Science News from ACC.14

American College of Cardiology Scientific Sessions | March 29–31 | Washington, D.C.
Welcome to Science News coverage of ACC.14 in Washington, D.C. Here you'll find coverage of selected science presented at the conference, plus in-depth interviews about the most important conclusions from key cardiovascular experts.

Selected Science for Saturday, March 29


Mark Creager, MD, and Tim Gardner, MD discuss the results of the CoreValve trial.


Donna Arnett, PhD, MSPH and Mark Creager, MD discuss the results of SYMPLICITY HTN-3.
A Randomized Comparison of Self-expanding Transcatheter and Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis Deemed High-Risk for Surgery
David H. Adams | Mount Sinai Medical Center, New York, NY
SYMPLICITY HTN-3: Renal Denervation in Patients With Uncontrolled Hypertension
Deepak L. Bhatt | Brigham and Women's Hospital Heart and Vascular Center, Boston, MA Related Science for SYMPLICITY HTN-3:

Selected Science for Sunday, March 30

Gordon Tomaselli, MD, past-president of the American Heart Association, discusses the MADIT CRT trial.

Co-investigator Deepak Bhat, MD, MPH discusses the results of the SYMPLICITY HTN-3 trial.

Co-investigator Aimee Armstrong, MD, discusses the results of the Melody trial.

Effect of Inhibition of Lipoprotein-Associated Phospholipase A2 with Darapladib on Ischemic Events in Patients with Chronic Coronary Heart Disease: The STABILITY Trial
Harvey D. White | Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand Related Science:
The Low-density Lipoprotein Cholesterol Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy - 2 Trial: A Phase 3, Double-blind, Randomized, Placebo and Ezetimibe Controlled, Multicenter Study to Evaluate Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Combination With Statin Therapy in Subjects With Primary Hypercholesterolemia and Mixed Dyslipidemia - (LAPLACE-2)
Jennifer Robinson | Amgen Inc., Thousand Oaks, CA, USA
Related Science:
Evaluation of the Dual PPAR-α/γ Agonist Aleglitazar to Reduce Cardiovascular Events in Patients with Acute Coronary Syndrome and Type 2 Diabetes Mellitus: the AleCardio Trial
A. Michael Lincoff | Cleveland Clinic, Cleveland, OH Related Links:
A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial
Mohamed Abdel-Wahab | Heart Center, Segeberger Kliniken, Bad Segeberg, Germany Related Science:
A Phase 3 Double-blind, Randomized Study to Assess the Safety and Efficacy of Evolocumab (AMG 145) in Hypercholesterolemic Subjects Unable to Tolerate an Effective Dose of Statin - GAUSS-2
Erik S.G. Stroes | Amgen Inc., Thousand Oaks, CA, USA Related Science:
Efficacy And Safety of Colchicine in Patients with Multiple Recurrences of Pericarditis: Results Of A Multicenter, Double-blind, Placebo-controlled, Randomized Study (CORP-2 Trial)
Massimo Imazio | Cardiology Department, Maria Vittoria Hospital, Torino, Italy Related Science:
The Global SYMPLICITY Registry: Safety and Effectiveness of Renal Artery Denervation In Real World Patients With Uncontrolled Hypertension
Michael Böhm | Universitätskliniken des Saarlandes, Klinik für Innere Medizin III, Homburg/Saar, Germany Related Science:
One Year Follow-up of the Melody Transcatheter Pulmonary Valve Multicenter Post Approval Study
Aimee K. Armstrong | University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI Related Science:
Long-term Survival with Cardiac Resynchronization Therapy in Patients with Mild Heart Failure (MADIT-CRT)
Ilan Goldenberg | University of Rochester Medical Center, Rochester, NY Related Science:
Negative High-Sensitive Troponins in the Emergency Department and Risk of Myocardial Infarction
Nadia Bandstein | Karolinska Institutet, Stockholm, Sweden Related Science:

Selected Science for Monday, March 31

Mariell Jessup, MD, president of the American Heart Association, and Elliott Antman, MD, president-elect, discuss the highlights of the science presented at ACC.14 in Washington, DC.

Clyde Yancy, MD, past-president of the American Heart Association, discusses the results of the MSC-HF trial.

Clyde Yancy, MD, past-president of the American Heart Association, discusses the results of MADIT CRT.

Bob Bonow, MD, past-president of the American Heart Association, discusses the results of the CHOICE trial.

PeriOperative ISchemic Evaluation-2 Trial (POISE-2)
P.J. Devereaux | Population Health Research Institute, Hamilton, Canada Related Science:
A Large International Trial Assessing the Effects of Clonidine on Major Arterial Events in Patients Having Noncardiac Surgery
Daniel I. Sessler | Outcomes Research, Cleveland Clinic, Cleveland, OH Related Science:
Steroids In caRdiac Surgery Trial (SIRS Trial)
Richard Whitlock | Population Health Research Institute, McMaster University/Hamilton Health Sciences, Hamilton, Canada Related Science:
Metformin in Acute Myocardial Infarction (GIPS-III)
Chris PH Lexis | Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Related Science:
Effect of Bariatric Surgery vs. Intensive Medical Therapy on Long-term Glycemic Control and Complications of Diabetes: 3-Year STAMPEDE Trial Results
Philip Raymond Schauer | Cleveland Clinic, Cleveland, OH Related Science:
One Year Outcomes from the STS/ACC Transcatheter Valve Therapy (TVT) Registry
David R. Holmes | Mayo Clinic, Rochester, MN Related Science:
Two-year Outcome of a Trial Comparing Second Generation Drug-eluting Stents Using Either Biodegradable Polymer or Durable Polymer: The NEXT trial
Masahiro Natsuaki | Saiseikai Fukuoka General Hospital, Fukuoka, Japan Related Science:
How Effective Are Antithrombotic Therapies in Primary Percutaneous Coronary Intervention (HEAT-PPCI)
Abdel Shahzad | Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital NHS Trust, Liverpool, United Kingdom Related Science:
Bare Metal vs. Zotarolimus-eluting stent in Uncertain Drug-eluting Stent Candidates: A Randomized Controlled Trial (ZEUS)
Marco Valgimigli | Erasmus MC, Rotterdam, The Netherlands Related Science:
Autotransplantation of Bone Marrow Derived Mesenchymal Stromal Cells in Patients with Severe Ischemic Heart Failure: The MSC-HF Trial
Anders Bruun Mathiasen | Copenhagen University Hospital, Copenhagen, Denmark
Related Science: