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Strategically Focused Research Network Awardees

List of Strategically Focused Network Awardees

Icahn School of Medicine at Mount Sinai

Center Director: Valentin Fuster, MD, PhD, FAHA
Training Director: Roger Hajjar, MD, FAHA

Basic
Project PI: Eric Schadt, PhD
Applying Cross-generation Genetic and Genomic Information to Improve Cardiovascular Disease Prevention

Clinical
Project PI: Zahi Fayad, PhD, FAHA
Two Intensive Life Style Intervention Programs in Related Caregivers of Preschool Children

Population
Project PI: Valentin Fuster, MD, PhD, FAHA
Children Heart Research Study Program


Northwestern University

Center Director: Philip Greenland, MD, FAHA
Training Director: Mercedes Carnethon, PhD, FAHA

Basic
Project PI: Lifang Hou, MD, PhD
Epigenetics of Cardiovascular Health Metrics

Clinical
Project PI: Bonnie Spring, PhD, FAHA
Behavioral Effects on CVH Metrics and Score

Population
Project PI: Norrina Allen, PhD
Trajectories in Cardiovascular Health (CVH) Metrics and Score From Childhood through Middle-Age


University of Texas Southwestern Medical Center

Center Director: Joseph Hill, MD, PhD, FAHA
Training Director: James de Lemos, MD, FAHA

Basic
Project PI: Joseph Hill, MD, PhD, FAHA
Molecular mechanisms in the transition from cardiomyocyte hypertrophy to HFpEF

Clinical
Project PI: Benjamin Levine, MD
Novel HFpEF Prevention Strategies In High Risk Individuals: High Intensity Exercise Training Plus Omega-3 Fatty Acids

Population
Project PI: Jarrett Berry, MD, MS, FAHA
Association Between Physical Activity and Modifiable Intermediate Heart Failure Phenotypes


Vanderbilt University

Center Director: David Harrison, MD, FAHA
Training Director: Meena Madhur, MD, PhD, FACC

Basic
Project PI: David Harrison, MD, FAHA
Effect of Salt on Innate and Adaptive Immune Cells in Hypertension

Clinical
Project PI: Jens Titze, MD
Lowering Tissue Na+ Stores to Reduce Blood Pressure, Systemic Inflammation, and Metabolic Derangement in Aging Humans

Population
Project PI: Thomas Jue-Fuu Wang, MD, FAHA
Prevention of Hypertension and its Complications in a Medically-Underserved Population  

Cincinnati Children's Hospital

Center Director: Elaine Urbina, MD, MS, FAHA
Training Director: Mark Mitsnefes, MD

Basic
Project PI: Richard Becker, MD, FAHA
Influence of Regulatory Genome on Target Organ Damage in Youth with Primary Hypertension

Clinical
Project PI: Joseph Flynn, MD, MS
Hemodynamic and Metabolic Predictors of Target Organ Damage in Youth with Primary Hypertension

Population
Project PI: Elaine Urbina, MD, MS, FAHA
Threshold for Development of Blood Pressure-Related Target Organ Damage in Youth


Medical College of Wisconsin

Center Director: Mingyu Liang, MB, PhD
Training Director: Allen W. Cowley, Jr., PhD

Basic
Project PI: David L. Mattson, PhD, FAHA
Epigenetic Modification of Immune Mechanisms in Salt-Sensitive Hypertension and Renal Damage

Clinical
Project PI: Srividya Kidambi, MD, MS
Epigenomics of Hypertension in Monozygotic Twins and Effect of Salt Intake

Population
Project PI: Theodore A. Kotchen, MD, FAHA
Epigenomic Modifications in Hypertension and Hypertension-Related Cardiovascular Diseases


University of Alabama at Birmingham

Center Director: Paul Muntner, PhD, MHS
Training Director: Suzanne Oparil, MD, FACC, FAHA, FASH

