Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System
Published: July 14, 2016
- Reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to cardiovascular disease (CVD) initiation, progression, and severity.
- Reliable measures of ROS/RNS are difficult to achieve due to short half-lives and high reactivity, but are critical for consistency across studies.
- This statement aims to review current methods for measuring ROS, RNS, and their secondary products; to discuss the strengths of limitations of specific approaches; and to provide guidance for the reliable and reproducible measurement of reactive species.
Supporting Materials
- Commentary: A Conceptual Guide to the Measurement of Different Reactive Oxygen and Reactive Nitrogen Species in Cardiovascular Tissue by Ruhul Abid, MD, PhD
- Top Things to Know: Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System
Recommended Reading
- Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation
- Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet?Induced Metabolic Heart Disease
- Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling