Strategically Focused Research Network Awardees
Strategically Focused Network Awardees
Strategically Focused Prevention Research Network - Award Activation: July 1, 2014
Icahn School of Medicine at Mount Sinai
Center Director: Valentin Fuster, MD, PhD, FAHA
Training Director: Roger Hajjar, MD, FAHA
Basic
Project PI: Eric Schadt, PhD
Applying Cross-generation Genetic and Genomic Information to Improve Cardiovascular Disease Prevention
Clinical
Project PI:
Zahi Fayad, PhD, FAHA
Two Intensive Life Style Intervention Programs in Related Caregivers of Preschool Children
Population
Project PI: Valentin Fuster, MD, PhD, FAHA
Children Heart Research Study Program
Northwestern University
Center Director: Philip Greenland, MD, FAHA
Training Director: Mercedes Carnethon, PhD, FAHA
Basic
Project PI: Lifang Hou, MD, PhD
Epigenetics of Cardiovascular Health Metrics
Clinical
Project PI: Bonnie Spring, PhD, FAHA
Behavioral Effects on CVH Metrics and Score
Population
Project PI: Norrina Allen, PhD
Trajectories in Cardiovascular Health (CVH) Metrics and Score From Childhood through Middle-Age
University of Texas Southwestern Medical Center
Center Director: Joseph Hill, MD, PhD, FAHA
Training Director: James de Lemos, MD, FAHA
Basic
Project PI: Joseph Hill, MD, PhD, FAHA
Molecular mechanisms in the transition from cardiomyocyte hypertrophy to HFpEF
Clinical
Project PI: Benjamin Levine, MD
Novel HFpEF Prevention Strategies In High Risk Individuals: High Intensity Exercise Training Plus Omega-3 Fatty Acids
Population
Project PI: Jarrett Berry, MD, MS, FAHA
Association Between Physical Activity and Modifiable Intermediate Heart Failure Phenotypes
Vanderbilt University Center
Director: David Harrison, MD, FAHA
Training Director: Meena Madhur, MD, PhD, FACC
Basic
Project PI: David Harrison, MD, FAHA
Effect of Salt on Innate and Adaptive Immune Cells in Hypertension
Clinical
Project PI: Jens Titze, MD
Lowering Tissue Na+ Stores to Reduce Blood Pressure, Systemic Inflammation, and Metabolic Derangement in Aging Humans
Population
Project PI: Thomas Jue-Fuu Wang, MD, FAHA
Prevention of Hypertension and its Complications in a Medically-Underserved Population
Strategically Focused Hypertension Research Network - Award Activation: April 1, 2015
Cincinnati Children's Hospital
Center Director: Elaine Urbina, MD, MS, FAHA
Training Director: Mark Mitsnefes, MD
Basic
Project PI: Richard Becker, MD, FAHA
Influence of Regulatory Genome on Target Organ Damage in Youth with Primary Hypertension
Clinical
Project PI: Joseph Flynn, MD, MS
Hemodynamic and Metabolic Predictors of Target Organ Damage in Youth with Primary Hypertension
Population
Project PI: Elaine Urbina, MD, MS, FAHA Threshold for Development of Blood Pressure-Related Target Organ Damage in Youth
Medical College of Wisconsin
Center Director: Mingyu Liang, MB, PhD
Training Director: Allen W. Cowley, Jr., PhD
Basic
Project PI: David L. Mattson, PhD, FAHA
Epigenetic Modification of Immune Mechanisms in Salt-Sensitive Hypertension and Renal Damage
Clinical
Project PI: Srividya Kidambi, MD, MS
Epigenomics of Hypertension in Monozygotic Twins and Effect of Salt Intake
Population
Project PI: Theodore A. Kotchen, MD, FAHA
Epigenomic Modifications in Hypertension and Hypertension-Related Cardiovascular Diseases
University of Alabama at Birmingham
