Programming – Vascular Discovery 2024

Vascular Discovery 2024 Schedule-at-a-Glance

All times are Central Daylight Time (CDT, GMT -5)

Wednesday, May 15
Wed., May 15 schedule
Time Activity
8:00 a.m. to 6:00 p.m. Vascular Research Initiatives Conference(link opens in new window)
This event is not part of the official Vascular Discovery Scientific Sessions as planned by the Program Committee.
Separate registration is required to attend.

3:00 p.m. to 7:00 p.m. Vascular Discovery Scientific Sessions Registration
6:30 p.m. to 8:00 p.m. Poster Session 1 & Reception
Thursday, May 16
Thu., May 16 schedule
Time Activity
7:00 a.m. to 6:00 p.m. Registration, Exhibits
7:00 a.m. to 8:00 a.m. Morning Coffee
7:00 a.m. to 8:00 a.m. Early Career Training Session 1 – Academic Roundtables

7:00 - Getting Your Training Grant Funded
Bishuang Cai, PhD, Icahn School of Medicine at Mt. Sinai
Casey Romanoski, PhD, The University of Arizona

7:00 - Saying No and Difficult Conversations
Robert Bauer, PhD, Columbia University
Jaume Amengual, PhD, University of Illinois

7:00 - Setting Up Your Lab, Hiring and Switching Universities
Brian Kim, MD, Stanford University

7:00 - The Importance of Mentoring and Being Mentored
Mabruka Alfaidi, MD, PhD, LSU Health Sciences Center-Shreveport
Jesse Williams, PhD, University of Minnesota Medical School

7:00 - Work-Life Balance
Mireille Ouimet, PhD, University of Ottawa Heart Institute
Gregory Payne, MD, PhD, University of Alabama at Birmingham

7:00 - Strategies for Project Management
Cynthia St. Hillaire, PhD, FAHA, University of Pittsburgh

8:00 a.m. to 8:30 a.m.

Conference Opening Welcome

8:00 Welcome Remarks from AHA President
Joseph C. Wu, MD, PhD, FAHA, Stanford University

8:15 Welcome Remarks from the Program Chair
Kathleen Martin, PhD, Yale University

8:30 a.m. to 10:00 a.m.

Plenary Session 1: Hot Topics in Cardiovascular Disease
Moderators: Kathleen Martin, PhD, and Peter Henke, MD

8:30 Complementing Human Organoids for Vascular Discovery
Takanori Takebe, MD, PhD, Cincinnati Children’s Hospital Medical Center

9:00 Clonal hematopoiesis, aging, and CVD
Kenneth Walsh, PhD, FAHA, University of Virginia

9:30 Functional Multiomics to Identify Genetic Mechanisms Underlying Atherosclerosis
Minna Kaikkonen-Maata, PhD, A.I.Virtanen Institute, University of Eastern Finland

10:00 a.m. to 10:30 a.m. BREAK/Exhibits
10:30 a.m. to 12:15 p.m.

Concurrent Session 1a: Molecular and Cellular Mechanisms of Atherosclerosis

10:30 Title TBA
Muredach Reilly, MD, Columbia University

11:00 100 - Omics Strategies To Identify Senescent Cells Mediating Extracellular Matrix Remodeling During Vascular Disease
Allison B Herman, Krystyna Mazan-Mamczarz, Natl Inst on Aging, Baltimore, MD; Dimitrios Tsitsipatis, Natl Insts of Health, Baltimore, MD; Bennett Childs, Mayo Clinic, Rochester, MN; Darren J Baker, Mayo Clinic, Rochester, MN; Carla Rocha Dos Santos, Olga Fedorova, Myriam Gorospe, Natl Inst on Aging, Baltimore, MD

11:15 101 – The Smooth Muscle-specific Long Non-coding RNACarmnIs Critical For Maintaining Vascular Smooth Muscle Contractility
Xiangqin He, Anil Sakamuri, Guoqing Hu, Augusta Univ, Augusta, GA; Kunzhe Dong, Augusta Univ, Martinez, GA; Benard O Ogola, Medical Coll of Georgia-Augusta, Augusta, GA; Michael Brands, David Fulton, Jiliang Zhou, Augusta Univ, Augusta, GA

11:30 102 - Trained Immunity Impairs Inflammation Resolution And Dampens Efferocytosis
Azuah L Gonzalez, Katherine Gu, Vanderbilt University, Nashville, TN; Matthew Mayes Dungan, Vanderbilt Univ, Nashville, TN; Blenda Wong, Harvard Medical School, Boston, MA; Kristin Fuller, Vanderbilt Univ, Nashville, TN; Danielle L Michell, Vanderbilt University Medical Center, Nashville, TN; Jamshed Rahman, Vanderbilt Univ, Nashville, TN; Matthew R Spite, Harvard Medical School, Boston, MA; Kasey C Vickers, Vanderbilt University Medical Center, Nashville, TN; Jonathan D Brown, Vanderbilt, Nashville, TN; Amanda C Doran, Vanderbilt University Medical Center, Nashville, TN

11:45 103 - Acly Inhibition As A Novel Therapeutic Approach For Vascular Remodeling In Coronary Artery Disease
Yann Grobs, Charlotte Romanet, Sarah-Eve S Lemay, Alice Bourgeois, CRIUCPQ, Quebec, QC, Canada; Charlie Theberge, CRIUCPQ-ULaval, Quebec, QC, Canada; Melanie Sauvaget, Sandra Breuils-Bonnet, Sandra Martineau, Reem El Kabbout, Francois Potus, CRIUCPQ, Quebec, QC, Canada; Pierre Voisine, IUCPQ, Quebec, QC, Canada; Steeve Provencher, Laval Univ, Quebec, QC, Canada; Olivier Boucherat, IUCPQ RESEARCH CENTRE, Quebec, QC, Canada; Sebastien Bonnet, Quebec Heart and Lung institute, Quebec, QC, Canada

12:00 104 - Endothelial Restoration Of CAD GWAS Gene PLPP3 By Nanomedicine Suppresses Mechano-sensitive YAP/TAZ Activity And Reduces Atherosclerosis In Vivo
Jiayu Zhu, Univ of chicago, Chicago, IL; Yun Fang, Univ of Chicago, Chicago, IL

10:30 a.m. to 12:15 p.m.

Concurrent Session 1b: Inflammation & Immunity in the Vessel Wall
Moderators: Bo Liu, PhD and Hanrui Zhang, PhD

10:30 Macrophages in Aortic Aneurysm
Bo Liu, PHD, University of Wisconsin-Madison

11:00 105 - Neutrophil Cracr2a Is Crucial For Calcium Signaling And Enhances Neutrophil Adhesive Function Under Thromboinflammatory Conditions
Jingu Lee, Brett Balzraine, Vasilisa Kuzmanova, Washington Univ Sch of Med, St. Louis, MO; Yousang Gwack, Univ of California Los Angeles, Los Angeles, CA; Deane Mosher, Univ of Wisconsin-Madison, Madison, WI; Jaehyung Cho, Washington Univ. Sch of Med, Saint Louis, MO

11:15 106 - Cd40 Is Required For B1b Cell Homeostasis In Atherosclerosis
Katrin Nitz, Dept of Cardiovascular Med and Immunology, Experimental Cardiovascular Immunology Lab, Mayo Clinic, Rochester, MN; Myrthe Reiche, Dept of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam Univ Medical Ctrs, Univ of Amsterdam, Amsterdam, Netherlands; Oom Pattarabajinard, Aditi Upadhye, Cardiovascular Div/Dept of Med, Beirne B. Carter Immunology Ctr, Univ of Virginia, Charlottesville, VA; Claudia van Tiel, Dept of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam Univ Medical Ctrs, Univ of Amsterdam, Amsterdam, Netherlands; Angela M Taylor, Cardiovascular Div/Dept of Med, Beirne B. Carter Immunology Ctr, Univ of Virginia, Charlottesville, VA; Stephen G Malin, Dept of Med and Ctr for Molecular Med, Karolinska Univ Hosp, Karolinska Instt, Stockholm, Sweden; Christoph J Binder, Dept of Lab Med, Medical Univ of Vienna, Vienna, Austria; Norbert Gerdes, Div of Cardiology, Pulmonology and Vascular Med, Medical Faculty and Univ Hosp Düsseldorf, Heinrich Heine Univ, Duesseldorf, Germany; Cornelia M. Weyand, Dept of Cardiovascular Med and Immunology, Experimental Cardiovascular Immunology Lab, Mayo Clinic, Rochester, MN; Christian Weber, Inst of Cardiovascular Prevention (IPEK), Ludwig-Maximilian’s Univ Munich, German Ctr of Cardiovascular Res (DZHK), partner site Munich Heart Alliance, Cardiovascular Res Inst Maastricht, Munich, Germany; Dorothee Atzler, Inst of Cardiovascular Prevention (IPEK), Ludwig-Maximilian’s Univ Munich, German Ctr of Cardiovascular Res (DZHK), partner site Munich Heart Alliance, Walter-Straub-Inst of Pharmacology and Toxicology, Munich, Germany; Coleen A McNamara, Cardiovascular Div/Dept of Med, Beirne B. Carter Immunology Ctr, Univ of Virginia, Charlottesville, VA; Esther Lutgens, Dept of Cardiovascular Med and Immunology, Experimental Cardiovascular Immunology Lab, Mayo Clinic, Rochester, MN

11:30 107 - Effects Of Immune-checkpoint Inhibitors On Atherosclerosis In Halted Progression Model
Burak T Cilhoroz, Dept of Med, Leon H Charney Div of Cardiology, New York Univ Grossman Sch of Med, NYU Langone Health, NYC, NY; Dayasagar Das, Letizia Amadori, Dept of Med, Leon H Charney Div of Cardiology, New York Univ Grossman Sch of Med, NYU Langone Health, NYC, NY, United States, New York, NY; Natalia Eberhardt, Dept of Med, Leon H Charney Div of Cardiology, New York Univ Grossman Sch of Med, NYU Langone Health, NYC, NY; Panagiotis Smyrnis, Dept of Med, Leon H Charney Div of Cardiology, New York Univ Grossman Sch of Med, NYU Langone Health, New York, NY; Morgane Gourvest, Dept of Med, Leon H Charney Div of Cardiology, New York Univ Grossman Sch of Med, NYU Langone Health, New York, USA, New York, NY; Michael Gildea, Dept of Med, Leon H Charney Div of Cardiology, New York Univ Grossman Sch of Med, NYU Langone Health, NYC, NY; Ravneet Kaur, Dept of Med, Leon H Charney Div of Cardiology, New York Univ Grossman Sch of Med, NYU Langone Health, New York, USA, New York, NY; Kathryn J Moore, NEW YORK UNIV MEDICAL CTR, New York, NY; Chiara Giannarelli, NYU Langone Health, New York, NY

11:45 108 - Inflammasome Activation Via BRCC3-mediated NLRP3 Deubiquitylation Promotes Atherosclerosis In Tet2 Clonal Hematopoiesis
Mustafa Yalcinkaya, Wenli Liu, Columbia Univ, New York, NY; TONG XIAO, Columbia Univ, NEW YORK, NY; Sandra Abramowicz, Nan Wang, Columbia Univ, New York, NY; Marit Westerterp, UNIVERSITY OF GRONINGEN, Groningen, Netherlands; Alan Tall, Columbia Univ, New York, NY

12:00 109 - Estrogen Receptor Alpha Inhibition Of Mineralocorticoid Receptor In Endothelial Cells As A Mechanism Of Protection From Atherosclerosis Inflammation
Nicole L Wolter, Alec Stepanian, Qing Lu, Joshua James Man, Iris Z Jaffe, Tufts Medical Ctr, Boston, MA

10:30 a.m. to 12:15 p.m.

Concurrent Session 1c: Endothelial Dysfunction in Thrombosis
Moderators: Alec Schmaier, MD, PhD, and Hasina Houttz Reed, MD, PhD

10:30 Regulation of Endothelial Procoagulant Activity by TMEM16 Proteins
Alec Schmaier, MD, PhD, Beth Israel Deaconess Medical Center

10:50 Genetic analysis of endothelial protease-activated receptors in disease contexts
Courtney Griffin, PhD, Oklahoma Medical Research Foundation

11:10 Presentation Title: TBD
Hasina Outtz-Reed, MD, PhD, Weill Cornell Medicine

11:30 110 - Pro-thrombotic BCR-ABL Tyrosine Kinase Inhibitors Ponatinib And Nilotinib, But Not The Novel Agent Asciminb, Impair Endothelial Cell Wound Healing
Richard James Travers, Alec Stepanian, Qing Lu, Gregory Martin, Iris Z Jaffe, Tufts Medical Ctr, Boston, MA

11:41 111- COL8A1 Modulates Endothelial Phenotype During Inflammatory Endothelial-to-Mesenchymal Transition
Qian Li, Sriharsha Talapaneni, Yonghong Meng, Linda L Demer, Yin Tintut, Jeffrey J Hsu, UCLA, Los Angeles, CA

11:52 112 - Endothelial Mixed Lineage Leukemia 1 (kmt2a/MLL1) As A Central Mediator Of Immunothrombosis During SARS-CoV-2 Infection
Nathaniel Parchment, Sriganesh Sharma, Kiran Kumar, Sabrina Rocco, Oscar Yesid Moreno, Univ of Michigan, Ann Arbor, MI; Catherine Luke, Hartland High Sch, Howell, MI; Katherine A Gallagher, UNIVERSITY MICHIGAN, Northville, MI; Peter Henke, UNIVERSITY MICHIGAN, Ann Arbor, MI; Andrea T Obi, UNIVERSITY OF MICHIGAN, Ann Arbor, MI

12:03 113 - Endothelial Argonaute 1: A Novel Regulator Of Hyperlipidemia And Atherosclerosis
Xuejing Liu, Dongqiang Yuan, Alonso Tapia, Yingjun Luo, Naseeb Kaur Malhi, Zhen Chen, CITY OF HOPE, Duarte, CA

12:15 p.m. to 2:00 p.m. The Mentor of Women Award Luncheon  - Presented by the ATVB Women's Leadership Committee (ticket required)

12:15 - Networking

12:30 - Thriving as Internationally Trained Scholars
Elena Aikawa, MD, PhD, Brigham and Women’s Hospital
Masanori Aikawa, MD, PhD, Brigham and Women’s Hospital

1:10 - Round Table Discussions
Masanori Aikawa, MD, PhD, Brigham and Women’s Hospital
Yabing Chen, PhD, University of Alabama at Birmingham
Alan Daugherty, PhD, University of Kentucky College of Medicine
Muredach Reilly, MD, Columbia University
Phil Tsao, PhD, Stanford University
Daisy Sahoo, PhD, Medical College of Wisconsin
Gissette Reyes-Soffer, MD, Columbia University
Shashi Kant, PhD, Harvard Medical School
Anberitha Matthews, PhD, Redefining Health

1:50 - Networking

or
PVD Annual Business Meeting & and Business Luncheon (ticket required)
Offsite at the Chicago Firehouse

or
Lunch on your own

2:15 p.m. to 3:45 p.m.  Plenary Session 2: Highlights from the ATVB Journal
Moderators: Yabing Chen, PhD, Hong Lu, MD, PhD, and Ravichandran Ramasay, PhD

2:15 - ATVB Journal Update
Ann Marie Schmidt, MD, NYU Langone Health

2:30 - Daniel Steinberg Early Career Investigator Award in Atherosclerosis/Lipoproteins: Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis
Partha Dutta, DVM, PhD, University of Pittsburgh

2:45 - Karl Link Early Career Investigator Award in Thrombosis: Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels
Maria Sabater-Lleal, PhD, Research Institute Hospital de la Santa Creu

3:00 - Werner Risau Early Career Investigator Award in Vascular Biology: Dedifferentiation and Proliferation of Artery Endothelial Cells Drive Coronary Collateral Development in Mice
Soumyashree Das, PhD, National Centre for Biological Sciences

3:15 - Presentation Title: TBA
Luisa Ireula-Arispe, PhD, Northwestern University Feinberg School of Medicine

3:45 p.m. to 4:15 p.m. Break/Exhibits 
4:15 p.m. to 6:00 p.m.