Basic
Project PI: Jennifer Pollock, PhD, FAHA
Novel Mechanisms of Salt-sensitivity and Diurnal Blood Pressure Rhythm

Clinical
Project PI: David Calhoun, MD, FAHA
Mechanisms of Nocturnal Hypertension and Non-dipping Blood Pressure

Population
Project PI: Paul Muntner, PhD, MHS
Racial Differences and US population estimates of Nocturnal Hypertension and Non-dipping 


University of Iowa

Center Director: Curt D. Sigmund, PhD, FAHA
Training Director: Kimberly K. Leslie, MD

Basic
Project PI: Justin L. Grobe, PhD, FAHA
Molecular Mechanisms of Vasopressin-Induced Preeclampsia

Clinical
Project PI: Gary L. Pierce, PhD
Early Vascular Dysfunction and Elevated Copeptin in Human Preeclampsia

Population
Project PI: Mark K. Santillan, MD, PhD, FACOG, FAHA
Predicting Preeclampsia via Copeptin: Underrepresented Minorities & Synergy with Other Biomarkers

Medical University of South Carolina

Center Director: Robert Adams, MD, MS
Training Director: Daniel Lackland, DrPH, FAHA

Basic
Project PI: Mark Kindy, PhD, FAHA 
Metabolic determinants of vascular stiffness in health disparities related stroke

Clinical
Project PI: Leonardo Bonilha, MD, PhD
Influence of pre-morbid brain health on stroke recovery

Population
Project PI: Gayenell Magwood, PhD
Community-based Intervention under Nurse Guidance after Stroke (CINGS)


Morehouse School of Medicine

Center Director: Herman Taylor Jr., MD, MPH, FACC, FAHA
Training Directors: Gregory Strayhorn, MD, PhD and Sandra Dunbar, RN, PhD, FAAN, FAHA, FPCNA

Basic
Project PIs: Charles Searles, MD, FAHA/Dean Jones, PhD
MicroRNA and metabolic profiles associated with social and environmental risk factors in blacks

Clinical
Project PIs: Arshed Quyyumi, MD/Priscilla Pemu, MBBS, MSCR, FACP
Impact of technology-based Intervention for improving self-management behaviors in Black adults

Population
Project PIs: Peter Baltrus, PhD/Tené Lewis, PhD
Social and Environmental Factors contributing to Cardiovascular Risk and Resilience among Blacks


Northwestern University

Center Directors: Myles Wolf, MD, MMSc and Mercedes Carnethon, PhD, FAHA
Training Director: Clyde Yancy, MD, MSc, MACC, FAHA, MACP

Basic
Project PI: Myles Wolf, MD, MMSc
Molecular Mechanisms of Cardiac Injury Induced by FGF23 in the Settings of High Phosphate Diet and CKD

Clinical
Project PI: Orlando Gutierrez, MD, MMSc
Impact of lowering phosphate additive intake on mineral metabolism and cardiovascular health in community-living adults

Population
Project PI: Mercedes Carnethon, PhD, FAHA
Contribution of Fibroblast Growth Factor 23 to Racial Disparities in Left Ventricular Mass and Albumin/Creatinine Ratio 


University of Colorado Denver

Center Director: Spero Manson, PhD
Training Director: Spero Manson, PhD

Basic
Project PI: Irene Blair, PhD
Discrimination and Allostatic Load Among American Indians

Clinical
Project PI: Edward Havranek, MD
An Intervention to Increase Engagement with Hypertension Care for American Indian Patients

Population
Project PI: John Steiner, MD, MPH
Improving Hypertension Care of American Indians and Alaska Natives through Interactive Voice Response Technology

Columbia University Medical Center

Center Director: Lori Mosca, MD, MPH, PhD, FAHA
Training Director: Anne Taylor, MD

Basic
Project PI: Sanja Jelic, MD
The Effects of Sleep Restriction on Endothelial Activation in Pre- and Post-Menopausal Women