Center Director: Paul Muntner, PhD, MHS
Training Director: Suzanne Oparil, MD, FACC, FAHA, FASH
Basic
Project PI: Jennifer Pollock, PhD, FAHA
Novel Mechanisms of Salt-sensitivity and Diurnal Blood Pressure Rhythm
Clinical
Project PI: David Calhoun, MD, FAHA
Mechanisms of Nocturnal Hypertension and Non-dipping Blood Pressure
Population
Project PI: Paul Muntner, PhD, MHS
Racial Differences and US population estimates of Nocturnal Hypertension and Non-dipping
University of Iowa
Center Director: Curt D. Sigmund, PhD, FAHA
Training Director: Kimberly K. Leslie, MD
Basic
Project PI: Justin L. Grobe, PhD, FAHA
Molecular Mechanisms of Vasopressin-Induced Preeclampsia
Clinical
Project PI: Gary L. Pierce, PhD
Early Vascular Dysfunction and Elevated Copeptin in Human Preeclampsia
Population
Project PI: Mark K. Santillan, MD, PhD, FACOG, FAHA
Predicting Preeclampsia via Copeptin: Underrepresented Minorities & Synergy with Other Biomarkers
Strategically Focused Disparities in Cardiovascular Disease Research Network - Award Activation: July 1, 2015
Medical University of South Carolina
Center Director: Robert Adams, MD, MS
Training Director: Daniel Lackland, DrPH, FAHA
Basic
Project PI: Mark Kindy, PhD, FAHA
Metabolic determinants of vascular stiffness in health disparities related stroke
Clinical
Project PI: Leonardo Bonilha, MD, PhD
Influence of pre-morbid brain health on stroke recovery
Population
Project PI: Gayenell Magwood, PhD
Community-based Intervention under Nurse Guidance after Stroke (CINGS)
Morehouse School of Medicine
Center Director: Herman Taylor Jr., MD, MPH, FACC, FAHA
Training Directors: Gregory Strayhorn, MD, PhD and Sandra Dunbar, RN, PhD, FAAN, FAHA, FPCNA
Basic
Project PIs: Charles Searles, MD, FAHA/Dean Jones, PhD
MicroRNA and metabolic profiles associated with social and environmental risk factors in blacks
Clinical
Project PIs: Arshed Quyyumi, MD/Priscilla Pemu, MBBS, MSCR, FACP
Impact of technology-based Intervention for improving self-management behaviors in Black adults
Population
Project PIs: Peter Baltrus, PhD/Tené Lewis, PhD
Social and Environmental Factors contributing to Cardiovascular Risk and Resilience among Blacks
Northwestern University
Center Directors: Myles Wolf, MD, MMSc and Mercedes Carnethon, PhD, FAHA
Training Director: Clyde Yancy, MD, MSc, MACC, FAHA, MACP
Basic
Project PI: Myles Wolf, MD, MMSc
Molecular Mechanisms of Cardiac Injury Induced by FGF23 in the Settings of High Phosphate Diet and CKD
Clinical
Project PI: Orlando Gutierrez, MD, MMSc
Impact of lowering phosphate additive intake on mineral metabolism and cardiovascular health in community-living adults
Population
Project PI: Mercedes Carnethon, PhD, FAHA
Contribution of Fibroblast Growth Factor 23 to Racial Disparities in Left Ventricular Mass and Albumin/Creatinine Ratio
University of Colorado Denver
Center Director: Spero Manson, PhD
Training Director: Spero Manson, PhD
Basic
Project PI: Irene Blair, PhD
Discrimination and Allostatic Load Among American Indians
Clinical
Project PI: Edward Havranek, MD
An Intervention to Increase Engagement with Hypertension Care for American Indian Patients
Population
Project PI: John Steiner, MD, MPH
Improving Hypertension Care of American Indians and Alaska Natives through Interactive Voice Response Technology
Go Red For Women Research Network - Award Activation: April 1, 2016
