Weight-Loss Strategies for Prevention and Treatment of Hypertension

Published: September 20, 2021

Figure 2. Critical gaps remain in research and implementation of appropriate therapies (diet, increased physical activity, reduced sedentariness, anti-obesity pharmacotherapy, and metabolic surgery) in obesity hypertension. BMI indicates body mass index; CKD, chronic kidney disease; and HF, heart failure.
  • Hypertension (HTN) is a major risk factor for cardiovascular and renal diseases in the United States and around the world.
  • Obesity contributes to much of the risk for primary hypertension through several mechanisms such as neurohormonal activation, inflammation, and kidney dysfunction.
  • In this context, effective pharmacotherapeutic and procedural strategies including metabolic surgeries are additional options to treat obesity and prevent or attenuate obesity induced HTN, target organ damage and subsequent disease.