Science News

International Stroke Conference 2020

State-of-the-Science Stroke Nursing Symposium: February 18
Pre-Conference Symposia: February 18
Sessions: February 19–21
Los Angeles Convention Center | Los Angeles, California

See presentations from: Tuesday | Wednesday | Thursday | Friday

Selected Science from Tuesday, Feb. 18


ISC 2020 Welcome and Program Highlights

Program Chair Miguel Perez-Pinzon, PhD and Vice Chair Louise McCullough, MD, PhD provide an overview of the scientific opportunities they have planned for ISC 2020 in Los Angeles.

ISC 2020 Precon II

Attendees listen during one of the PreCon lectures

ISC 20 attendees take note during Pre-Con Symposium I: Stroke in the Real World: A Star is Born: Thrombolysis & Thrombectomy on Tuesday in the Los Angeles Convention Center.

Suzanne Stone at ISC 2020

Use of a Multidisciplinary Approach to Successfully Improve Inpatient Diabetes Self-Management Education and Diabetes Medication Reconciliation at Discharge for Persons With Diabetes and Stroke at a Major Academic Medical Center
Suzanne Stone | UT Southwestern Medical Center, Dallas TX

Sylvia Coleman at ISC 2020

A Comprehensive Post-Acute Stroke Services (COMPASS) Website for Public Use
Sylvia Coleman | Wake Forest Baptist Medical Center, Winston Salem, NC

John Gwilliam at ISC 2020

Early Mobility Initiated at 12 Hours Post Thrombolytic Therapy for Stroke Increases Likelihood for Discharge to Home
John Gwilliam | Medical City Denton, Denton, TX

Marianne Klinke at ISC 2020

Screening for Spatial Neglect in a Ward-based Environment Within Two Weeks From Stroke Onset: Preliminary Results of a Pilot Study
Marianne Klinke | University of Iceland, Reykjavik, Iceland

Also published in Stroke

Industry Payment to Vascular Neurologists: A 6-Year Analysis of the Open Payments Program From 2013 Through 2018
Krishna Nalleballe, Sen Sheng, Chenghui Li, Ruchira Mahashabde, Amarnath R. Annapureddy, Kamran Mudassar, Krishna Pothineni, Poornachand Veerapaneni, Yohei Harada, Abhishek Chilkulwar, Saritha Ranabothu, Aliza Brown, Nidhi Kapoor, Sanjeeva Onteddu

Race and Ethnic Disparities in Stroke Incidence in the Northern Manhattan Study
Hannah Gardener, Ralph L. Sacco, Tatjana Rundek, Valeria Battistella, Ying Kuen Cheung, Mitchell S.V. Elkind

Temporal Trends in Stroke Incidence Over Time by Sex and Age in the GCNKSS
Tracy E. Madsen, Jane C. Khoury, Michelle Leppert, Kathleen Alwell, Charles J. Moomaw, Heidi Sucharew, Daniel Woo, Simona Ferioli, Sharyl Martini, Opeolu Adeoye, Pooja Khatri, Matthew Flaherty, Felipe De Los Rios La Rosa, Jason Mackey, Eva Mistry, Stacie L. Demel, Elisheva Coleman, Adam Jasne, Sabreena J. Slavin, Kyle Walsh, Michael Star, Joseph P. Broderick, Brett M. Kissela, Dawn O. Kleindorfer

Circulating SHBG (Sex Hormone-Binding Globulin) and Risk of Ischemic Stroke: Findings from the WHI
Tracy E. Madsen, Xi Luo, Mengna Huang, Ki E. Park, Marcia L. Stefanick, JoAnn E. Manson, Simin Liu

Endovascular Thrombectomy for Acute Ischemic Strokes: Current US Access Paradigms and Optimization Methodology
Amrou Sarraj, Sean Savitz, Deep Pujara, Haris Kamal, Kirsten Carroll, Faris Shaker, Sujan Reddy, Kaushik Parsha, Lauren E. Fournier, Erica M. Jones, Anjail Sharrief, Sheryl Martin-Schild, James Grotta