Columbia University Medical Center
Center Director: Lori Mosca, MD, MPH, PhD, FAHA
Training Director: Anne Taylor, MD
Basic
Project PI: Sanja Jelic, MD
The Effects of Sleep Restriction on Endothelial Activation in Pre- and Post-Menopausal Women
Clinical
Project PI: Marie Pierre St-Onge, PhD, FAHA
Impact of Sleep Restriction on Cardio Metabolic Risk Factors in Pre- vs Postmenopausal Women
Population
Project PI: Brooke Aggarwal, EdD, MS, CHES
Sleep and Cardio Metabolic Risk in Different Life Stages in a Diverse Population of Women
Johns Hopkins University School of Medicine
Center Director: Pamela Ouyang, MBBS, FAHA
Training Director: Erin Michos, MD, MHS, FAHA
Basic
Project PI: David Kass, MD, FAHA
Female Sex-Hormones and Cyclic GMP-PKG Modulation of Cardiac Disease and Metabolism
Clinical
Project PI: Sanjiv Shah, MD, FAHA
Role of Female Sex and Hormone Status on HFpEF Pathophysiology and Therapy
Population
Project PIs: Wendy Post, MD, MS/Dhananjay Vaidya, MBBS, PhD, MPH
Sex Differences in Hormonal and Cyclic GMP Dependent Pathways to Heart Failure with Preserved Ejection Fraction
Magee-Womens Research Institute and Foundation
Center Director: Carl Hubel, PhD
Training Director: James Roberts, MD
Basic
Project PI: Robert Powers, PhD
The Influence of Pregnancy on Future Vascular Dysfunction and Atherosclerosis
Clinical
Project PI: Carl Hubel, PhD Glycocalyx
Pathways Linking Pregnancy Profile with Microvascular Dysfunction Postpartum
Population
Project PI: Janet Catov, PhD, MS
The Placenta as a Window to Maternal Microvascular Disease Risk
New York University Medical Center
Center Director: Judith Hochman, MD, FAHA
Training Director: Glenn Fishman, MD, FAHA
Basic
Project PI: Jeffrey Berger, MD, FAHA
Comprehensive Assessment of Platelet Activity in Women with Myocardial Infarction
Clinical
Project PI: Harmony Reynolds, MD, FAHA
Mechanistic Insights into Myocardial Infarction with Non-obstructive Coronary Artery Disease (The MINOCA Study)
Population
Project PI: Tanya Spruill, PhD
Telephone-Based Stress Management for Women with Myocardial Infarction
University of California, San Diego
Center Director: Matthew Allison, MD, MPH, FAHA
Training Director: Matthew Allison, MD, MPH, FAHA
Basic
Project PI: Dorothy Sears, PhD
Mechanistic Transducers and Biomarkers of Sedentary Behavior-Associated Cardiovascular Disease Risk in Latina Women
Clinical
Project PI: Jacqueline Kerr, PhD, MSc
Randomized Control Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease
Population
Project PI: Sheila Castaneda, PhD
Biopsychosocial and Ecological Correlates of Latina Women's Sedentary Behavior
Strategically Focused Heart Failure Research Network - Award Activation: July 1, 2016
Duke University Medical Center
Center Director: G. Michael Felker, MD, MHS, FACC, FAHA
Training Director: Joseph Rogers, MD
Basic
Project PI: Svati Shah, MD, MHS, FAHA
Branched Chain Amino Acid and other Metabolic Pathways in Diabetic Heart Failure
Clinical
Project PI: G. Michael Felker, MD, MHS, FACC, FAHA
A randomized trial of a mobile health behavioral intervention in patients with heart failure and diabetes mellitus
Population
Project PI: Adam DeVore, MD, MHS
Improving Population Health for Patients with Diabetes and Heart Failure (IMPAcT-HF)
Massachusetts General Hospital
