, Cincinnati, Ohio
11:50 a.m.Break / Lunch on your own
12:35 p.m.BCVS 2018 Scientific Sessions: Opening Welcome
Ivor Benjamin, MD, President, American Heart Association
Joseph C. Wu, MD, PhD, FAHA, Stanford University School of Medicine, Stanford, California
1:00 p.m. – 2:35 p.m.
Concurrent Session 1A: Cardiac Fibrosis - Changing the Landscape
1:00 p.m.Novel Fibroblast Functional States in the MI Heart
Jeffrey D. Molketin, PhD, Children’s Hospital Medical Center, Cincinnati, Ohio
1:20 p.m.TBD
Amy Bradshaw, PhD, Medical University of South Carolina, Charleston, South Carolina
1:40 p.m.TBD
Taben M. Hale, PhD, University of Arizona, Phoenix, Arizona
2:00 p.m.Epigenetic Regulation of Cardiac Fibrosis
Timothy A. McKinsey, PhD, University of Colorado, Aurora, Colorado
2:20 p.m.Oral Abstract Presentation
PRDM16 is a Novel Regulator of Cardiac Hypertrophy, Remodeling and Mitochondrial Dynamics
Karla Maria Pires, Univ of Utah, Salt Lake Cty, UT
1:00 p.m. – 2:35 p.m.
Concurrent Session 1B: The On and Off of Redox
1:00 p.m.Cardiovascular Adaptation to Hypoxia and Redox Stress
Joseph Loscalzo, MD, PhD, Harvard Medical School, Boston, Massachusetts
1:20 p.m.Nitric Oxide and Cardioprotection
Elizabeth (Tish) Murphy, PhD, NHLBI, Bethesda, Maryland
1:40 p.m.New Aspects of NO-based Cellular Signaling
Jonathan S. Stamler, MD, Case Western Reserve University, Cleveland, Ohio
2:00 p.m.New Hope for Measuring and Targeting Redox Dysregulation in Cardiovascular Disease
Gemma Figtree, MBBS, PhD, Kolling Institute, University of Sydney, St. Leonards, Australia
2:20 p.m.Oral Abstract Presentation
Endothelial Arnt Regulates Microvascular Endothelial Barrier Function in Heart Failure Through a Novel Mmp3 Pathway
Rongxue (Rosie) Wu, University of Chicago, Chicago, IL
2:35 p.m. – 3:05 p.m.
Refreshment Break, Exhibits
3:05 p.m. – 4:40 p.m.
Concurrent Session 2A: Signaling Networks in Cardiac Myocyte
3:05 p.m.Proteostatsis Signaling in Heart Disease
Chris C. Glembotski, PhD, San Diego State University, San Diego, California
3:25 p.m.The Role of Co-chaperone BAG3 in Cardiomyocytes
Ju Chen, PhD, University of California San Diego, La Jolla, California
3:45 p.m.TBD
Peipei Ping, PhD, David Geffen School of Medicine at UCLA, Los Angeles, California
4:05 p.m.The Role of FGF23 in Uremic Cardiomyopathy
Christian Faul, PhD, The University of Alabama at Birmingham, Birmingham, Alabama
4:25 p.m.Oral Abstract Presentation
An Internal Pool of b-Adrenergic Receptors Activates PLC-mediated PI4P Hydrolysis in Cardiac Myocytes
Alan V Smrcka, Univ of Michigan Sch of Med, Ann Arbor, MI
3:05 p.m. – 4:40 p.m.
Concurrent Session 2B: Mitochondrion and Heart Failure
3:05 p.m.Non-canonical Mitophagy in the Heart
Asa Gustafsson, PhD, University of California San Diego, La Jolla, California
3:25 p.m.Role of Mitochondrial Calcium and Redox Regulation in Heart Failure
Christoph Maack, MD, University Clinic Würzburg, Wurtzberg, Germany
3:45 p.m.Molecular Regulation of Mitochondrial Calcium Uptake
John W. Elrod, PhD, Temple University, Philadelphia, Pennsylvania
4:05 p.m.Targeting Cellular Aging for the Treatment of Cardiovascular Diseases
Tohru Minamino, MD, PhD, Niigata University Graduate School of Medical and Dental Sciences, Nigata, Japan
4:25 p.m.Oral Abstract Presentation
Cytochrome b5 Reductase 3 Regulates Myoglobin Redox State and Controls Cardiac Function
Nolan Thorne Carew, Univ of Pittsburgh, Pittsburgh, PA
4:40 p.m. – 7:00 p.m.Poster Session 1 and Reception

Tuesday, July 31 - BCVS
7:00 a.m.Registration
7:00 a.m.Continental Breakfast / Exhibits
7:00 a.m.Women in Science Breakfast
Ticket required to attend
8:00 a.m. – 9:15 a.m.
Concurrent Session 3A: Emerging Cardiac Therapeutic Strategies
8:00 a.m.Gene Therapy & Genome Editing in Cardiomyopathies
Roger Hajjar, MD, Mount Sinai School of Medicine, New York, New York
8:20 a.m.Myosin Myopathies: Pathogenesis and Potential Therapeutics
Leslie Leinwand, PhD, University of Colorado, Boulder, Colorado
8:40 a.m.Cardiac Regeneration by Stimulating Endogenous Cardiomyocyte Proliferation
Mauro Giaccia, MD, PhD, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
9:00 a.m.Oral Abstract Presentation
9:00 a.m. – AAV-Exosomes: A Novel Platform for Myocardial Gene Delivery for Cardioprotection
Marta Adamiak, Icahn Sch of Med at Mount Sinai, New York, NY
8:00 a.m. – 9:15 a.m.
Concurrent Session 3B: Excitation-Contraction Coupling
8:00 a.m.Elucidating the Molecular Mechanisms for Increased Contractility in the "Fright or Flight" Response
Livia Hool, PhD, University of Western Australia, Crawley, Australia
8:20 a.m.Preconception Exposure to Air Pollution Alters Adult Excitation-Contraction Coupling
Loren E. Wold, PhD, The Ohio State University, Columbus, Ohio
8:40 a.m. Novel Roles of Junctophilin in Heart Disease Pathogenesis
Xander Wehrens, MD, PhD, Baylor College of Medicine, Houston, Texas
9:00 a.m.Oral Abstract Presentation
9:00 a.m. – Tuning EC-Coupling: β-Adrenergic Receptor Activation Stimulates Dynamic Augmentation of CaV1.2 Channel Sarcolemmal Abundance and Cooperativity
Rose E Dixon, Univ of California Davis, Davis, CA
9:15 a.m. – 9:45 a.m.
Refreshment Break, Exhibits
9:45 a.m. – 11:00 a.m.
Concurrent Session 4A: Transcriptional Regulation and Epigenetics
9:45 a.m.Cardiac all-trans Retinoic Acid Deficiency is an Early Feature of Heart Failure Progression
D. Brian Foster, PhD, Johns Hopkins School of Medicine, Baltimore, Maryland
10:05 a.m.Transcriptional Regulation of Heart Development and Regeneration
Enzo R. Porello, PhD, Murdoch Children’s Research Institute, Parkville, Australia
10:25 a.m.Chromatin Structure in Heart Failure
Tom M. Vondriska, PhD, University of California Los Angeles, Los Angeles, California
10:45 a.m.Oral Abstract Presentation
Identifying Cardiac Conduction System-specific Enhancers That Link Cell-type Specification with Human Conduction Defects
Samadrita Bhattacharyya, UT Southwestern Medical Ctr, Dallas, TX
9:45 a.m. – 11:00 a.m.
Concurrent Session 4B: How to Build a New Heart One Cell at a Time
9:45 a.m.Myocardial Tissue Engineering with Cells Derived from Human Induced-pluripotent Stem Cells and a Native-like, High-resolution, 3D Printed Scaffold
Jianyi (Jay) Zhang, MD, PhD, The University of Alabama at Birmingham, Birmingham, Alabama
10:05 a.m.Deconstructing Regenerative Medicine: Beyond Cells to Exosomes and Defined Factors
Eduardo Marban, MD, Cedars-Sinai Medical Center, Los Angeles, California
10:25 a.m.The Transcriptional Landscape of Cardiac Differentiation at Single Cell Resolution
Nathan Palpant, PhD, University of Queensland Institute for Molecular Bioscience, St. Lucia, Queensland, Australia
10:45 a.m.Oral Abstract Presentation
The Mevalonate Pathway Controls Cardiomyocyte Proliferation
James E Hudson, The Univ of Queensland, Brisbane, Australia
11:00 a.m. – 12:00 p.m.
General Session 5: Keynote Lecture
11:00 a.m.Cellular Heterogeneity and Plasticity in Cardiovascular Disease
Stephanie Dimmeler, PhD, Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany
12:00 p.m. – 1:30 p.m.Early Career Luncheon: Speed Networking / Mentoring Round Tables
Ticket required to attend

