Programming – BCVS Scientific Sessions

9:00 – 9:15
Immune cell imaging in cardiovascular disease
Kory Lavine, MD, PhD, Washington University in St. Louis, USA

9:15 – 9:30
T cell activation and cardiac remodeling
Pilar Alcaide, PhD, University of Miami, USA

9:30 – 9:45
Immune cell landscape in myocarditis
Pilar Martin, PhD, CNIC, Spain

9:45 – 10:00
Cart-T therapy for atherosclerosis
Robert Schwab, MD, University of Pennsylvania, USA

10:00 – 10:15
The role of monocyte mitochondria in propagating sterile inflammation in heart failure patients
Dennis Wang, MD, University of Washington, USA

10:15 – 10:45
BREAK

10:45 – 11:00
Macrophages as disease drivers in heart failure
Sumanth Prabhu, MD, Washington University in St. Louis, USA

11:00 – 11:15
Metabolic regulation of innate immunity in cardiac injury and repair
Alan Mouton, PhD, University of Mississippi Medical Center, USA

11:15 – 11:30
Targeting mitochondria genome for heart failure therapy
Matthew Walker, PhD, University of Washington, USA

11:30 – 11:45
Immunofibrotic axis in heart failure
Burkhard Ludewig, MD, PhD, University Hospital Zurich, Switzerland

12:00-1:00 Registration
Location: Meeting Planners Office, Level 2

1:00-4:00 – Breakout Sessions
Location: Level 3

SAHR

Chromatin Remodeler Regulation of Cell Fate in Cardiogenesis
Swetansu K Hota, PhD, Assistant Professor, Indiana University, USA

Mapping Genomic and Transcriptomic Remodeling in Ischemic Heart Disease at Single-Cell Resolution
Sangitha Choudary, PhD, Assistant Professor, Harvard Medical School, USA

The Redox Paradox in Heart Failure: When Biology Outpaces Therapeutics
Vinod Kumar, MD, DM, Associate Professor, Department of Cardiology, SRIHER, India

Macrophage metabolism and cardiovascular disease.
Partha Datta, DVM, PhD, Professor, University of Pittsburgh, USA

Considerations for Gene Therapy for Duchenne Muscular Dystrophy
Asuka Eguchi, PhD, Assistant Professor, University of California Irvine, USA

ACRE

Centrosome Dynamics in Cardiomyocyte Proliferation and Maturation
Lu Han, PhD, Department of Pediatrics, Medical College of Wisconsin, USA

Inflammation-Induced Cardiac Remodeling and Arrhythmogenesis
Xun Ai, MD, Department of Physiology and Cell Biology, The Ohio State University, USA

Engineered human cardiac organoids for heart repair
Ying Mei, PhD, Department of Bioengineering, Clemson University, USA

Splicing regulation of angiogenesis
Ziqing Liu, PhD, Department of Physiology, Medical College of Wisconsin, USA

KICS

• Il-man Kim, PhD, Indiana University School of Medicine, USA
• Chul-Hwan Lee, PhD, Seoul National University, Korea
• Bong Sook Jhun, PhD, University of South Florida, USA
• Youngkeun Ahn, MD, PhD, Chonnam National University, Korea
• Yi Hong, PhD, University of Texas, Arlington (ACRE guest speaker)

JCRA

• Arata Sano, MD, PhD, Boston Children's Hospital
• Hiroko Wakimoto, MD, PhD, Harvard Medical School
• Tadashi Yamamuro, MD, PhD, Beth Israel Deaconess Medical Center
• Harpreet Singh, PhD, Ohio State University

4:30-6:00 – Poster Session
Location: Back Bay Ballroom, Level 2

7:00-10:00 – ACS Dinner
Location: Grand Ballroom, Level 2

9:15-9:27 am
Cardiomyocyte Specific Deletion Of Cdk8 Leads To Cardiac Dysfunction And Premature Lethality
Kayla Henry, BS, University of Iowa, USA

9:27-9:39 am
Direct Mitochondrial Lactate Import Enables Cardiac Metabolic Flexibility During Stress
James Carrington, BA, University of Utah, USA

9:39-9:51 am
Understanding the spatial and temporal regulation of the βIV-spectrin/STAT3 complex in ischemic cardiac remodeling with spatial transcriptomics
Rebecca Shaheen, BS, The Ohio State University, USA

9:51-10:03 am
Cardiac Polyamine Metabolism in Heart Failure
Jialiu Liang, BS, University of Pennsylvania, USA

10:03-10:15 am
Desmoplakin Loss Leads to PKC- and Src-Mediated Contractile Dysfunction in Cardiomyocytes
Ilhan Gokhan, BSE, Yale University, USA

10:45-10:57 am
Cardiomyocyte Alignment as a Determinant of Cardiomyocyte Function and Health
Alok Kumar, BSC, MSc, MS, PhD, Massachusetts General Hospital, USA