Center Director: Anthony Rosenzweig, MD, FAHA Training Director: Christopher Newton-Cheh, MD, MPH
Basic
Project PI: Anthony Rosenzweig, MD, FAHA
Functional roles of circulating ncRNAs in pathological hypertrophy and heart failure
Clinical
Project PI: Saumya Das, MD, PhD, MSc
Extracellular RNAs as Mediators of Cardiac Remodeling in Human Heart Failure
Population
Project PI: Jane Freedman, MD, FAHA
Extracellular RNA, Adverse Left Ventricular Remodeling, and Heart Failure Progression
University of Colorado, Denver
Center Director: Peter Buttrick, MD, FAHA
Training Director: Peter Buttrick, MD, FAHA
Basic
Project PI: Timothy McKinsey, PhD, FAHA
Epigenetic Readers as Downstream Effectors of Beta1-Adrenergic Receptor Signaling in HFrEF
Clinical
Project PI: Michael Bristow, MD, PhD, FAHA
Therapeutic Molecular and Structural Phenotypic Changes of Heart Rate Reduction in HFrEF
Population
Project PI: Larry Allen, MD, MHSc, FAHA
Electronic health record-leveraged, Patient-centered, Intensification of Chronic care for Heart Failure (EPIC-HF)
University of Utah
Center Director: Craig Selzman, MD, FAHA
Training Director: James Fang, MD, FACC, FAHA
Basic
Project PI: E. Dale Abel, MD, PhD
Coupling glucose uptake and pyruvate utilization to increase myocardial recovery in heart failure
Clinical
Project PI: Stavros Drakos, MD, PhD, FAHA
Predictors of myocardial recovery in chronic heart failure
Population
Project PI: Josef Stehlik, MD, MPH, FAHA
Patient-reported outcomes as an indicator of disease transitions in heart failure
Strategically Focused Obesity Research Network - Award Activation: April 1, 2017
Johns Hopkins University
Center Director: Jeanne M. Clark, MD, MPH
Training Director: Edgar R. Miller, III, MD, PhD
Basic
Project PI: Rexford S. Ahima, MD, PhD
Metabolic and Cardiovascular Effects of Time-Restricted Feeding in Obese Mice
Clinical
Project PI: Nisa M. Maruthur, MD, MHS
The Effect of Time-Restricted, Isocaloric Feeding on Weight: A Randomized Feeding Study in Obese Adults
Population
Project PI: Wendy Bennett, MD, MPH
The impact of timing of eating on weight: A Multi-Site Cohort Study using The Metabolic Compass Mobile Application
New York University Medical Center
Center Director: Ann Marie Schmidt, MD
Training Director: Glenn Fishman, MD, FAHA
Basic
Project PI: Ann Marie Schmidt, MD
RAGE/DIAPH1: Inflammation and Suppression of Energy Expenditure in Obesity - Mechanisms and Therapeutic Strategies
Clinical
Project PI: Ira J. Goldberg, MD, FAHA
Obesity, Inflammation and Cardiovascular Risk
Population
Project PI: Mary Ann Sevick, ScD, RN Alternative technology-supported behavioral weight loss intervention programs
University of Alabama at Birmingham
Center Director: W. Timothy Garvey, MD
Training Director: David B. Allison, PhD, FAHA
Basic
Project PI: W. Timothy Garvey, MD
Intergenerational Transmission of Obesity in Mouse Models of in Utero Stress
Clinical
Project PI: Lorie M. Harper, MD
Intergenerational Transmission of Obesity: Antenatal Mother and Beyond Birth Offspring
Population
Project PI: Paula C. Chandler-Laney, PhD
Intergenerational Transmission of Obesity in a Cohort of mother-child dyads
Vanderbilt University
Center Director: Kevin Niswender, MD, PhD
Training Directors: Alyssa H. Hasty, PhD, FAHA and Joshua A. Beckman, MD, MSc, FAHA
Basic
Project PI: Kevin Niswender, MD, PhD
Glucagon-like peptide-1 receptor and cardiometabolic health
