Management of Inherited CNS Small Vessel Diseases: The CADASIL Example

Published: August 21, 2023

common pathologies encountered in the central nervous system
  • Lacunar infarcts and vascular dementia are phenotypic characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
  • CADASIL is caused by a mutation in the NOTCH3 gene expressed in endothelial smooth muscle cells.
  • This is the first paper from the American Heart Association published on the subject of inherited cerebrovascular small vessel diseases.