Concurrent Session 2a: Apolipoproteins, Lipoproteins, and Lipid Metabolism
Moderators: Brian Emmer, MD, PhD, and Thomas Vallim, PhD

4:15 Massively Parallel Interrogation of Lipoprotein Uptake Modifiers
Brian Emmer, MD, PhD, University of Michigan

4:45 114 - Inhibition Of Lecithin Cholesterol Acyl Transferase By A Novel Anti-apolipoprotein A1 Antibody Fragment
Bethany Coleman, Tabitha Cady, Univ of Cincinnati, Cincinnati, OH; Satchal Erramilli, Anthony Kossiakoff, Univ of Chicago, Chicago, IL; William Davidson, Univ of Cincinnati, Cincinnati, OH

5:00 115 - Scavenger Receptor-BI Mediates Endothelial Uptake Of Lipoprotein(a)
Ainara G Cabodevilla, Alimatou Bah, Waqas Younis, New York Univ Langone Health, New York, NY; M Mahmood Hussain, NYU Winthrop, Minoela, NY; Ira J Goldberg, NEW YORK UNIVERSITY, New York, NY; Narashima Anaganti, NYU Langone Long Island, Mineola, NY

5:15 116 - Apolipoprotein E Registry In Discoidal Lipoproteins Influences Uptake
Michael R Strickland, Brock Summers, Katherine Basore, John Wulf II, Hong Jiang, Washington Univ in Saint Louis, Saint Louis, MO; Mary G Sorci Thomas, MEDICAL COLLEGE OF WISCONSIN, Milwaukee, WI; Albert A Davis, Anil G Cashikar, David M. Holtzman, Gwendalyn J Randolph, Washington Univ in Saint Louis, Saint Louis, MO

5:30 117 - AIBP Deficiency Affects Inflammarafts Formation And Macrophage Reprogramming In Atherosclerosis
Shenglin Li, Univ of California, San Diego, San Diego, CA; Sooho Choi, UCSD, San Diego, CA; Juliana M Navia-Pelaez, Juliana Navia Pelaez, San Diego, CA; Yury I Miller, UNIV CALIFORNIA SAN DIEGO, La Jolla, CA

5:45 118 - Dennd5b Affects Dietary Lipid Absorption And Metabolism In Male And Female Mice
Khaga Neupane, Alexander Karakashian, Maura Mobilia, Olivia Hage, Univ of Kentucky, Lexington, KY; Scott M Gordon, Univ of Kentucky, Lexiton, KY

4:15 p.m. to 6:00 p.m.

Concurrent Session 2b: Thrombosis: Signaling, Mechanisms and Function

4:15 Targeting Neutrophils in Immunothrombosis
Lalitha Nayak, MD, Case Western Reserve University 

4:45 119 - LRRC8 Complex Is An ATP Release Channel Regulating Platelet Activation And Thrombosis
John D Tranter, Ashutosh Kumar, Gavriel Brown, Ryan Mikami, Yonghui Zhao, Nihil Abraham, Tarek M Abd El-Aziz, Washington Univ in St. Louis, St. Louis, MO; Abigail Ajanel, Univ of Utah, Salt Lake City, UT; Litao Xie, Katrina Ashworth, Juan Hong, Haixia Zhang, Tripti Kumari, Alice Liu, Adam Balutowski, Vinayak K Nair, Nina M Lasky, Yongmei Feng, Nathan O Stitziel, Washington Univ in St. Louis, St. Louis, MO; Daniel J Lerner, Senseion Therapeutics, St. Louis, MO; Robert A Campbell, Univ of Utah, Salt Lake City, UT; Jorge Di Paola, Jaehyung Cho, Rajan Sah, Washington Univ in St. Louis, St. Louis, MO

5:00 120 - Neutrophilic Mice Are Protected Against Staphylococcus Aureus Sepsis And Immunothrombosis Through Peptidylarginine Deiminase 4-mediated Neutrophil Extracellular Trap Formation
Caroline P Martens, Mathias Stroobants, Sara Zalghout, KU Leuven, Leuven, Belgium; Marleen Lox, KULeuven, Leuven, Belgium; Marijke Peetermans, Peter Verhamme, Thomas Vanassche, UZ Leuven, Leuven, Belgium; Kimberly Martinod, KU Leuven, Leuven, Belgium

5:15 121 - Ponatinib Promotes Endothelial Cell Inflammation And Leukocyte Trafficking Via Tumor Necrosis Factor Signaling: A Potential Mechanism Of Vascular Toxicity
Alec Stepanian, Richard James Travers, Angelina Tesfu, Qing Lu, Iris Z Jaffe, Tufts Medical Ctr, Boston, MA

5:30 122 - Deletion Of Pyruvate Dehydrogenase Kinases Reduces Susceptibility To Experimental Venous Thrombosis By Limiting Glycolysis In Neutrophils
Gagan D Flora, Madankumar Ghatge, Manasa K Nayak, Tarun Barbhuyan, Univ of Iowa, Iowa City, IA; Anil K Chauhan, UNIVERSITY IOWA, Iowa City, IA

5:45 123 - Hemostatic Fibrin Knob Triggered Microgel To Promote Clotting With Reduced Thrombotic Risks In Neonates
Nooshin Zandi, Kimberly Nellenbach, Biomedical engineering, Raleigh, NC; Michael Daniele, Dept of Electrical & Computer Engineering, Raleigh, NC; Ashley Brown, Biomedical engineering, Raleigh, NC

4:15 p.m. to 6:00 p.m.

Concurrent Session 2c: Investigator in Training Award Oral Abstract Competition
and Hot Off The Bench Oral Abstract Presentations
Moderators: Phillip Owens, PhD, and Marit Westeterp, PhD

4:15 124 - IRG1-Itaconate Axis Protects From Cholesterol-Induced Inflammation And Atherosclerosis
Fazli K Bozal, NYU Grossman Sch of Med, New York, NY; Yannick Cyr, NYU Langone Health, New York, NY; Jose Gabriel Barcia Duran, Alexandra AC Newman, Letizia Amadori, Panagiotis Smyrnis, Morgane Gourvest, Dayasagar Das, NYU Grossman Sch of Med, New York, NY; Michael Gildea, Ravneet Kaur, Tracy Zhang, NYU Langone Health, New York, NY; Kristin M Wang, Richard Von Itter, Ann Marie Schmidt, Edward A Fisher, NYU Grossman Sch of Med, New York, NY; Coen van Solingen, Leiden Univ Medical Ctr, Leiden, Netherlands; Chiara Giannarelli, Kathryn J Moore, NYU Langone Health, New York, NY

4:30 125 - The X Chromosome Gene Kdm6a Confers Sex Differences In Mature Adipocyte Function Impacting Cardiometabolic Health
Carrie B Wiese; Zoey Agle; Laurent Vergnes; Karen Reue, UCLA, Los Angeles, CA

4:45 126 - Reduction Of Abdominal Aortic Aneurysm Rupture By Modulating Smooth Muscle Cell Phenotype Switching
Jack Bontekoe; Ting Zhou; Huan Yang; Michelle Conte; Zulmari Silva-Pedraza; Courtney Morgan; David Aufhauser; Paul D Dimusto; Bo Liu, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI

5:00 127 - Pushing The Limits Of Macrophage Efferocytosis In Atherosclerosis
Xun Wu; Fang Li; Tyler Preston Shern; Alan Tall; Ira Tabas; Hanrui Zhang, Columbia University Medical Center, New York, NY

5:15 128 - Blood TMAO Predicts Abdominal Aortic Aneurysm Growth Rate And Need For Surgical Intervention
Scott J Cameron, CLEVELAND CLINIC, Solon, OH; Xinmin Li, Cleveland Clinic, Cleveland, OH; Tyler W Benson, Univ of Cincinnati, Cincinnati, OH; Kelsey Conrad, Smith Coll, Northampton, MA; Zeneng Wang, CLEVELAND CLINIC FOUNDATION, Cleveland, OH; Robert N Helsley, Univ of Kentucky, Lexiton, KY; Rebecca Schugar, CLEVELAND CLINIC, Cleveland, OH; Salma Fleifil, Univ of Michigan, Ann Arbor, MI; JENNIFER BUFFA, Cleveland Clinic, Cleveland, OH; Lars Maegdefessel, KAROLINSKA INSTITUTE, Stockholm, Sweden; Kevin Mani, Uppsala Univ,, Uppsala, Sweden; Martin Björck, CLEVELAND CLINIC, Upssala, Sweden; Alliefair Scalise, CLEVELAND CLINIC, Cleveland, OH; Scott J Cameron, Sharon Shim, Cleveland Clinic, Cleveland, OH; Anders Wanhainen, Karolinska Inst, UPPSALA, Sweden; Betemariam Sharew, Cleveland Clinic, Cleveland, OH; Aldons J Lusis, CLEVELAND CLINIC, Solon, OH; Sean Lyden, Cleveland, Cleveland, OH; Wilson Tang, Cleveland Clinic, Cleveland, OH; Philip Owens, Cleveland Clinic, CLEVELAND, OH; Stanley L Hazen, CLEVELAND CLINIC FOUNDATION, Cleveland, OH