Clinical
Project PI: Nancy J. Brown, MD, FAHA
Vascular effects of GLP-1 receptor activation
Population
Project PI: Nancy J. Cox, PhD
Genome and Phenome Studies on Obesity and CVD to Dissect GLP1R Mechanism
Strategically Focused Children's Research Network - Award Activation: July 1, 2017
Children’s National Health System
Center Director: Craig Sable, MD, FAHA
Training Director: Craig Sable, MD, FAHA
Basic
Project PI: James Dale, MD
Human Immunity to Potential Group A Streptococcal Vaccine Antigens in Subjects at High Risk for Rheumatic Heart Disease
Clinical
Project PI: Andrea Beaton, MD
Working Towards a Better Understanding of Acute Rheumatic Fever
Population
Project PI: David Watkins, MD, MPH
Building a Case to Invest in Rheumatic Heart Disease Prevention and Control in Limited Resource Settings
University of Utah
Center Director: Martin Tristani-Firouzi, MD
Training Director: H. Joseph Yost, PhD
Basic
Project PI: Mark Yandell, PhD
An integrated data-science, transcriptomics, and genomics approach to understanding Complex CHD
Clinical
Project PI: Robert Silver, MD
Maternal-fetal environment, epigenetics and complex congenital heart disease
Population
Project PI: Angela Fagerlin, PhD, MA
Improving Patient and Family Health Using Family-Centered Outcomes and Shared Decision-Making
Northwestern University
Center Directors: Bradley Marino, MD, MPP, MSCE, FAHA and Donald M Lloyd-Jones, MD, ScM, FAHA
Training Director: Matthew Davis, MD
Basic
Project PI: Lifang Hou, MD, MSc
Characterizing Dynamic Epigenomic Markers of CVH in Early Life
Clinical
Project PI: Linda Van Horn, PhD, RD, FAHA
Keeping Ideal Cardiovascular Health Family Intervention Trial: KIDFIT
Population
Project PI: Norrina Allen, PhD, MPH, FAHA
Cardiovascular Health Trajectories from Birth Through Adolescence
Duke University Medical School
Center Director: Jennifer Li, MD, MHSc
Training Director: Asheley Skinner, PhD
Basic
Project PI: Svati Shah, MD, MHS, FAHA
Microbiota Related Molecular Pathways in Pediatric Obesity
Clinical
Project PI: Sarah Armstrong, MD
A randomized trial of an integrated clinic-community intervention in children and adolescents with obesity
Population
Project PI: Asheley Skinner, PhD
Effectiveness and implementation of tertiary-care pediatric obesity treatment programs
Strategically Focused Vascular Disease Research Network - Award Activation: April 1, 2018
Brigham and Women’s Hospital/Dartmouth-Hitchcock Medical Center
Center Director: Marc Bonaca, MD, MPH and Mark Creager, MD, FAHA, FACC
Training Director: Marc Bonaca, MD, MPH and Philip Goodney, MD, MS
Basic
Project PI: Mark Feinberg, MD
Non-Coding RNAs in Diabetic Critical Limb Ischemia: Discovery, Pathobiology, and Therapeutic Intervention
Clinical
Project PI: Marc Bonaca, MD, MPH
Risk Prediction and Personalizing Therapy to Prevent Critical Limb Ischemia in Patients with PAD and Diabetes
Population
Project PIs: Philip Goodney, MD, MS and Mark Creager, MD, FAHA, FACC
Integrated Management Strategies to Reduce Amputation and Limit Disparities for Patients with Diabetes and CLI
Northwestern University
Center Director: Mary M. McDermott, MD, FAHA
Training Director: Mercedes Carnethon, PhD, FAHA
Basic
Project PI: Christiaan Leeuwenburgh, PhD
Calf Muscle Mitochondrial Dysfunction and Impaired Autophagy in Peripheral Artery Disease
