Programming – Vascular Discovery: From Genes to Medicine
Boston Marriott Copley Place | Boston, Massachusetts
Navigating the conference
Download these PDFs, or navigate the daily schedule by opening the mobile friendly tabs below.
- Online Program Planner (link opens in new window)(link opens in new window)(link opens in new window)
- Final Program (PDF, 9.8MB)
- 2023 Vascular Discovery Awardees (PDF)
- 2023 Poster Presentations (PDF, 30 MB) - use Online Program Planner to see full abstract text
- 2023 Invited Lecturers Brochure (PDF)
- 2023 Room Locator (PDF)
| Time | Activity |
|---|---|
| 8:00 a.m. – 6:00 p.m. | Vascular Research Initiatives Conference(link opens in new window) This event is not part of the official Vascular Discovery Scientific Sessions as planned by the Program Committee. Separate registration is required to attend. Grand Ballroom Salons F-G, 4th Floor |
| 3:00 p.m. – 7:00 p.m. | Registration Atrium Foyer, 4th floor |
| 3:00 p.m. – 6:30 p.m. | Speaker Resource Room Falmouth, 4th floor |
| 7:45 p.m. – 8:15 p.m. | Childcare Yarmouth, 4th floor |
| 6:30 p.m. – 8:00 p.m. | Poster Session 1 & Reception Gloucester/Back Bay, 3rd Floor For a full list of poster presentations, visit the Online Program Planner |
| Time | Activity |
|---|---|
| 6:00 a.m. to 6:00 p.m. | Speaker Resource Room Falmouth, 4th Floor |
| 6:45 a.m. to 7:45 p.m. | Childcare Yarmouth, 4th Floor |
| 7:00 a.m. to 6:00 p.m. | Registration Atrium Foyer, 4th Floor |
| 7:00 a.m. to 8:00 a.m. | Continental Breakfast Atrium Foyer, 4th Floor |
| 7:00 a.m. to 4:30 p.m. | Exhibits Atrium Foyer, 4th Floor |
| 7:00 a.m. to 8:00 a.m. |
Early Career Training Session 1: Academic Roundtable Discussions Saying No and Difficult Conversations |
| 8:00 a.m. to 8:30 a.m. | Conference Opening Welcome Grand Ballroom Salons E-F, 4th Floor 8:00 - American Heart Association Presidential Remarks Michelle Albert, MD, MPH, FACC, FAHA, University of California, San Francisco 8:15 - Welcome Remarks Katey Rayner, PhD, FHA, Chair |
| 8:00 a.m. to 10:00 a.m. |
Plenary Session 1: Gene-Environment Interactions in Cardiovascular Disease Moderators: |
| 10:00 a.m. to 10:30 a.m. |
Break/Exhibits |
| 10:30 a.m. to 12:15 p.m. |
Concurrent Session 1a: Molecular and Cellular Mechanisms of Atherosclerosis 11:15 - Presentation Number 101 |
| 10:30 a.m. to 12:15 p.m. |
Concurrent Session 1b: Inflammation & Immunity in the Vessel Wall Moderators: 11:15 - Presentation Number 106 11:30 - Presentation Number 107 11:45 - Presentation Number 108 12:00 - Presentation Number 109 |
| 10:30 a.m. to 12:15 p.m. |
Concurrent Session 1c: Translational Science in Vascular Disease: New Insights into Abdominal Aortic Aneurysms Moderators: 11:30 - Presentation Number 112 |
| 12:15 p.m. to 2:15 p.m. | The Mentor of Women Award Luncheon - Ticket Required 2023 Mentor of Women Award Luncheon Program (PDF) Grand Ballroom Salons A-D, 4th Floor |
| 12:15 p.m. to 2:15 p.m. | Or Lunch on Your Own |
| 12:45 p.m. to 2:00 p.m. | Single Cell and Single Nucleus RNA Sequencing: A Practical Guide to Design and Analysis Omics Bootcamp 1 - Wet Lab Practical Considerations Ticket required. Lunch on your own. Organized in cooperation with the Council on Genomics and Precision Medicine. Grand Ballroom Salons H-K, 4th Floor In this Bootcamp, participants will learn about best practices in tissue handling, single cell and nuclei isolation methods, and sequencing platforms for your single cell and single nuclear RNA-seq experiment. Moderators: Matt Nayor MD, MPH, Boston University Medical Center Lisa Wilsbacher, MD, PHD, FAHA, Feinberg School of Medicine Bootcamp Facilitator/Discussion Leader: Amelia Hall, PhD, Broad Institute of MIT and Harvard |
| 2:15 p.m. to 3:45 p.m. |
Plenary Session 2: Highlights from the ATVB Journal Presentations by the 2023 ATVB Journal Early Career Investigator Award Recipients: 2:30 - Daniel Steinberg Early Career Investigator Award in Atherosclerosis/Lipoproteins |