5:26 129 - Hypercholesterolemia-induced Lxr Signaling In Smc Contributes To Atherosclerotic Lesion Remodeling And Regulates Vascular And Visceral Smc Function
Hanming Zhang, Yale Univ Sch of Med, New Haven, CT; Lauren Biwer, Diego Saenz de Urturi, Pablo Fernandez-Tussy, Daniel Jovin, Yale Univ, New Haven, CT; Yan Huang, YALE UNIV, Orange, CT; Xinbo Zhang, YALE UNIVERSITY, New Haven, CT; Enric Esplugues, Yale Sch of Med, New Haven, CT; Daniel Greif, Yale Univ Sch of Med, New Haven, CT; Yajaira Suarez, Yale Univ Sch of Med, Madison, CT; Carlos F Fernandez-Hernando, YALE UNIVERSITY SCHOOL MEDICINE, New Haven, CT

5:37 130 - Cftr Is Essential For Endothelium-dependent Vasorelaxation
Shravan Kumar Uppulapu, UNIVERSITY OF IOWA, IOWA, IA; JITENDRA KUMAR, Univ of Iowa,, Iowa City, IA; Sujata Kumari, Univ of Iowa, iowa city, IA; Craig Hodges, Case Western Reserve Univ, Cleveland, OH; David Stoltz, Santosh Kumar, Univ of Iowa, Iowa City, IA

5:48 162 - Post-transcriptional Regulation Of FGF21 In Obesity And Metabolism
Heidi M Schmidt, Kelsey E Jarrett, Gabriella Rubert, Michelle Steel, Angela Cheng, Elizabeth J Tarling, Thomas A Vallim, UCLA, Los Angeles, CA

6:00 p.m to 7:30 p.m.

Poster Session 2 & Reception
Sponsored by the ATVB Journal 


Friday, May 17
Fri., May 17 schedule
Time Activity
7:00 a.m. to 6:00 p.m. Registration and Exhibits
7:00 a.m. to 8:00 a.m. Morning Coffee
7:00 a.m. to 8:00 a.m. Early Career Training Session 2 – Academic Success Stories (Panel Discussion)

7:00 - Panel Discussants
Jeff Hsu, MD, PhD, UCLA Health
Christina Espinosa-Diez, PhD, Wayne State School of Medicine
Colin Evans, PhD, University of South Carolina
Ada Weinstock, PhD, University of Chicago

8:00 a.m. to 9:30 a.m.

Plenary Session 3: Advances in Cardiometabolic Disease

8:00 Presentation title TBA
Zoltan Arany, MD, PhD, University of Pennsylvania

8:30 16 Years of GWAS - From a Single Locus to 393 Genome-wide Significant CAD Associations
Ruth McPherson, MD, PhD, FRCPC, University of Ottawa Heart Institute

9:00 Gut Bacterial Metabolism and Cardiometabolic Disease
Federico E. Rey, PhD, University of Wisconsin-Madison

9:30 a.m. to 10:00 a.m. BREAK/Exhibits
10:00 a.m. to 11:45 a.m.

Concurrent Session 3a: Therapeutic Targets in Atherosclerosis

10:00 Enhanced endothelial cell retention within tissue engineered vascular grafts
Brandon Tefft, PhD, Medical College of Wisconsin

10:30 131 - Local Pcsk6 Inhibition Attenuates VSMC Response In Vascular Injury And Restenosis
Melody Chemaly, Karolinska Instt, Solna, Sweden; Hong Jin, Karolinska Univ Hosp, Stockholm Sweden, Sweden; Sofija Vuckovic, Karolinska Inst, Stockholm, Sweden; Bianca E Suur, Karolinska Instt, Solna, Sweden; Xiang Zhang, Karolinska Inst, Solna, Sweden; Malin Kronqvist, Karolinska Inst, Stockholm, Sweden; Mariette Lengquist, Karolinska Institutet, Stockholm, Sweden; Anna Uryga, Novo Nordisk, Bagsvaerd, Denmark; Karin Conde Knape, Michael Nyberg, Novo Nordisk, Malov, Denmark; Ulf Hedin, Ljubica Matic, Karolinska Institute, Stockholm, Sweden; Ljubica Matic, Karolinska Inst, Solna, Stockholm, Sweden

10:45 132 - Immunosenescence-related Biomarkers And Potential Therapeutic Targets For Coronary Artery Disease Identified Via Plasma Proteome And Immune Cell Traits
Shuyang Lin, WUSTL, Chesterfield, MO

11:00 133 - Trem2 Agonist Promotes Atherosclerotic Plaque Stability
Michael Patterson, Yingzheng Xu, Hannah Hillman, Victoria Osinski, Patricia Schrank, Ainsley Kennedy, Fanta Barrow, Samuel Tollison, Sia Shekhar, Xavier Revelo, Bryce Binstadt, Jesse W Williams, Univ of Minnesota, Minneapolis, MN

11:15 134 - Lesion-specific Suppression Of YAP/TAZ By Biomimetic Nanoparticles Ameliorates Atherosclerosis
Ting Yun Wang, Arizona state university, Tempe, AZ; HUI-CHUN HUANG, Joshua Rousseau, Mark Kuei-Chun Kuei-Chun Wang, Arizona State Univ, Tempe, AZ

11:30 135 - Monocytes Reprogrammed By 4-PBA Potently Contribute To The Resolution Of Inflammation And Atherosclerosis
Shuo Geng, Virginia Tech, Blacksburg, VA; Liwu Li, Virginia Tech University , Blacksburg, VA

10:00 a.m. to 11:45 a.m.

Concurrent Session 3b: Blood Coagulation in Health & Disease

10:00 Presentation title TBA
Nirav Dhanesha, PhD, LSU Health

10:30 136 - Protease-activating Receptor-4 Antagonism In Coronary Artery Disease
Jennifer Nash
, Mohammed M Meah, Beth Whittington, Samuel Debono, Jennifer Raftis, Mark R Miller, Andrew Sorbie, Nicholas L Mills, Josselin Nespoux, Lorraine Bruce, Rodger Duffin, Neeraj Dhaun, Mairi Brittan, Univ of Edinburgh, Edinburgh, United Kingdom; Longfei Chao, Samira Merali, Minji Kim, Zhaoqing Wang, Yue Zhang, Shiqiang Jin, Beqing Wang, Marc Kozinn, Bristol Myers Squibb, Lawrenceville, NJ; David E Newby, Univ of Edinburgh, Edinbugh, United Kingdom

10:45 137 - Identification Of A Noncoding Genetic Variant In The Tissue Factor Locus That Reverses Lethal Thrombosis In Mice
Arina Rodionova, Oakland Univ, Rochester, MI; Marisa Brake, Beth Israel Deaconess Medical Ctr, Boston, MA; Amy E Siebert-Mckenzie, Versiti Blood Res Inst, Milwaukee, WI; Randal Westrick, Oakland Univ, Rochester, MI

11:00 138 - Platelet RIPK1 Promotes Platelet Activation And Aggregation In Arteriolar Thrombosis And Ischemic Stroke
Jae-Sung Kim, Washington Univ. Sch of Med, Saint louis, MO; Jaehyung Cho, Washington Univ. Sch of Med, Saint Louis, MO; Gavriel Brown, Washington Univ. Sch of Med, Saint louis, MO

11:15 139 - Contribution Of Platelet Granule Cargo Uptake And Secretion To The Initiation And Progression Of Aortic Aneurysms
Danielle M Coenen, Sidney W Whiteheart, Univ of Kentucky, Lexington, KY

11:30 140 - Exploring Protein Kinase C Theta (PKCΘ) Signaling In The Generation Of Procoagulant Platelet: Insights From Phosphoproteomics And Systems Analysis
Yiheng Zheng, Oregon Health & Science Univ, Portland, OR; Stephanie Reitsma, UNC at Chapel hill, Chapel Hill, NC; Sandler Jordan, Oregon State Univ, Corvallis, OR; Ozgun Babur, Univ of Massachusetts Boston, Milton, MA; Alexander Melrose, Oregon Health Science Univ, Portland, OR; jiaqing pang, Oregon Health Science University, Portland, OR; Stefanie Hodapp, Alexandra Newton, UC San Diego, La Jolla, CA; Phillip Wilmarth, Ashok Reddy, OHSU, Portland, OR; Owen J McCarty, Oregon Health Science University, Portland, OR; Joseph E Aslan, Oregon Health Science Univ, Portland, OR

10:00 a.m. to 11:45 a.m.

