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Strategically Focused Research Network Awardees

List of Strategically Focused Network Awardees

Icahn School of Medicine at Mount Sinai

Center Director: Valentin Fuster, MD, PhD, FAHA
Training Director: Roger Hajjar, MD, FAHA

Project PI: Eric Schadt, PhD
Applying Cross-generation Genetic and Genomic Information to Improve Cardiovascular Disease Prevention

Project PI: Zahi Fayad, PhD, FAHA
Two Intensive Life Style Intervention Programs in Related Caregivers of Preschool Children

Project PI: Valentin Fuster, MD, PhD, FAHA
Children Heart Research Study Program

Northwestern University

Center Director: Philip Greenland, MD, FAHA
Training Director: Mercedes Carnethon, PhD, FAHA

Project PI: Lifang Hou, MD, PhD
Epigenetics of Cardiovascular Health Metrics

Project PI: Bonnie Spring, PhD, FAHA
Behavioral Effects on CVH Metrics and Score

Project PI: Norrina Allen, PhD
Trajectories in Cardiovascular Health (CVH) Metrics and Score From Childhood through Middle-Age

University of Texas Southwestern Medical Center

Center Director: Joseph Hill, MD, PhD, FAHA
Training Director: James de Lemos, MD, FAHA

Project PI: Joseph Hill, MD, PhD, FAHA
Molecular mechanisms in the transition from cardiomyocyte hypertrophy to HFpEF

Project PI: Benjamin Levine, MD
Novel HFpEF Prevention Strategies In High Risk Individuals: High Intensity Exercise Training Plus Omega-3 Fatty Acids

Project PI: Jarrett Berry, MD, MS, FAHA
Association Between Physical Activity and Modifiable Intermediate Heart Failure Phenotypes

Vanderbilt University

Center Director: David Harrison, MD, FAHA
Training Director: Meena Madhur, MD, PhD, FACC

Project PI: David Harrison, MD, FAHA
Effect of Salt on Innate and Adaptive Immune Cells in Hypertension

Project PI: Jens Titze, MD
Lowering Tissue Na+ Stores to Reduce Blood Pressure, Systemic Inflammation, and Metabolic Derangement in Aging Humans

Project PI: Thomas Jue-Fuu Wang, MD, FAHA
Prevention of Hypertension and its Complications in a Medically-Underserved Population  

Cincinnati Children's Hospital

Center Director: Elaine Urbina, MD, MS, FAHA
Training Director: Mark Mitsnefes, MD

Project PI: Richard Becker, MD, FAHA
Influence of Regulatory Genome on Target Organ Damage in Youth with Primary Hypertension

Project PI: Joseph Flynn, MD, MS
Hemodynamic and Metabolic Predictors of Target Organ Damage in Youth with Primary Hypertension

Project PI: Elaine Urbina, MD, MS, FAHA
Threshold for Development of Blood Pressure-Related Target Organ Damage in Youth

Medical College of Wisconsin

Center Director: Mingyu Liang, MB, PhD
Training Director: Allen W. Cowley, Jr., PhD

Project PI: David L. Mattson, PhD, FAHA
Epigenetic Modification of Immune Mechanisms in Salt-Sensitive Hypertension and Renal Damage

Project PI: Srividya Kidambi, MD, MS
Epigenomics of Hypertension in Monozygotic Twins and Effect of Salt Intake

Project PI: Theodore A. Kotchen, MD, FAHA
Epigenomic Modifications in Hypertension and Hypertension-Related Cardiovascular Diseases

University of Alabama at Birmingham

Center Director: Paul Muntner, PhD, MHS
Training Director: Suzanne Oparil, MD, FACC, FAHA, FASH

Project PI: Jennifer Pollock, PhD, FAHA
Novel Mechanisms of Salt-sensitivity and Diurnal Blood Pressure Rhythm