Clinical
Project PI: Mary M. McDermott, MD, FAHA
NICotinamidE Riboside with and without Resveratrol to Improve Functioning in Peripheral Artery Disease: The NICE Trial
Population
Project PI: Philip Greenland, MD, FAHA Mitochondrial Dysfunction and Disability in Peripheral Artery Disease
University of Kentucky
Center Directors: Alan Daugherty, PhD, DSc
Training Director: Nancy Webb, PhD
Basic
Project PI: Alan Daugherty, PhD, DSC
Role of Sex Hormones on Elastin Stability in Formation of Thoracic Aortopathies
Basic Project PI: Lisa Cassis, PhD
Sexual Dimorphism of Aortopathies
Clinical
Project PI: Scott LeMaire, MD
Molecular Signature of Sex Chromosome Genes Associated with Sex-Dependent Susceptibility to Ascending Aortic Aneurysms
Vanderbilt University
Center Director: Joshua Beckman, MD, MS
Training Director: Joshua Beckman, MD, MS
Basic
Project PI: David Wasserman, PhD
The Link between Microcirculatory Dysfunction and Skeletal Muscle Insulin Resistance
Clinical
Project PI: Joshua Beckman, MD, MS
The Impact of Branched-Chain Amino Acids Metabolism on Limb Dysfunction in PAD
Population
Project PIs: Matthew Freiberg, MD and Quinn Wells, PharmD, MD
Clinical and Genetic Determinants of Peripheral Artery Disease, Microvascular Disease, and Major Adverse Limb Outcomes
Atrial Fibrillation Strategically Focused Research Network - Award Activation: July 1, 2018
Boston University
Advancing Atrial Fibrillation Precision Medicine
Center Director: Emelia Benjamin, MD, ScM
Training Director: Emelia Benjamin, MD, ScM
Basic
Project PI: Patrick Ellinor, MD, PhD
Genomics and Epigenetics of Atrial Fibrillation
Clinical
Project PI: Project PI: Steven Lubitz, MD, MPH
Precision Medicine in Ischemic Stroke and Atrial Fibrillation (PreMISe-AF)
Population
Project PI: Ludovic Trinquart, PhD, MPH
Clinical and genetic prediction of lifetime risk of atrial fibrillation and its complications
Cleveland Clinic Foundation
Translational Strategies for the Prevention of Atrial Fibrillation Development and Progression
Center Director: Mina Chung, MD, FAHA, FHRS
Training Director: Christine Moravec, PhD
Basic
Project PI: Jonathan Smith, PhD
Gene-Aging-Metabolism Interaction in Atrial Fibrillation Pathogenesis
Clinical
Project PI: Mina Chung, MD, FAHA, FHRS
Upstream Targeting for the Prevention of AF: Targeting Risk Interventions and Metformin for AF (TRIM-AF)
Population
Project PIs: David Van Wagoner, PhD, FAHA, FHRS
Multi-omic analysis of atrial metabolism, electrophysiology and AF progression
Northwestern University
Atrial Myopathy in Atrial Fibrillation
Center Director: Rod Passman, MD, MSCE
Training Director: Phil Greenland, MD
Basic
Project PI: Rishi Arora, MD
The role of oxidative stress in creating a vulnerable substrate for atrial fibrillation in the intact atrium
Clinical
Project PI: Rod Passman, MD, MSCE
Atrial Myopathy: Structure and Function in AF Ablation
Population
Project PI: Phil Greenland, MD
Atrial Substrate in Atrial Fibrillation and AF-Associated Brain Disease
Stanford University
Decision-Making Pathway for Atrial Fibrillation Stroke Prevention
Center Director: Paul Wang, MD
Clinical
Project PI: Randall Stafford, MD, PhD
Behavioral Science (Prevention / Intervention)
University of Utah
Studying Effectiveness in Patient-centered care
Center Director: Angie Fagerlin, PhD
Clinical
