Programming – Vascular Discovery: From Genes to Medicine

Navigating the conference

Download these PDFs, or navigate the daily schedule by opening the mobile friendly tabs below.

Wednesday, May 10

Wed., May 10 schedule
Time Activity
8:00 a.m. – 6:00 p.m. Vascular Research Initiatives Conference(link opens in new window)
This event is not part of the official Vascular Discovery Scientific Sessions as planned by the Program Committee.
Separate registration is required to attend.

Grand Ballroom Salons F-G, 4th Floor
3:00 p.m. – 7:00 p.m. Registration
Atrium Foyer, 4th floor
3:00 p.m. – 6:30 p.m. Speaker Resource Room
Falmouth, 4th floor
7:45 p.m. – 8:15 p.m. Childcare
Yarmouth, 4th floor
6:30 p.m. – 8:00 p.m. Poster Session 1 & Reception
Gloucester/Back Bay, 3rd Floor

For a full list of poster presentations, visit the Online Program Planner

Thursday, May 11

Thu., May 11 schedule
Time Activity
6:00 a.m. to 6:00 p.m. Speaker Resource Room
Falmouth, 4th Floor
6:45 a.m. to 7:45 p.m. Childcare
Yarmouth, 4th Floor
7:00 a.m. to 6:00 p.m. Registration
Atrium Foyer, 4th Floor
7:00 a.m. to 8:00 a.m. Continental Breakfast
Atrium Foyer, 4th Floor
7:00 a.m. to 4:30 p.m. Exhibits
Atrium Foyer, 4th Floor
7:00 a.m. to 8:00 a.m.

Early Career Training Session 1: Academic Roundtable Discussions
Presented by the ATVB Early Career Committee
Grand Ballroom Salons A-D, 4th Floor


Getting Your Training Grant Funded
Bishuang Cai, PhD, Ichan School of Medicine at Mount

Saying No and Difficult Conversations
Jaume Amengual, PhD, University of Illinois
Milka Koupenova, PhD, University of Massachusetts Medical School

Setting Up Your New Lab and Hiring
Mabruka Alfaidi, MD, PhD, LSU Health Sciences Center

The Importance of Mentoring and Being Mentored
Brian Kim, MD, MPH, Stanford School of Medicine
Casey Romanoski, PhD, University of Arizona

Work-Life Balance
Mireille Ouimet, PhD, University of Ottawa Heart Institute
Gregory Payne, MD, PhD, University of Alabama at Birmingham

Strategies for Project Management
Cynthia St. Hilaire, PhD, University of Pittsburgh

8:00 a.m. to 8:30 a.m. Conference Opening Welcome
Grand Ballroom Salons E-F, 4th Floor

8:00 -  American Heart Association Presidential Remarks
Michelle Albert, MD, MPH, FACC, FAHA, University of California, San Francisco

8:15 - Welcome Remarks
Katey Rayner, PhD, FHA, Chair
8:00 a.m. to 10:00 a.m. 

Plenary Session 1:  Gene-Environment Interactions in Cardiovascular Disease
Grand Ballroom Salons E-G, 4th Floor

Moderators:
Katey Rayner, PhD, FHA, Chair, University of Ottawa Heart Institute
Philip Tsao, PhD, Stanford University School of Medicine

8:30 - A Roadmap for Sustainable Cardiovascular Health in the Anthropocene Era
Sanjay Rajagopalan, MD, FACC, FAHA, Case Western Reserve University

9:00 - Gene-Environment Interactions for Coronary Artery Disease
Hooman Allayee, PhD, University of Southern California Keck School of Medicine

9:30 - Vascular Complications of Obstructive Sleep Apnea
Sanja Jelic, MD, Columbia University Medical Center

10:00 a.m. to 10:30 a.m.

Break/Exhibits 
Atrium foyer, 4th floor

10:30 a.m. to 12:15 p.m.

Concurrent Session 1a: Molecular and Cellular Mechanisms of Atherosclerosis
Grand Ballroom Salon E, 4th Floor

Moderators:
Lars Maegdefessel, MD, PhD, Technical University Munich
Cornelia M. Weyand, MD, PhD, Mayo Clinic

10:30 Innate and Adaptive Immunity in Vascular Inflammation
Cornelia M. Weyand, MD, PhD, Mayo Clinic

Oral Abstract Presentations: (see abstracts and authors in the Online Program Planner)
11:00 - Presentation Number 100
Multi-omics and Single Nucleus Transcriptomics Reveal Aberrant Adaptive Immune Responses in Human Bicuspid Aortic Valves

11:15 - Presentation Number 101
Crosstalk of Pluripotency and Innate Immunity in Smooth Muscle Cell Phenotypic Transitions

11:30 -
Presentation Number 102
Hyperlipidemia-induced Hematopoiesis is Repressed by MLKL in Endothelial Cells of the Splenic Niche

11:45 -
Presentation Number 103
Epigenetic and Phenotypic Modulation of Adventitial Fibroblasts in Atherosclerosis by Coronary Artery Risk Gene TCF21

12:00 -
Presentation Number 104
Gene Regulation by RNA Granule Formation in Atherosclerosis

10:30 a.m. to 12:15 p.m.