Project PI: David Calhoun, MD, FAHA
Mechanisms of Nocturnal Hypertension and Non-dipping Blood Pressure

Project PI: Paul Muntner, PhD, MHS
Racial Differences and US population estimates of Nocturnal Hypertension and Non-dipping 

University of Iowa

Center Director: Curt D. Sigmund, PhD, FAHA
Training Director: Kimberly K. Leslie, MD

Project PI: Justin L. Grobe, PhD, FAHA
Molecular Mechanisms of Vasopressin-Induced Preeclampsia

Project PI: Gary L. Pierce, PhD
Early Vascular Dysfunction and Elevated Copeptin in Human Preeclampsia

Project PI: Mark K. Santillan, MD, PhD, FACOG, FAHA
Predicting Preeclampsia via Copeptin: Underrepresented Minorities & Synergy with Other Biomarkers 

Medical University of South Carolina

Center Director: Robert Adams, MD, MS
Training Director: Daniel Lackland, DrPH, FAHA

Project PI: Mark Kindy, PhD, FAHA 
Metabolic determinants of vascular stiffness in health disparities related stroke

Project PI: Leonardo Bonilha, MD, PhD
Influence of pre-morbid brain health on stroke recovery

Project PI: Gayenell Magwood, PhD
Community-based Intervention under Nurse Guidance after Stroke (CINGS)

Morehouse School of Medicine

Center Director: Herman Taylor Jr., MD, MPH, FACC, FAHA
Training Directors: Gregory Strayhorn, MD, PhD and Sandra Dunbar, RN, PhD, FAAN, FAHA, FPCNA

Project PIs: Charles Searles, MD, FAHA/Dean Jones, PhD
MicroRNA and metabolic profiles associated with social and environmental risk factors in blacks

Project PIs: Arshed Quyyumi, MD/Priscilla Pemu, MBBS, MSCR, FACP
Impact of technology-based Intervention for improving self-management behaviors in Black adults

Project PIs: Peter Baltrus, PhD/Tené Lewis, PhD
Social and Environmental Factors contributing to Cardiovascular Risk and Resilience among Blacks

Northwestern University

Center Directors: Myles Wolf, MD, MMSc and Mercedes Carnethon, PhD, FAHA
Training Director: Clyde Yancy, MD, MSc, MACC, FAHA, MACP

Project PI: Myles Wolf, MD, MMSc
Molecular Mechanisms of Cardiac Injury Induced by FGF23 in the Settings of High Phosphate Diet and CKD

Project PI: Orlando Gutierrez, MD, MMSc
Impact of lowering phosphate additive intake on mineral metabolism and cardiovascular health in community-living adults

Project PI: Mercedes Carnethon, PhD, FAHA
Contribution of Fibroblast Growth Factor 23 to Racial Disparities in Left Ventricular Mass and Albumin/Creatinine Ratio 

University of Colorado Denver

Center Director: Spero Manson, PhD
Training Director: Spero Manson, PhD

Project PI: Irene Blair, PhD
Discrimination and Allostatic Load Among American Indians

Project PI: Edward Havranek, MD
An Intervention to Increase Engagement with Hypertension Care for American Indian Patients

Project PI: John Steiner, MD, MPH
Improving Hypertension Care of American Indians and Alaska Natives through Interactive Voice Response Technology

Columbia University Medical Center

Center Director: Lori Mosca, MD, MPH, PhD, FAHA
Training Director: Anne Taylor, MD

Project PI: Sanja Jelic, MD
The Effects of Sleep Restriction on Endothelial Activation in Pre- and Post-Menopausal Women

Project PI: Marie Pierre St-Onge, PhD, FAHA
Impact of Sleep Restriction on Cardio Metabolic Risk Factors in Pre- vs Postmenopausal Women

Project PI: Brooke Aggarwal, EdD, MS, CHES
Sleep and Cardio Metabolic Risk in Different Life Stages in a Diverse Population of Women

