The Bugher Foundation

Published: August 17, 2020

ASA/Bugher Foundation Centers of Excellence in Hemorrhagic Stroke Request for Applications

The Henrietta B. and Frederick H. Bugher Foundation and the American Heart Association/American Stroke Association (ASA) announce a Request for Applications (RFA) for the Centers of Excellence in Hemorrhagic Stroke Research.


Applications must be submitted using the AHA’s new online submission portal. Frederick McLean Bugher established the Henrietta B. and Frederick H. Bugher Foundation in 1961 to support research in cardiovascular and cerebrovascular disease in Washington, D.C. Bugher wanted to honor his parents, both of whom suffered heart ailments. Since then, the foundation has expanded its reach, leading to advances in heart and stroke research throughout the world. In 1984, the Bugher Foundation sought guidance from the American Heart Association on how to best leverage research funds, forging the beginning of a longstanding, collaborative relationship. The AHA suggested a program that would bring molecular biology training to clinically trained investigators, which led to the creation of the Centers for Molecular Biology in the Cardiovascular System in 1986. This cross-disciplinary research and training program developed 122 fellows and resulted in an additional $161 million in NIH funding. The Bugher Foundation-AHA collaborative partnership continues to spur innovation through multi-disciplinary approaches to cardiovascular and cerebrovascular research, investing more than $51 million and training more than 150 post-doctoral fellows to date.

ASA/Bugher Foundation Centers of Excellence in Hemorrhagic Stroke

CENTER Applicant

TRAINING CENTER Applicant

RESEARCH PROJECT PI Applicant

Third Party Personnel

American Stroke Association-Bugher Foundation Centers for Excellence in Stroke Collaborative Research for Regeneration, Resilience and Secondary Prevention – 2014

In 2011, the Bugher Foundation committed $9.24 million to create a new network of three centers for excellence in stroke collaborative research for a period of four years. This new initiative will support the collaboration of basic, clinical and population researchers from different specialties, whose collective efforts will lead to new approaches to prevent and treat stroke. Efforts will expand upon previous Bugher initiatives by inviting research on recovery after a stroke, including the areas of repair, regeneration, neuroplasticity and rehabilitation. These Centers activate on April 1, 2014. The centers are located at the following institutions:

  • University of California, Los Angeles
  • University of Colorado, Denver
  • University of Miami

American Stroke Association-Bugher Foundation Centers for Stroke Prevention Research - 2007

In 2006 the Bugher Foundation joined with the American Stroke Association, a division of the American Heart Association, to support a network of three Centers for Stroke Prevention Research for four years. The initiative produced a network of interacting institutions and scientists for collaborative, multidisciplinary research and training to improve the prevention of stroke. The goals of the initiative were:

  • Generating innovative ideas
  • Creating dramatic gains in the field
  • Networking to fill knowledge gaps and expertise in research

These awards were activated July 1, 2007 and funded through June 30, 2011, with a total commitment of $8.4 million.

AHA-Bugher Awards for the Investigation of Stroke - 1998 In 1998, the Bugher Foundation committed $7.5 million over the next eight years to support AHA-Bugher Foundation Awards for the Investigation of Stroke. In 1999, the Bugher Foundation increased its commitment to this AHA-Bugher initiative by offering the American Heart Association a challenge grant of $1 million to match two for one with new dollars in the community. The additional contribution from the Bugher Foundation and the community at large supported eight more stroke grants. The AHA-Bugher Foundation Awards for the Investigation of Stroke encourage development of better stroke preventive measures and better stroke interventions. The association activated a total of 35 awards in January 2000, January 2001 and July 2005. This commitment enabled the association to support another of its goals: to expand research funded through the National Center to promising new areas by launching targeted research programs, focusing on any aspect of brain vascular function related to stroke. Such investigations included but were not limited to:

  • Blood brain barrier function
  • Endothelial mechanisms in cerebral vessels
  • Interaction of stroke risk factors with cerebral blood vessels
  • Male/female differences in cerebral blood vessel function
  • Mechanisms of ischemic injury (involving cerebral blood vessels)
  • Molecular biology of cerebral vessels
  • Molecular genetics (of disorders of cerebral blood vessels)
  • Regulation of cerebral blood vessels

Centers for Molecular Biology in the Cardiovascular System - 1984

In 1984 the foundation sought the guidance of the American Heart Association in identifying a focus for its research support. The association suggested a program to bring molecular biology training to clinically-trained investigators. This was the beginning of a continuing relationship with the association.

As a result of a partnership between the Bugher Foundation and the American Heart Association, the Centers for Molecular Biology in the Cardiovascular System was established. The association administered six Centers for Molecular Biology in the Cardiovascular System from 1986-96, using a $9.4 million contribution from the Bugher Foundation. About 120 clinically-trained fellows learned molecular biology techniques through the efforts of these six centers. The centers were located at the following institutions:

  • Baylor College of Medicine, Houston
  • Brigham and Women's Hospital
  • Children's Hospital, Boston
  • Stanford University
  • University of California, San Diego
  • University of Texas Southwestern Medical Center at Dallas

View Bugher Foundation Current and Past Award Recipients

Contact Us

For program questions/inquiries, call (214) 360-6107 (option 1) or email apply@heart.org

In 1984 the foundation sought the guidance of the American Heart Association in identifying a focus for its research support. The association suggested a program to bring molecular biology training to clinically-trained investigators. This was the beginning of a continuing relationship with the association.

As a result of a partnership between the Bugher Foundation and the American Heart Association, the Centers for Molecular Biology in the Cardiovascular System was established. The association administered six Centers for Molecular Biology in the Cardiovascular System from 1986-96, using a $9.4 million contribution from the Bugher Foundation. About 120 clinically-trained fellows learned molecular biology techniques through the efforts of these six centers. The centers were located at the following institutions:

  • Baylor College of Medicine, Houston
  • Brigham and Women's Hospital
  • Children's Hospital, Boston
  • Stanford University
  • University of California, San Diego
  • University of Texas Southwestern Medical Center at Dallas

View the Bugher Foundation Current and Past Award Recipients