Programming - Hypertension Scientific Sessions

Session 1 - Opening Remarks and Keynote Lecture
Continental Ballroom
Chairs: R. Ariel Gomez, MD, FAHA and Jane Reckelhoff, PhD, FAHA

7:30 - Presidential Remarks
Keith Churchwell, MD, FAHA

7:40 - Opening Remarks
Chair: R. Ariel Gomez, MD, FAHA

7:50 - Welcome
Jane Reckelhoff, PhD, FAHA

8:00 - Opening Keynote Lecture
Chairs: Sylvia Medrano, PhD, and Justin Grobe, PhD, FAHA

Insights into Acute Kidney Injury and Transition to Chronic Kidney Disease Revealed by Multiomic and Spatial Technologies
Benjamin D. Humphreys, MD, PhD

Session 2 - Keynote Lecture
Continental Ballroom
Chairs: Cameron G. McCarthy, PhD, FAHA and Denise C. Cornelius, PhD, FAHA 

9:10 - Immune Mechanisms of Hypertension
David Harrison, MD, PhD

Session 3 - Recent Advances Session (plenary) -  New Drugs in the Treatment of Hypertension
Continental Ballroom
Chairs: Licy L. Yanes Cardozo, MD and Brandi Wynne, PhD, FAHA

10:30 - Mechanisms of Endothelin, ETA and ETB Receptors in Hypertension
David M. Pollock, PhD

11:00 - Endothelin Antagonists for Hypertension: Has Their Time Finally Arrived? 
Ernesto L. Schiffrin, CM, MD, PhD, FRSC, FRCPC, FACP, FAHA

11:30 - The Potential Role of Aldosterone Synthase Inhibition to More Effectively Treat Hypertension
Luke Laffin, MD

Session 4 - Meet the Keynote Speakers Luncheon
Salon A3
Benjamin D. Humphreys, MD, PhD
David G. Harrison, MD, FAHA
Alexander Staruschenko, PhD, FAHA 
NOTE - Early Career Networking Event; space is limited

Session 5 - Recent Advances Session (plenary) The Evolving Story of APOL1-Mediated Kidney Disease: Transforming Understanding of Hypertension and Kidney Disease in those of African Ancestry
Continental Ballroom
Chairs: Thu Le, MD, FAHA and Mildred A. Pointer, PhD, FAHA

1:30 - Review of the Evolution of the Mechanistic Understanding of APOL1 High Risk Variants on Kidney Disease and Hypertension
John R. Sedor, MD

2:00 - Understanding the Impact of APOL-1 Pore-Forming Function: From Epidemiology to In Vitro Studies
Adriana M. Hung, MD, MPH

2:30 - A 14 Year Journey from Genetic Discovery to Rethinking Hypertensive Kidney Disease
Ogo Egbuna, MD

Session 6 - TAC Oral Abstract Sessions
Concurrent O6A - Please Select Your Method of Payment: Kidney Damage in Hypertension
Continental Ballroom
Moderators: Sachin Aryal and Daria Golosova, MD, PhD

3:30 - 01 Spatial Transcriptomics Reveals How Smooth Muscle Cells Transform to Renin-Expressing Cells During Homeostatic Challenge
Jason P. Smith, Manako Yamaguchi, Maria Luisa S. Sequeira, Roberto A. Gomez
UNIVERSITY OF VIRGINIA, Charlottesville, Virginia, United States

3:45 - 02 Time restricted feeding reduces kidney fibrosis in diet-induced obesity through limiting kidney CD8+ T cell infiltration
Claudia Edell2, Savannah C. Walker2, John D. Erickson1, Jackson Colson2, Patrick Molina2, Carmen De Miguel2, Jennifer S. Pollock2
1University of Evansville, Birmingham, Alabama, United States, 2University of Alabama at Birmingham, Birmingham, Alabama, United States

4:00 - 03 Glomerular Hyperfiltration Promotes Chronic Kidney Disease through Interleukin 17A-Mediated Inflammation
Jing Liu2, Luojing Chen2, Thu H. Le2, Jing Wu1
1Medicine, University of Rochester Medical Ctr, Rochester, New York, United States, 2University of Rochester, Rochester, New York, United States

4:15 - 04 Renal- and TAL-Specific Inhibition of Traf2 and NCK Interacting Kinase (TNIK) Decreases NKKC2 Phosphorylation and Blunts Salt-Sensitive Hypertension in Dahl Salt-Sensitive Rats
Jessica Granados, Pablo A. Ortiz
HENRY FORD HEALTH, Wayne State U, Detroit, Michigan, United States

4:30 - 05 Renal Resident Tissue Macrophages Contribute to Salt-Dependent Increases in IL-6
Craig Cowley1, Landon Fairbanks1, Masaaki Yoshigi1, Patricio A. Araos2, Anna Beaudin1, Brandi Wynne1
1University of Utah, Salt Lake Cty, Utah, United States, 2Automomous University of Chile, Santiago, Chile

4:45 - 06 Role of the Atrial Natriuretic Peptide in Mitochondria-mediated Proximal Tubule Epithelial Oxidative Stress in Type 1 Diabetic Kidney Disease
Denisha Spires1, Alena Cherezova1, Oleg Palygin2, Daria Ilatovskaya1
1Physiology, Augusta University, Augusta, Georgia, United States, 2Medical University of SC, Charleston, South Carolina, United States

5:00 - 07 Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort
Rushelle Byfield1, Debbie L. Cohen2, Raymond R. Townsend3, Rachel Zhang2, Alavi Hossain2, Daichi Shimbo4, Jordana Cohen5
1Pediatrics, Columbia University, New York, New York, United States, 2UNIV OF PENNSYLVANIA, Philadelphia, Pennsylvania, United States, 3PENNSYLVANIA SCHOOL MED UNIV, Philadelphia, Pennsylvania, United States, 4COLUMBIA UNIVERSITY, New York, New York, United States, 5University of Pennsylvania, Philadelphia, Pennsylvania, United States

5:15 - 08 Genome-wide Maps of Human Kidney Proximal Tubules and Thick Ascending Limbs of Henle reveal an Enrichment for Human Blood Pressure associated Polymorphisms
Atrayee Ray1, Chun Yang2, Cary Stelloh1, Monika Tutaj2, Pengyuan Liu3, Yong Liu3, Chien-Wei Lin2, Michael Widlansky2, Anne E. Kwitek2, Aron M. Geurts2, Allen Cowley2, Mingyu Liang3, Andrew Greene4, Sridhar Rao1
1Versiti Blood Research Institute, Milwaukee, Wisconsin, United States, 2Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 3Physiology, University of Arizona, Tucson, Arizona, United States, 4The Jackson Laboratory, Bar Harbor, Maine, United States

4:30 – 5:30
06.B Intensifying the Resistance: Vascular Dysfunction in Hypertension
Salon A3
Moderators: C. Javier Rendon and Emily Waigi, MS

3:30 - 09 Leucine Rich Repeat Containing 8A Anion Channels Modulate Vascular Reactivity in ApoE Knockout Mice
Hyehun Choi, Sourav Panja, Hong Nguyen, Fred S. Lamb
Vanderbilt University Medical center, Nashville, Tennessee, United States