Concurrent Session 1b: Inflammation & Immunity in the Vessel Wall
Grand Ballroom Salon F, 4th Floor

Moderators:
Esther Lutgens, MD, PhD, Mayo Clinic
Holger Winkels, PhD, University of Cologne

10:30 Recent Insights into Immune Mechanisms of Atherosclerosis by Single Cell Technologies
Holger Winkels, PhD, University of Cologne

Oral Abstract Presentations: (see full abstract text & author blocks in the Online Program Planner)

11:00 - 
Presentation Number 105
Lipid Regulation of Senescent Effector CD8 T Cells in Type 2 Diabetes

11:15 - Presentation Number 106
Single Cell High Dimensional Analysis of Human Peripheral Blood Mononuclear Cells Reveals Unique Intermediate Monocyte Subsets Associated with Sex Differences in Coronary Heart Disease

11:30 - Presentation Number 107
CaMK4 is a Novel Regulator of Myeloid Phenotype and Function in Atherosclerosis

11:45 - Presentation Number 108
Il-1β Inhibition Promotes Fibrous Cap Thickening and Accumulation of Fibroblast Like Cells in Atheromas in Clonal Hematopoiesis

12:00 - Presentation Number 109
A Spatial Transcriptomic Approach to Understanding Coronary Atherosclerotic Plaque Stability

10:30 a.m. to 12:15 p.m.

Concurrent Session 1c: Translational Science in Vascular Disease: New Insights into Abdominal Aortic Aneurysms
Organized in cooperation with the Council on Peripheral Vascular Disease
Grand Ballroom Salon G, 4th Floor

Moderators:
Derek Klarin, MD, Stanford University
Jean M. Ruddy, MD, Medical University of South Carolina

10:30- Modern Epidemiology of AAA, with a Focus on Women
Rebecka Hultgren, MD, PhD, Professor, Karolinska Institute

10:45- AAA Genetics and Integration of Human Genetics and Mouse Data
Philip Tsao, PhD, Stanford University School of Medicine

11:00- Insights into the Pathogenesis of Abdominal Aortic Aneurysms: Human Tissues and Animal Models
Frank M. Davis, MD, University of Michigan

Oral Abstract Presentations: (see full list in the Online Program Planner)

11:15 - Presentation Number 111
Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T-cells, Decrease Effector Th17 Cells, And Decrease Aneurysm Volume In A Dose Dependent Fashion In Patients With Small Abdominal Aortic Aneurysms - Results Of The Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial)

11:30 - Presentation Number 112
PCSK6 Ablation in Vascular Smooth Muscle Cells Promotes Abdominal Aortic Aneurysm Development and Rupture

11:45 - Presentation Number 113
Transcriptomic Profile of Macrophage-mediated Energy Metabolism in Sporadic Aortic Aneurysms and Acute Dissections

12:00 - Presentation Number 110
The Histone Methyltransferase Setdb2 Modulates Macrophage TIMP-MMP Activity During Abdominal Aortic Aneurysm Development

12:15 p.m. to 2:15 p.m. The Mentor of Women Award Luncheon - Ticket Required
2023 Mentor of Women Award Luncheon Program (PDF)
Grand Ballroom Salons A-D, 4th Floor
12:15 p.m. to 2:15 p.m.  Or Lunch on Your Own 
12:45 p.m. to 2:00 p.m. Single Cell and Single Nucleus RNA Sequencing: A Practical Guide to Design and Analysis
Omics Bootcamp 1
 - Wet Lab Practical Considerations
Ticket required.  Lunch on your own.
Organized in cooperation with the Council on Genomics and Precision Medicine.
Grand Ballroom Salons H-K, 4th Floor

In this Bootcamp, participants will learn about best practices in tissue handling, single cell and nuclei isolation methods, and sequencing platforms for your single cell and single nuclear RNA-seq experiment.

Moderators:
Matt Nayor MD, MPH, Boston University Medical Center
Lisa Wilsbacher, MD, PHD, FAHA, Feinberg School of Medicine

Bootcamp Facilitator/Discussion Leader: 
Amelia Hall, PhD, Broad Institute of MIT and Harvard
2:15 p.m. to 3:45 p.m.

Plenary Session 2:  Highlights from the ATVB Journal
Grand Ballroom Salons E-G, 4th Floor

Moderators:
Elena Aikawa, MD, PhD, FAHA, Brigham and Women’s Hospital
Daniel Tyrrell, PhD, The University of Alabama at Birmingham

2:15 - ATVB Journal Report
Ann Marie Schmidt, MD, NYU School of Medicine

Presentations by the 2023 ATVB Journal Early Career Investigator Award Recipients:

2:30 - Daniel Steinberg Early Career Investigator Award in Atherosclerosis/Lipoproteins
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
Ljubica Matic, PhD, Karolinska Institute

2:45 - Karl Link Early Career Investigator Award in Thrombosis
Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity co-exists with Thrombin Resistance
Sonali R. Gnanenthiran, MBBS, PhD, The George Institute for Global Health

3:00 - Werner Risau Early Career Investigator Award in Vascular Biology
Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells
Arvind K. Pandey, MD, Brigham and Women’s Hospital

3:15 - Medical Engineering and Science – Advancing Therapeutic Opportunities for Vascular Diseases
Elazer R. Edelman, MD, PhD, Massachusetts Institute of Technology

3:45 p.m. to 4:15 p.m. Break/Exhibits 
Atrium Foyer / 4th Floor
4:15 p.m. to 6:00 p.m. Concurrent Session 2a: Apolipoproteins, Lipoproteins and Lipid Metabolism
Grand Ballroom Salon E, 4th Floor

Moderators:
Edward Fisher, MD, MPH, PhD, NYU Langone Health
Gissette Reyes-Soffer, MD, FAHA, Columbia University Medical Center

4:15 - FITM2: A New Factor for the Lipidation of VLDL and the Atherogenicity of apoB-lipoproteins
Edward Fisher, MD, MPH, PhD, NYU Langone Health

Oral Abstract Presentations: (see full list in the Online Program Planner)
4:45 - Presentation Number 114
Glycosylation of PCSK9 Impairs Its Interaction with LDLR But Assures its Stability


5:00 - Presentation Number 115
Angptl3 Deficiency Impairs Triglyceride-rich Lipoprotein Production and Produces Adaptive Changes in Hepatic Lipid Metabolism

5:15 - Presentation Number 116
Variation In Lipoprotein (a) Level Reduction with Potent Lipid Lowering: An Analysis of The Cholesterol Reduction and Residual Risk in Diabetes Study

5:30 - Presentation Number 117
Structure Function Analysis of Guinea Pig and Human Apolipoprotein E to Obtain Insight into Their Role in Cardiovascular Disease

5:45 - Presentation Number 118
Positive Adipose Liver Crosstalk Protects Adipose MTP Knockout Mice from Hepatic Steatosis on an Obesogenic Diet
4:15 p.m. to 6:00 p.m. Concurrent Session 2b: Thrombosis: Signaling, Mechanisms & Function
Grand Ballroom Salon F, 4th Floor

Moderators:
Milka Koupenova, PhD, FAHA, University of Massachusetts Medical School
A. Valance Washington, PhD, Oakland University

4:15 - Novel Insights into Platelet Functionalization of Fibrinogen
A. Valance Washington, PhD, Oakland University

Oral Abstract Presentations: (see full list in the Online Program Planner)
4:45 -
Presentation Number 119
Aging-related Activation of Platelet Mtor Promotes Platelet Hyperreactivity and Thrombosis


5:00 -
Presentation Number 120
Eosinophils And Eosinophil Extracellular Traps (eets) In Arterial Thrombosis in Lnk(sh2b3) Deficiency

5:15 -
Presentation Number 121
TMEM16E and TMEM16F Are Required for the Formation of Prothrombotic Extracellular Vesicles from Endothelial Cells

5:30 -
Presentation Number 122
The Eicosanoid Analogue Cs585 Represents a First-in-class In Prevention of Platelet Activation and Thrombosis Through Direct Activation of the Prostacyclin Receptor

5:45 -
Presentation Number 123
Protein Kinase C Theta (PKCθ) Signaling Associated with The Generation of Procoagulant Platelets Revealed By Phosphoproteomics And Systems Analysis
 
4:15 p.m. to 6:00 p.m.