Melbourne Mobile Stroke Unit and Reperfusion Therapy: Greater Clinical Impact of Thrombectomy Than Thrombolysis
Henry Zhao, Skye Coote, Damien Easton, Francesca Langenberg, Michael Stephenson, Karen Smith, Stephen Bernard, Dominique A. Cadilhac, Joosup Kim, Christopher F. Bladin, Leonid Churilov, Douglas E. Crompton, Helen M. Dewey, Lauren M. Sanders, Tissa Wijeratne, Geoffrey Cloud, Duncan M. Brooks, Hamed Asadi, Vincent Thijs, Ronil V. Chandra, Henry Ma, Patricia M. Desmond, Richard J. Dowling, Peter J. Mitchell, Nawaf Yassi, Bernard Yan, Bruce C.V. Campbell, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis

Introduction for Focused Updates in Cerebrovascular Disease
Larry B. Goldstein

Disability After Minor Stroke and Transient Ischemic Attack in the POINT Trial
Brett Cucchiara, Jordan Elm, J. Donald Easton, Shelagh B. Coutts, Joshua Z. Willey, Michelle H. Biros, Michael A. Ross, S. Claiborne Johnston

Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Nils H. Petersen, Andrew Silverman, Sumita M. Strander, Sreeja Kodali, Anson Wang, Lauren H. Sansing, Joseph L. Schindler, Guido J. Falcone, Emily J. Gilmore, Adam S. Jasne, Branden Cord, Ryan M. Hebert, Michele Johnson, Charles C. Matouk, Kevin N. Sheth

Fully Automated Segmentation Algorithm for Perihematomal Edema Volumetry After Spontaneous Intracerebral Hemorrhage
Natasha Ironside, Ching-Jen Chen, Simukayi Mutasa, Justin L. Sim, Dale Ding, Saurabh Marfatiah, David Roh, Sugoto Mukherjee, Karen C. Johnston, Andrew M. Southerland, Stephan A. Mayer, Angela Lignelli, Edward Sander Connolly

Wednesday, Feb. 19


Milestone Anniversaries for tPA and Endovascular Trials

Patrick Lyden, MD and Tudor Jovin, MD discuss the significance of two key milestone anniversaries in the treatment of acute stroke: the 25th anniversary of the tPA trial and the 5th anniversary of the endovascular trials.


ISC 2020 Presidential Address

Hundreds of people gathered during the opening session to hear the annual Presidential Address, given this year by Robert A. Harrington, MD.

Speakers at the ASA/Japan Stroke Society Joint Symposium at ISC 2020 in Los Angeles, February 19, 2020.

ASA/Japan Stroke Society Joint Symposium Debate

Members of the Japan Stroke Society and the ASA chose a debate for their ISC 2020 symposium. The topic was, "Antiplatelets made in Japan: really effective for stroke?" and presenters argued both for and against the position.

Attendees at ISC 2020 concurrent sessions on Wednesday, Feb. 19.

Attendees at Wednesday's concurrent sessions

International Stroke Conference attendees had a number of sessions to choose from on Wednesday morning, in categories like acute neuroimaging, clinical rehabilitation and recovery, intracerebral hemorrhage, and much more.

ISC 2020 photo - Controversies in Stroke

Controversies in Stroke: A Three-Way Debate

This afternoon session that compared two different cases and several different viewpoints drew a large crowd, and even had some attendees standing outside the room to hear. The session was just one of several extremely popular learning opportunities.