3:45 - 10 Adrenal Zona Glomerulosa Long Form Leptin Receptor (LepRb) Protects from Leptin-Mediated Vascular Disorders in Female Mice
Yoichi Ono1, Simone Kennard2, David Breault4, Eric J. Belin De Chantemele3
1Augusta University, Augusta, Georgia, United States, 2Augusta University, Augusta, Georgia, United States, 3MEDICAL COLLEGE OF GEORGIA AT AU, Augusta, Georgia, United States, 4Boston Children's Hospital, Boston, Massachusetts, United States

4:00 - 11 The prostaglandin E2 receptor 4 in endothelial cells regulates the aorta integrity in hypertension mice model
Ting Yang1, Jiaohui Wu1, Lisheng Zhang2, Neil J. Freedman1, Thomas Coffman1
1DUKE UNIVERSITY, Durham, North Carolina, United States, 2DUKE UNIV MEDICAL CTR, Durham, North Carolina, United States

4:15 - 12 Deficiency of Progranulin Decreases Mitochondrial Function and Induces a Whitening Phenotype in Perivascular Adipose Tissue, Suppressing Its Anti-Contractile Effects
Rafael Costa1, Ariane Bruder Nascimento1, Adam Richert1, Eric Goetzman1, Thiago B. Bruder2
1University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2University of Pittsburgh, Pittsburgh, Pennsylvania, United States

4:30 - 13 Vascular Chemerin, Particularly from PVAT, contributes to Norepinephrine and Serotonin-Induced Vasoconstriction and Vascular Stiffness in a Sex-Dependent Manner
Emma A. Wabel, Teresa Krieger-Burke, Stephanie W. Watts
Michigan State University, Lansi, Michigan, United States

4:45 - 14 Arterial Stiffness in Obese Normotensive Children: The First Cardiovascular Risk Biomarker?
Mariano Duarte, Analia Aquieri, Silvia Rivas, Gimena Donth Leger, Valeria Pardo, Javier Coyle, Andrea Curia, Esteban Gonzalez Ballerga
Hospital de Clinicas Facultad de Medicina Universidad de Buenos Aires, Buenos Aires, Buenos Aires, Argentina

5:00 - 15 Cell-Free Mitochondrial DNA Drives Endothelial Cell Activation and Vascular Dysfunction via Toll-Like Receptor 9 and Inflammasome Pathway Activation
Rinaldo R. dos Passos1, Gisele Bomfim1, Cintia Vieira1, Fernanda Priviero2, Fernando Silva Carneiro3, R Clinton C. Webb4
1University of South Carolina, Columbia, South Carolina, United States, 2University of South Carolina, Columbia, South Carolina, United States, 3University of São Paulo, Ribeirão Preto, Brazil, 4UNIVERSITY OF SOUTH CAROLINA, Columbia, South Carolina, United States

5:15 - 16 A Novel H2 Relaxin B-Chain-Only Peptide Variant B7-33 Improves The Pathophysiology Of Placental Ischemia In The Reduced Uterine Perfusion Pressure Rat Model Of Preeclampsia
Ahmed F Pantho2, Lorena M. Amaral3, Nathan Campbell4, Syeda Afroze2, Niraj Vora5, Thomas Kuehl2, Steven Lindheim5, Babbette B. Lamarca6, Ross Bathgate7, Mohammed A. Hossain7, Mohammad N. Uddin1
1Medical Physiology, TAMU SOM BSWH, Temple, Texas, United States, 2Artemis Biotechnologies LLC, Temple, Texas, United States, 3MEDICAL CENTER- UMMC, Jackson, Mississippi, United States, 4University of Mississippi Medical C, Jackson, Mississippi, United States, 5Baylor Scott and White Hospital, Leander , Texas, United States, 6UNIVERSITY MISSISSIPPI MEDICAL CTR, Jackson, Mississippi, United States, 7Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia

Session 6C - Clinical Practice/Clinical Science
Salon A5

3:30 to 4:30
6C1: Primary Aldosteronism - What you need to know
Salon A5
Moderators: Adina Turcu, MD, MS and Matt Luther

3:30 - Who and when to screen?
Vivek Bhalla, MD, FASN, FAHA

3:45 - What testing should you perform?
Jenifer M. Brown, MD

4:00 - How to titrate treatment?
Gregory L. Hundemer, MD MPH

4:15 - Discussion/Q&A

4:30 - Just give me a med!
Jennifer L. Cluett, MD, FAHA

4:42 - Just fix it with a catheter!
Debbie Cohen, MD

4:54 - Lifestyle is the way to go!
Stephen P. Juraschek, MD, PhD

5:06 - Rebuttals

5:18 - Discussion/Q&A

Astra Zeneca Industry Learning Studio
Salon A3

Session 7 - American Heart Association Research: Grant Funding and Other Opportunities
Continental Ballroom
Glenn Dillon, PhD

Session 8 - Recent Advances Session (plenary) : Mechanisms of Neurovascular Coupling and Hypertension
Continental Ballroom
Chairs: Monica Santisteban, PhD and Yumei Feng-Earley, MD, PhD, FAHA

8:30 - Advanced Neuroimaging to Predict the Impact of Hypertension on Brain Health
Guiseppe Lembo, MD. PhD

9:00 - Hypertension and Brain Health: From Vascular Cognitive Impairment to Alzheimer’s Disease
Costantino Iadecola, MD

POSTER SESSION 2
Salon D
(with Breakfast reception)

Session 9 - Recent Advances Session (plenary): Hypertension without Borders
Continental Ballroom
Chairs: Anastasia Mihailidou, PhD and Marianne Bertagnoli, PhD

10:30 - Improving Hypertension Control in Populations With Health Disparities
Jiang He, MD, PhD

11:00 - Closing the Gap: Practical Strategies for Global BP Control Equity
Tazeen Hasan Jafar, MD, MPH

11:30 - Current Situation of Hypertension Incidence and Treatment in Japan
Shigeru Shibata, MD, PhD, FASN, FAHA

Session 11 - Recent Advances Session (plenary): Dietary Approaches to Hypertension
Continental Ballroom
Chairs: Bina Joe, PhD, FAHA, FAPS, ISHF and Daniela Carnevale, PhD, FAHA

1:30 - Dissecting the Good and Bad Effects of Dietary Potassium on Blood Pressure
Robert Fenton, PhD

2:00 Leveraging the Microbiota as Medicine for Hypertension
David Durgan, PhD

2:30 - Dietary Approaches to Stop Hypertension (DASH): 1994-2024
Laura P. Svetkey, MD MHS

3:30 p.m. to 5:00 p.m.