Clinical
Project PI: Marie Pierre St-Onge, PhD, FAHA
Impact of Sleep Restriction on Cardio Metabolic Risk Factors in Pre- vs Postmenopausal Women

Population
Project PI: Brooke Aggarwal, EdD, MS, CHES
Sleep and Cardio Metabolic Risk in Different Life Stages in a Diverse Population of Women


Johns Hopkins University School of Medicine

Center Director: Pamela Ouyang, MBBS, FAHA
Training Director: Erin Michos, MD, MHS, FAHA

Basic
Project PI: David Kass, MD, FAHA
Female Sex-Hormones and Cyclic GMP-PKG Modulation of Cardiac Disease and Metabolism

Clinical
Project PI: Sanjiv Shah, MD, FAHA
Role of Female Sex and Hormone Status on HFpEF Pathophysiology and Therapy

Population
Project PIs: Wendy Post, MD, MS/Dhananjay Vaidya, MBBS, PhD, MPH
Sex Differences in Hormonal and Cyclic GMP Dependent Pathways to Heart Failure with Preserved Ejection Fraction


Magee-Womens Research Institute and Foundation

Center Director: Carl Hubel, PhD
Training Director: James Roberts, MD

Basic
Project PI: Robert Powers, PhD
The Influence of Pregnancy on Future Vascular Dysfunction and Atherosclerosis

Clinical
Project PI: Carl Hubel, PhD
Glycocalyx Pathways Linking Pregnancy Profile with Microvascular Dysfunction Postpartum

Population
Project PI: Janet Catov, PhD, MS
The Placenta as a Window to Maternal Microvascular Disease Risk 


New York University Medical Center

Center Director: Judith Hochman, MD, FAHA
Training Director: Glenn Fishman, MD, FAHA

Basic
Project PI: Jeffrey Berger, MD, FAHA
Comprehensive Assessment of Platelet Activity in Women with Myocardial Infarction

Clinical
Project PI: Harmony Reynolds, MD, FAHA
Mechanistic Insights into Myocardial Infarction with Non-obstructive Coronary Artery Disease (The MINOCA Study)

Population
Project PI: Tanya Spruill, PhD
Telephone-Based Stress Management for Women with Myocardial Infarction 


University of California, San Diego

Center Director: Matthew Allison, MD, MPH, FAHA
Training Director: Matthew Allison, MD, MPH, FAHA

Basic
Project PI: Dorothy Sears, PhD
Mechanistic Transducers and Biomarkers of Sedentary Behavior-Associated Cardiovascular Disease Risk in Latina Women

Clinical
Project PI: Jacqueline Kerr, PhD, MSc
Randomized Control Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease

Population
Project PI: Sheila Castaneda, PhD
Biopsychosocial and Ecological Correlates of Latina Women's Sedentary Behavior

Duke University Medical Center

Center Director: G. Michael Felker, MD, MHS, FACC, FAHA
Training Director: Joseph Rogers, MD

Basic
Project PI: Svati Shah, MD, MHS, FAHA
Branched Chain Amino Acid and other Metabolic Pathways in Diabetic Heart Failure

Clinical
Project PI: G. Michael Felker, MD, MHS, FACC, FAHA
A randomized trial of a mobile health behavioral intervention in patients with heart failure and diabetes mellitus

Population
Project PI: Adam DeVore, MD, MHS
Improving Population Health for Patients with Diabetes and Heart Failure (IMPAcT-HF)

Massachusetts General Hospital

Center Director: Anthony Rosenzweig, MD, FAHA 
Training Director: Christopher Newton-Cheh, MD, MPH

Basic
Project PI: Anthony Rosenzweig, MD, FAHA 
Functional roles of circulating ncRNAs in pathological hypertrophy and heart failure

Clinical
Project PI: Saumya Das, MD, PhD, MSc
Extracellular RNAs as Mediators of Cardiac Remodeling in Human Heart Failure