Concurrent Session 2c:  Hot Off the Bench Oral Abstract Presentations 
Grand Ballroom Salon G, 4th Floor

Moderators:
Hong Chen, PhD, FAHA, Harvard Medical School
Jason Fish, PhD, University of Toronto

Oral Abstract Presentations: (see full list in the Online Program Planner)
4:15 - Presentation Number 161
Ablation of Intracellular Lipolytic Inhibitor G0S2 Promotes Vascular Lipolysis and Alleviates Diet-induced Atherosclerosis

4:30 Presentation Number 162
Multiancestry GWAS and Functional Genomics Analysis of HNF1A Locus to Define Novel Pathogenic Mechanism for Ischemic Stroke

4:45 - Presentation Number 163
Thrombocytopenia Independently Leads to Monocyte Immune Dysfunction

5:00 - Presentation Number 164
From Telomere Shortening to Atherosclerosis-associated Endothelial Senescence

5:15 - Presentation Number 165
Large Extracellular Vesicles-derived MicroRNA-150-5p Is Upregulated in Patients with Aortic Valve Stenosis and Regulates Valvular Endothelial Cell Function

5:30 - Presentation Number 166
Memory Cd8 T Cells Contribute to Atherosclerosis in Aged Mice

5:45 - Presentation Number 167
Immunomodulatory Properties of HDL are Associated with Lipidomic and Proteomic Composition and are Modifiable by Diet

 
6:00 p.m to 7:30 p.m.

Poster Session 2 & Reception
Sponsored by the ATVB Journal 
Gloucester/Back Bay, 3rd Floor

For a full list of poster presentations, see the Online Program Planner)


Friday, May 12

Friday, May 12 Activities
Time Activity
6:00 a.m. to 6:00 p.m. Speaker Resource Room
Falmouth, 4th Floor
6:45 a.m. to 7:45 p.m. Childcare
Yarmouth, 4th Floor
7:00 a.m. to 6:00 p.m. Registration
Atrium Foyer, 4th Floor
7:00 a.m. to 8:00 a.m. Continental Breakfast
Atrium Foyer, 4th Floor
7:00 a.m. to 4:30 p.m. Exhibits
Atrium Foyer, 4th Floor
7:00 a.m. to 8:00 a.m.

Early Career Training Session 2:  Industry Round Table Discussions
Presented by the ATVB Early Career Committee
Grand Ballroom Salons A-D, 4th Floor

  • Alexandra Chadwick, PhD, Verve Pharmaceuticals
  • Xixi Sun, JD, PhD, Cooley LLP
  • Rachel Roth-Flach, PhD, Pfizer
  • Victoria Llado, PhD, Laminar Pharma
  • Gerry Waters, PhD, Novartis
8:00 a.m. to 9:30 a.m. Plenary Session 3: Vascular Disease in the Post-Genomic Era
Grand Ballroom Salons E-G, 4th Floor

Moderators:
Kathleen Martin, PhD, Yale University
Kiran Musunuru, MD, PhD, University of Pennsylvania

8:00 - Multi-Omics in Cardiometabolic Diseases
Robert E. Gerszten, MD, FACC, FAHA, Beth Israel Deaconess Medical Center, Harvard Medical School, Broad Institute

8:30 - Identifying Effects of Common Genetic Variation in Human Endothelial Cells
Casey Romanoski, PhD, University of Arizona

9:00 - Therapeutic Gene Editing
David R. Liu, PhD, Broad Institute, Harvard University
9:30 a.m. to 10:00 a.m. Break/Exhibits
Atrium foyer, 4th floor 
10:00 a.m. to 11:45 a.m.

Concurrent Session 3a:  Therapeutic Targets in Atherosclerosis
Grand Ballroom Salon E, 4th Floor

Moderators:
Mete Civelek, PhD, University of Virginia
Yun Fang, PhD, University of Chicago

10:00 - Precision Nanomedicine and Endothelial Mechanotransduction in Vascular Diseases and Therapeutics
Yun Fang, PhD, University of Chicago

Oral Abstract Presentations: (see full list in the Online Program Planner)
10:30 - Presentation Number 124
Synthetic High-density Lipoprotein Attenuates Abdominal Aortic Aneurysm Formation Via Restoring Vascular Smooth Muscle Cell Mitochondrial Function

10:45 - Presentation Number 125
Sex-dependent Effects of Sortilin Antisense Oligonucleotide on Vascular Calcification

11:00 - Presentation Number 126
Effect of Icospaent Ethyl on In Vivo Atheroma Progression and Inflammatory Protease Activity

11:15 - Presentation Number 127
A Targeted Nanofiber Loaded with Liver X Receptor Agonist Reduces Atherosclerotic Plaque and Prevents Hepatotoxicity

11:30 - Presentation Number 128
Safety and Efficacy of Pro-efferocytic Nanoparticles To Treat Atherosclerosis in a Porcine Model

10:00 a.m. to 11:45 a.m. Concurrent Session 3b:  Blood Coagulation in Health & Disease
Grand Ballroom Salon F, 4th Floor

Moderators:
Katerina Akassoglou, PhD, University of California, San Francisco
Hanrui Zhang, MB, PhD, Columbia University Medical Center

10:00 - Fibrinogen in Neurological Diseases: Mechanisms, Imaging, Therapeutics
Katerina Akassoglou, PhD, University of California, San Francisco

Oral Abstract Presentations: (see full list in the Online Program Planner)
10:30 - Presentation Number 129
Bleeding Diathesis in Ehlers-danlos Syndrome Patients Is Caused by Impaired Platelet Inside-out Signaling and Integrin αIIbβ3 Activation

10:45 - Presentation Number 130
The Integrin β3 Subunit Directly Inhibits the Galpha13 -p115RhoGEF Interaction to Regulate G Protein Signaling and Platelet Exocytosis

11:00 - Presentation Number 131
Identification of a Molecule to Modulate a Platelet Olfactory Receptor and Limit Thrombosis

11:15 - Presentation Number 132
Mechanism by Which Coagulation Factor XI Regulates Endothelial Cell Permeability and Barrier Function In Vitro and In Vivo

11:30 - Presentation Number 133
Engineering Plasminogen Activator Inhibitor-1 Variants with Novel Protease Inhibitor Activity

10:00 a.m. to 11:45 a.m.

Concurrent Session 3c: Translational Science in Vascular Disease: Updates from the AHA Strategically Focused Vascular Disease Research Network
Organized in cooperation with the Council on Peripheral Vascular Disease
Grand Ballroom Salon G, 4th Floor


Moderators:
Leili Behrooz, MD, MPH, Boston University School of Medicine
Scott J. Cameron, MD, Cleveland Clinic

10:00 - Understanding the Pathobiology and Predictors of Critical Limb Ischemia to Improve Outcomes in Peripheral Artery Disease and Diabetes
Mark A. Creager, MD, FAHA, Dartmouth Hitchcock Medical Center

10:10 - Interactions of LRP1 and Angiotensinogen in Aortopathies
Alan Daugherty PhD, DSc, FAHA, University of Kentucky

10:20 - The Impact of Microvascular Disease in PAD
Joshua A. Beckman, MD, FAHA, UT Southwestern Medical Center

10:30 - Skeletal Muscle Damage in Peripheral Artery Disease
Mary McGrae McDermott, MD, FAHA, Feinberg School of Medicine, Northwestern University

10:40 - Panel Discussion

Rapid Fire Oral Abstract Presentations -  (see full list in the Online Program Planner)

10:55 - Presentation Number 134
A Single-cell Atlas of Human Skeletal Muscle Tissue in Chronic Limb-threatening Ischemia

11:03 - Presentation Number 135
The Aim2 Inflammasome Deters Myogenic Potential of Muscle Satellite Cells Affected by Peripheral Artery Disease (pad) and is a Therapeutic Target to Attenuate Myopathy

11:11 - Presentation Number 136
Chronic Kidney Disease Aggravates Ischemic Leg Myopathy in Patients with Peripheral Artery Disease

11:19 - Presentation Number 137
Identification of Human Gut Microbial Markers in Patients with Peripheral Artery Disease Using Different Sample Preservation Methods

11:27 - Presentation Number 138
Delivery of Allogeneic Mitochondria Accelerates Revascularization in a Murine Model of Peripheral Arterial Disease and Reverses Metabolic Signatures of Endothelial Senescence

11:35 - Presentation Number 139
Semi-automated Classification of Peripheral Artery Disease Lesion Composition from Multi-Contrast Magnetic Resonance Histology at 9.4 Tesla with A 2 Dimensional Convolutional Neural Network Variational AutoEncoder Algorithm

11:45 a.m. to 1:45 p.m. PVD Annual Business Meeting and Networking Luncheon (ticket required)
Grand Ballroom Salons C-D, 4th Floor
2023 PVD Annual Networking and Business Luncheon Program (PDF)
11:45 a.m. to 12:45 p.m. Career Development Session: Building Inclusive Mentoring Relationships
Sponsored by the ATVB Diversity Committee
Lunch will be provided.
Simmons, 3rd Floor

Panelists/Facilitators:
Jaume Amengual, PhD, University of Illinois
Ngan F. Huang, PhD, FAHA, Stanford University
Sashi Kant, PhD, Harvard Medical School, Brigham and Women’s Hospital
Adil Rasheed, PhD, Ottawa Heart Institute
Francine K. Welty, MD, PhD, Harvard Medical School

Inclusive mentoring/panel discussion on the following topics:
  • Best practices to mentor diverse mentees
  • Different research habits
  • Different mentoring styles/habits
  • How to develop an Inclusive lab culture
  • Inclusive communication methods
  • A list of research grants available
11:45. a.m. to 1:45 p.m. Or lunch on your own
12:30 p.m. to 1:30 p.m.