10:57-11:09 am
Carbonic anhydrase inhibition attenuates cardiac amyloid-β pathology and rescues BDNF signaling deficits, improving heart function in the Tg2576 Alzheimer’s mouse model
Andrea Elia, PhD, Temple University, USA

11:09-11:21 am
Targeting Acetyl-CoA Carboxylase 2 Ameliorates Heart Failure with Preserved Ejection Fraction
Yajun Wang, PhD, University of Washington, USA

11:21-11:33 am
Genetic and Functional Evidence of Cerebral Cavernous Malformation 2 Regulates Vascular Inflammation and Reduces Early Coronary Atherosclerosis
Shi Fang, PhD, Brigham and Women’s Hospital, USA

11:33-11:45 am
Pathogenesis of acquired left ventricle non-compaction
Luqi Zhao, MD, MS, University of Houston, USA

Speakers:
1:30-1:50
How titin springs orchestrate cardiac structure and function: Lessons from an in vivo cleavage model
Wolfgang A Linke, PhD, University of Münster, Germany

1:50-2:10
Stretch and relax: Modulation of strain dependent cross bridge detachment by MyBP-C
Samantha Harris, PhD, University of Arizona, USA

2:10-2:30
Molecular Regulation of Sarcomere Function in Cardiomyopathies
Farid Moussavi-Harami, MD, University of Washington, USA

2:30-2:45
Titin N2A–MARP1 Tethering Regulates Passive Tension and Cardiac Function
Robbert van der Pijl, PhD, University of Arizona, USA

Speakers:
3:15-3:35
Obesity-metabolic Syndrome and HFpEF
David A Kass, MD, Johns Hopkins University School of Medicine, USA

3:35-3:55
Pulmonary hypertension and right heart failure
Kurt Prins, MD, PhD, Medical University of South Carolina, USA

3:55-4:15
Cardiokines, diabetes and ischemic heart failure
Yajing Wang, MD, PhD, The University of Alabama at Birmingham, USA

4:15-4:30
Cytoplasmic RBM20 granules are sufficient to drive severe dilated cardiomyopathy
Zachery Gregorich, PhD, University of Wisconsin, USA

4:30-4:45
FAP-CAR iNKT Cells Penetrate the Plaque Microenvironment to Mitigate Atherosclerotic Progression
Enbo Zhu, PhD, University of California Los Angeles

Speakers:
8:00-8:20
Hypertrophic cardiomyopathy
Christine Seidman, MD, Harvard University, USA

8:20-8:40
TBD
Da-Zhi Wang, PhD, University of South Florida, USA

8:40-9:00
Mechanistic insight into cardiac growth and hypertrophy
Junichi Sadoshima, PhD, MD, Rutgers Health New Jersey Medical School, USA

9:00-9:15
Isoform-Specific BRD4 Epigenetic Reader Programs Uniquely Govern Cardiac Homeostasis and Hypertrophy
Anip Anand, BS, MS, UT Southwestern, USA

9:45-10:05
Endocardial derived fibroblast subpopulation in pressure overload-induced fibrosis
Bin Zhou, MD, PhD, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

10:05-10:25
Chromatin remodeling as a driver of fibroblast activation
Michael Alexanian, PhD, University of California San Francisco, USA

10:25-10:45
Sex differences in cardiac fibrosis
Katarzyna A Cieslik, PhD, Houston Methodist Research Institute, USA

10:45-11:00
METTL3-mediated fibronectin mRNA m6A methylation promotes cardiac fibrosis following myocardial ischemia
Roshan Dutta, PhD, University of Alabama at Birmingham, USA

Speakers:
1:30-1:50
Zebrafish heart development and regeneration
Caroline Burns, PhD, Harvard University, USA

1:50-2:10
Long distance cell-cell communication in ventricular wall formation
Mingfu Wu, PhD, University of Houston College of Pharmacy, USA

2:10-2:30
An unexpected role of Zip8, a zinc importer, during early myocardial morphogenesis
Deqiang Li, MD, PhD, Nationwide Children’s Hospital, USA

2:30-2:45
Spatiotemporal Mechanisms of Ventricular Chamber Development in Human Fetal Hearts
Arushi Samal, BS, Icahn School of Medicine at Mount Sinai, USA

3:15-3:35
Organ on Chip Modeling of Heart Disease
Gordana Vunjak-Novakovic, PhD, Columbia University, USA

3:35-3:55
FRESH 3D cardiac bioprinting
Adam W Feinberg, PhD, Carnegie Mellon University, USA

3:55-4:15
Gene Circuits In Cardiac Development
Laurie Boyer, PhD, Massachusetts Institute of Technology, USA

4:15-4:30
An Evolutionary Conserved Cardiomyocyte Population Promotes Heart Regeneration
Kathryn Berg, PhD, Boston Children’s Hospital, USA

8:00-8:20
Engineering Smart Delivery Systems for Cardiovascular Therapeutics
Daniele Catalucci, PhD, National Research Council, Institute of Genetic and Biomedical Research, Italy