Concurrent Session 3c: Translational Studies in Non-Coronary Vascular Disease
Moderators: Scott Damrauer, MD and Jean Marie Ruddy, MD

10:00 Presentation title TBA
Wei Zhou, MD, University of Arizona

10:20 Presentation title TBA
Santhi Ganesh, MD, University of Michigan

10:40 Exploring Carotid Plaque Instability: a BIKE-ride from Identification of Molecular Disease Targets to Improved Stroke-risk Prediction
Ulf Heden, MD, PhD, Karolinska University Hospital & Karolinska Institute

11:00 Endothelial Dysfunction in Carotid Atherothrombosis and Stroke
Kathryn Howe, MD, PhD, FRCSC, University Health Network, Peter Munk Cardiac Centre

11:20 141 - Lesion Site-specific Mass Spectrometry Analysis Of Human Carotid Plaques Reveals Strongest Association Of The Necrotic Core And Fibrous Cap Proteome With Plaque Stability
Nadja Sachs, Klinikum rechts der Isar der TUM, Munich, Germany; Ankit Sinha, Elena Kratz, Max-Planck-Institue of Biochemistry, Martinsried, Germany; Jessica Pauli, Molecular Vascular Med, TUM, Munich, Germany; Marie-Luise Engl, Klinikum rechts der Isar der TUM, Munich, Germany; Hanna Winter, Molecular Vascular Med, TUM, Munich, Germany; Hans-Henning Eckstein, Klinikum rechts der Isar der technischen Univ München, Munich, Germany; Matthias Mann, Max Planck Inst of Biochemistry, Martinsried, Germany; Lars Maegdefessel, Molecular Vascular Med, TUM, Munich, Germany

11:32 142 - Nr3c1-Sfrp1 Axis Regulates The Adipogenic Differentiation Of Vcam1+ Fibro-adipogenic Progenitors In Chronic Limb Threatening Ischemia
Qunsheng Dai, Changxin Wan, Yueyuan Xu, Brianna Garrett, Leo Akers, Derek Peters, James Otto, Duke Univ, Durham, NC; Christopher D Kontos, Duke University Medical Center, Durham, NC; Jason Ji, Yarui Diao, Kevin W Southerland, Duke Univ, Durham, NC

11:45 a.m. to 12:45 p.m. Building Inclusive Mentoring Relationships
Presented by the ATVB Diversity Committee
11:45 a.m. to 1:45 p.m. Lunch on your own
1:45 p.m. to 3:45 p.m. Plenary Session 4:  Early Career Investigator Award Competition: Brinkhous Prize and Page Jr Faculty Research Award
Moderators: Milka Koupenova, PhD, Sidney Whiteheart, PhD, Nick Leeper, MD, and Wayne Orr, PhD

1:45 153 - Multi-parametric Thrombus Profiling Microfluidics Uncovers Mechanobiology Of Hypertension And Aging-related Thrombosis
Misbahud Din; Souvik Paul; Sana Ullah; Haoyi Yang, University of Texas Medical Branch, Galveston, TX; Rongguang Xu, The Pennsylvania State University, University Park, PA; Nurul Aisha Zainal Abidin, University of Texas Medical Branch, Galveston, TX; Bari Chowdhury, University of Sydney, Sydney, Australia; Fangyuan Zhou, University of Texas Medical Branch, Galveston, TX; Stephenie Rogers, Georgia Institute of Technology, Atlanta, GA; Mariel Miller, University of Texas Medical Branch, Galveston, TX; Atreyee Biswas, UTMB, Galveston, TX; Liang Hu, University of Texas Medical Branch, Galveston, TX; Zhichao Fan, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Christopher Zahner, UConn Health, Farmiton, CT; Megan Berman; Lingzhou Xue, University of Texas Medical Branch, Galveston, TX; Lining Ju, The Pennsylvania State University, University Park, PA; Yunfeng Chen, University of Sydney, Sydney, Australia, University of Texas Medical Branch, Galveston, TX

2:00 154 - Hierarchical Redundancy And Contextual Roles Of Vesicle-associated Membrane Proteins (VAMPs) In Platelet Function
Smita Joshi; Alexis Smith, Morehead State University, Morehead, KY; Hammodah R. Alfar; Kanakanagavalli Shravani prakhya; Harry Chanzu; Sidney W Whiteheart, University of Kentucky, Lexington, KY

2:15 155 - Plasma Kallikrein Is A Key Driver Of Basal Activation Of Coagulation Under Conditions Of C1 Inhibitor Deficiency
Steven P Grover; Hanga R Horvath, University of North Carolina, Chapel Hill, NC; Zsofia Polai; Linda Sundler Bjorkman, Semmelweis University, Budapest, Hungary; Pavan K Bendapudi, University of North Carolina, Chapel Hill, NC; Nigel Mackman, Harvard Medical School, Boston, MA; Henriette Farkas, University of Chapel Hill, Chapel Hill, NC, Semmelweis University, Budapest, Hungary

2:30 156 - Pyruvate Kinase M2 Regulates SNAP23-mediated Platelet Granule Exocytosis, Neutrophil Extracellular Traps Formation And Experimental Venous Thrombosis
Manasa K Nayak; Gagan D Flora; Tarun Barbhuyan, University of Iowa, Iowa City, IA; Rakeshkumar B Patel, University of Iowa, iowa, IA; Madankumar Ghatge; Mariia Kumskova; Aditi Jain; Jitendra Kumar, University of Iowa, Iowa City, IA; Santosh Kumar, University of Iowa,, Iowa City, IA; Anil K Chauhan, University of Iowa, Iowa City, IA, UNIVERSITY IOWA, Iowa City, IA

2:45 157 - Atherosclerosis Is A Smooth Muscle Cell-driven Tumor-like Disease
Huize Pan; Sebastian E Ho, Vanderbilt University Medical Center, Nashville, TN; Chenyi Xue; Jian Cui; Quinian Johanson; Nadja Sachs, Columbia University Irving Medical Center, New York, NY; Leila Ross, Technical University Munich, Munich, Germany; Fang Li; Robert A Solomon, Columbia University Irving Medical Center, New York, NY; Edward Connolly; Virendra Patel; Lars Maegdefessel, New York-Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY; Hanrui Zhang, Technical University Munich, Munich, Germany; Muredach P Reilly, Columbia University Irving Medical Center, New York, NY

3:00 158 - The Role Of Ehbp1 In Hypercholesterolemia
Bishuang Cai, Icahn School of Medicine at Mount S, New York, NY

3:15 159 - Endothelial Fatty Acid-binding Proteins Contribute To The Pathogenesis Of Pulmonary Hypertension
Zhiyu Dai; Bin Liu, University of Arizona, Phoenix, AZ; Dan Yi, THE UNIVERSITY OF ARIZONA, Phoenix, AZ; Karina Ramirez; Xiaomei Xia; Ruslan Rafikov, University of Arizona, Phoenix, AZ; Vinicio A Dejesus, Indiana University, Indianapolis, IN; Sarah-Eve S Lemay, STANFORD UNIVERSITY, Palo Alto, CA; Sebastien Bonnet, CRIUCPQ, Quebec, QC, Canada; Olivier Boucherat, Quebec Heart and Lung institute, Quebec, QC, Canada, IUCPQ RESEARCH CENTRE, Quebec, QC, Canada

3:30 160 - Macrophage-specific Ablation Of Bmal1 Regulates Cholesterol Transport And Enhances Atherosclerosis
Xiaoyue Pan; John O'Hare; Cyrus Mowdawalla, NYU Grossman Long Island School of Medicine, Mineola, NY; Samantha Mota, NYU Grossman Long Island School of Medicine, New York, NY; Nan Wang, NYU Grossman Long Island School of Medicine, Mineola, NY; M.Mahmood Hussain, Columbia University, New York, NY, NYU Grossman Long Island School of Medicine, Mineola, NY

3:45 p.m. to 4:15 p.m. Break/Exhibits
4:15 p.m to 6:00 p.m.