Project PI: Victor Montori, MD, MSc
Scan & Optimization of Decision Aids for Atrial Fibrillation (SODA-AF)
Population
Project PI: Elissa Ozanne, PhD
RED-AF: Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation
Vanderbilt University
A novel molecular target in atrial fibrillation
Center Director: Dan Roden, MD
Training Director: Bjorn Knollmann, MD, PhD
Basic
Project PI: Katherine Murray, MD
Reactive lipid metabolites as mediators of AF susceptibility in clinical and genetic risk models
Clinical
Project PI: Gregory Michaud, MD
A first-in-AF trial of a reactive lipid metabolite scavenger
Population
Project PI: Dan Roden, MD
Identifying AF subtypes driven by inflammation
Strategically Focused Arrhythmias & Sudden Cardiac Death Research Network - Award Activation: July 1, 2019
University of Michigan
Center Director: Robert Neumar, MD, PhD, FAHATraining Director: David Pinsky, MD
Basic
Project PI: Thomas Sanderson, PhD
Early Neuroprotective Therapies for Out-of-Hospital Cardiac Arrest
Clinical
Project PI: Robert Silbergleit, MD, FAHA
Bystander and First Responders Clinical Trials for Early Neuroprotective Therapies in Out-of-Hospital Cardiac Arrest
Population
Project PI: Brahmajee Nallamothu, MD, MPH, FAHA
Optimizing Bystander and First Responder Time to Treatment in Out-of-Hospital Cardiac Arrest
Northwestern University
Center Director: Elizabeth McNally, MD, PhDTraining Director: Rishi Arora, MD, FAHA
Basic
Project PI: Alfred “Al” George, MD
Correlating SCD Risk with Cell Autonomous Susceptibility
Clinical
Project PI: Elizabeth McNally, MD, PhD
Genomics of Arrhythmias and Sudden Death
Population
Project PI: Laura Rasmussen- Torvik, PhD, MPH, FAHA
Integration of Genomics into Clinical Care for SCD
Vanderbilt University
Center Director: Bjorn Knollman, MD, PhDTraining Director: Dan Roden, MD, FAHA
Basic
Project PI: Bjorn Knollman, MD, PhD
The Mechanistic Role of RyR2 Hyperactivity for Ventricular Arrhythmia in Animal Models of Structural Heart Disease
Basic
Project PI: Igor Efimov, PhD
Test the Mechanistic Role of RyR2 Hyperactivity for Ventricular Arrhythmia in the Ex Vivo Human Heart
Clinical
Project PI: William Stevenson, MD
Project Co-PIs: Scott Akers, PharmD, PhD and Benjamin Shoemaker, MD
A Clinical Trial of RyR2 Inhibition to Prevent Ventricular Arrhythmias in Patients with Structural Heart Disease
University of Washington
Center Director: Nona Sotoodehnia, MD, MPHD
Training Director: Francis Kim, MD and Michael Sayre, MD, FAHA
Clinical
Project PI: Ilan Goldenberg, MD
Project Co-PI: Wojciech Zareba, MD, PhD
Sex-Specific Risk for QTc Prolongation and Arrhythmic Events in Congenital Long QT Syndrome and Drug-Induced LQTS
Clinical
Project PI: Thomas Rea, MD, MPH
Project Co-PI: Peter Kudenchuk, MD
Precision Medicine Resuscitation: Novel Strategy for Real-Time Rhythm Assessment during CPR in Men and Women
Population
Project PI: Dan Arking, PhD
Project Co-PI: Nona Sotoodehnia, MD, MPH
Genomics of Sudden Cardiac Arrest Risk among Men and Women
Strategically Focused Cardiometabolic Health & Type 2 Diabetes Mellitus Research Network - Award Activation: January 1, 2020
Brigham & Women's Hospital
Training Directors: Vanita Aroda, MD and Jessica Fetterman, PhD
Basic
Project PI: Mark Feinberg, MD, FAHA
Non-coding RNAs in Ischemic Myocardial Disease and Diabetes: Discovery, Pathobiology, and Therapeutic
