Mitochondrial Function, Biology, and Role in Disease
Published: April 28, 2016
- Cardiovascular disease (CVD) is the leading cause of death worldwide, and mitochondrial function is increasingly being recognized as a contributing factor.
- Mitochondrial protein mutations or acquired defects can hinder mitochondrial quality control and lead to more defects, which have the potential to affect mechanisms related to metabolic signaling, reactive oxygen species generation, and cell death.
- This statement aims to better define the key mitochondrial processes that play a role in CVD, which are potential targets for novel therapeutic interventions.
- Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure
- Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings
- Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels