Skip to main content
1005-2016, 1006-2026, 1006-2023
class com.aha.ucm.component.cis.TagListPageData=[,docNativeURL=null,docName=UCM_504306,docStatus=RELEASED,dOutDate=null,docSSFileName=UCM_504306_JAHA-Conference-Reads-ESH2019.jsp,docTitle=JAHA Conference Reads| ESH2019,xWebsites=professional,dDocAuthor=amy.stefanos,xNextReviewDate=09/22/2016 5:42 PM,xTier1=36,xFeaturedItem=No,xElectronicRegistration=No,UserLocale=null,xSubCategory=,dpEvent=null,xComments=JAHA Conference Reads for the ESH2019,NoHttpHeaders=null,UserTimeZone=null,xRegionDefinition=GENERIC_RD_COL_1,xVideoRenditions=,xSnippetItem=,xNotes=,UserDateFormat=null,encodeDocUrl=null,isDocProfileDone=null,xKeywords=JAHA, Hypertension, ESH, European Meeting of Hypertension and Cardiovascular Protection 2019, ESH, ESH2019,xTier2=,refreshSubMonikers=null,xEditorStepReassignedUsers=null,xLinkTextToDisplay=,dDocAccount=WCM/SOP/SPUB,xEndDateTime=null,xClbraAliasList=null,ClientEncoding=null,xCpdIsLocked=0,xUsageRightsDate=null,xModifyDate=12/17/2019 3:35 PM,xTier3=,xEventDate=null,dSubscriptionType=null,xCopyright=No,xPackagedConversions=,dSubscriptionAlias=null,xStorageRule=,dpName=null,xDepartment=Science Operations,dStatus=RELEASED,dPublishType=,xCopyrightDetails=,xSubType=64,isDocProfileUsed=null,xWebsiteObjectType=Data File,xWebFlag=,xSeeAlsoLinks=,xClbraUserList=null,xPartitionId=,xCpdIsTemplateEnabled=0,xLinkWebAddress=,xDontShowInListsForWebsites=,xStartDateTime=null,dInDate=12/17/2019 3:34 PM,xWebsiteSection=professional:1463,dDocName=UCM_504306,dpAction=null,dRevLabel=4,dSecurityGroup=AHAMAH-Public,xCategory=,refreshMonikers=null,xDamConversionType=,dDocFormats=null,xAssociatedImage=,dDocType=SingleColumn,xBusinessOwner=Business Owner,xUploadDate=null,xDiscussionCount=0,xMainFlowEntryCriteria=True,xItemInformation=,xUsageRights=,xDiscussionType=N/A,xRecipeTaxonomy=,dSubscriptionID=null,dOriginalName=UCM_504306.xml,xProfileTrigger=SingleColumn,dLocation=,dRevisionID=4,dPublishState=,dReleaseState=Y,xTrashDeleter=null,dMessage=,dWebExtension=xml,dExtension=xml,dProcessingState=Y,xTrashDeleteName=null,dIsCheckedOut=0,xForceFolderSecurity=null,dRevClassID=504306,dIsPrimary=1,dFileSize=13633,dIndexerState=,dFlag1=,xviaAddNewContentService=,dIsWebFormat=0,xCollectionID=null,dRevRank=0,xReadOnly=null,dCheckoutUser=,dFormat=Application/xml,dWorkflowState=,dDocID=1915049,dRendition2=,dRendition1=,xInhibitUpdate=null,dReleaseDate=01/02/2020 7:07 PM,xTrashDeleteLoc=null,dCreateDate=12/17/2019 3:35 PM,xHidden=null,labelTier1=ScienceNews,labelTier2=,labelTier3=,labelTier4=,mobileNavURL=DEFAULT2_VALUE_FROM_getDataForAdvanceSearch,xContactPhoneNumber=,xContactEmailAddress=,xContactName=,xATGRolesDisciplines=,xPublishDate=06/21/2019 5:00 AM,xRobotParameter=,xCommunities=1005-2016, 1006-2026, 1006-2023,xMembershipLevel=,rsCalories=null,rsSodium=null,rsRecipeTaxonomy=null,rsServings=null,rsTotalTime=null,rsTotalFat=null,rsTotalCarbs=null,rsFeaturedImage=null,xDisplayComments=

JAHA Conference Reads Hero banner 750

JAHA Conference Reads | ESH2019

To coincide with the 29th European Meeting on Hypertension and Cardiovascular Protection (ESH2019), currently underway in Milan, Italy, the JAHA Editors have selected 5 articles related to hypertension for their readers. If you’re attending the 2019 meeting, stop by the AHA booth (No. 23).

