Vascular Disease

Research Focus:
Understanding pathobiology and predictors of limb ischemia to improve outcomes in PAD and diabetes.

Center Director:
Marc Bonaca, MD, MPH and Mark Creager, MD, FAHA, FACC

Training Director:
Marc Bonaca, MD, MPH and Philip Goodney, MD, MS

Principal Investigators:

• Mark Feinberg, MD
  Non-Coding RNAs in Diabetic Critical Limb Ischemia: Discovery, Pathobiology, and Therapeutic Intervention


• Marc Bonaca, MD, MPH
  Risk Prediction and Personalizing Therapy to Prevent Critical Limb Ischemia in Patients with PAD and Diabetes


• Philip Goodney, MD, MS and Mark Creager, MD, FAHA, FACC
  Integrated Management Strategies to Reduce Amputation and Limit Disparities for Patients with Diabetes and CLI

Research Focus:
Calf skeletal muscle pathology and disability in PAD.

Center Director:
Mary M. McDermott, MD, FAHA

Training Director:
Mercedes Carnethon, PhD, FAHA

Principal Investigators:

• Christiaan Leeuwenburgh, PhD
  Calf Muscle Mitochondrial Dysfunction and Impaired Autophagy in Peripheral Artery Disease


• Mary M. McDermott, MD, FAHA
  NICotinamidE Riboside with and without Resveratrol to Improve Functioning in Peripheral Artery Disease: The NICE Trial


• Philip Greenland, MD, FAHA
  Mitochondrial Dysfunction and Disability in Peripheral Artery Disease

Research Focus:
Microcirculatory disease determines limb outcomes in PAD.

Center Director:
Joshua Beckman, MD, MS

Training Director:
Joey Barnett, PhD

Principal Investigators:

• David Wasserman, PhD
  The Link between Microcirculatory Dysfunction and Skeletal Muscle Insulin Resistance


• Joshua Beckman, MD, MS
  The Impact of Branched-Chain Amino Acids Metabolism on Limb Dysfunction in PAD


• Matthew Freiberg, MD and Quinn Wells, PharmD, MD
  Clinical and Genetic Determinants of Peripheral Artery Disease, Microvascular Disease, and Major Adverse Limb Outcomes

Research Focus:
Defining and understanding mechanisms of sex differences in aortopathies

Center Director:
Alan Daugherty, PhD, DSc, FAHA

Training Director:
Nancy Webb, PhD, FAHA

Principal Investigators:

• Alan Daugherty, PhD, DSc, FAHA
  Role of Sex Hormones on Elastin Stability in Formation of Thoracic Aortopathies


• Lisa Cassis, PhD
  Sexual Dimorphism of Aortopathies


• Scott LeMaire, MD, FAHA
  Molecular Signature of Sex Chromosome Genes Associated with Sex-Dependent Susceptibility to Ascending Aortic Aneurysms