Intensive Glycemic Control and the Prevention of Cardiovascular Events

Published: December 17, 2008

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  • Results from randomized controlled trials (RCT) in the past have demonstrated conclusively that the risk of microvascular complications can be reduced by intensive glycemic control in patients with type 1 and type 2 diabetes.
  • Three new RCTs have recently been published to definitively determine the detrimental effects of elevated glucose on the vascular walls and examine the hypothesis of whether lowering glucose can prevent further vascular damage and reduce CVD events.
  • This joint statement examines clinical guidelines and statements, summarizes these recent RCTs to provide guidance in clinical practice settings, and makes critically important points about the state of the science which will impact future research directions.