8:20-8:40
Human Cardiac Organoids as Translational Platforms for Cardiovascular Disease
Aitor Aguirre, PhD, Michigan State University, USA

8:40-9:00
Transcriptional Rewiring as Therapy: CRISPRa in Cardiac Disease
Laura Zelarayán-Behrend, PhD, University Medical Center Göttingen, Germany

9:00-9:15
Identification and in vivo validation of chamber-specific cardiac markers for therapeutic targeting
Robin Perelli, PhD, Stanford University, USA

Speakers:
9:45-10:00
Immune-Electrical Crosstalk: How Cardiac Inflammation Shapes Arrhythmia Mechanisms
Matthias Nahrendorf, MD, PhD, Harvard University, USA

10:00-10:20
Novel Neural Mechanisms Underlying Ventricular Arrhythmias
Olujimi A Ajijola, MD, PhD, David Geffen School of Medicine at UCLA, USA

10:20-10:45
Cardiac Radiation Therapy as Mechanism to Circumvent Cardiac Arrhythmias
Stacey Rentschler, MD, PhD, Washington University in St. Louis, USA

10:45-11:00
LMNA Mutation Drives Electromechanical Remodeling and Arrhythmogenicity in Human iPSC-Derived Cardiac Microtissues
Janay Walters, BS, University of Wisconsin-Madison, USA

11:00-11:20
Trained Macrophages Drive Maladaptive Remodeling Following Recurrent Cardiac Injury
Shibali Das, PhD, Washington University in St. Louis, USA

11:20-11:40
Association of RANBP2 and VDAC1 at the Nuclear Pore Complex regulates nuclear energetics and cardiomyocyte differentiation
Ivan Menendez-Montes, PhD, University of Arizona, USA

11:40-12:00
Nascent Matrix Targeted Interleukin-4 Bolsters Cardiac Repair After Myocardial Infarction
Noor Momin, PhD, University of Pennsylvania, USA

Panelists:
Eric Adler, MD, Myoventive, USA
Sek Kathiresan, MD, Eli Lilly and Company; Verve Therapeutics, USA
Leslie Leinwand, PhD, University of Colorado Boulder, USA
Christopher J. O'Donnell, MD, MPH, Novartis, USA
Milica Radisic, PhD, University of Toronto, Canada
Christine Seidman, MD, Harvard University, USA
Joseph Wu, MD, PhD, Stanford University, USA
Linda Yu, PhD, American Heart Association, USA

Speakers:
1:30-1:50 pm
Clonal Hematopoiesis or Update on Inflammation in Atherosclerosis
Peter Libby, MD, Brigham and Women’s Hospital, USA

1:50-2:10pm
Immune Checkpoint Inhibitor Myocarditis: From Immune Dysregulation to Precision Cardio-Oncology
Han Zhu, MD, Stanford University, USA

2:10-2:30pm
Lifestyle and genetic interactions in atherosclerosis
Cameron McAlpine, PhD, Icahn School of Medicine at Mount Sinai, USA

2:30-2:45pm
Single cell atlas of Chagas Cardiomyopathy
Gabriela Venturinida Silva, PhD, Harvard University, USA

Speakers:
3:15-3:35
BCAA Metabolism in Healthy Longevity: From Mechanism to Intervention
Yibin Wang, PhD, Duke-NUS Medical School, Singapore

3:35-3:55
Identifying Links Between Cardiac Metabolism and Cancer
Anja Karlstaedt, MD, PhD, Cedars-Sinai Medical Center, USA

3:55-4:15
TBD
Orian Shirihai, MD, PhD, University of California, Los Angeles, USA

4:15-4:30
One carbon metabolism defect in human failing hearts
Jae Woo Jung, PhD, University of Pennsylvania, USA

8:00-8:20
Class IIa HDAC signaling in cardiometabolic disease
Johannes Backs, MD, Institute of Experimental Cardiology Heidelberg University Hospital, Germany

8:20-8:40
Mitochondria orchestrate tissue remodeling in HFpEF hearts
Rong Tian, MD, PhD, University of Washington, USA

8:40-9:00
Inhibiting Hippo Signaling in Ischemic Heart Failure
James F Martin, MD, PhD, Baylor College of Medicine, USA

9:00-9:15
Engineered Small Nuclear RNAs Reduce Toxic CUG Repeat RNA foci in Myotonic Dystrophy Cardiomyocytes
Nicole Lopez, MS, University of California San Diego, USA

9:45-10:05
A multipotent cell type from term human placenta
Hina Chaudhry, MD, Mount Sinai, USA

10:05-10:25
Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function
Raj Kishore, PhD, Temple University, USA

10:25-10:45
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
Kristin Stanford, PhD, The Ohio State University, USA

10:45-11:00
Post-transcriptional Regulation of Adrenal-Heart Crosstalk in Heart Failure with Preserved Ejection Fraction
Francisca Omokhefe Akhigbe, DVM, University of Cincinnati, USA