Session 12 - Annual Hypertension Awards Session
Continental Ballroom
Moderators: Monica M. Santisteban, PhD and Brandi Wynne, PhD, FAHA

3:30 - The Stephanie Watts Award Finalist Presentations
Cristina Espinosa-Diez, PhD
Tiago Januário Da Costa, PhD

3:45 - British-Irish Hypertension Award
The effects of potassium supplementation on the renin-angiotensin-aldosterone system and blood pressure: a systematic review/meta-analysis and a cross-sectional study
Ryan McNally, MPharm, PhD

4:00 - Council on Hypertension Research Award cosponsored by Hypertension Australia Effects of sodium ascorbate versus ascorbic acid in improving vasopressor response in sepsis
Pei Chen Connie Ow, PhD

4:15 - New Investigator Award for Japanese Fellows:
Hyperinnervation and Immune-endocrine Interactions in Renal-Angiotensin System
Manako Yamaguchi, MD, PhD

4:30 - Harry Goldblatt Award for New Investigators:
Deciphering the NETwork of Inflammation in Hypertension
David M. Patrick, MD, PhD

Session 12C - Clinical Practice/Clinical Science (CPCS)

3:30 - 4:30: 12C1 - What is CKM and PREVENT?
Moderators: Kristi Reynolds, PhD, MPH and Eugene Yang, MD, MS

3:30 - Overview of AHA CKM
Chiadi Ndumele, MD, PhD, FAHA

3:45 - PREVENT Risk Calculator
Sadiya Khan, MD, MSc

4:00 - Pros and Cons of PREVENT
Clyde W Yancy, MD, MSc

4:15 - Discussion/Q&A

4:30 – 5:30 
12C2- Debate: Management of Obesity Associated Hypertension- Drugs, Surgeries, or Lifestyle
Salon A5
Moderators: John D. Bisognano, MD PhD and Meena Madhur, MD, PhD

4:30 - Just give me the shot!
Tamar Polonsky, MD

4:42 - Just give me the surgery!
Alfonso Torquati MD, MSCI, FACS

4:54 - Just focus on your diet!
Ron Blankstein, MD

5:06 - Rebuttals

5:18 - Discussion/Q&A

Oral Abstract Sessions

12A - Anti-Hypertensive Drugs
Continental Ballroom
Moderators: Jennifer S. Pollock, PhD, and Daniel Batlle, MD

5:00 - 17 First-Line Beta Blocker Use Among >3.1 Million Veterans Initiating Hypertension Treatment, 2000-2022
Catherine G. Derington1, Ransmond O. Berchie2, April Mohanty11, Joshua Jacobs4, Yizhe Xu2, Jordan B. King5, Leah B. Rethy6, William C. Cushman7, Susan L. Zickmund3, Michael Ho8, Jordana Cohen9, Adam P. Bress10
1Population Health Sciences, University of Utah School of Medicine, Centennial, Colorado, United States, 2University of Utah, Salt Lake City, Utah, United States, 3VA SLC HEALTHCARE SYSTEMS, Seattle, Utah, United States, 4University of Utah, Salt Lake City, Utah, United States, 5University of Utah, Salt Lake Cty, Utah, United States, 6Perelman School of Medicine, University of Pennsyl, Philadelphia, Pennsylvania, United States, 7University of Tennessee Health Scie, Memphis, Tennessee, United States, 8University of Colorado, Aurora, Colorado, United States, 9University of Pennsylvania, Philadelphia, Pennsylvania, United States, 10UNIVERSITY OF UTAH, Salt Lake City, Utah, United States, 11University of Utah School of Med, Salt Lake City, Utah, United States

5:15 - 18 Persistent beneficial effects of angiotensinogen small interfering RNA (siRNA) and valsartan in spontaneously hypertensive rats after drug removal
Edwyn O. Cruz-Lopez1, Dien Ye1, Richard Van veghel1, Ingrid Garrelds1, Anne Kasper2, Kelly Wassarman2, Ho-Chou Tu2, Ivan Zlatev2, Jan H. Danser3
1Erasmus MC, Rotterdam, Zuid-Holland, Netherlands, 2Alnylam Pharmaceuticals, Roslindale, Massachusetts, United States, 3ERASMUS MC, Rotterdam, Netherlands

5:30 - 19 Effect of the endothelin receptor antagonist aprocitentan on plasma endothelin, renin and aldosterone concentrations in patients with resistant hypertension. A biomarker analysis of the PRECISION study.
Marc Iglarz, Peter Blattmann, Roland F. Dreier, Parisa Danaietash, Mouna Sassi-Sayadi, Martine Clozel
Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland

5:45 - 20 Orthostatic Hypotension in Patients with Heart Failure taking Carvedilol or Metoprolol
Daniel Carranza Leon1, Ryan Samarakoon3, Lauren Lee Shaffer2, Quinn Wells3, Luis E. Okamoto4, Italo Biaggioni5
1Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States, 2Vanderbilt University Medical Center, Kingston Springs, Tennessee, United States, 3VANDERBILT UNIVERSITY, Nashville, Tennessee, United States, 4Vanderbilt University Medical Ctr, Nashville, Tennessee, United States, 5VANDERBILT UNIVERSITY, Nashville, Tennessee, United States

12.B Influence of Hypertension on Cognition
Salon A3
Moderators: Monica M. Santisteban, PhD and Gregory Fink, PhD, FAHA

5:00 - 21 The Detrimental Effects of a Comorbidity of Increased Blood Pressure Variability and High Salt Diet on Cardiovascular and Neurovascular Outcomes
Perenkita Mendiola1, Kun Xie1, Philip Oherron2, Michael W. Brands3, Rachel Patterson1, Cameron Folk1, Jessica A. Filosa1
1Augusta University, Augusta, Georgia, United States, 2Augusta University, Augusta, Georgia, United States, 3Augusta University, Augusta, Georgia, United States

5:15 - 22 Evaluation of the effects of CD8 knock-out on cognitive decline in the TAC-induced hypertension mouse model
Jacopo Pacella1, Valentina Fardella1, Agnese Migliaccio1, Fabio Pallante1, Daniela Carnevale2, Giuseppe Lembo3, Lorenzo Carnevale1
1I.R.C.C.S. Neuromed, Pozzilli, Italy, 2Sapienza University of Rome, Rome, Italy, 3Sapienza University of Rome, Pozzilli, Italy

5:30 - 23 Cognitive impairment during chronic i.c.v. angiotensin II is associated with increased tau phosphorylation in the cortex and hippocampus
Sara Zarate1, Ava Santner2, Udaykiran Vissa2, Monica M. Santisteban1
1Vanderbilt University Medical Cente, Nashville, Tennessee, United States, 2Vanderbilt University, Nashville, Tennessee, United States

5:45 - 24 Effects Of Intensive Blood Pressure Lowering on Brain Tissue Pulsatility in Hypertensive Patients
Wanpen Vongpatanasin1, John M. Giacona1, Ashley Murillo1, Brooke Bates1, Danielle Pittman1, Anna L. Tomlinson2, Song Zhang3, Rong Zhang4, David Zhu5
1UNIVERSITY TX SOUTHWESTERN MED, Dallas, Texas, United States, 2Institute of Exercise and Environmental Medicine, Dallas, Texas, United States, 3Peter O’Donnell Jr. School of Public Health, UT Southwestern Medical Center,, Dallas, Texas, United States, 4UTSW Medical Center, Dallas, Texas, United States, 5Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, New York, United States

Session 13
Continental Ballroom

6:00 - The Arthur C. Corcoran Memorial Lecture:
Cardiovascular Disease after Hypertensive Disorders of Pregnancy: Back to the Future
Vesna D. Garovic, MD, PhD, FAHA, FASN

6:30 - The Lewis K. Dahl Memorial Lecture:
Renal Mechanisms of Salt Sensitive Hypertension: What We Still Don't Know
Pablo A. Ortiz, PhD

Session 14
Continental Ballroom

7:30 to 8:00 - The Donald Seldin Lecture:
The Collecting Duct at the Forefront of Hypertension and Kidney Disease: Roles of Soluable (Pro)Renin Receptor and Intrarenal RAAS
Tianxin Yang, MD, PhD, FAHA

8:00 to 9:30 - Oral Abstract Sessions

14A - Novel Interventions in Improving BP control in the digital era
Continental Ballroom
Moderators: Vuddhidej Ophascharoensuk, MD and Angela L. Price, MD