JAHA Conference Reads

Selected Articles
Upward Shift and Steepening of the Blood Pressure Response to Exercise in Hypertensive Subjects at High Altitude
Sergio Caravita, Andrea Faini, Claudia Baratto, Grzegorz Bilo, Josè Luis Macarlupu, Morin Lang, Miriam Revera, Carolina Lombardi, Francisco C. Villafuerte, Piergiuseppe Agostoni, and Gianfranco Parati

In this double-blind, randomized study, Caravita and colleagues evaluated the extent and the rate of rise of blood pressure in response to cardiopulmonary exercise at sea level, and after acute exposure to high altitude. Their study population consisted of a group of 55 hypertensive patients who were randomized to a placebo or a fixed dose combination of an angiotensin receptor blocker and a calcium channel blocker. They showed that, compared to the response at sea-level, the acute altitude exposure not only results in an upward shift of the BP response but also results in a steeper rate of the rise of systolic blood pressure/oxygen consumption relationship during the exercise. They then showed that this trend of the increase in blood pressure and the reactivity to exercise was seen independent of the treatment received; however, the treatment was associated with the downward shift of the blood pressure/oxygen consumption and with better oxygen delivery. These findings provide an important message: that the high blood pressure during exercise at altitude does not seem to be a physiological compensation for reduced blood oxygen content but rather a potentially harmful mechanism in hypertensive individuals who were sub-optimally controlled at sea-level. Thus, it indicates the importance of prior sea-level BP control among those who are likely to be exposed acutely to high altitude. 

Blood Pressure Lowering With Nilvadipine in Patients With Mild?to?Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension
Rianne A. A. de Heus, MSc; Rogier Donders, PhD; Angelina M. M. Santoso, MSc; Marcel G. M. Olde Rikkert, MD, PhD; Brian A. Lawlor, MD; Jurgen A. H. R. Claassen, MD, PhD; for the Nilvad Study Group

In this secondary analysis of a randomized controlled trial, De Heus et al. assessed whether antihypertensive treatment with a calcium-channel blocker, Nilvadipine, as compared to a placebo, increases the prevalence of orthostatic hypotension (OH) in patients with mild-to-moderate Alzheimer disease (AD). This is an important clinical question because many of patients with AD have associated hypertension but are also prone to OH and falls. Their findings suggest that the use of Nilvadipine compared to placebo in this patient group was associated with a reduction in blood pressure with no evidence of an increase in OH-related adverse events. These findings help in the ongoing discussion related to the benefit vs the risk of treating hypertension in patients with dementia. 

Body Mass Index Trajectories During Young Adulthood and Incident Hypertension: A Longitudinal Cohort in Chinese Population
Bingbing Fan, Yachao Yang, Alim Dayimu, Guangshuai Zhou, Yanxun Liu, Shengxu Li, Wei Chen, Tao Zhang, and Fuzhong Xue

In this article, Fan et al. assessed the relationship of both the actual body mass index (BMI), and the change in BMI trajectory, with the incidence of hypertension amongst a cohort of young Chinese adults during a median follow up of 5.5 years. They showed that in this age group of 20-30 year old individuals, a sharp rise in BMI, independent of baseline and final BMI, was associated with a significantly higher risk of the development of hypertension. These findings, if replicated, have important implications for the prevention of hypertension in this age group, and provide a public health message of the importance of maintaining a low and stable BMI trajectory.

Effects of Repeated Binge Drinking on Blood Pressure Levels and Other Cardiovascular Health Metrics in Young Adults: National Health and Nutrition Examination Survey, 2011?2014
Mariann R. Piano, Larisa Burke, Minkyung Kang, and Shane A. Phillips

In this study of the effects of binge drinking, Piano et al. used the US National Health and Nutrition Examination Study (NHANES) to show that men age 18-45 who binge drink had higher blood pressures and total cholesterol than those who did not binge drink. Interestingly, the findings were not true for women of the same age. The findings are important because they highlight a potentially reversible cause of hypertension in young men and suggest a currently unappreciated difference in the physiological mechanisms controlling blood pressure between men and women. 

Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses
Mario Kaßmann, István András Szijártó, Concha F. García?Prieto , Gang Fan , Johanna Schleifenbaum, Yoland?Marie Anistan, Christoph Tabeling, Yu Shi, Ferdinand le Noble, Martin Witzenrath, Yu Huang, Lajos Markó, Mark T. Nelson, and Maik Gollasch

In this study using gene-targeted ice, Kabmann et al. asked whether the ion channel (Ryr2) responsible for release of calcium from the sarcoplasmic reticulum in heart cells and contraction also plays a role in vascular smooth muscle. They showed that when they genetically removed Ryr2 from vascular smooth muscle, a calcium-activated potassium current that mediates relaxation was eliminated. This caused increased resistance peripheral arteries that led to higher blood pressure and increased resistance of the pulmonary arteries in low oxygen environments. Of interest, there were no changes in the response of the arteries to changes in flow and sheer stress. The findings are important because they show a new function for Ryr2 in the control of systemic and pulmonary pressure that could be susceptible to pharmacological manipulation. 


JAHA is the American Heart Association | American Stroke Association's Open Access journal. All articles are available online, free for everyone to read, download, and share.