ISC 2020 John R Marler

25th Anniversary of the tPA Trial Results
John R Marler | Rockville, MD

ISC 2020 Tudor G Jovin

5th Anniversary of the Endovascular Trials’ Results
Tudor G Jovin, Pittsburgh, PA

Also published in Stroke

Special Reports from Stroke's 50th Anniversary:

Late-breaking science from Thursday


EXTEND IA TNK Part 2 Results

Bruce Ovbiagele, MD, the immediate past chair for ISC, interviews Bruce Campbell, principal investigator of the EXTEND-IA TNK Part 2 trial, about the results and what they suggest for optimizing acute stroke care.


ESCAPE NA1 Trial

Karen Furie, MD, interviews co-principal investigators of the ESCAPE-NA1 trial, Michael D. Hill, MD, MSc and Mayank Goyal, MD, PhD.

ISC 2020 Bruce C. Campbell

Determining the Optimal Dose of Tenecteplase Before Endovascular Thrombectomy (EXTEND-IA TNK Part 2): A Multicenter, Randomized, Controlled Trial
Bruce C Campbell | Royal Melbourne Hospital, University of Melbourne, Parkville, Australia

ISC 2020 Michael D. Hill

ESCAPE-NA1 Trial
Michael D Hill, University of Calgary, Calgary, AB, Canada

ISC 2020 David Chiu

Multifocal Transcranial Rotating Permanent Magnet Stimulation in Chronic Ischemic Stroke
David Chiu | Houston Methodist Hospital, Houston, TX

ISC 2020 Michael J Alexander

The Woven Study: Wingspan One-year Vascular Imaging, Events, and Neurologic Outcomes
Michael J Alexander | Cedars-Sinai Medical Center, Los Angeles, CA

ISC 2020 Heinrich Audebert

Effects of Pre-hospital Acute Stroke Treatment as Measured with the Modified Rankin Scale; the Berlin - Pre-hospital Or Usual care Delivery (B_PROUD) trial
Heinrich J Audebert | Charité Univsmedizin Berlin, Berlin, Germany

ISC 2020 Fadi Nahab

Retinal Microvascular Changes Differentiate Mild Stroke and Transient Ischemic Attack (TIA) From Mimics Among Patients Presenting to the Emergency Department (ED) With Suspected TIA: The FOTO-TIA Study
Fadi Nahab | Emory University, Atlanta, GA

ISC 2020 Heinrich Audebert - 2nd presentation

Patient-centered Outcomes in the Intensified Secondary Prevention Intending a Reduction of Re-events in Patients With Tia and Minor Stroke (inspire-tms) Trial
Heinrich J Audebert | Charité Univsmedizin Berlin, Berlin, Germany

The Cost of Implementing and Sustaining the COMprehensive Post-Acute Stroke Services Model
William S Bayliss | Dept. of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC

ISC 2020 Pierre Amarenco

Benefit of Targeting a LDL Cholesterol Less than 70 mg/dL after an Ischemic Stroke of Atherosclerotic Origin. The 5-year Results of the French Part of the TST Trial
Pierre Amarenco, BICHAT HOSPITAL, Paris, France

ISC 2020 Steven Warach

Prospective Observational Cohort Study of Tenecteplase as Standard of Care Thrombolysis in a Multihospital Network. Initial Safety and Feasibility Results
Steven J Warach | University of Texas at Austin, Austin, TX

  • RESULTS: Initial 2-year safety and feasibility observational cohort results in 50 patients comparing tenecteplase to alteplase (ALT) for thrombolysis in AIS suggested consistency between the two, but more study is needed.
  • Warach's abstract
ISC 2020 Laura K Stein

Associations Between Endovascular Thrombectomy Volumes and Outcomes: A Nationwide Analysis
Laura K Stein | Icahn School of Medicine at Mount Sinai, New York, NY

ISC 2020 Ashkan Shoamanesh

Non-vitamin K Oral Anticoagulants in Intracerebral Hemorrhage Survivors With Atrial Fibrillation: Primary Results of the NASPAF-ICH Randomized Trial
Ashkan Shoamanesh | McMaster University, Hamilton, ON, Canada