| 3:45 p.m. to 4:15 p.m. | Break/Exhibits Atrium Foyer / 4th Floor |
| 4:15 p.m. to 6:00 p.m. | Concurrent Session 2a: Apolipoproteins, Lipoproteins and Lipid Metabolism Grand Ballroom Salon E, 4th Floor Moderators: Edward Fisher, MD, MPH, PhD, NYU Langone Health Gissette Reyes-Soffer, MD, FAHA, Columbia University Medical Center 4:15 - FITM2: A New Factor for the Lipidation of VLDL and the Atherogenicity of apoB-lipoproteins Edward Fisher, MD, MPH, PhD, NYU Langone Health Oral Abstract Presentations: (see full list in the Online Program Planner) 4:45 - Presentation Number 114 Glycosylation of PCSK9 Impairs Its Interaction with LDLR But Assures its Stability 5:00 - Presentation Number 115 Angptl3 Deficiency Impairs Triglyceride-rich Lipoprotein Production and Produces Adaptive Changes in Hepatic Lipid Metabolism 5:15 - Presentation Number 116 Variation In Lipoprotein (a) Level Reduction with Potent Lipid Lowering: An Analysis of The Cholesterol Reduction and Residual Risk in Diabetes Study 5:30 - Presentation Number 117 Structure Function Analysis of Guinea Pig and Human Apolipoprotein E to Obtain Insight into Their Role in Cardiovascular Disease 5:45 - Presentation Number 118 Positive Adipose Liver Crosstalk Protects Adipose MTP Knockout Mice from Hepatic Steatosis on an Obesogenic Diet |
| 4:15 p.m. to 6:00 p.m. | Concurrent Session 2b: Thrombosis: Signaling, Mechanisms & Function Grand Ballroom Salon F, 4th Floor Moderators: Milka Koupenova, PhD, FAHA, University of Massachusetts Medical School A. Valance Washington, PhD, Oakland University 4:15 - Novel Insights into Platelet Functionalization of Fibrinogen A. Valance Washington, PhD, Oakland University Oral Abstract Presentations: (see full list in the Online Program Planner) 4:45 - Presentation Number 119 Aging-related Activation of Platelet Mtor Promotes Platelet Hyperreactivity and Thrombosis 5:00 - Presentation Number 120 Eosinophils And Eosinophil Extracellular Traps (eets) In Arterial Thrombosis in Lnk(sh2b3) Deficiency 5:15 - Presentation Number 121 TMEM16E and TMEM16F Are Required for the Formation of Prothrombotic Extracellular Vesicles from Endothelial Cells 5:30 - Presentation Number 122 The Eicosanoid Analogue Cs585 Represents a First-in-class In Prevention of Platelet Activation and Thrombosis Through Direct Activation of the Prostacyclin Receptor 5:45 - Presentation Number 123 Protein Kinase C Theta (PKCθ) Signaling Associated with The Generation of Procoagulant Platelets Revealed By Phosphoproteomics And Systems Analysis |
| 4:15 p.m. to 6:00 p.m. |
Concurrent Session 2c: Hot Off the Bench Oral Abstract Presentations Moderators: |
| 6:00 p.m to 7:30 p.m. |
Poster Session 2 & Reception For a full list of poster presentations, see the Online Program Planner) |
| Time | Activity |
|---|---|
| 6:00 a.m. to 6:00 p.m. | Speaker Resource Room Falmouth, 4th Floor |
| 6:45 a.m. to 7:45 p.m. | Childcare Yarmouth, 4th Floor |
| 7:00 a.m. to 6:00 p.m. | Registration Atrium Foyer, 4th Floor |
| 7:00 a.m. to 8:00 a.m. | Continental Breakfast Atrium Foyer, 4th Floor |
| 7:00 a.m. to 4:30 p.m. | Exhibits Atrium Foyer, 4th Floor |
| 7:00 a.m. to 8:00 a.m. |
Early Career Training Session 2: Industry Round Table Discussions
|
| 8:00 a.m. to 9:30 a.m. | Plenary Session 3: Vascular Disease in the Post-Genomic Era Grand Ballroom Salons E-G, 4th Floor Moderators: Kathleen Martin, PhD, Yale University Kiran Musunuru, MD, PhD, University of Pennsylvania 8:00 - Multi-Omics in Cardiometabolic Diseases Robert E. Gerszten, MD, FACC, FAHA, Beth Israel Deaconess Medical Center, Harvard Medical School, Broad Institute 8:30 - Identifying Effects of Common Genetic Variation in Human Endothelial Cells Casey Romanoski, PhD, University of Arizona 9:00 - Therapeutic Gene Editing David R. Liu, PhD, Broad Institute, Harvard University |