8:00 - 25 The Blood Pressure Effects of a Just-in-time-adaptive Intervention for Physical Activity and Diet in Patients with Hypertension: A Randomized Controlled Trial
Michael P. Dorsch1, Jessica R. Golbus1, Tanima Basu1, Evan Luff1, Kimberly Warden2, Michael Giacalone2, Sarah Bailey3, Gabriella VanAken1, Sonali Mishra1, Predrag Klasnja1, Mark Newman1, Lesli E. Skolarus4, Brahmajee K. Nallamothu1
1University of Michigan, Ann Arbor, Michigan, United States, 2Hamilton Community Health Network, Flint, Michigan, United States, 3Bridges Into The Future, Inc., Flint, Michigan, United States, 4Northwestern University, Chicago, Michigan, United States

8:15 - 26 An Effective mHealth Intervention to Close the Guideline-to-Practice Gap in Hypertension Treatment: mGlide RCT
Kamakshi Lakshminarayan1, THOMAS Murray1, Teresa McCarthy1, Russell V. Luepker4, Paul Drawz1, Christopher D. Streib2, Susan A. Everson-Rose3, John Connett1, Sarah Westberg1
1UNIVERSITY OF MINNESOTA, Minneapolis, Minnesota, United States, 2UNIVERSITY OF MINNESOTA, Minneapolis, Minnesota, United States, 3UNIVERSITY OF MINNESOTA, Minneapolis, Minnesota, United States, 4UNIVERSITY OF MINNESOTA, Minneapolis, Minnesota, United States

8:30 - 27 A Randomized Clinical Trial for Asymptomatic Elevated Blood Pressure in Patients Discharged from Emergency Department
heather prendergast2, Spyros Kitsiou2, Renee Petzel Gimbar2, Sally Freels2, Anissa Sanders2, Martha L. Daviglus2, Barry L. Carter4, Marina Del Rios5, Sara Heinert3, Shaveta Khosla1
1Emergency Medicine, University of Illinois Chicago, Chicago, Illinois, United States, 2University of Illinois at Chicago, Chicago, Illinois, United States, 3University of Illinois at Chicago, Chicago, Illinois, United States, 4UNIVERSITY IOWA COLLEGE PHARMACY, Coralville, Iowa, United States, 5University of Iowa, Iowa City, Iowa, United States

8:45 - 28 A major effect of aprocitentan on albuminuria in patients with resistant hypertension
Markus P. Schlaich1, George L. Bakris2, John M. Flack3, Alberto Gimona4, Krzysztof Narkiewicz5, Mouna Sassi-Sayadi4, Jiguang Wang6, Michael A. Weber7
1UNIVERSITY OF WESTERN AUSTRALIA, Perth, Western Australia, Australia, 2UNIVERSITY CHICAGO MEDICINE, Chicago, Illinois, United States, 3SIU SCHOOL MEDICINE, Sprifield, Illinois, United States, 4IDORSIA Pharmaceuticals Ltd., Allschwil, Switzerland, 5Medical University of Gdansk Department of Hypertension and Diabetology, Gdansk, Poland, 6Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 7SUNY Downstate College of Medicine, Springfield, Illinois, United States

9:00 - 29 Blood Pressure Phenotypes in an Interventional Study of Participants with Heart Failure with Preserved Ejection Fraction
Alavi Hossain1, Audrey Greenip1, Jessica Loren Afable2, Hannah Maynard1, Julio Chirinos1, Raymond R. Townsend1, Jordana Cohen1
1University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2University of Maryland, College Park, Maryland, United States

9:15- 30 Acute Effects Of Sodium Chloride Or Its Substitute Potassium Chloride On Microvascular Function In Healthy Volunteers
Annika Stock-Schrooer1, Lukas Streese1, Randa Rammo1, Marta Kantauskaite1, Lars Christian Rump2, Dominik N. Mueller3, Johannes Stegbauer1
1Heinrich-Heine University, Duesseldorf, Germany, 2Heinrich-Heine-University, Dusseldorf, Germany, 3MAX DELBRUCK CTR, Berlin, Germany

14.B Oxidative Stress and Immune Mechanisms in Hypertension
Salon A3
Moderators: John Henry Dasinger, PhD and Justin P. Van Beusecum, PhD

8:00 - 31 Deacetylation Mimetic Mutation of Mitochondrial Superoxide Dismutase Attenuates Angiotensin II-Induced Hypertension by Protecting Against Oxidative Stress
Anna Dikalova, Mingfang Ao, Liliya Tkachuk, Sergey Dikalov
Vanderbilt University Medical Center, Nashville, Tennessee, United States

8:15 - 32 Vγ6+ γδ T cells protect against angiotensin II-induced hypertension and vascular injury in male mice
Pierre Paradis1, Ahmad Mahmoud2, Antoine Caillon1, Brandon Shokoples3, Nathanne d. Ferreira2, Kevin Comeau1, Shinya Hatano4, Yasunobu Yoshikai4, Julia M. Lewis5, Robert Tigelaar5, Ernesto L. Schiffrin1
1Lady Davis Institute, Montreal, Quebec, Canada, 2Lady Davis Institute, Montreal, Quebec, Canada, 3Lady Davis Institute, Montreal, Quebec, Canada, 4Kyushu University,, Fukuoka, Japan, 5Yale University, New Haven, Connecticut, United States

8:30 - 33 CD4+ T Cell-Induced Renal Damage and Salt-Sensitive Hypertension is Not Modified by CD8+ T Cells
Samuel Walton, Justine M. Abais-Battad, John Henry H. Dasinger, Emily Burns-Ray, Kaitlyn E. Baldwin, Mary C. Shaw, David L. Mattson
Medical College Of Georgia, Augusta, Georgia, United States

8:45 - 34 Elevation of Plasma anti-Endothelin A Receptor Autoantibodies in Lupus Subjects Correlates with Plasma Vascular Adhesion Molecule-1 Independent of Blood Pressure
Marice McCrorey, Kennedy P. Hawkins, Jim Oates, Betty P. Tsao, Yasir Abdul, Adviye Ergul, Melissa Cunningham, Justin P. Van Beusecum
Medical University of South Carolina, Charlotte, North Carolina, United States

9:00 - 35 The Dual Endothelin-1 Antagonist Aprocitentan Attenuates Mitochondrial Oxidative Stress in Human Cardiac Fibroblasts
Fahimeh Varzideh1, Stanislovas Jankauskas1, Esther Densu Agyapong1, Urna Kansakar2, Gaetano Santulli1
1Medicine-Cardiology, Albert Einstein College of Medicine, Bronx, New York, United States, 2Albert Einstein College of Medicine, Bronx, New York, United States

9:15 - 36 Ablation of T-Lymphocyte β-Arrestins Reduces Inflammation and Increases Salt Retention in the Absence of Blood Pressure Changes Following Angiotensin II Infusion
Mina Ghobrial1, Eva M. Fekete2, Patricia Muskus Veitia3, Daniel Brozoski4, Ko-Ting Lu5, Ana Hantke Guixa6, Kelsey Wackman7, Curt D. Sigmund8, Pablo Nakagawa9
1Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2Medical College of Wisconsin, Wauwatosa, Wisconsin, United States, 3Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 4Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 5Physiology, Medical College of Wisconsin, Wauwatosa, Wisconsin, United States, 6Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 7Physiology, Medical College of Wisconsin, Wauwatosa, Wisconsin, United States, 8Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 9Medical college of Wisconsin, Milwaukee, Wisconsin, United States