Johns Hopkins University School of Medicine

Center Director: Pamela Ouyang, MBBS, FAHA
Training Director: Erin Michos, MD, MHS, FAHA

Project PI: David Kass, MD, FAHA
Female Sex-Hormones and Cyclic GMP-PKG Modulation of Cardiac Disease and Metabolism

Project PI: Sanjiv Shah, MD, FAHA
Role of Female Sex and Hormone Status on HFpEF Pathophysiology and Therapy

Project PIs: Wendy Post, MD, MS/Dhananjay Vaidya, MBBS, PhD, MPH
Sex Differences in Hormonal and Cyclic GMP Dependent Pathways to Heart Failure with Preserved Ejection Fraction

Magee-Womens Research Institute and Foundation

Center Director: Carl Hubel, PhD
Training Director: James Roberts, MD

Project PI: Robert Powers, PhD
The Influence of Pregnancy on Future Vascular Dysfunction and Atherosclerosis

Project PI: Carl Hubel, PhD
Glycocalyx Pathways Linking Pregnancy Profile with Microvascular Dysfunction Postpartum

Project PI: Janet Catov, PhD, MS
The Placenta as a Window to Maternal Microvascular Disease Risk 

New York University Medical Center

Center Director: Judith Hochman, MD, FAHA
Training Director: Glenn Fishman, MD, FAHA

Project PI: Jeffrey Berger, MD, FAHA
Comprehensive Assessment of Platelet Activity in Women with Myocardial Infarction

Project PI: Harmony Reynolds, MD, FAHA
Mechanistic Insights into Myocardial Infarction with Non-obstructive Coronary Artery Disease (The MINOCA Study)

Project PI: Tanya Spruill, PhD
Telephone-Based Stress Management for Women with Myocardial Infarction 

University of California, San Diego

Center Director: Matthew Allison, MD, MPH, FAHA
Training Director: Matthew Allison, MD, MPH, FAHA

Project PI: Dorothy Sears, PhD
Mechanistic Transducers and Biomarkers of Sedentary Behavior-Associated Cardiovascular Disease Risk in Latina Women

Project PI: Jacqueline Kerr, PhD, MSc
Randomized Control Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease

Project PI: Sheila Castaneda, PhD
Biopsychosocial and Ecological Correlates of Latina Women's Sedentary Behavior

Duke University Medical Center

Center Director: G. Michael Felker, MD, MHS, FACC, FAHA
Training Director: Joseph Rogers, MD

Project PI: Svati Shah, MD, MHS, FAHA
Branched Chain Amino Acid and other Metabolic Pathways in Diabetic Heart Failure

Project PI: G. Michael Felker, MD, MHS, FACC, FAHA
A randomized trial of a mobile health behavioral intervention in patients with heart failure and diabetes mellitus

Project PI: Adam DeVore, MD, MHS
Improving Population Health for Patients with Diabetes and Heart Failure (IMPAcT-HF)

Massachusetts General Hospital

Center Director: Anthony Rosenzweig, MD, FAHA 
Training Director: Marc Semigran, MD

Project PI: Anthony Rosenzweig, MD, FAHA 
Functional roles of circulating ncRNAs in pathological hypertrophy and heart failure

Project PI: Saumya Das, MD, PhD, MSc
Extracellular RNAs as Mediators of Cardiac Remodeling in Human Heart Failure

Project PI: Jane Freedman, MD, FAHA
Extracellular RNA, Adverse Left Ventricular Remodeling, and Heart Failure Progression

University of Colorado, Denver

Center Director: Peter Buttrick, MD, FAHA
Training Director: Peter Buttrick, MD, FAHA

Project PI: Timothy McKinsey, PhD, FAHA
Epigenetic Readers as Downstream Effectors of Beta1-Adrenergic Receptor Signaling in HFrEF

Project PI: Michael Bristow, MD, PhD, FAHA
Therapeutic Molecular and Structural Phenotypic Changes of Heart Rate Reduction in HFrEF

