Science News from ESC 2023

STEP-HFpEF - Once-weekly semaglutide in people with HFpEF and obesity

Circulation Editor-in-Chief Nancy Sweitzer, MD interview investigator Mikhail Kosiborod, MD about the results of STEP HFpEF, which found that weekly administration of 2.4 mg semaglutide resulted in more pronounced decreases in HF–related symptoms and physical constraints, along with a higher level of weight loss compared to the placebo over the course of 52 weeks.

COP-AF - Colchicine for the prevention of perioperative atrial fibrillation after major thoracic surgery

Jose Joglar, MD interviews investigator David Conen, MD MPH about the results of the COP-AF trial which found that colchicine did not significantly reduce incidence of co-primary outcomes of clinically important AF or MINS in patients undergoing major noncardiac thoracic surgery.
A still frame from a video about the COP-AF Trial presented at ESC 2023 in August, 2023.

QUEST - Qiliqiangxin in patients with heart failure and reduced ejection fraction

Presenter: Xinli Li | The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
This is a thumbnail image of theQUEST trial summary. To read the entire slide, download the PowerPoint slide.

ECLS-SHOCK - venoarterial membrane oxygenation in cardiogenic shock

Manesh Patel, MD interviews investigator Holger Thiele, MD about the results of ECLS-SHOCK, which found that adding extracorporeal life support (ECLS) did not improve 30-day all-cause mortality outcomes in patients presenting with acute myocardial infarction and cardiogenic shock compared to standard medical care.

STOPDAPT-3: An Aspirin-Free antithrombotic strategy for percutaneous coronary intervention

Presenter: Masahiro Natsuaki | Saga University, Saga, Japan
This is a thumbnail image of the STOPDAPT-3 trial summary. To read the entire slide, download the PowerPoint slide.

The FRAIL-AF randomized controlled trial

Presenter: Linda Joosten| Julius Center for Health Sciences and Primary Care, Ulrecht, The Netherlands
This is a thumbnail image of the FRAIL-AF trial summary. To read the entire slide, download the PowerPoint slide.