Session 14C -
Clinical Practice/Clinical Science (CPCS)

7:30 to 8:30 -
14C1: Hypertension Cases with the Experts- How would you manage these patients?
Salon A5
Moderators: Jan Basile, MD and Raven Voora, MD

7:30 - Case 1: Patient cannot tolerate any medications
Presented by Johnathan Ravid, MD

7:45 - Case 2: Wide Pulse Pressure, SBP remains high, DBP low
Presented by Mason Yoder, MD

8:00 - Case 3: Intermittent BP elevations / "spikes"
Presented by Naome Mwesigwa, MD

8:15 - Case 4: Severe autonomic dysfunction
Presented by Pedro Ortiz, MD

8:30 to 9:30
14C2: Clinical Trials- How do we make them better!
Salon A5
Moderators: Sydney Hartsell, MD, MPH and Matthew Alexander, MD, PhD

8:30 - For which patients do we need more evidence?
William C. Cushman, MD, FAHA

8:45 - Do decentralized trials in hypertension make sense?
Lama Ghazi, MD PhD

9:00 How should we measure BP in clinical trials?
Joseph Ebinger, MD

9:15 - Discussion/Q&A

10:30 to 12:00 -
Oral Abstract Sessions

15.A Renal hemodynamics, tubular transport, salt and renovascular hypertension
Continental Ballroom
Moderators: Jing (Jason) Wu, PhD, FAHA and Brandi M. Wynne, PhD

10:30 - 37 Targeted Deletion of NKCC1 in Vascular Smooth Muscle Cells Lowers Blood Pressure in Normotensive and Hypertensive Mice
Anika Seniuk1, Claudius Steffen1, Helga Vitzthum1, Christian A. Hubner2, Heimo Ehmke1
1Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany

10:45 - 38 Loop Diuretic Resistance in a Preclinical Model of Cardiorenal Syndrome 2: Role of Enhanced Distal Convoluted Tubule Sodium Transport
Isaac Baiden, Mariela E. Mendez, Pablo A. Ortiz, NourEddine E. Rhaleb, Tang-Dong Liao, Jiang Xu
Hypertension and Vascular Research Division, Internal Medicine Department, Henry Ford Hospital, Detroit, Michigan, United States

11:00 - 39 Tryptophan contributes to the sex-dependent loss of diurnal sodium excretion in BMAL1 knockout rats.
Mary Latimer1, David M. Pollock2
1Nephrology, UNIVERSITY OF ALABAMA BIRMINGHAM, Birmiham, Alabama, United States, 2University of Alabama at Birmingham, Birmingham, Alabama, United States

11:15 - 40 Sodium-mediated Blood Pressure Increase in Chronic Kidney Disease and Diabetic Kidney Disease Patients Coincides With Vasodysfunction.
Robert van Duin1, Jetta Oppelaar1, Bert-Jan Van den Born2, Rik Olde Engberink1, Liffert Vogt1
1Nephrology, Amsterdam UMC, Amsterdam, Netherlands, 2Amsterdam UMC, Amsterdam, Netherlands

15.B Diabetes, Obesity and Microbiome15.B Diabetes, Obesity and Microbiome
Salon A3
Moderators: Thiago Bruder, PhD and Daria Golosova, MD, PHD

10:30 - 41 SerpinA3N in Leptin Receptor Neurons Regulates Metabolic Homeostasis and Cardiovascular Function
Deng-Fu Guo, Donald Morgan, Alexis Olson, Kamal Rahmouni
UNIVERSITY IOWA, Iowa City, Iowa, United States

10:45 - 42 Fecal Microbiota Transplantation Decreases Autoantibody Production and Lowers Blood Pressure in an Experimental Model of Autoimmune Disease
Erin Taylor, Aja Ceesay, Luciano Mendoza, Jayla Sandifer, Jordan A. Hart, Clinton Case
Physiology and Biophysics, UNIVERSITY OF MS MEDICAL CENTER, Jackson, Mississippi, United States

11:00 - 43 PAR1 Inhibition with Vorapaxar Enhances Renal Function and Modulates Inflammation Mediators in Diabetic Nephropathy
Ruslan Bohovyk1, Olha Kravtsova2, Melissa S. Lowe3, Gunjan Upadhyay1, Vladislav Levchenko1, Ganesh V. Halade4, Oleg Palygin5, Alexander Staruschenko6
1University of South Florida, Tampa, Florida, United States, 2University of South Florida, Tampa, Florida, United States, 3University of South Florida, Tampa, Florida, United States, 4UNIVERSITY SOUTH FLORIDA, Tampa, Florida, United States, 5Medical University of SC, Charleston, South Carolina, United States, 6University of South Florida, Tampa, Florida, United States

11:15 - 44 Transcutaneous hydrogen sulfide measurement as a way to evaluate skin blood flow
Samuel A. Moghaddam1, Jessica Neff1, Reza Shekarriz2, Debra Fredrichson2, Ross Clark3, Eric Lew1, Nancy Kanagy1
1UNIVERSITY NEW MEXICO, Albuquerque, New Mexico, United States, 2Exhalix, LLC, Albuquerque, New Mexico, United States, 3University of New Mexico, Albuquerque, New Mexico, United States

Session 15C - Primary Care

10:00 to 11:00
15C1 - Picking the Right Drugs for the Right Patient
Salon A5
Moderators: C. Adair Blyler, PharmD and Farah Allouch, MPH

10:00 - Classy treatment of hypertension: Everything you wanted to know about hypertension drug classes and side effects
Adam Bress, PharmD

10:15 - Tailoring therapy for distinct populations
Karen A. Griffin, MD, FAHA

10:30 - Combination therapy
Brent M. Egan, MD

10:45 - Discussion/Q&A

11:00 to 12:00
15C2 - Partnering with Patients to Initiate and Adhere to Treatment
Salon A5
Moderators: Ruth-Alma Turkson-Ocran, PhD, MPH, RN, CRNP and Bunmi Ogungbe, PhD, MPH, RN

11:00 - Patient communication
Aisha Langford, MPH, PhD

11:15 - Social determinants of health
Ruth-Alma Turkson-Ocran, PhD, MPH, RN, CRNP

11:30 - Strategies for Developing and Implementing Treatment Plans from a Health Equity Lens
Stephanie Fitzpatrick, PhD, FSBM

11:45 - Discussion/Q&A

Recor - Industry Sponsored Learning Studio
Salon A3

Session 16 - Grantsmanship for Early Career Investigators
Sponsored by the Trainee Advocacy Committee
Continental Ballroom
Chairs: Cameron McCarthy, PhD, FAHA and Carmen De Miguel, PhD, MS, FAHA

NIH Grant Review Process
Youngsuk Oh, PhD

Panelists:
Richard Wainford, PhD, FAHA
Michelle Gumz, PhD, FAHA
Camilla Ferreira Wenceslau, PhD, FAHA
Alexander Staruschenko, PhD, FAHA
Paul Welling, MD, FAHA

Session 17
Clinical Practice Guidelines for Hypertension: What you need to know
(sponsored by Hypertension)
Salon A5
Moderators: Rhian M Touyz MBBCh, PhD, FRCP, FRSE, FMedSci and David G Harrison, MD FAHA