Concurrent Session 4a:  Metabolic Disorders in Atherosclerosis
Organized in cooperation with the Chinese International Congress of Vascular Medicine

4:15 Unlocking the Potential of Microbial-Host-Isozyme for Precision Treatment of Metabolic Diseases
Changtao Jiang, MD, PhD, Peking University Health Science Center

4:45 Comprehensive Management of Metaboic Vascular Disease - 20 Years Vascular Health Promotion in China
Hongyu Wang, MD, PhD, FASH, Peking University Shougang Hospital

5:15 Deubiquitinase BRCC3 Orchestra Metabolic Remodeling in Cardiovascular Disease
Kaizheng Gong, MD, PhD, Affiliated Hospital of Yangzhou University

5:30 Prevention of Cardiovascular Disease: the Traditional Chinese Medicine Strategy
Chaoping Yu, MD, The Third Affiliated Hospital of Chengdu Medical College

5:45 143 - Multi-omics Integration From A Large Human Biobank Identifies Key Molecular Mechanisms And Signatures Of Atherosclerotic Plaque Instability
Vivek Das, Novo Nordisk, Målov, Denmark; Xiang Zhang, Karolinska Inst, Solna, Stockholm, Sweden; Djordje Djordjevic, Novo Nordisk, Malov, Denmark; Otto Bergman, Karolinska Inst, Stockholm, Sweden; Sampath Narayanan, Karolinska Inst, STOCKHOLM, Sweden; Dmitry Shungin, Novo Nordisk, Målov, Denmark; Melody Chemaly, Karolinska Inst, Stockholm, Sweden; Glykeria Karadimou, Karolinska Instt, Stockholm, Sweden; Sofija Vuckovic, Inika Prasad, Karolinska Inst, Solna, Stockholm, Sweden; Karin Conde Knape, Natasha Barascuk Michaelsen1, Novo Nordisk, Målov, Denmark; Ulf Hedin, KAROLINSKA INSTITUTE, Stockholm, Sweden; Ljubica Matic, Karolinska Inst, Solna, Stockholm, Sweden

5:50 144 - Pyruvate Dehydrogenase Kinase 4 Contributes To Abdominal Aortic Aneurysm Through Accelerating Smooth Muscle Cell Metabolic Reprogramming And Nlrp3 Inflammasome-dependent Pyroptosis
Qin-Bao Peng, Li Zhao, Tian-Xiao Lin, Fang-Ze Huang, Xiao-Xia He, Wei Huang, De-Shen Liu, Ling-Na Zhao, Jun Lu, Shao-Yi Zheng, Xiu Liu, Dept of Cardiovascular Surgery, Nanfang Hosp, Southern Medical Univ, Guangzhou, China

4:15 p.m to 6:00 p.m.

Concurrent Session 4b: Vascular Cells, Inflammation and Thrombosis
Moderators: Cynthia St. Hilaire, PhD, and Timothy Stalker, PhD

4:15 Cardiovascular Calcification
Cynthia St. Hilaire, PhD, FAHA, University of Pittsburgh

4:45 145 - Chronic Electronic Cigarette Exposure Accelerates SMC Phenotypic Modulation And Activates The NMDA-type Glutamate Receptor (NMDAR) Pathway In Mediating Vascular Calcification
Isabella Damiani, Chad Weldy, Meena Easwaran, Guyu Qin, Sugandha Basu, Elizabeth Direnzo, Thomas Quertermous, Juyong Brian Kim, Stanford Univ, Palo Alto, CA

5:00 146 - Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling
Ying Jin, Yangzhouyun Xie, Alexa Berezowitz, Sean Davis, Yale Sch of Med, New Haven, CT; Alyssa M. Flores, Harvard Medical Sch, Boston, MA; Xue-Lin Wang, BIDMC, Boston, MA; Raul J Guzman, Yale New Haven Hosp, New Haven, CT; Yujun Cai, Yale Sch of Med, New Haven, CT

5:15 147 - Monocyte-derived Extracellular Delta-like 4 Contributes To Pulmonary Hypertension Progression By Inhibiting Endothelial Notch1 Activation
Shumin Wang, Yutiancheng Yang, Tengge Wang, CVRI, Univ of Rochester, Rochester, NY; Jordan Rhen, Univ of Rochester, ROCHESTER, NY; Nathaniel Beam, CVRI, Univ of Rochester, Rochester, NY; Jasmine Xu, Univ of Rochester, Rochester, NY; Heqing Jia, CVRI, Univ of Rochester, Rochester, NY; Sara Ture, Univ of Rochester, Rochester, NY; mary dutheil, Univ Paris-Saclay, Le Plessis Robinson, France; Fabrice Antigny, INSERM U999, Le Plessis Robinson, France; David Montani, APHP HOPITAL BICETRE INSERM, Le Kremlin-bicetre, France; Craig Morrell, UNIVERISTY ROCHESTER, Rochester, NY; Jinjiang Pang, AAB CVRI UNIVERSITY ROCHESTER, Rochester, NY

5:30 148 - Loss Of Tlr4 Signaling Inhibits Thrombus Resolution In A Non-monocyte Dependent Manner
Kiran Kumar, Oscar Yesid Moreno, Nathaniel Parchment, Sriganesh Sharma, Univ of Michigan, Ann Arbor, MI; Sabrina Rocco, Univ of Michigan, ann arbor, MI; Catherine Luke, Hartland High Sch, Howell, MI; Sylviane Lambert, UNIVERSITY OF MICHIGAN, Ann Arbor, MI; Michael A Holinstat, Michael Holinstat, Ann Arbor, MI; Frank Davis, The Univ of Michigan, Ann Arbor, MI; Katherine A Gallagher, UNIVERSITY MICHIGAN, Ann Arbor, MI; Bethany Moore, Univ. of Michigan, Ann Arbor, MI; Peter Henke, UNIVERSITY MICHIGAN, Ann Arbor, MI; Andrea T Obi, UNIVERSITY OF MICHIGAN, Ann Arbor, MI

5:45 149 - The Protective Effect Of Vamp8 Deficiency In Aortopathies: Potential Impact Of Impaired Platelet Cargo Release
Shayan Mohammadmoradi, Elizabeth Driehaus, Kory Heier, Hammodah Alfar, Joshua Lykins, Univ of Kentucky, Lexiton, KY; Bryana Levitan, Univ of Kentucky, Lexington, KY; Ming Zhang, Univ of Kentucky, lexington, KY; Smita Joshi, Morehead State Univ, Lexington, KY; Kristen McQuerry, Univ of Kentucky, Lexiton, KY; Sidney W Whiteheart, Univ of Kentucky, Lexington, KY

4:15 p.m to 6:00 p.m.

Concurrent Session 4c: Genomics and Multi-Omics in Vascular Disease
Moderators: Clint Miller, PhD, and Catherine Tcheandjieu, PhD

4:15 Presentation Title TBA
Clint Miller, PhD, University of Virginia

4:45 Presentation Title TBA
Catherine Tcheandjieu, DVM, PhD, Gladstone Institutes

5:15 150 - Decoding The Variant-to-function Relationship For LIPA, A Risk Locus For Cad
Fang Li, Xun Wu, Columbia Univ Medical Ctr, New York, NY; Philip Ha, Macaulay Honors Colleage at Hunter Coll; Columbia Univ Medical Ctr, New York, NY; Mazal Zebak, Chenyi Xue, Columbia Univ Medical Ctr, New York, NY; Elise Flynn, Columbia Univ; New York Genome Ctr, New York, NY; Haoxiang Cheng, Icahn Sch of Med at Mount Sinai, new york, NY; Ke Hao, Icahn Sch of Med at Mount Sinai, New York, NY; Tuuli Lappalainen, Columbia Univ Medical Ctr;New York Genome Ctr, New York, NY; Hanrui Zhang, COLUMBIA UNIVERSITY MEDICAL CENTER, fort lee, NY

5:30 151 - Single Cell Transcriptional And Epigenetic Map Of Human Coronary Artery Disease In A Multi-ethnic Population
Junedh M Amrute, Paul Lee, Wahsington Univ in St Louis Sch of Med, Saint Louis, MO; Ittai Eres, Amgen, San Francisco, CA; Andrea Bredemeyer, Washington Univ in St Louis Sch of Med, St Louis, MO; Tracy Yamawaki, Amgen, San Francisco, CA; Chul Joo Kang, Washington Univ in St Louis Sch of Med, St Louis, MO; Mick Jie Lee, Rijan Gurung, Natl Univ of Singapore, Singapore, Singapore; Daniel Li, Stanford, San Jose, CA; Quanyi Zhao, Stanfod, San Jose, CA; Maya Sheth, Anthony Tan, Andreas Gschwind, Stanford, San Jose, CA; Paul Cheng, Stanford, San jose, CA; Simon Jackson, Yi-Hsiang Hsu, Amgen, San Francisco, CA; Roger Foo, Natl Univ of Singapore, Singapore, Singapore; Ira Hall, Yale, New Haven, CT; Rajat M Gupta, Brigham and Women's Hosp, Boston, MA; Jesse Engreitz, Stanford, San Jose, CA; Chi-Ming Li, Amgen, San Francisco, CA; Thomas Quertermous, Stanford, San Jose, CA; Brandon Ason, Amgen, San Francisco, CA; Kory J Lavine, Nathan O Stitziel, Washington Univ in St Louis Sch of Med, Saint Louis, MO

5:45 152 - Osteochondrogenic Transcription Factor SOX9 Regulates The Epigenetic Mechanisms Of Atherosclerosis And Intimal Calcification
Matthew D Worssam, Chad S Weldy, Joao P. Monteiro, Brian T Palmisano, Ramendra K Kundu, Trieu Nguyen, Thomas Quertermous, Stanford Univ, Palo Alto, CA

6:00 p.m. to 7:30 p.m.

