Hypertension
April 2015-March 2019
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Research Focus:
Improve identification and diagnosis of
target organ damage in youth with
primary hypertension.
Center Director:
Elaine Urbina, MD, MS, FAHA
Training Director:
Mark Mitsnefes, MD
Richard Becker, MD, FAHA
Principal Investigators:
- Richard Becker, MD, FAHA
Influence of Regulatory Genome on Target Organ Damage in Youth with Primary Hypertension - Joseph Flynn, MD, MS
Hemodynamic and Metabolic Predictors of Target Organ Damage in Youth with Primary Hypertension - Elaine Urbina, MD, MS, FAHA
Threshold for Development of Blood Pressure-Related Target Organ Damage in Youth
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Research Focus:
Study epigenetic changes throughout the
genome in humans and animals with
hypertension to identify new approaches for
controlling high blood pressure.
Center Director:
Mingyu Liang, MB, PhD
Training Director:
Allen W. Cowley, Jr., PhD
Principal Investigators:
- David L. Mattson, PhD, FAHA
Epigenetic Modification of Immune Mechanisms in Salt-Sensitive Hypertension and Renal Damage - Srividya Kidambi, MD, MS
Epigenomics of Hypertension in Monozygotic Twins and Effect of Salt Intake - Theodore A. Kotchen, MD, FAHA
Epigenomic Modifications in Hypertension and Hypertension-Related Cardiovascular Diseases
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Research Focus:
Determine how blood pressure patterns over
24 hours impact risk for cardiovascular and
renal disease.
Center Director:
Paul Muntner, PhD, MHS, FAHA, FASH
Training Director:
Suzanne Oparil, MD, FACC, FAHA, FASH
David Pollock, PhD
Principal Investigators:
- Jennifer Pollock, PhD, FAHA
Novel Mechanisms of Salt-sensitivity and Diurnal Blood Pressure Rhythm - David Calhoun, MD, FAHA
Mechanisms of Nocturnal Hypertension and Non-dipping Blood Pressure - Paul Muntner, PhD, MHS, FAHA, FASH
Racial Differences and US population estimates of Nocturnal Hypertension and Non-dipping
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Research Focus:
Aim to find a reliable early predictor of
pre-eclampsia to help doctors in areas with
lower levels of obstetric care identify the
highest-risk patients as early as the sixth
week of pregnancy.
Center Director:
Curt D. Sigmund, PhD, FAHA
Training Director:
Kimberly K. Leslie, MD
Principal Investigators:
- Justin L. Grobe, PhD, FAHA
Molecular Mechanisms of Vasopressin-Induced Preeclampsia - Gary L. Pierce, PhD
Early Vascular Dysfunction and Elevated Copeptin in Human Preeclampsia - Mark K. Santillan, MD, PhD, FACOG, FAHA
Predicting Preeclampsia via Copeptin: Underrepresented Minorities & Synergy with Other Biomarkers