12:30 - Is this the right time for new ACC/AHA guidelines?
Jordana B. Cohen, MD, MSCE

12:45 - The 2024 ESC guidelines
John William McEvoy, MB, MHS

1:00 - Risk scores and hypertension management
Cian McCarthy, MB, BCh, BAO

1:15 - Effectiveness of guideline implementation
Paul K. Whelton, MB, MD, MSc

18.A TAC Oral Abstract Award Competition
Continental Ballroom
Moderators: Cam McCarthy, PhD, and Monica M. Santisteban

1:30 - 45 Deletion of a 4-bp noncoding genomic segment orthologous to human rs1882961 results in sex-divergent changes in salt-induced hypertension in Dahl salt-sensitive rats
Hong Xue1, Michael Grzybowski1, Rajan Pandey2, Yong Liu2, Pengyuan Liu2, Bhavika Therani2, Mark Vanden Avond1, Allen W. Cowley1, Aron M. Geurts1, Mingyu Liang3
1Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2University of Arizona, Tucson, Arizona, United States, 3Physiology, University of Arizona, Tucson, Arizona, United States

1:45 - 46 Reduced Angiotensin II Type 2 Receptor-Mediated Responses Contribute to Increased Angiotensin II Vasoconstrictor Sensitivity in Otherwise Healthy Women With a History Of Preeclampsia
Kelsey Schwartz, Diana I. Jalal, Anna E. Stanhewicz
Iowa City, Iowa, United States

2:00 - 47 Deletion of PRR in AgRP Neurons of the Arcuate Nucleus Contributes to the Development of DOCA-Salt Hypertension
Shiyue Pan1, Yuma Mizuno4, gang chen4, Gregory Morton2, Michael Schwartz3, Yumei Feng Earley4
1Pharmacology, University of Nevada, Reno, Reno, Nevada, United States, 2University of Washington, Seattle, Washington, United States, 3Medicine, University of Washington, Seattle, Washington, United States, 4UNIVERSITY OF NEVADA, RENO, Reno, Nevada, United States

2:15 - 48 Cardiovascular Health Modifies Genetic Risk for the Hypertensive Disorders of Pregnancy
Vineetha Mathew1, Raiyan Khan2, Rebecca McNeil3, Qi Yan2, Itsik Pe er2, Buu Truong1, Pradeep Natarajan4, Lynn Yee5, Garima Sharma6, Aniruddh Patel4, So Mi J. Cho1, Amanda Jowell7, Maria Pabon8, Robert Silver9, Lisa Levine10, William Grobman11, Janet M. Catov12, David Haas13, Michael C. Honigberg4
1Broad Institute of MIT and Harvard, Boston, Massachusetts, United States, 2Columbia University, New York, New York, United States, 3RTI International, Durham, North Carolina, United States, 4Massachusetts General Hospital, Brookline, Massachusetts, United States, 5Northwestern, Chicago, Illinois, United States, 6Inova Fairfax Medical Campus, Falls Church, Virginia, United States, 7Harvard Medical School, Brookline, Massachusetts, United States, 8Brigham and Women's Hospital, Boston, Massachusetts, United States, 9University of Utah, Salt Lake City, Utah, United States, 10University of Pennsylvania, Philadelphia, Pennsylvania, United States, 11The Ohio State University Medical Center, Tulsa, Oklahoma, United States, 12UNIVERSITY OF PITTSBURGH, Pittsburgh, Pennsylvania, United States, 13Indiana University School of Medicine, Indianapolis, Indiana, United States

2:30 - 49 Activator protein 1 (AP-1) Complex in Antigen Presenting Cells contributes to Salt-Sensitive Blood Pressure in Humans
Taseer Ahmad1, Mohammad Saleem3, Ashley Mutchler4, Lale A. Ertuglu1, Claude F. Albritton2, Alexandria P. Haynes1, Mert Demirci1, Mohd M. Khan1, Annet Kirabo1
1Vanderbilt University Medical Cente, Nashville, Tennessee, United States, 2Meharry Medical College, Nashville, Tennessee, United States, 3Vanderbilt university medical cente, Nashville, Tennessee, United States, 4Vanderbilt University Medical Cente, Nashville, Tennessee, United States

2:45- 50 The Comparison of Office Blood Pressure with Morning Home Blood Pressure: Self-Automated Measurement
Nutnicha Suntornlekha1, Srun Kuanprasert1, Chatree Chai-Adisaksopha2, Panas Jesadaporn2, Warangkana Mekara1, KRIT LEEMASAWAT1
1Cardiology , Chiang Mai University, Chiang Mai, Thailand, 2Internal Medicine, Chiang Mai University, Chiang Mai, Thailand

18.B Too Much Potential: New Paradigms in Brain Mechanisms of Hypertension
Salon A3
Moderators: Mona Elgazzaz, MD, PhD and Pablo Nakagawa, PhD

1:30 - 51 Targeted Apoptosis of the Angiotensin AT1R-Expressing Subtype of Agouti-Related Peptide Neurons Increases Resting Metabolism and Blood Pressure
Jhonatan Pasos2, Valerie Wagner1, Samuel Lawton1, Patricia Muskus Veitia1, Connie Grobe1, Daniel Brozoski1, John J. Reho1, Natalia Mathieu1, Ko-Ting Lu1, Jeffrey Segar1, Curt D. Sigmund1, Pablo Nakagawa1, Justin L. Grobe1
1Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2Biomedical Engineering, Universidad CES, Medellín, Colombia

1:45 - 52 HIV-derived Proteins Induce Neuroinflammation, Hypertension, and Sympatho-activation via T cell-dependent mechanisms in the Tg26 Mouse Model
Beryl N. Khakina, Taylor Kress, Simone Kennard, Eric J. Belin De Chantemele
Vascular Biology, MEDICAL COLLEGE OF GEORGIA AT AU, Augusta, Georgia, United States

2:00 - 53 Chronic Angiotensin-(1-7) Treatment May Enhance GABAergic Neurotransmission onto Melanocortin-4 Receptor Neurons in The Hypothalamic Paraventricular Nucleus in a Sex-Specific Manner
Victoria Vernail, Sarah Bingaman, Yuval Silberman, Amy C. Arnold
Penn State College of Medicine, Hershey, Pennsylvania, United States

2:15 - 54 The kidney-OVLT axis in renovascular hypertension: Individual and combined effects of afferent renal denervation and OVLT lesion in 2K1C rats.
Mariana Ruiz Lauar1, John P. Collister3, Louise C. Evans2, John W. Osborn4
1University of Minnesota, Minneapolis, Minnesota, United States, 2University of Minnesota, Minneapolis, Minnesota, United States, 3University of Minnesota, Saint Paul, Minnesota, United States, 4University of Minnesota, Minneapolis, Minnesota, United States

2:30 - 55 Mouse Offspring Exposed to Preeclampsia/Eclampsia-like Symptoms Exhibit Changes in Regional Cerebral Perfusion at 2 months of age
Karen Saffold1, Andrea Tall2, Tyranny Pryor2, Qingmei Shao2, Maria Jones- Muhammad3, Kennedi Stancil2, Junie P. Warrington2
1Program in Neuroscience, University of Mississippi Medical Center, Brandon, Mississippi, United States, 2University of Mississippi Medical Center, Jackson, Mississippi, United States, 3University of Mississippi Medical C, Jackson, Mississippi, United States