ISC 2020 Reem Waziry

Trends in Survival Following First Hemorrhagic or Ischemic Stroke Over 25-years of Follow-up in the General Population. Findings From the Rotterdam Study
Reem Waziry | Harvard T.H. Chan School of Public Health, Boston, MA

ISC 2020 Maria Clara Zanon Zotin

Peak Width of Skeletonized Mean Diffusivity is Associated With Cognitive Impairment in Cerebral Amyloid Angiopathy
Maria Clara Zanon Zotin | Massachusetts General Hospital, Boston, MA

  • RESULTS: Peak width of skeletonized mean diffusivity (PSMD) was better associated with cognitive endpoints in cerebral amyloid angiopathy (CAA) than MR markers, suggesting a possible role as a surrogate marker. More confirmation needed.
  • Zotin's Abstract
  • Zotin's presentation slides (PDF)
ISC 2020 Adam de Havenon

Optimizing Outcome Prediction After Supratentorial Intracerebral Hemorrhage: A Secondary Analysis of ATACH 2, CLEAR III, and MISTIE III
Adam H de Havenon | University of Utah, Salt Lake Cty, UT

ISC 2020 Raul Nogueira

A Nationwide Prospective Registry of Standard Medical Treatment Plus Endovascular Treatment versus Standard Medical Treatment Alone for Ischemic Stroke Patient With Acute Basilar Artery Occlusion
Raul Nogueira | Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, GA

Selected late-breaking science from Friday


SKIP study

Ralph Sacco, MD, past president of the American Heart Association interviews Kentaro Suzuki, MD about the results of the SKIP study, and what they reveal about skipping tPA in AIS.


ISC 2020: what we learned

Miguel Perez-Pinzon, PhD, Louise McCullough, MD, PhD, and Tudor Jovin, MD review the big science stories of ISC 2020 in Los Angeles.

The Randomized Study of Endovascular Therapy With versus Without Intravenous Tissue Plasminogen Activator in Acute Stroke With ICA and M1 Occlusion (SKIP Study)
Kentaro Suzuki, Nippon Medical School, Tokyo, Japan

Comparative Effectiveness of Home BP Telemonitoring plus Nurse Case Management (HBPTM+NCM) versus HBPTM Alone on Systolic BP (SBP) Reduction among Minority Stroke Survivors
Gbenga Ogedegbe | NYU School of Medicine, New York, NY

The Spot Sign and Tranexamic Acid on Preventing ICH Growth - Australasia Trial (STOP-AUST): A Multicenter, Randomized, Double-blind, Placebo-controlled Trial
Nawaf Yassi | Dept. of Medicine and Neurology, Melbourne Brain Center @ Royal Melbourne Hospital, University of Melbourne, Parkville, Australia

Cilostazol versus Other Anti-platelet Drugs for the In-stent Restenosis After Carotid Artery Stenting: The Carotid Artery Stenting With Cilostazol Addition for Restenosis (CAS-CARE) Trial
Hiroshi Yamagami | National Hospital Organization Osaka National Hospital, Osaka, Japan

  • RESULTS: The addition of cilostazol to other anti-platelet drugs in CAS patients inhibited carotid in-stent restenosis (ISR) more than in the non-cilostazol group within two years of CAS.
  • Yamagami's Abstract

Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or PCI in Patients With Atrial Fibrillation and Prior Stroke: Insights From the AUGUSTUS Trial
M. Cecilia Bahit | INECO Neurociencias, Rosario, Argentina

  • RESULTS: Insights from the AUGUSTUS trial: with or without a history of stroke, TIA, or TE, apixaban safety and efficacy compared to vitamin K antagonists (VKA) was consistent with the major trial results.
  • Bahit's Abstract
  • Bahit's presentation slides (PDF)

World First Robotic Neurovascular Intervention Experience: Opening the Doors to Remote Procedures
Vitor Mendes Pereira | Toronto Western Hospital, Toronto, ON, Canada