Single Cell and Single Nucleus RNA Sequencing: A Practical Guide to Design and Analysis
Omics Bootcamp 2: Practical Coding Considerations

Organized in cooperation with the Council on Genomics and Precision Medicine.
Ticket required, lunch on your own
Grand Ballroom Salons H-K, 4th Floor

During this Bootcamp, participants will walk through a public code notebook with Dr. Hall to learn how to process and analyze your single cell and single nuclear RNA-seq data.

Moderators:
Matthew Nayor MD, MPH, Boston University Medical Center
Lisa Wilsbacher, MD, PHD, FAHA, Feinberg School of Medicine

Bootcamp Facilitator/Discussion Leader:
Amelia Hall, PhD

1:45 p.m. to 3:45 p.m. Plenary Session 4:  Early Career Investigator Award Competition
Grand Ballroom Salons E-G, 4th Floor

Kenneth M. Brinkhous Early Career Investigator Prize in Thrombosis Competition
Moderators:
Milka Koupenova, PhD, FAHA, University of Massachusetts Medical School
Kellie Machlus, PhD, Harvard Medical School

Finalists: 
(see full abstracts and author list in the Online Program Planner)

1:45 - Presentation Number 140
A Common, Racially Diverse Protease Activated Receptor 4 Functional Variant Impacts Ischemic Stroke Outcomes: Evidence for a Pharmacogenetic Effect
Frederik Denorme, Univ of Utah, Salt Lake Cty, UT

2:00 - Presentation Number 141
Lung Thrombosis Upregulates Endothelial Pla2g2d to Inhibit Inflammatory Lung Injury
Colin E Evans, Northwestern Univ, Chicago, IL

2:15 - Presentation Number 142
Actin Bundling Protein L-plastin Regulates Platelet Production, Spreading and Thrombosis
Li Amily Guo, Bloodworks Res Inst, Univ of Washington, Seattle, WA

2:30 - Presentation Number 143
Differential Suppression of Arterial Versus Venous Thrombosis but Preserved Hemostasis in Mice Expressing Fibrinogen that Cannot Support Fibrin Formation
Woosuk Steve Hur, Tomohiro Kawano, Univ of North Carolina, Chapel Hill, NC

Irvine H. Page Junior Faculty Research Award Competition
Moderators:
Marlys Koschinsky, PhD, Robarts Research Institute
Nick J. Leeper, MD, Stanford University

Finalists
(see full abstracts and author list in the Online Program Planner)

2:45 - Presentation Number 144
Enhancement of High Density Lipoprotein-associated Elastase Inhibitor Activity Prevents Atherosclerosis Progression
Scott M Gordon, Univ of Kentucky, Lexington, KY

3:00 - Presentation Number 145
CRISPRi-Perturb-seq In Endothelial Cells Links Atherosclerosis Risk Loci to Novel Klf2/4 Regulatory Genes
Rajat M Gupta, Brigham and Women's Hosp, Boston, MA

3:15 - Presentation Number 146
Foamy Macrophages Rely on Trem2 For Survival During Atherosclerosis
Jesse W Williams, Univ of Minnesota, Minneapolis, MN

3:30 Presentation Number 147
Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging
Arif Yurdagul Jr., LSUHSC SHREVEPORT, Shreveport, LA
3:45 p.m. to 4:15 p.m. Break/Exhibits
Atrium foyer, 4th floor
4:15 p.m to 6:00 p.m. Concurrent Session 4a:  Metabolic Disorders in Atherosclerosis
Grand Ballroom Salon E, 4th Floor

Moderators:
Babak Razani, MD, PhD, University of Pittsburgh and UPMC
Ze Zheng, MD, PhD, Medical College of Wisconsin

4:15 - The Intertwining Duality of Fibrinolysis and Lipid Metabolism
Ze Zheng, MD, PhD, Medical College of Wisconsin

Oral Abstract Presentations (see full abstracts and author list in the Online Program Planner)