Featured Presentation: The Importance of Mentoring
Merry L. Lindsey, PhD, FAHA, University of Mississippi Medical Center, Jackson, Mississippi
12:00 p.m. – 1:30 p.m.Lunch on your own; Poster viewing; Exhibits
1:30 p.m. – 2:45 p.m.
Concurrent Session 6A: Ion Channels and Arrhythmias
1:30 p.m.CaMKII-dependent Regulation of Nav1.5, Late Sodium Current and Arrhythmias
Thomas Hund, PhD, The Ohio State University, Columbus, Ohio
1:50 p.m.TBD
Joshua I. Goldhaber, MD, Cedars-Sinai Medical Center, Los Angeles, California
2:10 p.m.Identification of an ATP-sensitive Potassium Channel in the Inner Mitochondrial Membrane
Diego De Stefani, PhD, University of Padova, Padova, Italy
2:30 p.m.Oral Abstract Presentation
Molecular and Electrophysiologic Characterization of Obesity Mediated Atrial Fibrillation in Mc4r-KO Mice 
Ambili Menon, Univ of Illinois at Chicago, Chicago, IL
1:30 p.m. – 2:45 p.m.
 Concurrent Session 6B: The Resurgence of Cardiac Metabolism
1:30 p.m.Novel Players in Mitophagy
Zoltan P. Arany, MD, PhD, University of Pennsylvania, Philadelphia, Pennsylvania
1:50 p.m.Feeding the Starving Failing Heart
Daniel P. Kelly, MD, University of Pennsylvania, Philadelphia, Pennsylvania
2:10 p.m.Metabolism and Myocardial Autopoiesis
Bradford G. Hill, PhD, University of Louisville, Louisville, Kentucky
2:30 p.m.Oral Abstract Presentation
Protein-coupled Receptor Kinase 2 Impairs Fatty Acid Metabolism in the Failing Heart Through Novel Mechanisms 
Jessica M Pfleger, Temple Univ, Philadelphia, PA
2:45 p.m. – 3:15 p.m.
Refreshment Break, Exhibits
3:15 p.m. – 4:30 p.m.
Concurrent Session 7A: Functional Genomics and Pathogenicity Assessment
3:15 p.m.TBD
Quinn S. Wells, MD, Vanderbilt University, Nashville, Tennessee
3:35 p.m.Genetic Mechanisms in Cardiomyopathy
Elizabeth (Beth) McNally, MD, PhD, Northwestern University, Chicago, Illinois
3:55 p.m.Functional Annotation of Variants of Uncertain Significance in Cardiovascular Disease Genes
Kiran Musunuru, MD, PhD, University of Pennsylvania, Philadelphia, Pennsylvania
4:15 p.m.Oral Abstract Presentation
Numb Family Proteins Modulate Cardiac Morphogenesis by Regulating N-cadherin Trafficking to Plasma Membrane
Mingfu Wu, Albany Medical Coll, Albany, NY
3:15 p.m. – 4:30 p.m.
Concurrent Session 7B: Workshop 1: Imaging in vitro and in vivo
3:15 p.m.Single-cell Imaging, Robotics and Deep Learning in Biology and Disease
Irina Epstein, PhD, UCSF Gladstone Institute, San Francisco, California
3:33 p.m.Hyperpolarized 13C MRI of Myocardial Metabolism
Charles Cunningham, University of Toronto, Toronto, Ontario, Canada
3:51 p.m.Phosphodiesterases Dictate Sub-microscopic Compartmentalisation of cAMP
Manuela Zaccolo, MD, PhD, Oxford Balliol College, Oxford, United Kingdom
4:09 p.m.Optogenetic Tools for Visualizing and Manipulating Cell Metabolism
Yi Yang, PhD, East China University of Science and Technology, Shanghai, China
4:30 p.m. – 7:00 p.m.
Poster Session 2 and Reception
7:00 p.m.
Early Career Investigator Social Event