Project PI: Larry Allen, MD, MHSc, FAHA
Electronic health record-leveraged, Patient-centered, Intensification of Chronic care for Heart Failure (EPIC-HF) 

University of Utah

Center Director: Craig Selzman, MD, FAHA
Training Director: James Fang, MD, FACC, FAHA

Project PI: E. Dale Abel, MD, PhD
Coupling glucose uptake and pyruvate utilization to increase myocardial recovery in heart failure

Project PI: Stavros Drakos, MD, PhD, FAHA 
Predictors of myocardial recovery in chronic heart failure

Project PI: Josef Stehlik, MD, MPH, FAHA 
Patient-reported outcomes as an indicator of disease transitions in heart failure  

Johns Hopkins University

Center Director: Jeanne M. Clark, MD, MPH
Training Director: Edgar R. Miller, III, MD, PhD

Project PI: Rexford S. Ahima, MD, PhD
Metabolic and Cardiovascular Effects of Time-Restricted Feeding in Obese Mice

Project PI: Nisa M. Maruthur, MD, MHS
The Effect of Time-Restricted, Isocaloric Feeding on Weight: A Randomized Feeding Study in Obese Adults

Project PI: Wendy Bennett, MD, MPH
The impact of timing of eating on weight: A Multi-Site Cohort Study using The Metabolic Compass Mobile Application

New York University Medical Center

Center Director: Ann Marie Schmidt, MD
Training Director: Glenn Fishman, MD, FAHA

Project PI: Ann Marie Schmidt, MD
RAGE/DIAPH1: Inflammation and Suppression of Energy Expenditure in Obesity - Mechanisms and Therapeutic Strategies

Project PI: Ira J. Goldberg, MD, FAHA
Obesity, Inflammation and Cardiovascular Risk

Project PI: Mary Ann Sevick, ScD, RN
Alternative technology-supported behavioral weight loss intervention programs

University of Alabama at Birmingham

Center Director: W. Timothy Garvey, MD
Training Director: David B. Allison, PhD, FAHA

Project PI: W. Timothy Garvey, MD
Intergenerational Transmission of Obesity in Mouse Models of in Utero Stress

Project PI: Lorie M. Harper, MD
Intergenerational Transmission of Obesity: Antenatal Mother and Beyond Birth Offspring

Project PI: Paula C. Chandler-Laney, PhD
Intergenerational Transmission of Obesity in a Cohort of mother-child dyads

Vanderbilt University

Center Director: Kevin Niswender, MD, PhD
Training Directors: Alyssa H. Hasty, PhD, FAHA and Joshua A. Beckman, MD, MSc, FAHA

Project PI: Kevin Niswender, MD, PhD
Glucagon-like peptide-1 receptor and cardiometabolic health

Project PI: Nancy J. Brown, MD, FAHA
Vascular effects of GLP-1 receptor activation

Project PI: Nancy J. Cox, PhD
Genome and Phenome Studies on Obesity and CVD to Dissect GLP1R Mechanism 

Children’s National Health System

Center Director: Craig Sable, MD, FAHA
Training Director: Craig Sable, MD, FAHA

Project PI: James Dale, MD
Human Immunity to Potential Group A Streptococcal Vaccine Antigens in Subjects at High Risk for Rheumatic Heart Disease


Project PI: Andrea Beaton, MD
Working Towards a Better Understanding of Acute Rheumatic Fever

Project PI: David Watkins, MD, MPH
Building a Case to Invest in Rheumatic Heart Disease Prevention and Control in Limited Resource Settings

University of Utah

Center Director: Martin Tristani-Firouzi, MD
Training Director: H. Joseph Yost, PhD

Project PI: Mark Yandell, PhD
An integrated data-science, transcriptomics, and genomics approach to understanding Complex CHD

