Pre-proposal (required letter of intent) due by Thursday, December 1, 2022
Full applications will be by invitation only and will be due by Thursday, March 9, 2023
- Proposals must be received no later than 3 p.m. Central Time on the deadline date. Early submission is encouraged.
- Potential applicants should review the Features of All AHA Awards on the AHA Application Information page for answers to commonly asked questions about eligibility and award details
- All proposals must be submitted electronically via ProposalCentral. The system will open eight weeks prior to the application deadline to complete your proposal and upload documents. You can begin to create your documents now; please refer to the AHA Application Instructions (PDF).
- Applicants invited to submit full proposals must be AHA Professional Members at the time of application. This must be done online. Join or begin the membership process well before the deadline. This requirement is not applicable for the pre-proposal.
To foster innovative collaborative approaches to research projects that propose novel pairings of investigators from at least two broadly disparate disciplines. The proposal must focus on the collaborative relationship, such that the scientific objectives could not be achieved without the efforts of at least two co-principal investigators and their respective disciplines.
The combination and integration of studies may be inclusive of basic, clinical, population, behavioral, and/or translational research. Projects must include at least one Co-PI from a field outside cardiovascular and cerebrovascular disease.
This award is also intended to foster collaboration between established and early- or mid-career investigators.
Applications by existing collaborators are permitted, provided that the proposal is for a new and novel idea or approach that has not been funded before.
An application must be submitted jointly by at least two co-principal investigators, but no more than four.
- At least one Co-PI must work in cardiovascular or cerebrovascular-related research.
- At least one Co-PI must work in a divergent/disparate discipline (e.g. engineering, computer science, chemistry, mathematics, psychology, health law, etc.) and/or without prior focus in cardiovascular or cerebrovascular-related research.
- At least one Co-PI must be an early-career (assistant professor or equivalent) or mid-career (associate professor or equivalent) investigator.
- Co-PIs must each hold faculty/staff appointments.
- Co-PIs must be independent researchers (i.e. must meet their institutions’ eligibility to apply for independent awards). This award is not intended for individuals in research training or fellowship positions.
- Co-PIs may be from the same institution, or from different institutions.
- Co-PIs must be from different disciplines and/or areas of expertise. For example: A collaboration between a clinician and a basic scientist or other collaboration that would not arise otherwise (organically).
- Examples of partnerships that have been funded:
- A materials scientist with no previous cardiovascular or cerebrovascular-related research collaborating with an interventional cardiac electrophysiologist;
- A synthetic biologist collaborating with a cardiac biologist;
- A chemist specializing in RNA molecular biology collaborating with a practicing neonatologist with research in cell signaling, hemostasis and thrombosis;
- A kidney disease/ciliopathy researcher collaborating with a clinical researcher in genetic causes of bicuspid aortic valve disease and a basic science researcher also studying genetic valvular diseases.
- The applicants should adequately convey that they are of equal stature in the project.
- If more than three co-PIs are proposed, the applicants should provide clear evidence that they are equal co-PIs. If this will not be the case, then the applicants should classify additional personnel as collaborating investigators or consultants.
- Each Co-PI must hold an M.D., Ph.D., D.O., D.D.S., D.V.M. or equivalent post-baccalaureate terminal (highest-level) degree in his/her discipline.
- One of the Co-PIs’ institutions must be designated as the institution of record, agreeing to sponsor the application and accept award payments and ensuring that annual progress reports and expenditure reports are submitted to AHA.
While no minimum percent effort is specified, the Co-PIs must demonstrate that adequate time will be devoted to ensuring the successful completion of the proposed project.
$250,000 per year, including 10% institutional indirect costs.
The award may be used for salary and fringe benefits of the Co-principal investigators, collaborating investigator(s), and other participants with faculty appointments, consistent with percent effort, and for project-related expenses, such as salaries of technical personnel essential to the conduct of the project, supplies, equipment, computers/electronics, travel (including international travel), volunteer subject costs, data management, and publication costs, etc.
Award Duration: Three years
Total Award Amount: $750,000
Pre-proposal (required letter of intent)
A pre-proposal is required to ensure responsiveness to the novel, collaborative nature of this program. Only applicants who are invited by the AHA will submit a full application.
Applicants to the Collaborative Sciences Award program will submit one application jointly.
- Applicants must determine which of their respective institutions will administer the project (if applicants are from more than one institution). The Co-Principal Investigator from the institution that will administer the award should initiate the application process. The investigator who initiates the application will be considered the administrative Co-Principal Investigator on the application.
- The Co-Principal Investigator who initiates the application in ProposalCentral must add the names of the other Co-Principal Investigator(s) in the application. The Collaborative Sciences Team is limited to four Co-Principal Investigators.
- Each Co-Principal Investigator will receive an email invitation to join the application. This email is specific to the receiving investigator and should not be shared. A Co-Principal Investigator who does not receive an email from ProposalCentral should call 214-360-6107 (option 1) .
- Once joined to the application, each Co-Principal Investigator must review and update their own Advanced Profile and upload a biosketch. Each biosketch has a 5-page limit.