Wednesday, Aug. 1 BCVS
7:00 a.m.Registration
7:00 a.m.Continental Breakfast; Exhibits
8:00 a.m. – 9:15 a.m.
Concurrent Session 8A: Personalized Cell Models of Arrhythmia
8:00 a.m.TBD
Joseph C. Wu, MD, PhD, FAHA, Stanford University, Stanford, California
8:20 a.m.Incorporating the Person in Personalized Cell Models
Jennifer L. Strande, MD, Medical College of Wisconsin, Milwaukee, Wisconsin
8:40 a.m.Advances in Using iPSCs for Arrhythmia Modeling
Lior Gepstein, MD, PhD, Technion, Haifa, Israel
9:00 a.m.Oral Abstract Presentation
Dysregulation of Pdgfrb Contributes to the Pathogenesis of LMNA-related Dilated Cardiomyopathy
Jaecheol Lee, Cardiovascular Inst, Stanford Univ, Stanford, CA
8:00 a.m. – 9:15 a.m.
Concurrent Session 8B: Getting the Message – New Ways to Think About RNA
8:00 a.m.Circular RNA, What They Do, and Other RNA Species
Roger S. Foo, MD, PhD, University of Singapore, Singapore
8:20 a.m.miRNA-based Therapy of Myocardial Disease
Stefan Engelhardt, MD, TU Munich, Munich, Germany
8:40 a.m.Single Cell Transcriptomics to Study Cardiomyocyte Cell Fate Control
Li Qian, PhD, University of North Carolina, Chapel Hill, North Carolina
9:00 a.m.Oral Abstract Presentation
Doxorubicin Alters Cardiac Fibroblast Phenotype
Trevi R Mancilla, UT Health San Antonio, San Antonio, TX
9:15 a.m. – 10:00 a.m.
General Session 9: Outstanding Early Career Investigator Award Competition
9:15 a.m.Steering Fibroblast Phenotype to Promote Left Ventricular Scar Maturation and Function Post-MI 
Lisandra E de Castro Brás, East Carolina Univ, Greenville, NC
9:30 a.m.A Role for Brain-derived Neurotrophic Factor in Duchenne Cardiomyopathy 
Cristi L Galindo, Vanderbilt Univ Med Ctr, Nashville, TN
9:45 a.m.Chromatin Microenvironments with Distinct Functionality During Cardiac Stress 
Manuel Rosa-Garrido, UCLA, Los Angeles, CA
10:00 a.m. – 10:30 a.m.
Refreshment break; Exhibits
10:30 a.m. – 11:45 a.m.
Concurrent Session 10A: Early Career Session
Navigating Your Career: Finding Success and Happiness with a PhD
10:30 a.m.Omnivert A Misunderstood Personality
Mark A. Sussman, PhD, San Diego State University, San Diego, California
10:45 a.m.Postdoc Perspective
Catherine A. Makarewitch, PhD, UT Southwestern Medical Center, Dallas, Texas
11:00 a.m.Graduate Student Perspective
Adrian Arrieta, San Diego State University, San Diego, California
11:15 a.m.Panel Discussion / Q & A
10:30 a.m. – 11:45 a.m.
Concurrent Session 10B: Workshop 2
Towards Single Cell Analysis
10:30 a.m.TBD
Peggi Angel, Medical University of South Carolina, Charleston, South Carolina
10:48 a.m.Proteomics of a Single Cell and Its Lineage in the Developing Frog Embryo using Ultrasensitive Mass Spectrometry
Aparna Baxi, University of Maryland, College Park, Maryland
11:07 a.m.TBD
Baljit Ubhi, PhD, SCIEX, Redwood City, CA
11:26 a.m.Association of Apolipoprotein A1 Proteoforms and Inter-Individual Differences in HDL Efflux Capacity
Neil Kelleher, PhD, Northwestern University, Chicago, Illinois
11:45 a.m. – 1:30 p.m.
Lunch on Your Own; Poster Viewing; Exhibits
1:30 p.m. – 2:45 p.m.
Concurrent Session 11A: The Architecture of Contraction
1:30 p.m.TBD
Jill Tardiff, MD, PhD, University of Arizona, Tucson, Arizona
1:50 p.m.Cosegregation of MYBPC3Δ25bp with MYBPC3 D389V is Associated with a Cardiomyopathic Substrate
Sakthivel Sadayappan, PhD, MBA, University of Cincinnati College of Medicine, Cincinnati, Ohio
2:10 p.m.Genetically Linked Cardiomyopathies, From Molecular Basis to New Treatments.
Beata M. Wolska, PhD, University of Illinois, Chicago, Illinois
2:30 p.m.Oral Abstract Presentation
Mybphl is a Novel Myofilament Component Implicated in Arrhythmia and Dilated Cardiomyopathy
David Y Barefield, Northwestern Univ, Chicago, IL
1:30 – 2:45 p.m.
Concurrent Session 11B: Cell Death and Cardiomyopathy
1:30 p.m.Molecular mechanisms of cell survival by FoxO1
Jun Sadoshima, MD, Rutgers New Jersey Medical School, Newark, New Jersey
1:50 p.m.Understanding Alzheimer's Beyond the Brain
Frederica Del Monte, MD, PhD, Medical University of South Carolina, Charleston, South Carolina
2:10 p.m.Regulation of Cardiac Cell Death in Autophagy in Cardiac Myocytes 
Lorrie A. Kirshenbaum, PhD, University of Manitoba, Winnipeg, Manitoba, Canada
2:30 p.m.Oral Abstract Presentation
Regulation of Cardiac Mitochondrial Function by Chaperone Mediated Autophagy 
Yun Chen, Albert Einstein Coll of Med, Bronx, NY
2:45 p.m. – 3:15 p.m.
Refreshment Break, Exhibits
3:15 p.m. – 4:30 p.m.
Concurrent Session 12A: Workshop 3 – Single and Multi-omics
3:15 p.m.Top-down Proteomics in Cardiac Disease and Regeneration 
Ying Ge, PhD, University of Wisconsin, Madison, Wisconsin
3:33 p.m.A Multi-omics Approach to Cardiovascular Disease
Manuel Mayr, MD, Kings College, London, United Kingdom
3:52 p.m.The Role of Protein Citrullination in Cardiovascular Disease
Justyna P. Fert-Bober, PhD, Cedars-Sinai Medical Center, Los Angeles, California
4:11 p.m.Quantitative Temporal Analysis of Protein Dynamics in Maladaptive Cardiac Remodeling
John R. Yates, III, PhD, The Scripps Research Institute, La Jolla, California
3:15 p.m. – 4:30 p.m.
Concurrent Session 12B: Cardiovascular Stress and Inflammation
3:15 p.m.Macrophages and Interorgan Crosstalk in Cardiac Adaptation
Ichiro Manabe, MD, PhD, Chiba University Graduate School of Medicine, Chiba, Japan
3:35 p.m.HFpEF: Epidemiology and Mechanisms
Joseph A. Hill, MD, PhD, UT Southwestern Medical Center, Dallas, TX
3:55 p.m.Igniting the Flame of Inflammation Through Cardiomyocyte CaMKII
Joan Heller Brown, University of California San Diego, La Jolla, California
4:15 p.m.Oral Abstract Presentation
NLRP3 Inflammasome Mediates the Obesity-induced Pathogenesis of Atrial Fibrillation
Larry Scott Jr., Baylor Coll of Med, Houston, TX
4:30 p.m. – 7:00 p.m.
Poster Session 3 and Reception
7:00 p.m.
BCVS Council Dinner

