Arrhythmias and Sudden Cardiac Death

Michigan Medicine

Research Focus:
Michigan Resuscitation Innovation and Science Enterprise (M-RISE)

Center Director:
Robert Neumar, MD, PhD, FAHA

Training Director:
David Pinsky, MD


Principal Investigators

  • Thomas Sanderson, PhD
    Early Neuroprotective Therapies for Out-of-Hospital Cardiac Arrest

  • Robert Silbergleit, MD, FAHA
    Bystander and First Responders Clinical Trials for Early Neuroprotective Therapies in Out-of-Hospital Cardiac Arrest

  • Brahmajee Nallamothu, MD, MPH, FAHA
    Optimizing Bystander and First Responder Time to Treatment in Out-of-Hospital Cardiac Arrest

Northwestern Medicine Feinberg School of Medicine

Research Focus:
Northwestern Sudden Cardiac Death Collaboration

Center Director:
Elizabeth McNally, MD, PhD

Training Director:
Richi Arora, MD, FAHA

Principal Investigators:

  • Alfred “Al” George, MD
    Correlating SCD Risk with Cell Autonomous Susceptibility

  • Elizabeth McNally, MD, PhD
    Genomics of Arrhythmias and Sudden Death

  • Laura Rasmussen-Torvik, PhD, MPH, FAHA
    Integration of Genomics into Clinical Care for SCD


University of Washington

Research Focus:
Genomic and Precision Medicine Approaches to Evaluate Sex- Specific SCA Risk and Resuscitation Outcomes

Center Director:
Nona Sotoodehnia, MD, MPHD

Training Director:
Francis Kim, MD, FACC, FACP
Michael Sayre, MD, FAHA

Principal Investigators:

  • Ilan Goldenberg, MD
    Sex-Specific Risk for QTc Prolongation and Arrhythmic Events in Congenital and Drug Induced LQTS

  • Thomas Rea, MD, MPH
    Precision Medicine Resuscitation: Novel Strategy for Real- Time Rhythm Assessment during CPR

  • Dan Arking, PhD
    Genomics of Sudden Cardiac Arrest Risk among Men and Women

Vanderbilt University Medical Center

Research Focus:
Targeting Intracellular Calcium Leak for Ventricular Arrhythmia Prevention in Structural Heart Disease

Center Director:
Bjorn Knollmann, MD, PhD

Training Director:
Dan Roden, MD, FAHA

Principal Investigators:

  • Bjorn Knollmann, MD, PhD
    The Mechanistic Role of RyR2 Hyperactivity for Ventricular Arrhythmia in Animal Models

  • Igor Efimov, PhD
    The Mechanistic Role of RyR2 Hyperactivity for Ventricular Arrhythmia in the Ex Vivo Human Heart

  • William Stevenson, MD
    A Clinical Trial of RyR2 Inhibition to Prevent Ventricular Arrhythmias

July 2019-June 2023