- The initiating Co-PI will upload a pre-proposal (three pages maximum) describing an innovative, collaborative approach to research that incorporates a novel grouping of investigators from at least two widely disparate disciplines and/or areas of expertise. The written summary must focus on the collaborative relationship of the investigators, such that the scientific objectives cannot be achieved without the efforts of at least two co-principal investigators and their respective disciplines and expertise. The combination and integration of studies may be inclusive of basic, clinical, population, behavioral, and/or translational research.
The novel relationship and proposed collaboration of investigators from at least two widely disparate disciplines will be given the most weight in evaluating the pre-proposal to determine which teams will be invited to submit full applications.
Pre-proposals to the Collaborative Sciences Award will be assigned to a group of multidisciplinary reviewers and may be reviewed by someone working in a related area and/or experts directly related to an applicant’s science area. The pre-proposal should be appropriate for reviewers who have a broad knowledge of the scientific area.
- An applicant may be the Co-PI on only one Collaborative Sciences Award application per deadline.
- A Collaborative Sciences awardee may also apply for or hold another AHA research award (e.g., Established Investigator Award, Innovative Project Award, Transformational Project Award, AHA Institutional Research Enhancement Award, or Career Development Award) and may be the program director or sponsor on an AHA Institutional Undergraduate Fellowship Program award.
- Strategically Focused Research Network personnel may hold individual AHA awards, including a Collaborative Sciences Award.
- Awards are not intended to supplement or duplicate currently funded work. Rather, it is expected that submitted applications will describe projects that are clearly distinct from ongoing research activities. Minor variations from existing research projects are not sufficient to constitute independent and distinct projects.
Peer Review Criteria (for invited applicants)
Contacting AHA peer reviewers concerning your application is deemed a form of scientific misconduct and will result in the removal of your application from funding consideration and institutional notification of ethical concerns.
To judge the merit of the application, reviewers will comment on the following criteria.
The proposal must expand on the pre-proposal (letter of intent) detailing the collaborative relationship, such that the scientific objectives cannot be achieved without the efforts of at least two co-principal investigators and their respective disciplines. The combination and integration of studies may be inclusive of basic, clinical, population, behavioral, and/or translational research.
1. Collaboration: It is incumbent upon the applicants to convey the highly novel nature of their relationship. Are the investigators from at least two widely disparate disciplines and/or areas of expertise? How does the proposed collaborative relationship strengthen or weaken the proposal? Does the proposal focus on the collaborative relationship, such that the proposed objectives could not be reached without the efforts of both principal investigators and both (or all) disciplines? Does the effort of each Co-PI reflect proper equity in the project?
2. Investigators and Environment:
Investigators: Does the investigative team bring diverse, complementary, and integrated expertise to the project? Are the investigators appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience levels of the principal investigators and other researchers? How does the investigators’ previous work (which is not required to be directly related to cardiovascular or cerebrovascular disease) strengthen and ensure the project’s success?
Environment: Does the environment in which the work will be done contribute to the probability of success? Does the proposal benefit from unique features of the investigative environment(s), or subject populations, or employ useful collaborative arrangements?
3. Significance: Does this study address an important problem broadly related to cardiovascular or cerebrovascular disease? If the aims of the application are achieved, how will scientific knowledge or clinical practice be advanced? What will be the effect of these studies on the concepts, methods and technologies that drive this field?
4. Approach: Are the conceptual framework, design, methods and analyses adequately developed, well-integrated, well-reasoned, feasible (as determined by preliminary data), and appropriate to the aims of the proposal? Is the project scope likely to be completed within the award period? Does the applicant acknowledge potential problem areas and consider alternative tactics?
5. Innovation: Is the proposal original and innovative? For example: Does the proposal challenge existing paradigms and address an innovative hypothesis or critical barrier to progress in the field? Will the project foster or employ novel concepts, approaches, methodologies, tools or technologies for this area? How does the diversity of disciplines and/or expertise of the collaborators make the innovation possible?
6. Impact: Applications for research funding will be assessed for their potential impact on the AHA Mission, and on the applicant’s ability to effectively describe the proposal and its potential outcomes to non-scientists. This potential impact assessment will be based primarily on the Summary for Non-scientists. This assessment will be factored into the Impact peer review criterion, which will account for 5-10% of the overall priority score.
AHA Awardees: Register for a Precision Medicine Platform Workspace
The AHA Precision Medicine Platform provides users with a secure cloud computing workspace equipped with analytical tools via a friendly web user interface. The tools allow you to write code in various languages (e.g., Python, R, SAS, and more), execute the code, and view results as they are processed. These software packages range from machine learning, statistical analysis, data analysis, visualization, and genomic and bioinformatic tools. Researchers can also upload their own software. View a complete list of languages, packages, and kernels available.
As an awardee of the AHA, you are encouraged to request a workspace and are eligible for cloud computing credits at no cost during the term of your AHA award.
Take advantage of this offer to learn how to use a cloud computing platform. Learning to use the Precision Medicine Platform with free cloud computing credits will put you in a strong position for more AHA and NIH funding.