Thursday, Aug. 2 - BCVS
7:00 a.m.Registration
7:00 a.m.Continental Breakfast
8:00 a.m. – 9:00 a.m.
General Session 13: Basic Science and Precision Medicine – The Interface
8:00 a.m.Big Data and Health
Michael P. Snyder, Stanford University, Stanford, California
8:20 a.m.TBD
Ioannis Karakikes, PhD, Stanford University, Palo Alto, California
8:40 a.m.Human iPSC as Tools for Guiding Patients Out of the Genetic Purgatory
Bjorn C. Knollman, MD, PhD, Vanderbilt University, Nashville, Tennessee
9:00 a.m. – 9:30 a.m.
Refreshment Break, Exhibits
9:30 a.m. – 10:45 a.m.
General Session 14: Metabolic Pathways to Cardiovascular Disease
9:30 a.m.Signaling Pathways Downstream of Mitochondrial Dynamics
E. Dale Abel, MD, PhD, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa
9:50 a.m.Metabolic Dysregulation in Cardiovascular Disease
Svati H. Shah, MD, Duke University Medical Center, Durham, North Carolina
10:10 a.m.TBD
Deborah Muoio, PhD, Duke University, Durham, North Carolina
10:30 a.m.Oral Abstract Presentation
Aberrant Caesin Kinase 2 Signalling Predisposes the Heart to an Apoptotic Phenotype in Type 2 Diabetes 
Melanie Y White, Univ of Sydney, Sydney, Australia
10:45 – 11:45 a.m.
General Session 15: Novel Cardiac Regulatory Mechanisms
10:45 a.m.Downregulation of Cardiac Sympathetic Tone in Heart Failure
David J. Lefer, PhD, Louisiana State University, New Orleans, Louisiana
11:05 a.m.mAKAP: A Master Regulator of Cardiac Hypertrophy
Kimberly Dodge-Kafka, PhD, University of Connecticut Health Center, Farmington, Connecticut
11:25 a.m.Role of NF2 in Cardiac Injury
Dominic Del Re, PhD, Rutgers New Jersey Medical School, Newark, New Jersey
11:45 a.m.
Closing Remarks / Conference Adjourns