2:45 - 56 High Blood Pressure Is Associated with Lower Brain Volume and Cortical Thickness in Healthy Young Adults
Junyeon Won1, John Ashley2, Danilo Cardim3, Wanpen Vongpatanasin4, Rong Zhang1
1Neurology, UT Southwestern Medical Center, Dallas, Texas, United States, 2UT Southwestern Medical Center, Garland, Texas, United States, 3Institute for Exercise and Environmental, Dallas, Texas, United States, 4UNIVERSITY TX SOUTHWESTERN MED, Dallas, Texas, United States

Session 18C -Hypertension Case Study Session
Salon A5
Moderators: Rhian M Touyz MBBCh, PhD, FRCP, FRSE, FMedSci, and David G. Harrison, MD, FAHA

Hickam’s Dictum in Hypertension
Gregory L. Hundemer, MD, MPH
Swapnil Hiremath, MD, MPH 

Contemporary Use of an Old Drug: Minoxidil for Resistant/Refractory Hypertension
Michael Bursztyn, MD 
Iddo Z. Ben-Dov, MD, PhD 

Session 19
Continental Ballroom

3:30 - KCVD Mid-Career Achievement Award: Hypertension in persons with kidney disease— different population, different disease.
Nisha Bansal, MD, MAS, FAHA, FASN, FACP

4:30 - 5:30 Oral Abstract Sessions

19.A Aldosterone
Continental Ballroom
Moderators: Gian Paolo Rossi, MD, FAHA, FACC and Wanpen Vongpatanasin, MD, FAHA

4:30 - 57 Macrolides for KCNJ5–mutated Aldosterone-Producing Adenoma (MAPA): a Study for Personalized Management of Primary Aldosteronism
Gian Paolo D. ROSSI1, Teresa M. Seccia1, Brasilina Caroccia1, Alessandro Bressan1, Giacomo Rossitto1, Clement Byiringiro1, Giulio Ceolotto1, Ana M. Briones2
1University of Padua, Padova, Italy, 2Universidad Autónoma de Madrid, Madrid, Spain

4:45 - 58 The 5-HT7 receptor contributes to increased hindquarter blood flow caused by skeletal muscle contraction
Teresa Krieger-Burke1, Hannah Garver1, Elise Yoder1, Stephanie Watts1, Gregory D. Fink2
1MICHIGAN STATE UNIVERSITY, East Lansing, Michigan, United States, 2MICHIGAN STATE UNIVERSITY, East Lansi, Michigan, United States

5:00 - 59 Beclin-1-Dependent Autophagy Prevents Hyperaldosternism-Induced Endothelial Dysfunction And Hypertension
Rafael Costa1, Ariane Bruder Nascimento1, Rita C. Tostes3, Thiago B. Bruder2
1University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 3UNIVERSITY SAO PAULO, Ribeirao Preto, Brazil

5:15 - 60 Atlas of Distal Nephron Mineralocorticoid Receptor-Dependent Transcriptome Reveals Novel Aldosterone Actions
Paul A. Welling1, Hyun Jun Jung2, Xiao-Tong Su3, Boyoung Kim1, Lama Alqusairi4, Robert Fenton5, David H. Ellison6
1Johns Hopkins Medical School, Baltimore, Maryland, United States, 2Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 3Oregon Health and Science University, Portland, Oregon, United States, 4Johns Hopkins University, Baltimore, Maryland, United States, 5Aarhus University, Aarhus, Denmark, 6OREGON HEALTH & SCIENCE UNIVERSITY, Portland, Oregon, United States

19.B Pressure Sensing and Vascular Disease
Salon A3
Moderators: Heimo Ehmke and Maria Luisa Sequeira Lopez, MD

4:30 - 61 Protective role of caspase-1 inhibition in experimental model of neonatal hyperoxia-induced cardiopulmonary dysfunction in adults born preterm.
Sydne Ballengee1, Runxia Tian1, Aden Jamal1, Jacqueline F. Machi2, Augusto Schmidt1, Claudia Rodrigues2, Karen C. Young1, Shu Wu3, Merline Benny1
1University of Miami, Miami, Florida, United States, 2Florida Atlantic University, Boca Raton, Florida, United States, 3University of Miami, Palmetto Bay, Florida, United States

4:45 - 62 Notch3 and the Vascular-Adipose Interactome in the Regulation of Adiponectin and Vascular Contraction
Augusto Montezano2, Raquel Sarafian2, Prashant Rao1, Ying He2, Francisco J. Rios2, Livia L. Camargo2, Zsu-Zsu Chen1, Jacob Barber1, Robert E. Gerszten1, Rhian M. Touyz2
1Harvard Medical School Teaching Hospital, Beth Israel Deaconess Medical Centre, Boston, Massachusetts, United States, 2McGill University, . Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

5:00 - 63 Acetylation of Mitochondrial Cyclophilin D Increases vascular Oxidative Stress, Induces Glycolitic Switch, Promotes Endothelial Dysfunction and Hypertension
Sergey Dikalov1, Daniel J. Fehrenbach2, Vladimir Mayorov3, Alexander Panov1, Mingfang Ao1, Louise Lantier4, Venkataraman Amarnath1, Marcos G. Lopez1, Frederic T. Billings1, Michael N. Sack5, Anna Dikalova1 1Vanderbilt University Medical Center, Nashville, Tennessee, United States, 2Indiana University School of Med, Indianapolis, Indiana, United States, 3Mercer University School of Medicine, Macon, Georgia, United States, 4Vanderbilt University, Nashville, Tennessee, United States, 5National Institutes of Health, Bethesda, Maryland, United States

5:15 - 64 Smooth Muscle Cullin-3 Regulates the Renal Baroreceptor Mechanism: a Link Between CUL3 and Integrin β1
Daria Golosova2, Gaurav Kumar3, Ko-Ting Lu4, Nisita Chaihongsa5, Daniel Brozoski1, Patricia Muskus Veitia6, John J. Reho7, Pablo Nakagawa8, Curt D. Sigmund1
1Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 3Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 4Physiology, Medical College of Wisconsin, Wauwatosa, Wisconsin, United States, 5Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 6Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 7Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 8Medical college of Wisconsin, Milwaukee, Wisconsin, United States

Session 19C - Primary Care

3:30 to 4:30 - 19C1: Blood Pressure Measurement
Salon A5
Moderators: Steven A Yarows, MD and Hilary K. Wall, MPH

3:30 - Standardization: Getting the most out of the office measurement
Paul E. Drawz, MD

3:45 - Incorporating patient-measured blood pressure into clinical care: best practices/use cases
Karen Margolis, MD, MPH

4:00 - Numbers you can use: devices and approaches
Beverly B. Green, MD, MPH, FAHA

4:15 - Discussion/Q&A

4:30 to 5:30 - 19C2: Off the Cuff: "Podcast" Interview with the Experts
Salon A5
Podcaster: Swapnil Hiremath, MD, MPH

Hypertension Experts
William B. Cushman, MD,
Shawna D. Nesbitt MD, MS
Michael Rakotz, MD, FAHA, FAAFP

Session 20
Continental Ballroom

Excellence Award for Hypertension Research Lecture: Discovery of the Microbiome as a Key Regulator of Salt-Sensitivity and Blood Pressure
Bina Joe, PhD, FAHA, FAPS, ISHF

