Revisiting the Open Vein Hypothesis to Reduce the Postthrombotic Syndrome: Implications for Multidisciplinary Care and Research
Published: May 13, 2025
- Post-thrombotic syndrome (PTS) is a common and often debilitating complication of deep vein thrombosis (DVT), despite anticoagulation. The open vein hypothesis (OVH) suggests that early thrombus clearance may reduce PTS, but evolving research highlights the need for a broader approach to venous health.
- PTS remains a major challenge despite current treatments. New insights into genetic, inflammatory, and environmental factors are reshaping the OVH, driving a more comprehensive approach to prevention and long-term vein health.
- Refining OVH with advances in science, technology, and multidisciplinary care can improve DVT outcomes and PTS prevention. Collaborative efforts across specialties are essential to enhance patient-centered strategies and raise awareness of thrombosis management.
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