Population
Project PI: Jane Freedman, MD, FAHA
Extracellular RNA, Adverse Left Ventricular Remodeling, and Heart Failure Progression

University of Colorado, Denver

Center Director: Peter Buttrick, MD, FAHA
Training Director: Peter Buttrick, MD, FAHA

Basic
Project PI: Timothy McKinsey, PhD, FAHA
Epigenetic Readers as Downstream Effectors of Beta1-Adrenergic Receptor Signaling in HFrEF

Clinical
Project PI: Michael Bristow, MD, PhD, FAHA
Therapeutic Molecular and Structural Phenotypic Changes of Heart Rate Reduction in HFrEF

Population
Project PI: Larry Allen, MD, MHSc, FAHA
Electronic health record-leveraged, Patient-centered, Intensification of Chronic care for Heart Failure (EPIC-HF) 

University of Utah

Center Director: Craig Selzman, MD, FAHA
Training Director: James Fang, MD, FACC, FAHA

Basic
Project PI: E. Dale Abel, MD, PhD
Coupling glucose uptake and pyruvate utilization to increase myocardial recovery in heart failure

Clinical
Project PI: Stavros Drakos, MD, PhD, FAHA 
Predictors of myocardial recovery in chronic heart failure

Population
Project PI: Josef Stehlik, MD, MPH, FAHA 
Patient-reported outcomes as an indicator of disease transitions in heart failure  

Johns Hopkins University

Center Director: Jeanne M. Clark, MD, MPH
Training Director: Edgar R. Miller, III, MD, PhD

Basic
Project PI: Rexford S. Ahima, MD, PhD
Metabolic and Cardiovascular Effects of Time-Restricted Feeding in Obese Mice

Clinical
Project PI: Nisa M. Maruthur, MD, MHS
The Effect of Time-Restricted, Isocaloric Feeding on Weight: A Randomized Feeding Study in Obese Adults

Population
Project PI: Wendy Bennett, MD, MPH
The impact of timing of eating on weight: A Multi-Site Cohort Study using The Metabolic Compass Mobile Application

New York University Medical Center

Center Director: Ann Marie Schmidt, MD
Training Director: Glenn Fishman, MD, FAHA

Basic
Project PI: Ann Marie Schmidt, MD
RAGE/DIAPH1: Inflammation and Suppression of Energy Expenditure in Obesity - Mechanisms and Therapeutic Strategies

Clinical
Project PI: Ira J. Goldberg, MD, FAHA
Obesity, Inflammation and Cardiovascular Risk

Population
Project PI: Mary Ann Sevick, ScD, RN
Alternative technology-supported behavioral weight loss intervention programs

University of Alabama at Birmingham

Center Director: W. Timothy Garvey, MD
Training Director: David B. Allison, PhD, FAHA

Basic
Project PI: W. Timothy Garvey, MD
Intergenerational Transmission of Obesity in Mouse Models of in Utero Stress

Clinical
Project PI: Lorie M. Harper, MD
Intergenerational Transmission of Obesity: Antenatal Mother and Beyond Birth Offspring

Population
Project PI: Paula C. Chandler-Laney, PhD
Intergenerational Transmission of Obesity in a Cohort of mother-child dyads

Vanderbilt University

Center Director: Kevin Niswender, MD, PhD
Training Directors: Alyssa H. Hasty, PhD, FAHA and Joshua A. Beckman, MD, MSc, FAHA

Basic
Project PI: Kevin Niswender, MD, PhD
Glucagon-like peptide-1 receptor and cardiometabolic health

Clinical
Project PI: Nancy J. Brown, MD, FAHA
Vascular effects of GLP-1 receptor activation

Population
Project PI: Nancy J. Cox, PhD
Genome and Phenome Studies on Obesity and CVD to Dissect GLP1R Mechanism 

Children’s National Health System

Center Director: Craig Sable, MD, FAHA
Training Director: Craig Sable, MD, FAHA

Basic
Project PI: James Dale, MD
Human Immunity to Potential Group A Streptococcal Vaccine Antigens in Subjects at High Risk for Rheumatic Heart Disease