Poster Session 3 and Reception

7:30 p.m. to 10:00 p.m.

Joint Council Dinner
Ticket Required to attend


Saturday, May 18
Sat., May 18 schedule
Time Activity
7:00 a.m. to 12:00 p.m. Registration
7:00 a.m. to 8:30 a.m. Morning Coffee
8:30 a.m. to 10:00 a.m.

Plenary Session 5: Cardio-oncology: The Role of the Vasculature
Moderators: Iris Jaffe, MD, PhD, and Isabella Grumbach, MD, PhD

8:30 Cardio-oncology Through a Vascular Lens
Iris Jaffe, MD, PhD, Tufts Medical Center

9:00 Racial Disparities in Cardio-oncology - Defining Differences in Endothelial Function in Response to Anti-Cancer Therapy
Andreas Beyer, PhD, Medical College of Wisconsin

9:30 Presentation title TBA
Carl Ade, PhD, Kansas State University

9:45 161 - Myocardial Infarction Accelerates Melanoma Tumor Progression
Richard Von Itter, Alexandra Newman, NYU Grossman Sch of Med, New York, NY; Gabrielle Pilla, NYU, New York, NY; Fazli Bozal, NYU Sch of Med, New York, NY; Kristin M Wang, NYU Grossman Sch of Med, New York, NY; Morgane Gourvest, NYU Grossman school of Med, New York, NY; Tracy Zhang, NYU Langone, New York, NY; Brian Lim, NYU Grossman Sch of Med, New York, NY; Kathryn J Moore, NEW YORK UNIV MEDICAL CTR, New York, NY

10:00 a.m. to 10:15 a.m. BREAK/Exhibits
10:15 a.m. to 12:15 p.m.

Plenary Session 6: Invited Lecture Series

10:15 Hoeg Award Lecture
Chiara Giannarelli, MD, PhD, NYU Langone Health

10:45 Keynote Lecture
Kristy R. Red-Horse, PhD, Howard Hughes Medical Institute/Stanford University

11:15 Distinguished Lecture: Targets for New Anticoagulants: XI Before XII
Jeffrey Weitz, MD, FAHA, FRCPC, FACP, FRSC, FACC, FESC, FCAHS, McMaster University, Thrombosis and Atherosclerosis Research Institute

11:45 PVD Mid-Career Award Lecture
Scott Damrauer, MD, University of Pennsylvania School of Medicine

12:15 p.m. Closing Remarks / Adjourn

Keynote Lecture and Distinguished Lecture Speakers

Keynote Lecture
Kristy Red-Horse, PhD

Kristy Red-Horse, PhD

Invited Lecture Series
Presentation Title: TBD

Kristy Red-Horse is a Professor at Stanford University’s Department of Biology and Institute for Stem Cell Biology & Regenerative Medicine. She is also an Investigator with the Howard Hughes Medical Institute. Her PhD research explored how the vasculature of the placenta incorporates within the uterine arterial network. As a postdoc at Stanford, Dr. Red-Horse identified the progenitors of coronary arteries in mouse hearts. In her own lab, she and her team went on to explore many different aspects of how coronary arteries develop from these progenitors. The Red-Horse group also studies how coronaries regenerate and respond to injury, and devises methods for increasing their growth to enhance cardiac recovery. Dr. Red-Horse has received awards such as the NIH Pathway to Independence Award (K99/R00) and the Searle Scholar’s Award. She was also a New York Stem Cell Foundation—Robertson Investigator and received the Judah Folkman Award in vascular biology. In 2021, Dr. Red-Horse was named a Howard Hughes Investigator. In 2023, Dr. Red-Horse became a member of the National Academy of Medicine.

Distinguished Lecture
Jeffrey Weitz, MD, FAHA, FRCPC, FRSC, FACP

Jeffrey Weitz, MD, FAHA, FRCPC, FRSC, FACP

Invited Lecture Series
Presentation Title: Targets for new anticoagulants: XI before XII

Dr. Weitz is Professor of Medicine and Biochemistry and Biomedical Sciences at McMaster University, Executive Director of the Thrombosis and Atherosclerosis Research Institute and Past President of Council for the International Society on Thrombosis and Haemostasis. Board Certified in Internal Medicine, Hematology, and Medical Oncology, Dr. Weitz focuses his clinical practice on patients with thrombotic disorders. His research spans the spectrum from basic studies in the biochemistry of blood coagulation and fibrinolysis to animal models of thrombosis and on to clinical trials of antithrombotic therapy. The breadth of his work is highlighted by his over 640 publications in journals as diverse as the Journal of Clinical Investigation, Journal of Biological Chemistry, Biochemistry, Circulation, Blood, Annals of Internal Medicine, New England Journal of Medicine and Lancet, and 76 book chapters. The recipient of numerous awards, Dr. Weitz was appointed as an Officer of the Order of Canada and is a Fellow of the Royal Society of Canada and the Canadian Academy of Health Sciences.

Hoeg Award Lecture
CHiara Giannarelli, MD, PhD

Chiara Giannarelli, MD, PhD

Hoeg Award Lecture
Presentation Title: TBA

Chiara Giannarelli, MD, PhD, is an Associate Professor of Medicine and Pathology at the Department of Medicine, Division of Cardiology, and Cardiovascular Research Center at NYU Langone NYU Grossman School of Medicine, New York. She completed her medical degree and subsequent residency and clinical fellowship before pursuing a PhD in pharmacological sciences and pathophysiological mechanisms of cardiovascular disease at the University of Pisa, Italy. In 2008, she relocated to the USA, where she conducted a research fellowship at the Icahn School of Medicine at Mount Sinai, eventually being appointed Assistant Professor in 2014. Joining NYU in 2021, Dr. Giannarelli's research integrates systems pharmacology and systems immunology with molecular biology and imaging to uncover novel mechanisms underlying cardiovascular disease. A groundbreaking accomplishment of her laboratory was the pioneering use of single-cell proteomic and transcriptomic analyses (CyTOF, CITE-seq, scRNA-seq) of human vascular samples, recognized as a significant milestone in inflammation research in atherosclerosis (Nature Medicine, 2019). Dr. Giannarelli has leveraged systems immunology and drug repositioning approaches to identify new compounds targeting the innate immune system in atherosclerosis, mitigating plaque inflammation (Nature Cardiovascular Research, June 2023). Her work has also explored how SARS-CoV-2 infection triggers proatherogenic immune responses in the human vasculature (Nature Cardiovascular Research, October 2023). Continuously funded by the NIH/NHLBI, NIH/NCATS, and prestigious programs such as the American Heart Association Strategically-Focused Research Networks, Chan-Zuckerberg Foundation, and PolyBio Foundation, Dr. Giannarelli's expertise in translational systems immunology and drug repurposing approaches has made her a vital contributor to large multiple-PI programs.

PVD Mid-Career Award Lecture
Scott. M. Damrauer, MD, FAHA

Scott M. Damrauer, MD, FAHA

PVD Mid-Career Award Lecture
Presentation Title: TBD

Dr. Scott Damrauer is a surgeon-scientist dedicated to advancing the understanding of the biological pathways and mechanisms most relevant in the etiology, progression and treatment of heart and vascular disease. His research leverages his clinical vascular surgery experience to inform population-scale genomic research. In this, he has focused primarily on peripheral artery disease (PAD), venous thromboembolism (VTE), abdominal aortic aneurysm (AAA) and thoracic aortic disease (TAD). As part of the VA Million Veteran Program and the Penn Medicine BioBank, Dr. Damrauer’s work has significantly advanced our understanding of the genetic architecture of these diseases. He’s currently exploring the causal relationship of risk factors across traits, identifying novel therapeutic targets, and developing new ways to use genetics to identify people at risk.

