Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets
Published: June 17, 2024
- Valvular Heart Disease (VHD) is a common cause of global morbidity and mortality, yet there is no effective medical therapy and severe disease must be treated surgically.
- Research is elucidating the molecular pathways that underlie the pathogenesis of VHD, but there are challenges to translating this knowledge into potential treatments.
- This scientific statement focuses on the most common primary valvular heart diseases, including calcific aortic stenosis, bicuspid aortic valves, mitral valve prolapse and rheumatic heart disease, and outlines the molecular discoveries contributing to each, potential therapeutic targets, and key areas of research priorities.
Supporting Materials
- Commentary: Valvular Heart Disease: Moving Towards Translational Medicine by Lydia D. Hellwig, PhD, ScM, CGC
- Top Things to Know: Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets
Recommended Reading
- 2024 ACC/AHA Clinical Performance and Quality Measures for Adults with Valvular and Structural Heart Disease
- Evaluation and Management of Chronic Heart Failure in Children and Adolescents with Congenital Heart Disease
- The Tricuspid Valve: A Review of Pathology, Imaging and Current Treatment Options
- Implementation Science to Achieve Equity in Heart Failure Care
- 2020 ACC/AHA Guideline for the Management of Patients with Valvular Heart Disease