Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator

Published: May 28, 2009

Hand drawing a cardiogram heartbeat wave and a person
  • Approximately 795,000 strokes occur in the United States each year; about 600,000 are ischemic.
  • Current guidelines recommend administration of tissue plasminogen activator (rtPA) for acute ischemic stroke within 3 hours of stroke symptom onset.
  • Recent results of the European Cooperative Acute Stroke Study (ECASS-3) show evidence of an expanded time window between 3.0 and 4.5 hours for persons experiencing acute ischemic stroke symptoms.