2023 Stroke Council Award Lecturer - Patrick D. Lyden, MD, FAHA

Dr. Lyden is Professor of Physiology & Neuroscience and Neurology at the Zilkha Neurogenetic Institute in the Keck School of Medicine at the University of Southern California. Dr. Lyden helped lead the pivotal NINDS t-PA for Acute Stroke Trial, the first proven therapy for stroke. He is recognized globally for leadership in stroke therapy, having led large, multi-national trials for NIH and industry.

Dr. Lyden is the principal investigator of the NINDS-sponsored Stroke Preclinical Assessment Network, or SPAN, the first multi-site trial intended to identify candidate treatments likely to succeed in human clinical trials, and also Principal Investigator of the pivotal phase 3 trial RHAPSODY-2.

He is the Immediate Past Chair of the Stroke Council of the American Heart Association/American Stroke Association and a Fellow of the American Academy of Neurology, American Neurology Association, American Heart Association, and the European Stroke Organization. In 2019 he was awarded the prestigious William M. Feinberg Award for Excellence in Clinical Stroke by the American Heart Association.

Dr. Lyden’s laboratory works on finding new treatments for stroke, and understanding how the brain acts to save itself during stroke. Previously, the Lab pioneered therapeutic hypothermia for ischemic stroke. Recently, the Lyden Lab discovered a novel ‘help-me’ signal from neurons to astrocytes, the serine protease thrombin. Now the Lab seeks to translate this finding into novel treatment for acute stroke.