Clinical

Project PI: Andrea Beaton, MD
Working Towards a Better Understanding of Acute Rheumatic Fever

Population
Project PI: David Watkins, MD, MPH
Building a Case to Invest in Rheumatic Heart Disease Prevention and Control in Limited Resource Settings
 

University of Utah

Center Director: Martin Tristani-Firouzi, MD
Training Director: H. Joseph Yost, PhD

Basic
Project PI: Mark Yandell, PhD
An integrated data-science, transcriptomics, and genomics approach to understanding Complex CHD

Clinical
Project PI: Robert Silver, MD
Maternal-fetal environment, epigenetics and complex congenital heart disease

Population
Project PI: Angela Fagerlin, PhD, MA
Improving Patient and Family Health Using Family-Centered Outcomes and Shared Decision-Making
 

Northwestern University

Center Directors: Bradley Marino, MD, MPP, MSCE, FAHA and Donald M Lloyd-Jones, MD, ScM, FAHA
Training Director: Matthew Davis, MD

Basic
Project PI: Lifang Hou, MD, MSc
Characterizing Dynamic Epigenomic Markers of CVH in Early Life

Clinical
Project PI: Linda Van Horn, PhD, RD, FAHA
Keeping Ideal Cardiovascular Health Family Intervention Trial: KIDFIT

Population
Project PI: Norrina Allen, PhD, MPH, FAHA
Cardiovascular Health Trajectories from Birth Through Adolescence


Duke University Medical School

Center Director: Jennifer Li, MD, MHSc
Training Director: Asheley Skinner, PhD

Basic
Project PI: Svati Shah, MD, MHS, FAHA
Microbiota Related Molecular Pathways in Pediatric Obesity

Clinical
Project PI: Sarah Armstrong, MD
A randomized trial of an integrated clinic-community intervention in children and adolescents with obesity

Population
Project PI: Asheley Skinner, PhD
Effectiveness and implementation of tertiary-care pediatric obesity treatment programs
 

Brigham and Women’s Hospital/Dartmouth-Hitchcock Medical Center

Center Director: Marc Bonaca, MD, MPH and Mark Creager, MD, FAHA, FACC
Training Director: Marc Bonaca, MD, MPH and Philip Goodney, MD, MS

Basic
Project PI: Mark Feinberg, MD
Non-Coding RNAs in Diabetic Critical Limb Ischemia: Discovery, Pathobiology, and Therapeutic Intervention

Clinical

Project PI: Marc Bonaca, MD, MPH
Risk Prediction and Personalizing Therapy to Prevent Critical Limb Ischemia in Patients with PAD and Diabetes

Population
Project PIs: Philip Goodney, MD, MS and Mark Creager, MD, FAHA, FACC
Integrated Management Strategies to Reduce Amputation and Limit Disparities for Patients with Diabetes and CLI
 

Northwestern University

Center Director: Mary M. McDermott, MD, FAHA
Training Director: Mercedes Carnethon, PhD, FAHA

Basic
Project PI: Christiaan Leeuwenburgh, PhD
Calf Muscle Mitochondrial Dysfunction and Impaired Autophagy in Peripheral Artery Disease

Clinical
Project PI: Mary M. McDermott, MD, FAHA
NICotinamidE Riboside with and without Resveratrol to Improve Functioning in Peripheral Artery Disease: The NICE Trial

Population
Project PI: Philip Greenland, MD, FAHA
Mitochondrial Dysfunction and Disability in Peripheral Artery Disease
 

University of Kentucky

Center Directors: Alan Daugherty, PhD, DSc
Training Director: Nancy Webb, PhD

Basic
Project PI: Alan Daugherty, PhD, DSC
Role of Sex Hormones on Elastin Stability in Formation of Thoracic Aortopathies

