Depression as a Risk Factor for Poor Prognosis Among Patients With Acute Coronary Syndrome: Systematic Review and Recommendations

Published: February 24, 2014

  • Although the association between depression and increased morbidity and mortality has been well documented in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute coronary syndrome (ACS).
  • A systematic literature review on depression and adverse medical outcomes after acute coronary syndrome was conducted that included all-cause mortality, cardiac mortality, and composite outcomes for mortality and nonfatal events.
  • Based on available evidence, recommendation is made to elevate depression to the status of a risk factor for patients with acute coronary syndrome.