Science News – Scientific Sessions 2022
Scientific Sessions: November 5–7, 2022
Chicago, IL + Virtual
Welcome to #AHA22 Science News!
This is where you will find in-depth interviews from investigators and AHA experts on the Tier 1 late-breaking clinical trials during Scientific Sessions 2022. Expect at-a-glance summaries, analysis, and more!
Here are some important links:
TRANSFORM-HF
Comparative Effectiveness of Torsemide versus Furosemide in Heart Failure: Primary Results of the TRANSFORM-HF Trial
Robert J Mentz | Duke University Hospital, Durham, North Carolina
DCP
Chlorthalidone Compared to Hydrochlorothiazide for the Prevention of Cardiovascular Events in Patients With Hypertension
Areef Ishani | Minneapolis VA Health Care System, Minneapolis, Minnesota
PROMINENT
A Randomized Trial of Pemafibrate for Triglyceride Reduction in the Prevention of Cardiovascular Disease
Aruna D Pradhan, Brigham and Women's Hospital | Boston, Massachusetts
CRISPR ATTR
First-in-Human in vivo CRISPR/Cas9 Editing of the TTR Gene by NTLA-2001 in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Julian D Gillmore | University College of London, London, United Kingdom
IRONMAN
A Randomized Trial of Intravenous Ferric Derisomaltose in Heart Failure With Reduced Ejection Fraction
Paul R Kalra | Portsmouth Hospital, University NHS Trust, Portsmouth, United Kingdom
- IRONMAN Study Data Slide (PPTX)
- Simultaneously Published in The Lancet (new window)(link opens in new window)
- ClinicalTrials ID: NCT02642562
- IRONMAN official website (new window)(link opens in new window)
- AHA Press Release: Intravenous iron improved long-term outcomes for people with heart failure and iron deficiency
2022 Scientific Sessions Presidential Session
Don't miss the Presidential Session -- with AHA CEO Nancy Brown and AHA President Michelle A. Albert, as well as this year's distinguished scientists and Chairman's Award winners.
STRESS
Steroids to Reduce Systemic Inflammation After Infant Heart Surgery: The STRESS Trial
Kevin D Hill | Duke Pediatric and Adult Congenital Heart Center, Durham, North Carolina
ECMO-CS
Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Primary Results From the Multicenter, Randomized ECMO-CS Trial
Petr Ostadal, Na Homolce Hosp, Prague, Czech Republic
MB-BP
The Effect of Adapted Mindfulness Training in Participants With Elevated Office Blood Pressure: The Mindfulness-Based Blood Pressure Reduction (MB-BP) Randomized Clinical Trial
Eric B. Loucks | Brown University, Providence, Rhode Island
EMPA-KIDNEY
Empagliflozin and Cardiovascular Outcomes in Patients With Chronic Kidney Disease: The EMPA-KIDNEY Trial
David Preiss | University of Oxford, Oxford, United Kingdom
PRECISE
Comparison of a Precision Care Strategy With Usual Testing to Guide Management of Stable Patients With Suspected Coronary Artery Disease: The Precise Randomized Trial
Pamela S Douglas | Duke University School of Medicine, Durham, North Carolina
BEST-CLI
Best Endovascular versus Best Surgical Therapy for Patients With Chronic Limb Threatening Ischemia (BEST-CLI) Trial: Clinical Results
Alik Farber | Boston Medical Center, Boston, Massachusetts
- BEST-CLI trial summary (PPTX)
- Farber Abstract
- Published in NEJM
- AHA News Release: Surgery is best to prevent amputations in certain people with poor leg circulation
- ClinicalTrials ID: NCT02060630
Best Endovascular versus Best Surgical Therapy for Patients With Chronic Limb Threatening Ischemia (BEST-CLI) Trial: Quality of Life Analyses
Matthew T Menard | Brigham and Women's Hospital, Boston, MA
STRONG HF
Successful Post-Discharge of Heart Failure
Alexandre Mebazaa | University de Paris, Paris, France
RAPID
Self-Administered Etripamil for Termination of Spontaneous Paroxysmal Supraventricular Tachycardia: Primary Analysis From the RAPID Study
James E Ip | Weill Cornell School of Medicine, New York, NY
SPYRAL HTN
Effect of Radiofrequency Renal Denervation on Blood Pressure in the Presence of Antihypertensive Drugs: 6-Month Primary Results From the SPYRAL HTN-ON Med Expansion Randomized Trial
David E Kandzari | Piedmont Heart Institute, Atlanta, GA