| 9:30 a.m. to 10:00 a.m. | Break/Exhibits Atrium foyer, 4th floor |
| 10:00 a.m. to 11:45 a.m. |
Concurrent Session 3a: Therapeutic Targets in Atherosclerosis
Oral Abstract Presentations: (see full list in the Online Program Planner) |
| 10:00 a.m. to 11:45 a.m. | Concurrent Session 3b: Blood Coagulation in Health & Disease Grand Ballroom Salon F, 4th Floor Moderators: Katerina Akassoglou, PhD, University of California, San Francisco Hanrui Zhang, MB, PhD, Columbia University Medical Center 10:00 - Fibrinogen in Neurological Diseases: Mechanisms, Imaging, Therapeutics Katerina Akassoglou, PhD, University of California, San Francisco Oral Abstract Presentations: (see full list in the Online Program Planner) 10:30 - Presentation Number 129 Bleeding Diathesis in Ehlers-danlos Syndrome Patients Is Caused by Impaired Platelet Inside-out Signaling and Integrin αIIbβ3 Activation 10:45 - Presentation Number 130 The Integrin β3 Subunit Directly Inhibits the Galpha13 -p115RhoGEF Interaction to Regulate G Protein Signaling and Platelet Exocytosis 11:00 - Presentation Number 131 Identification of a Molecule to Modulate a Platelet Olfactory Receptor and Limit Thrombosis 11:15 - Presentation Number 132 Mechanism by Which Coagulation Factor XI Regulates Endothelial Cell Permeability and Barrier Function In Vitro and In Vivo 11:30 - Presentation Number 133 Engineering Plasminogen Activator Inhibitor-1 Variants with Novel Protease Inhibitor Activity |
| 10:00 a.m. to 11:45 a.m. |
Concurrent Session 3c: Translational Science in Vascular Disease: Updates from the AHA Strategically Focused Vascular Disease Research Network Rapid Fire Oral Abstract Presentations - (see full list in the Online Program Planner) |
| 11:45 a.m. to 1:45 p.m. | PVD Annual Business Meeting and Networking Luncheon (ticket required) Grand Ballroom Salons C-D, 4th Floor 2023 PVD Annual Networking and Business Luncheon Program (PDF) |
| 11:45 a.m. to 12:45 p.m. | Career Development Session: Building Inclusive Mentoring Relationships Sponsored by the ATVB Diversity Committee Lunch will be provided. Simmons, 3rd Floor Panelists/Facilitators: Jaume Amengual, PhD, University of Illinois Ngan F. Huang, PhD, FAHA, Stanford University Sashi Kant, PhD, Harvard Medical School, Brigham and Women’s Hospital Adil Rasheed, PhD, Ottawa Heart Institute Francine K. Welty, MD, PhD, Harvard Medical School Inclusive mentoring/panel discussion on the following topics:
|
| 11:45. a.m. to 1:45 p.m. | Or lunch on your own |
| 12:30 p.m. to 1:30 p.m. |
Single Cell and Single Nucleus RNA Sequencing: A Practical Guide to Design and Analysis During this Bootcamp, participants will walk through a public code notebook with Dr. Hall to learn how to process and analyze your single cell and single nuclear RNA-seq data. Moderators: |
| 1:45 p.m. to 3:45 p.m. | Plenary Session 4: Early Career Investigator Award Competition Grand Ballroom Salons E-G, 4th Floor Kenneth M. Brinkhous Early Career Investigator Prize in Thrombosis Competition Moderators: Milka Koupenova, PhD, FAHA, University of Massachusetts Medical School Kellie Machlus, PhD, Harvard Medical School Finalists: (see full abstracts and author list in the Online Program Planner) 1:45 - Presentation Number 140 A Common, Racially Diverse Protease Activated Receptor 4 Functional Variant Impacts Ischemic Stroke Outcomes: Evidence for a Pharmacogenetic Effect Frederik Denorme, Univ of Utah, Salt Lake Cty, UT 2:00 - Presentation Number 141 Lung Thrombosis Upregulates Endothelial Pla2g2d to Inhibit Inflammatory Lung Injury Colin E Evans, Northwestern Univ, Chicago, IL 2:15 - Presentation Number 142 Actin Bundling Protein L-plastin Regulates Platelet Production, Spreading and Thrombosis Li Amily Guo, Bloodworks Res Inst, Univ of Washington, Seattle, WA 2:30 - Presentation