About this Meeting

The 14th annual BCVS 2018 Scientific Sessions has become the premier conference for molecular cardiovascular biology and disease. Sponsored by the American Heart Association Basic Cardiovascular Sciences Council, the world’s leading organization of cardiovascular scientists, the conference attracts leading researchers in fields such as microRNAs, cardiac gene and cell therapy, cardiac development and most recently tissue engineering and iPS cells.

The planned agenda includes 15 fast-paced sessions during 3½ days, set in a forum that promotes the relaxed exchange and discussion of cutting edge research in molecular and translational cardiovascular biology and disease. The program includes a diversity of speakers representing the best cardiovascular scientists from around the world.

In addition, the symposium will be of great value to scientists and executives of pharmaceutical companies and biotechnology firms who are in the cardiovascular space.

Target Audience

  • Basic cardiovascular scientists
  • Molecular/cellular biologists
  • Physiologists
  • Translational investigators
  • Clinical trialists
  • Practicing cardiologists
  • Cardiovascular nurses and pharmacists

Learning Objectives

At the conclusion of the conference, participants will be able to:
  1. Discuss advances in the underlying mechanisms that contribute to pathological cardiac remodeling and development of targeted therapeutic strategies to improve outcomes for patients with CVD.
  2. Evaluate the most recent evidence on the pathophysiological mechanisms underlying myocardial perfusion injury, supporting the use of cardioprotective strategies, including advances in oxidative stress-activated mechanisms in CVD pathophysiology.
  3. Discuss recent advances in understanding the complex interplay between signal transduction cascades in modulating apoptotic and functional pathways (mitochondrial, ion channels, metabolism) to identify novel drug targets and preserve functional cardiac myocytes.
  1. Describe current research exploring the integrated role of novel "omics" technologies and "big data" analytics that may allow for precision medicine and may improve patient outcomes by examining more holistically the pathophysiological mechanisms underlying cardiovascular function.
  2. Discuss the importance of state-of-the-art clinically relevant reprogrammed human cellular and large animal model systems, including the challenges to bridge the gap between basic science and clinical application of these modalities for improving translational research and outcomes in patients with CVD.
  3. Discuss challenges and issues arising regarding the pursuit of cardiovascular research, including future research directions, issues of responsibility in research and the move towards translation into clinical practice.
  4. Describe recent and emerging advances into the genetic and molecular mechanisms driving cardiomyopathy and heart failure that are guiding the development of interventions such as targeted gene therapy and regenerative stem cell therapy.