Project PI: Robert Silver, MD
Maternal-fetal environment, epigenetics and complex congenital heart disease

Project PI: Angela Fagerlin, PhD, MA
Improving Patient and Family Health Using Family-Centered Outcomes and Shared Decision-Making

Northwestern University

Center Directors: Bradley Marino, MD, MPP, MSCE, FAHA and Donald M Lloyd-Jones, MD, ScM, FAHA
Training Director: Matthew Davis, MD

Project PI: Lifang Hou, MD, MSc
Characterizing Dynamic Epigenomic Markers of CVH in Early Life

Project PI: Linda Van Horn, PhD, RD, FAHA
Keeping Ideal Cardiovascular Health Family Intervention Trial: KIDFIT

Project PI: Norrina Allen, PhD, MPH, FAHA
Cardiovascular Health Trajectories from Birth Through Adolescence

Duke University Medical School

Center Director: Jennifer Li, MD, MHSc
Training Director: Asheley Skinner, PhD

Project PI: Svati Shah, MD, MHS, FAHA
Microbiota Related Molecular Pathways in Pediatric Obesity

Project PI: Sarah Armstrong, MD
A randomized trial of an integrated clinic-community intervention in children and adolescents with obesity

Project PI: Asheley Skinner, PhD
Effectiveness and implementation of tertiary-care pediatric obesity treatment programs

Brigham and Women’s Hospital/Dartmouth-Hitchcock Medical Center

Center Director: Marc Bonaca, MD, MPH and Mark Creager, MD, FAHA, FACC
Training Director: Marc Bonaca, MD, MPH and Philip Goodney, MD, MS

Project PI: Mark Feinberg, MD
Non-Coding RNAs in Diabetic Critical Limb Ischemia: Discovery, Pathobiology, and Therapeutic Intervention


Project PI: Marc Bonaca, MD, MPH
Risk Prediction and Personalizing Therapy to Prevent Critical Limb Ischemia in Patients with PAD and Diabetes

Project PIs: Philip Goodney, MD, MS and Mark Creager, MD, FAHA, FACC
Integrated Management Strategies to Reduce Amputation and Limit Disparities for Patients with Diabetes and CLI

Northwestern University

Center Director: Mary M. McDermott, MD, FAHA
Training Director: Mercedes Carnethon, PhD, FAHA

Project PI: Christiaan Leeuwenburgh, PhD
Calf Muscle Mitochondrial Dysfunction and Impaired Autophagy in Peripheral Artery Disease

Project PI: Mary M. McDermott, MD, FAHA
NICotinamidE Riboside with and without Resveratrol to Improve Functioning in Peripheral Artery Disease: The NICE Trial

Project PI: Philip Greenland, MD, FAHA
Mitochondrial Dysfunction and Disability in Peripheral Artery Disease

University of Kentucky

Center Directors: Alan Daugherty, PhD, DSc
Training Director: Nancy Webb, PhD

Project PI: Alan Daugherty, PhD, DSC
Role of Sex Hormones on Elastin Stability in Formation of Thoracic Aortopathies

Project PI: Lisa Cassis, PhD
Sexual Dimorphism of Aortopathies

Project PI: Scott LeMaire, MD
Molecular Signature of Sex Chromosome Genes Associated with Sex-Dependent Susceptibility to Ascending Aortic Aneurysms

Vanderbilt University

Center Director: Joshua Beckman, MD, MS
Training Director: Joshua Beckman, MD, MS

Project PI: David Wasserman, PhD
The Link between Microcirculatory Dysfunction and Skeletal Muscle Insulin Resistance

Project PI: Joshua Beckman, MD, MS
The Impact of Branched-Chain Amino Acids Metabolism on Limb Dysfunction in PAD

Project PIs: Matthew Freiberg, MD and Quinn Wells, PharmD, MD
Clinical and Genetic Determinants of Peripheral Artery Disease, Microvascular Disease, and Major Adverse Limb Outcomes