Session 21 -
Continental Ballroom

Recent Advances (plenary) - Hypertension and Women's Health
Chairs: Jessica Faulkner, PhD, FAHA and Amy C. Arnold, PhD, FAHA

7:30 - Sex Differences in Resilience to Hypertension
Heddwen Brooks, PhD

8:00 - New Concepts in Immune Mechanisms of Preeclampsia
Babbette LaMarca, PhD

8:30 - Renal Hemodynamics in Pregnancy
Phyllis August, MD, MPH

22.A Preeclampsia and Developmental Programming
Continental Ballroom
Moderators: Evangeline Deer, PhD and Analia Loria-Kinsey, PhD

9:30 - 65 Postpartum Alterations of Middle Cerebral Artery Reactivity and Hemodynamics in a Transgenic Rat Model of Preeclampsia
Victor M. Pulgar1, Jonathan Ray2, Xuming Sun2, Liliya M. Yamaleyeva2
1Pharmaceutical & Clinical Sciences, Campbell University, Buies Creek, North Carolina, United States, 2Wake Forest School of Medicine, Winston Salem, North Carolina, United States

9:45 - 66 Early-Life Sodium Restriction Programs Salt-Sensitivity of Autonomics and Blood Pressure in Adult C57BL/6J Mice
Samuel Lawton, Alisha Ziegler, Connie Grobe, Valerie Wagner, Daniel Brozoski, Eva M. Fekete, Curt D. Sigmund, Pablo Nakagawa, Justin L. Grobe, Jeffrey Segar
Medical College of Wisconsin, Milwaukee, Wisconsin, United States

10:00 - 67 Cardiac Biomarkers in Pregnancies with and without Hypertension – a Case Control Study
Lara Kovell1, Mawulorm Denu1, Cassie Shao1, Claire Meyerovitz2, Sheikh Moinul3, Angela Essa4, Gianna Wilkie1, Tiffany Moore Simas1, Stephen P. Juraschek5
1UMass Chan Medical School, Worcester, Massachusetts, United States, 2University of Virginia, Charlottesville, Virginia, United States, 3Boston Medical Center, Boston, Massachusetts, United States, 4Baystate Medical Center, Springfield, Massachusetts, United States, 5BIDMC-Harvard Medical School, Boston, Massachusetts, United States

10:15 - 68 Soluble FMS-Like Tyrosine Kinase 1 induces Vascular Endothelial Dysfunction in Pregnant Female Mice
Mona Elgazzaz1, Gibson Cooper1, Elisabeth Mellott1, James Maher2, Jessica L. Faulkner1
1Physiology, Augusta University, Augusta, Georgia, United States, 2Obstetrics and Gynecology, Augusta University, Augusta, Georgia, United States

10:30 - 69 Female Blood Pressure High 5 Mice Display Cerebral Hypoperfusion In the Non-Pregnant and Late Pregnant State
Chauncey Darden1, Karen Saffold1, Qingmei Shao1, Shanise Rouser2, Frank T. Spradley2, Junie P. Warrington1
1Neurology, University of Miss Med Center, Jackson, Mississippi, United States, 2Surgery, U of Mississippi Medical Center, Jackson, Mississippi, United States

10:45 - 70 Cellular senescence as a driver of preeclampsia
Sonja Suvakov, Tamara Gojkovic, Jennet Hatamova, Vladimir Dokic, Paul Gavrilovici, Vesna D. Garovic
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States

22.B Genomic Influences on Blood Pressure
Salon A3
Moderators: Mingyu Liang, MB, PhD and Curt D Sigmund, PhD, FAHA

9:30 - 71 Analysis of First Morning Urine Transcriptomes in Normotensive and Hypertensive Patients Identify Upregulated Inflammatory and Signaling Pathways Associated with Hypertension
Kausik Umanath1, Ryann Sohaney1, Douglas Atchison1, EMMY ABRAHAM1, Ze Meng1, Ruicong She1, Indra Adrianto1, Albert Levin1, Andrew Wu1, Pablo A. Ortiz2
1Henry Ford Hospital, Detroit, Michigan, United States, 2HENRY FORD HEALTH, Wayne State U, Detroit, Michigan, United States

9:45 - 72 Genetic variance in heparan sulfation is associated with salt-sensitivity: a gene-environment analysis in EPIC-Norfolk, UK biobank, and HELIUS
Jetta J. Oppelaar, Mohamed A. Romman, Ghazalah Sahebdin, Aeilko Zwinderman, Henrike Galenkamp, S Boekholdt, Bert-Jan Van den Born, Rik Olde Engberink, Liffert Vogt
Amsterdam UMC, Amsterdam, Netherlands

10:00 - 73 Extracellular vesicles-derived miR-125b-5p/miR-125a-5p promotes hypertension by regulating angiotensin-converting enzyme 2
Vahideh Tarhriz1, Mina MohammadiNasr4, Huijing Xia2, Eric D. Lazartigues3
1Cardiovascular Center of Excellence, Louisiana State University School of Medicine, New Orlens, Louisiana, United States, 2LOUISIANA STATE UNIVERSITY, New Orleans, Louisiana, United States, 3LSU HEALTH SCIENCES CENTER, New Orleans, Louisiana, United States, 4Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran (the Islamic Republic of)

10:15 - 74 The rs1173771 Haplotype Associated with Blood Pressure Influences Chromatin Interactions Involving the Natriuretic Peptide Receptor 3 Gene Promoter
Yong Liu2, Manoj Mishra2, Rajan Pandey2, Aron M. Geurts1, Mingyu Liang2
1Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2Physiology, University of Arizona, Tucson, Arizona, United States

10:30 - 75 CTCF and Rad21 Mediated Regulation of Gene Expression in Human-Induced Pluripotent Stem Cells-derived Endothelial Cells
Atrayee Ray1, Rajan Pandey3, Cary Stelloh1, Pengyuan Liu3, Yong Liu3, Anne E. Kwitek2, Aron M. Geurts2, Allen Cowley2, Andrew Greene4, Mingyu Liang3, Sridhar Rao1
1Versiti Blood Research Institute, Milwaukee, Wisconsin, United States, 2Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 3Physiology, University of Arizona, Tucson, Arizona, United States, 4The Jackson Laboratory, Bar Harbor, Maine, United States

10:45 - 76 CASC15 lncRNA as a Mediator of Vascular Senescence in the Renin-Angiotensin System
Warlley Cunha1, Maria Martin1, Ibrahim A. Ahmed3, Delphine A. Gomez2, Cristina Espinosa-Diez1
1Wayne State University, Detroit, Michigan, United States, 2UNIVERSITY OF PITTSBURGH, Pittsburgh, Pennsylvania, United States, 3University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Session 22C
Primary Care
Clinical Lectures
Salon A5

9:30 - 10:00
Moderator: Joyce P. Samuel, MD
Hypertension Management in Young People
Joshua Samuels, MD, MPH

10:00 - 10:30
Moderator: Jordana Cohen, MD, MSCE
Secondary Hypertension
Richard J. Auchus, MD, PhD

10:30 - 11:00
Moderator: Jesus Melgarejo, MD, PhD
Hypertension Management in Older Adults
Jeff Williamson, MD, MHS            

Session 23 -
Continental Ballroom

Final Keynote
KCVD Past Chair Lecture

Kidney Metabolism and its Role in Hypertension
Alexander Staruschenko, PhD, FAHA

Meeting Adjourns