4:45 - Presentation Number 148
Lipoprotein Lipase Deficiency Reprograms Bone Marrow Cellular Metabolic Activity and Inflammatory Responses

5:00 - Presentation Number 149
Manipulating Bile Acid Production Using Genome Editing to Modulate Cardio-metabolic Disease

5:15 - Presentation Number 150
Targeting The Lipogenic Enzyme ATP Citrate Lyase as a Potential Therapy Against Coronary Artery Disease

5:30 - Presentation Number 151
Evaluation on the Therapeutic Potential of Targeting the Amino Acid-mtorc1 Pathway in Atherosclerosis

5:45 -
Presentation Number 152
Metabolism and Therapeutic Potential of Lipidated Amino Acids in Nonalcoholic Steatohepatitis and Atherosclerosis

4:15 p.m to 6:00 p.m.

Concurrent Session 4b: Vascular Cells, Inflammation and Thrombosis
Grand Ballroom Salon F, 4th Floor

Moderators:
Marit Westerterp, PhD, University of Groningen, Gronien, Netherlands
Anirban Sen Gupta, PhD, Case Western Reserve University

4:15 - Platelet-inspired Nanomedicine Targeted to Thrombosis and Thromboinflammation
Anirban Sen Gupta, PhD, Case Western Reserve University

Oral Abstract Presentations 
(see full abstracts and author list in the Online Program Planner)

4:45 -
Presentation Number 153
Involvement of Peptidylarginine Deiminase 4 In Eosinophil Extracellular Trap Formation and Contribution to Citrullinated Histone Signal in Thrombi

5:00 - Presentation Number 154
Crossroads of Immunity and Coagulation: Protease Activity of Complement Component C1s Inhibits Protein C Activation in Covid-19

5:15 -
Presentation Number 155
Platelet-derived Transforming Growth Factor-β1 Ameliorates AAA in a Murine Model

5:30 -
Presentation Number 156
Role of Platelets in Maintaining Hemostasis and Coagulation Activation in Viral-induced Acute Respiratory Distress Syndrome (ards) in Mice

5:45 -
Presentation Number 157
Inkiln is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation Via Scaffolding Mkl1 and Usp10

4:15 p.m to 6:00 p.m. Concurrent Session 4c: Genomics and Multi-Omics in Vascular Disease
Organized in cooperation with the Council on Genomics and Precision Medicine
Grand Ballroom Salon G, 4th Floor


Moderators:
Clint Miller, PhD, University of Virginia
Ying Wang, PhD, University of British Columbia

4:15 - Applications of Mendelian Randomization and Polygenic Risk Scores in Abdominal Aortic Aneurysm
Michael Levin, MD, University of Pennsylvania

4:30 - Functional Genomics Screens to Identify Causal Pathways for Vascular Disease
Rajat M. Gupta, MD, Brigman and Women’s Hospital

4:45 - Positional Transcriptomics Defines Regionally Restricted Sex-Specific Differences of the Vessel Wall
Milagros Romay, PhD, Northwestern University

5:00 - Genetic Approaches to Evaluate APOL1 as a Therapeutic Target for Sepsis
QiPing Feng, PhD, Vanderbilt University Medical Center

Oral Abstract Presentations (see full abstracts and author list in the Online Program Planner)

5:15 - Presentation Number 158
The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation and is Associated with Blood Pressure


5:30 - Presentation Number 159
Palmitic Acid Alters Enhancers and Super Enhancers Near Inflammatory and Efferocytosis-associated Genes In Human Monocytes

5:45 -
Presentation Number 160
Atherosclerosis Regression at The Single-Cell Level
6:00 p.m. to 7:30 p.m.

Poster Session 3 and Reception
 (see full abstracts and author list in the Online Program Planner)

7:30 p.m. to 10:00 p.m.  Joint Council Dinner - ticket required
 2023 Joint Council Dinner Program (PDF)
Grand Ballroom Salons E-G, 4th floor

Saturday, May 13

Saturday, May 13 Activities
Time Activity
6:45 a.m. to 10:45 a.m.

Childcare
Yarmouth, 4th Floor

6:00 a.m. to 10:30 a.m. Speaker Resource Room
Falmouth, 4th Floor
7:00 a.m. to 10:30 a.m. Registration
Atrium Foyer, 4th Floor
7:00 a.m. to 8:00 a.m. Inside the AHA's Research Enterprise: Grant Funding and Other Opportunities
Glenn H. Dillon, PhD, American Heart Association
Grand Ballroom Salons E-G, 4th Floor 
8:00 a.m. to 9:00 a.m.

