PFO and Stroke

Published: May 11, 2009

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AHA/ASA/ACCF Percutaneous Device Closure of Patent Foramen Ovale for Secondary Stroke Prevention: A Call for Completion of Randomized Clinical Trials

  • Observational studies suggest a strong association between patent foramen ovale (PFO) and cryptogenic stroke (CS).
  • A causal relationship has not been convincingly established for most affected patients.
  • Randomized controlled trials offer the best means to help resolve the uncertainty regarding optimal care for patients with CS and PFO.