Basic
Project PI: Lisa Cassis, PhD
Sexual Dimorphism of Aortopathies

Clinical
Project PI: Scott LeMaire, MD
Molecular Signature of Sex Chromosome Genes Associated with Sex-Dependent Susceptibility to Ascending Aortic Aneurysms


Vanderbilt University

Center Director: Joshua Beckman, MD, MS
Training Director: Joshua Beckman, MD, MS

Basic
Project PI: David Wasserman, PhD
The Link between Microcirculatory Dysfunction and Skeletal Muscle Insulin Resistance

Clinical
Project PI: Joshua Beckman, MD, MS
The Impact of Branched-Chain Amino Acids Metabolism on Limb Dysfunction in PAD

Population
Project PIs: Matthew Freiberg, MD and Quinn Wells, PharmD, MD
Clinical and Genetic Determinants of Peripheral Artery Disease, Microvascular Disease, and Major Adverse Limb Outcomes

Boston University

Advancing Atrial Fibrillation Precision Medicine

Center Director: Emelia Benjamin, MD, ScM
Training Director: Emelia Benjamin, MD, ScM

Basic
Project PI: Patrick Ellinor, MD, PhD
Genomics and Epigenetics of Atrial Fibrillation

Clinical
Project PI: Project PI: Steven Lubitz, MD, MPH
Precision Medicine in Ischemic Stroke and Atrial Fibrillation (PreMISe-AF)

Population
Project PI: Ludovic Trinquart, PhD, MPH
Clinical and genetic prediction of lifetime risk of atrial fibrillation and its complications


Cleveland Clinic Foundation

Translational Strategies for the Prevention of Atrial Fibrillation Development and Progression

Center Director: Mina Chung, MD, FAHA, FHRS
Training Director: Christine Moravec, PhD

Basic
Project PI: Jonathan Smith, PhD
Gene-Aging-Metabolism Interaction in Atrial Fibrillation Pathogenesis

Clinical
Project PI: Mina Chung, MD, FAHA, FHRS
Upstream Targeting for the Prevention of AF: Targeting Risk Interventions and Metformin for AF (TRIM-AF)

Population
Project PIs: David Van Wagoner, PhD, FAHA, FHRS
Multi-omic analysis of atrial metabolism, electrophysiology and AF progression


Northwestern University

Atrial Myopathy in Atrial Fibrillation

Center Director: Rod Passman, MD, MSCE
Training Director: Phil Greenland, MD

Basic
Project PI: Rishi Arora, MD
The role of oxidative stress in creating a vulnerable substrate for atrial fibrillation in the intact atrium

Clinical
Project PI: Rod Passman, MD, MSCE
Atrial Myopathy: Structure and Function in AF Ablation

Population
Project PI: Phil Greenland, MD
Atrial Substrate in Atrial Fibrillation and AF-Associated Brain Disease


Stanford University

Decision-Making Pathway for Atrial Fibrillation Stroke Prevention

Center Director: Paul Wang, MD

Clinical
Project PI: Randall Stafford, MD, PhD
Behavioral Science (Prevention / Intervention)


University of Utah

Studying Effectiveness in Patient-centered care

Center Director: Angie Fagerlin, PhD

Clinical
Project PI: Victor Montori, MD, MSc
Scan & Optimization of Decision Aids for Atrial Fibrillation (SODA-AF)

Population
Project PI: Elissa Ozanne, PhD
RED-AF: Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation


Vanderbilt University

A novel molecular target in atrial fibrillation

Center Director: Dan Roden, MD
Training Director: Bjorn Knollmann, MD, PhD

Basic
Project PI: Katherine Murray, MD
Reactive lipid metabolites as mediators of AF susceptibility in clinical and genetic risk models

Clinical
Project PI: Gregory Michaud, MD
A first-in-AF trial of a reactive lipid metabolite scavenger

Population
Project PI: Dan Roden, MD
Identifying AF subtypes driven by inflammation