Meet the Professor / Continental Breakfast
Join us for breakfast and roundtable discussions with experts on various topics.  Hosted by faculty, this interactive session will provide opportunities to discuss, share and learn.  No ticket required to attend.
Grand Ballroom Salons A-D, 4th Floor

9:00 a.m. to 10:30 a.m.

Plenary Session 5 - Invited Lecture Series
(See speaker bios and more in 2023 Lectures Brochure [PDF])
Grand Ballroom Salons E-G, 4th Floor

Jeffrey M. Hoeg Arteriosclerosis, Thrombosis and Vascular Biology Award for Basic Science and Clinical Research Lecture
9:00 - Systems Approach to Target Discovery for Macrophage Activation and Vascular Disease
Masanori Aikawa, MD, PhD, Harvard Medical School, Brigham and Women’s Hospital

Keynote Lecture
9:30 - Regulation of Endothelial Cell Specification in Development and Disease
Karen K. Hirschi, PhD, University of Virginia

Distinguished Lecture
10:00 - Advances in Omega-3 Fatty Acid Research
Deepak L. Bhatt, MD, MPH, FACC, FAHA, FESC, MSCAI, Ichan School of Medicine at Mount Sinai

 
10:30 a.m. Closing Remarks / Adjourn
1:30 p.m. to 7:00 p.m.

Day 1 - HDL Workshop: Infection and Neurodegenerative Diseases (new window)
This event is not part of the official Vascular Discovery Scientific Sessions as planned by the program committee.
Separate Registration Required.
Grand Ballroom Salon H-K, 4th Floor

Sunday:
8:30 a.m. to noon

Sunday:
Day 2 - HDL Workshop: Infection and Neurodegenerative Diseases (new window)
This event is not part of the official Vascular Discovery Scientific Sessions as planned by the program committee.
Separate Registration Required.
Grand Ballroom Salon H-K, 4th Floor

Other Meetings of Interest

Vascular Research Initiatives Conference(link opens in new window)(link opens in new window)
May 10, 2023, Marriott Copley Place in Boston, Massachusetts
7:00 a.m. – 6:00 p.m.
A separate registration fee is required to attend.

The Vascular Research Initiatives Conference (VRIC), presented by the Society for Vascular Surgery® (SVS), is a one-day conference preceding the main Vascular Discovery 2023 meeting, uniquely designed to foster interaction among top scientists of diverse disciplines who are investigating peripheral vascular disease and its treatments. The conference is also dedicated to stimulating and encouraging interest in research among trainees who are aspiring academic vascular surgeons, or those interested in vascular research or biology.


11th Annual HDL Workshop
May 13–14, 2023, Boston Marriott Copley Place, Boston, Massachusetts
Saturday: 1:30 p.m. – 7:00 p.m.
Sunday: 8:30 a.m. – Noon

The HDL Workshop provides an opportunity for researchers in the HDL community to discuss the latest developments in the field. In addition to a panel discussion by leaders in the field, this highly interactive international forum features short talks and stimulating discussions among the attendees and speakers. Separate registration required.

In addition to invited speakers, brief oral abstract and poster presentations will be selected from submitted abstracts. Trainees and early career investigators are encouraged to submit their abstracts, as there will be an award for the top-scoring abstract.

About this Meeting

This 2 ½-day meeting is sponsored by the Council on Arteriosclerosis, Thrombosis and Vascular Biology, the Peripheral Vascular Disease Council, and the Council on Genomic and Precision Medicine, in cooperation with and the Society for Vascular Surgery's Vascular Research Initiatives Conference.

Vascular Discovery 2023 will provide unique opportunities to meet with colleagues from around the world with wide-ranging research interests and expertise for the timely exchange of information about new and emerging scientific research in the areas of arteriosclerosis, thrombosis and vascular biology, peripheral vascular disease, vascular surgery research, genomics and precision medicine. We expect a broad representation from many disciplines and encourage young scientists to attend.

See the American Heart Association Policies and Guiding Values (PDF).

Target Audience

The conference will especially appeal to scientists and clinicians interested in: 

  • Allergy and Immunology
  • Arteriosclerosis
  • Biochemistry
  • Biological Sciences
  • Diabetes and Metabolism
  • Functional Genomics
  • Genetics
  • Hematology
  • Internal Medicine
  • Molecular/Cellular Biology
  • Nutrition
  • Pathology
  • Peripheral Artery Disease
  • Pharmacology
  • Physiology
  • Vascular Surgery
  • Thrombosis
  • Vascular Biology
  • Vascular Medicine