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22nd Annual Scientific Meeting
of the Heart Failure Society of America

JAHA Conference Reads

To coincide with the 22nd Annual Scientific Meeting of the Heart Failure Society of America, taking place on September 15-18 in Nashville, the JAHA Editors have selected 5 recently published heart failure articles.

The Conference Reads collections can also be accessed via the journal's website.

 Characteristics and Treatments of Patients Enrolled in the CHAMP?HF Registry Compared With Patients Enrolled in the PARADIGM?HF Trial
Adam D. DeVore, Xiaojuan Mi, Laine Thomas, Puza P. Sharma, Nancy M. Albert, Javed Butler, Adrian F. Hernandez, J. Herbert Patterson, John A. Spertus, Fredonia B. Williams, Carol I. Duffy, Kevin McCague, Gregg C. Fonarow

Devore et al. compares the characteristics of heart failure with reduced ejection fraction (HFrEF) patients enrolled in the pivotal PARADIGM-HF trial showing the efficacy of sacubitril/valsartan (Entresto) to those in a large heart failure registry (CHAMP-HF). They showed that the patients enrolled in the registry are similar to those in the randomized trial, but that only 13% of the patients in the registry were prescribed sacubitril/valsartan. These findings suggest that a large number of heart failure patients would be candidates for therapy with sacubitril/valsartan, and that the slow adoption of this therapy likely results from other factors including the cost of the medication.

Association Between Mineralocorticoid Receptor Antagonist Use and Outcome in Myocardial Infarction Patients With Heart Failure
Ida Löfman, Karolina Szummer, Henrik Olsson, Juan?Jesus Carrero, Lars H. Lund, Tomas Jernberg

Lofman et al. studies whether treatment with a mineralocorticoid receptor antagonist (MRA, spironolactone or eplerenone) is associated with improved survival in patients enrolled in a large Swedish registry who had a myocardial infarction complicated my heart failure. They showed that MRA use was limited in this population, that MRA therapy was associated with improved survival in patients with a reduced ejection fraction, and that outcomes did not appear to be affected by chronic renal insufficiency. These findings suggest that MRA therapy appears indicated for heart failure with reduced ejection fraction (HFrEF) patients following myocardial infarction.

Reasons for Guideline Nonadherence at Heart Failure Discharge
Lauren G. Gilstrap, Lynne W. Stevenson, Roy Small, Ron Parambi, Rose Hamershock, Jeffrey Greenberg, Christina Carr, Roya Ghazinouri, Lisa Rathman, Elizabeth Han, Mandeep R. Mehra, Akshay S. Desai

Gilstrap et al. compares guideline adherence at discharge for patients admitted with heart failure exacerbations in academic and community hospitals. They showed more deviations related to residual congestion and medication use in academic practices, and that these are often associated with renal insufficiency, hypotension and recent inotrope use. These findings suggest quality metrics developed for stable heart failure populations may not be practical for acutely decompensated heart failure patients.

Cardiac Resynchronization Therapy and Clinical Outcomes in Continuous Flow Left Ventricular Assist Device Recipients
Rakesh Gopinathannair, Henri Roukoz, Adarsh Bhan, Ashwin Ravichandran, Mustafa M. Ahmed, Dmitry Familtsev, Geetha Bhat, Jennifer Cowger, Munazzah Abdullah, Chirag Sandesara, Rahul Dhawan, Emma J. Birks, Jaimin R. Trivedi, Mark S. Slaughter

Gopinathannair et al. compares the outcomes of patients with continued cardiac resynchronization therapy (CRT) versus those with implantable cardioverter defibrillators (ICDs) following continuous flow LVAD placement. Taking into account significant differences between the groups, they showed that ongoing CRT is not associated with a significant advantage related to survival, arrhythmias, or hospitalization, and that pulse generator changes are more frequent in the CRT group. These findings suggest the need for a randomized controlled study in patients with CRT devices who undergo LVAD placement.

Bedside Ultrasound Assessment of Jugular Venous Compliance as a Potential Point?of?Care Method to Predict Acute Decompensated Heart Failure 30?Day Readmission
Marc A. Simon, Rick G. Schnatz, Jared D. Romeo, John J. Pacella

Simon et al. studies a bedside method of estimating right sided filling pressures in patients with acute decompensated heart failure at admission and after treatment at time of discharge. They showed that a change of less than 66% in the cross sectional area of the right internal jugular vein during Valsalva is a good predictor of elevated right atrial pressure both before and after therapy, and that an elevated predicted right atrial pressure at discharge predicts hospital readmission. These findings suggest that a novel noninvasive measurement may be useful for predicting adequate in-hospital diuresis during admissions for acute decompensated heart failure.

JAHA is the American Heart Association | American Stroke Association's Open Access journal. All articles are available online, free for everyone to read, download, and share.


AHA journal sites are best viewed in Google Chrome.


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