Led by Jonathan Rosand, M.D., M.Sc., a professor of neurology at Harvard and founder of the McCance Center for Brain Health at Massachusetts General Hospital, this team will undertake three projects designed to answer fundamental questions of brain health and health care disparities.
Their clinical project will study how social determinants of health and social networks influence blood pressure control, which is strongly associated with brain health after a hemorrhagic stroke. Those findings, combined with clinical, imaging and genetic data, will be used to design interventions to improve blood pressure control.
Within their population project, they will create a brain health risk assessment tool using the electronic health record, then perform a clinical trial among physicians to assess how improved resource use can optimize brain health after a bleeding stroke. They will also build and test polygenic risk scores and confirm their usefulness in diverse populations.
The team’s basic science project will investigate cortical superficial siderosis (CSS), a novel biomarker for recurrent bleeding in hemorrhagic strokes, to identify the biology linking CSS to clinical deterioration. Their goal is to generate targets for novel therapeutics that can ultimately be proven to preserve brain health after a hemorrhagic stroke.