Number 143 Differential Suppression of Arterial Versus Venous Thrombosis but Preserved Hemostasis in Mice Expressing Fibrinogen that Cannot Support Fibrin Formation Woosuk Steve Hur, Tomohiro Kawano, Univ of North Carolina, Chapel Hill, NC Irvine H. Page Junior Faculty Research Award Competition Moderators: Marlys Koschinsky, PhD, Robarts Research Institute Nick J. Leeper, MD, Stanford University Finalists (see full abstracts and author list in the Online Program Planner) 2:45 - Presentation Number 144 Enhancement of High Density Lipoprotein-associated Elastase Inhibitor Activity Prevents Atherosclerosis Progression Scott M Gordon, Univ of Kentucky, Lexington, KY 3:00 - Presentation Number 145 CRISPRi-Perturb-seq In Endothelial Cells Links Atherosclerosis Risk Loci to Novel Klf2/4 Regulatory Genes Rajat M Gupta, Brigham and Women's Hosp, Boston, MA 3:15 - Presentation Number 146 Foamy Macrophages Rely on Trem2 For Survival During Atherosclerosis Jesse W Williams, Univ of Minnesota, Minneapolis, MN 3:30 Presentation Number 147 Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging Arif Yurdagul Jr., LSUHSC SHREVEPORT, Shreveport, LA |
| 3:45 p.m. to 4:15 p.m. | Break/Exhibits Atrium foyer, 4th floor |
| 4:15 p.m to 6:00 p.m. | Concurrent Session 4a: Metabolic Disorders in Atherosclerosis Grand Ballroom Salon E, 4th Floor Moderators: Babak Razani, MD, PhD, University of Pittsburgh and UPMC Ze Zheng, MD, PhD, Medical College of Wisconsin 4:15 - The Intertwining Duality of Fibrinolysis and Lipid Metabolism Ze Zheng, MD, PhD, Medical College of Wisconsin Oral Abstract Presentations (see full abstracts and author list in the Online Program Planner) 4:45 - Presentation Number 148 Lipoprotein Lipase Deficiency Reprograms Bone Marrow Cellular Metabolic Activity and Inflammatory Responses 5:00 - Presentation Number 149 Manipulating Bile Acid Production Using Genome Editing to Modulate Cardio-metabolic Disease 5:15 - Presentation Number 150 Targeting The Lipogenic Enzyme ATP Citrate Lyase as a Potential Therapy Against Coronary Artery Disease 5:30 - Presentation Number 151 Evaluation on the Therapeutic Potential of Targeting the Amino Acid-mtorc1 Pathway in Atherosclerosis 5:45 - Presentation Number 152 Metabolism and Therapeutic Potential of Lipidated Amino Acids in Nonalcoholic Steatohepatitis and Atherosclerosis |
| 4:15 p.m to 6:00 p.m. |
Concurrent Session 4b: Vascular Cells, Inflammation and Thrombosis 5:00 - Presentation Number 154 |
| 4:15 p.m to 6:00 p.m. | Concurrent Session 4c: Genomics and Multi-Omics in Vascular Disease Organized in cooperation with the Council on Genomics and Precision Medicine Grand Ballroom Salon G, 4th Floor Moderators: Clint Miller, PhD, University of Virginia Ying Wang, PhD, University of British Columbia 4:15 - Applications of Mendelian Randomization and Polygenic Risk Scores in Abdominal Aortic Aneurysm Michael Levin, MD, University of Pennsylvania 4:30 - Functional Genomics Screens to Identify Causal Pathways for Vascular Disease Rajat M. Gupta, MD, Brigman and Women’s Hospital 4:45 - Positional Transcriptomics Defines Regionally Restricted Sex-Specific Differences of the Vessel Wall Milagros Romay, PhD, Northwestern University 5:00 - Genetic Approaches to Evaluate APOL1 as a Therapeutic Target for Sepsis QiPing Feng, PhD, Vanderbilt University Medical Center Oral Abstract Presentations (see full abstracts and author list in the Online Program Planner) 5:15 - Presentation Number 158 The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation and is Associated with Blood Pressure 5:30 - Presentation Number 159 Palmitic Acid Alters Enhancers and Super Enhancers Near Inflammatory and Efferocytosis-associated Genes In Human Monocytes 5:45 - Presentation Number 160 Atherosclerosis Regression at The Single-Cell Level |
| 6:00 p.m. to 7:30 p.m. |
Poster Session 3 and Reception |