Genomic medicine has been criticized for the lack of studies in diverse populations. To address these disparities, Dr. Damrauer has led a large interagency collaboration between the VA and the Department of Energy to map the genetic architecture of health and disease traits in more than 650,00 diverse veterans as part of the VA Million Veteran Program. These analyses represent the largest existing effort to understand the genetics of health and disease in diverse populations in the United States.

Dr. Damrauer’s work is supported by the NIH and the VA Office of Research and Development.

Vascular Discovery 2024
Invited Speakers

Carl Ade

Carl Ade, PhD

Session: Cardio-oncology: the Role of the Vasculature
Presentation Title: TBD
Zoltan Arany

Zoltan Arany, MD, PhD

Session: Advances in Cardiometabolic Disease
Presentation Title: TBD
Andreas Beyer, PhD, Medical College of Wisconsin

Andreas Beyer, PhD

Session: Cardio-oncology – The Role of the Vasculature
Presentation Title: Racial disparities in cardio-oncology – Defining Differences in Endothelial Function in Response to Anti-Cancer Therapy
Nirav Dhanesha, PhD

Nirav Dhanesha, PhD

Session: Blood Coagulation in Health and Disease
Presentation Title: TBA
Brian Emmer, MD, PhD

Brian Emmer MD, PhD

Session: Apolipoproteins, Lipoproteins and Lipid Metabolism
Presentation Title: Massively Parallel Interrogation of Lipoprotein Uptake Modifiers
Santhi Ganesh

Santhi Ganesh, MD

Session: Translational Studies in Non-Coronary Vascular Disease
Presentation Title: TBD
Courtney Griffin

Courtney Griffin, PhD

Session: Endothelial Dysfunction in Thrombosis
Presentation Title: Genetic analysis of endothelial protease-activated receptors in disease contexts
Kaizheng Gong, MD, PhD

Kaizheng Gong, MD, PhD

Session: Metabolic Disorders in Atherosclerosis - Organized in Cooperation with the Chinese International Congress of Vascular Medicine
Presentation Title: Deubiquitinase BRCC3 Orchestra Metabolic Remodeling in Cardiovascular Disease
Ulf Hedin

Ulf Hedin, MD, PhD

Session: Translational Studies in Non-Coronary Vascular Disease
Presentation Title: Exploring carotid plaque instability: a BiKE-ride from identification of molecular disease targets to improved stroke-risk prediction
Kathryn Howe

Kathryn L Howe MD, PhD, FRCSC

Session: Translational Studies in Non-Coronary Vascular Disease
Presentation Title: Endothelial Dysfunction in Carotid Atherothrombosis and Stroke
Iris Jaffe

Iris Jaffe, MD, PhD

Session: Cardio-oncology the Role of the Vasculature
Presentation Title: Cardio-oncology Through a Vascular Lens 
Changtao Jiang, MD, PhD

Changtao Jiang, MD, PhD

Session: Metabolic Disorders in Atherosclerosis - Organized in Cooperation with the Chinese International Congress of Vascular Medicine
Presentation Title: Unlocking the Potential of Microbial-Host-Isozyme for Precision Treatment of Metabolic Diseases
Minna Kaikkonen

Minna Kaikkonen, PhD

Session: Hot Topics in Cardiovascular Disease
Presentation Title: Functional Multiomics to Identify Genetic Mechanisms Underlying Atherosclerosis
Bo Liu, PhD, University of Wisconsin-Madison

Bo Liu, PhD

Session: Inflammation & Immunity in the Vessel Wall
Presentation Title: Macrophages in Aortic Aneurysm
Ruth McPherson, MD

Ruth McPherson, MD, PhD, FRCPC

Session: Advances in Cardiometabolic Disease
Presentation Title: 16 years of GWAS – From a Single Locus to 393 Genome-wide Significant CAD Associations
Clint L. Miller

Clint Miller, PhD

Session: Genomics and Multi-Omics in Vascular Disease
Presentation Title: TBD
Lalitha Nayak, MD

Lalitha Nayak, MD

Session: Thrombosis, Signaling Mechanisms, & Function
Presentation Title: Targeting Neutrophils in Immunothrombosis
Hasina Outtz Reed, MD, PhD

Hasina Outtz Reed, MD, PhD

Session: Endothelial Dysfunction in Thrombosis
Presentation Title: TBD
Muredach Reilly, MD

Muredach Reilly, MD

Session: Molecular and Cellular Mechanisms of Atherosclerosis
Presentation Title: TBD
 
Federico E. Rey, MD

Federico E. Rey, PhD

Session: Advances in Cardiometabolic Disease
Presentation Title: Gut Bacterial Metabolism and Cardiometabolic Disease
Alec Schmaier

Alec A. Schmaier, MD, PhD

Session: Endothelial Dysfunction in Thrombosis
Presentation Title: Regulation of endothelial procoagulant activity by TMEM16 proteins
Cynthia St. Hilaire, PhD, FAHA

Cynthia St. Hilaire, PhD, FAHA

Session: Vascular Cells, Inflammation and Thrombosis
Presentation Title: Cardiovascular Calcification
Takanori Takebe

Takanori, Takebe, MD, PhD

Session: Hot Topics in Cardiovascular Disease
Presentation Title: Complementing Human Organoids for Vascular Discovery
Catherine Tcheandjieu, DVM, PhD

Catherine Tcheandjieu, DVM, PhD

Session: Genomics and Multi-Omics in Vascular Disease
Presentation Title: TBD
Brandon Tefft, PhD

Brandon Tefft, PhD

Session: Therapeutic Targets in Atherosclerosis
Presentation Title: Enhanced endothelial cell retention within tissue engineered vascular grafts
Kenneth Walsh, PhD

Kenneth Walsh, PhD

Session: Hot Topics in Cardiovascular Disease
Presentation Title: Clonal Hematopoiesis, Aging, and CVD
Hongyu Wang, MD, PhD, FASH

Hongyu Wang, MD, PhD

Session: Metabolic Disorders in Atherosclerosis - Organized in Cooperation with the Chinese International Congress of Vascular Medicine
Presentation Title: Comprehensive Management of Metabolic Vascular Disease: 20 Years Vascular Health Promotion in China
Chaoping Yu, MD, The 3rd Affiliated Hospital of Chengdu Medical College

Chaoping Yu, MD

Session: Metabolic Disorders in Atherosclerosis
Presentation Title: Prevention of Cardiovascular Disease: the Traditional Chinese Medicine Strategy
Wei Zhou

Wei Zhou, MD

Session: Translational Studies in Non-Coronary Vascular Disease
Presentation Title: TBD

About this Meeting

This 2 ½-day meeting is sponsored by the Council on Arteriosclerosis, Thrombosis and Vascular Biology, the Peripheral Vascular Disease Council, and the Council on Genomic and Precision Medicine, in cooperation with and the Society for Vascular Surgery's Vascular Research Initiatives Conference.

Vascular Discovery 2024 will provide unique opportunities to meet with colleagues from around the world with wide-ranging research interests and expertise for the timely exchange of information about new and emerging scientific research in the areas of arteriosclerosis, thrombosis and vascular biology, peripheral vascular disease, vascular surgery research, genomics and precision medicine. We expect a broad representation from many disciplines and encourage young scientists to attend.

See the American Heart Association Policies and Guiding Values (PDF).

Target Audience

The conference will especially appeal to scientists and clinicians interested in: 

  • Allergy and Immunology
  • Arteriosclerosis
  • Biochemistry
  • Biological Sciences
  • Diabetes and Metabolism
  • Functional Genomics
  • Genetics
  • Hematology
  • Internal Medicine
  • Molecular/Cellular Biology
  • Nutrition
  • Pathology
  • Peripheral Artery Disease
  • Pharmacology
  • Physiology
  • Vascular Surgery
  • Thrombosis
  • Vascular Biology
  • Vascular Medicine

Learning Objectives

At the conclusion of this conference, participants will be able to:

  1. Discuss recent advances and emerging experimental models in ATVB and peripheral vascular diseases that target primary acquired diseases and/or secondary factors contributing to vascular-related disorders.
  2. Summarize findings from recent translational research or clinical trials and the impact for future treatment and/or management of vascular-related disorders.
  3. Describe best practices associated with ATVB scientific research and/or the management of patients with vascular-related diseases.