Clinical
Project PI: Marc Sabatine, MD, MPH, FAHA
Risk Prediction and Personalizing Therapy to Reduce Major Vascular, Heart Failure, and Renal Events in Diabetes
Clinical
Project PI: Naomi Hamburg, MD, FAHA
Restoring Vascular and Endothelial Health in Patients with Diabetes
University of Iowa
Training Director: Kamal Rahmouni, PhD, FAHA
Basic
Project PI: Ethan Anderson, PhD
A Heart-Liver-Adipose Axis: The Role of Inter-organ Crosstalk in Cardiometabolic Risk
Clinical
Project PI: Saumya Das MD, PhD
Adipose-derived Regulators of Inter-organ Communication in Type II Diabetes Mellitus and Cardiometabolic Disease
Population
Project PI: Ravi Shah, MD, FAHA
Molecular Signatures of Dysfunctional Adiposity and Cardiometabolic Disease in Young Adulthood: the CARDIA Study
New York University
Basic
Project PI: Edward Fisher, MD, MPH, PhD, FAHA
Mechanisms that Retard Atherosclerosis Regression in Insulin Resistant and Obese Mice
Clinical
Project PI: Jeffrey Berger, MD, FAHA
Diabetes and the Platelet Phenotype: Influence of Sex, Cholesterol Lowering and Cardiovascular Events
Population
Project PI: Chiara Giannarelli, MD, PhD
Determinants of Pathological Changes in Atherosclerosis in Women and Men with Diabetes
John Hopkins University
Training Director: Erin Michos, MD, MHS, FAHA
Basic
Project PI: Rexford Ahima, MD, PhD
Divergent Adipokine Mouse Models and Diabetic Cardiomyopathy
Population
Project Co-PI: Chiadi Ndumele, MD, PhD, FAHA
Project Co-PI: Elizabeth Selvin, PhD, FAHA
Serum Adipokines, Metabolic Risk Progression, and Heart Failure
Strategically Focused Health Technologies & Innovation Research Network - Award Activation: April 1, 2020
Boston University
Integrated Digital Technology Platform for Optimization of Precision Brain Health
Center Director: Rhoda Au, PhD
Training Director: Vijaya Kolachalama, PhD
Clinical
Project PI: Rhoda Au, PhD
Digital Phenotyping of Brain Health
Clinical
Project PI: Honghuang Lin, PhD
Futurizing Brain Health Monitoring Platform
Clinical
Project PI: Vijaya Kolachalama, PhD
Discovery and Validation of Digital Biomarkers
Cincinnati Children's Hospital
Active Detection and Decentralized Dynamic Registry to Improve Uptake of Rheumatic Heart Disease Secondary PreventionCenter Director: Andrea Beaton, MD
Training Director: Elaine Urbina, MD, FAHA
Clinical
Project PI: Andrea Beaton, MD
Active Detection and Decentralized Dynamic Registry to Improve Uptake of Rheumatic Heart Disease Secondary Prevention
Johns Hopkins University
Center for Mobile Technologies to Reduce Disparities in Cardiovascular HealthCo-Center Directors: Seth Martin, MD, MHS and David Newman-Toker, MD, PhD
Co-Training Directors: Erin Michos, MD, MHS, FAHA and Najila Nassery, MD
Clinical
Project PI: Seth Martin, MD, MHS
Advancing Mobile Technologies to Reduce Disparities in Cardiovascular Health
Stanford University
Center for Heart Health Technology (H2T): Innovation to ImplementationCenter & Training Director: Mintu Turakhia, MD
Clinical
Project PI: Paul Wang, MD
Technology-Enabled Management of Hypertension in Underrepresented Communities and in the Gig Economy
University of Michigan
Center Director: Brahmajee Nallamothu, MD, MPHTraining Director: Bhramar Mukherjee, PhD
Population
Project PI: Lesli Skolarus, MD, MSc
Wearables In Reducing risk and Enhancing Daily Life-style (WIRED-L) Project