| 7:30 p.m. to 10:00 p.m. | Joint Council Dinner - ticket required 2023 Joint Council Dinner Program (PDF) Grand Ballroom Salons E-G, 4th floor |
| Time | Activity |
|---|---|
| 6:45 a.m. to 10:45 a.m. |
Childcare |
| 6:00 a.m. to 10:30 a.m. | Speaker Resource Room Falmouth, 4th Floor |
| 7:00 a.m. to 10:30 a.m. | Registration Atrium Foyer, 4th Floor |
| 7:00 a.m. to 8:00 a.m. | Inside the AHA's Research Enterprise: Grant Funding and Other Opportunities Glenn H. Dillon, PhD, American Heart Association Grand Ballroom Salons E-G, 4th Floor |
| 8:00 a.m. to 9:00 a.m. |
Meet the Professor / Continental Breakfast |
| 9:00 a.m. to 10:30 a.m. |
Plenary Session 5 - Invited Lecture Series Jeffrey M. Hoeg Arteriosclerosis, Thrombosis and Vascular Biology Award for Basic Science and Clinical Research Lecture |
| 10:30 a.m. | Closing Remarks / Adjourn |
| 1:30 p.m. to 7:00 p.m. |
Day 1 - HDL Workshop: Infection and Neurodegenerative Diseases (new window) |
| Sunday: 8:30 a.m. to noon |
Sunday: |
Other Meetings of Interest
Vascular Research Initiatives Conference(link opens in new window)(link opens in new window)
May 10, 2023, Marriott Copley Place in Boston, Massachusetts
7:00 a.m. – 6:00 p.m.
A separate registration fee is required to attend.
The Vascular Research Initiatives Conference (VRIC), presented by the Society for Vascular Surgery® (SVS), is a one-day conference preceding the main Vascular Discovery 2023 meeting, uniquely designed to foster interaction among top scientists of diverse disciplines who are investigating peripheral vascular disease and its treatments. The conference is also dedicated to stimulating and encouraging interest in research among trainees who are aspiring academic vascular surgeons, or those interested in vascular research or biology.
11th Annual HDL Workshop
May 13–14, 2023, Boston Marriott Copley Place, Boston, Massachusetts
Saturday: 1:30 p.m. – 7:00 p.m.
Sunday: 8:30 a.m. – Noon
The HDL Workshop provides an opportunity for researchers in the HDL community to discuss the latest developments in the field. In addition to a panel discussion by leaders in the field, this highly interactive international forum features short talks and stimulating discussions among the attendees and speakers. Separate registration required.
In addition to invited speakers, brief oral abstract and poster presentations will be selected from submitted abstracts. Trainees and early career investigators are encouraged to submit their abstracts, as there will be an award for the top-scoring abstract.
About this Meeting
This 2 ½-day meeting is sponsored by the Council on Arteriosclerosis, Thrombosis and Vascular Biology, the Peripheral Vascular Disease Council, and the Council on Genomic and Precision Medicine, in cooperation with and the Society for Vascular Surgery's Vascular Research Initiatives Conference.
Vascular Discovery 2023 will provide unique opportunities to meet with colleagues from around the world with wide-ranging research interests and expertise for the timely exchange of information about new and emerging scientific research in the areas of arteriosclerosis, thrombosis and vascular biology, peripheral vascular disease, vascular surgery research, genomics and precision medicine. We expect a broad representation from many disciplines and encourage young scientists to attend.
See the American Heart Association Policies and Guiding Values (PDF).
Target Audience
The conference will especially appeal to scientists and clinicians interested in:
- Allergy and Immunology
- Arteriosclerosis
- Biochemistry
- Biological Sciences
- Diabetes and Metabolism
- Functional Genomics
- Genetics
- Hematology
- Internal Medicine
- Molecular/Cellular Biology
- Nutrition
- Pathology
- Peripheral Artery Disease
- Pharmacology
- Physiology
- Vascular Surgery
- Thrombosis
- Vascular Biology
- Vascular Medicine