Programming - Vascular Discovery: from Genes to Medicine Scientific Sessions 2020

About this Meeting

Vascular Discovery: From Genes to Medicine is sponsored by the Council on Arteriosclerosis, Thrombosis and Vascular Biology and the Peripheral Vascular Disease Council, in cooperation with the Council on Genomic and Precision Medicine, and the Society for Vascular Surgery. The primary goal of this virtual event is to provide a forum for the exchange of information about new and emerging scientific research in lipids and lipoproteins, arteriosclerosis, thrombosis, vascular biology, genomics and peripheral vascular disease.

The format of the event, with many invited presentations as well as a dedicated focus on poster presentations, is intended to maximize a thought-provoking flow of information and discourse among scientists.

Target Audience

The conference will especially appeal to:

  • Basic scientists
  • Translational and clinical investigators
  • Clinicians interested in:
Target Audience
Vascular Health Vascular Medicine
Atherosclerosis Vascular Biology
Thrombosis Vascular surgery
Thromboembolism Peripheral artery disease
Molecular/cellular biology Functional genomics

Tools for Presenters

Reminder: All abstract presenters must register for the conference in order to present their research.

Vascular Discovery 2020 Final Program

See the Vascular Discovery 2020 Final Program (PDF) or click on a day below to see the schedule. Note: All presentations are in Central Daylight Time (UTC -5).

Tuesday, May 5

Time (Central Daylight Time)
Event
9:00am – 9:20am
Conference Opening Welcome
9:20am – 10:05am

Plenary Session I: From Discovery to Therapeutics – How Basic Science Can Help to Address Unmet Clinical Needs in Cardiovascular Medicine

  • Antisense Oligonucleotides for the Treatment of Cardio-Metabolic Diseases, Roseanne M. Crooke, PhD, Boston, Massachusetts
  • Altered Genes Triggering Acute Aortic Dissections Implicate Mechanotransduction as a Primary Driver of the Disease, Dianna M. Milewicz, MD, PhD, Houston, Texas
10:05am – 11:05am

Concurrent Moderated Poster Session I - Junior Investigator for Women Award Finalists

MP100 - Inhibition of MicroRNA-33 Reprograms the Transcriptional Landscape and Kinetic Processes of Immune Cells to Promote Atherosclerotic Plaque Regression
Milessa Silva Afonso | New York University, New York, NY

MP101 - Vascular Aging Alters Mitophagy to Lead to Galectin 3 Secretion
Muriel Blin | University of Michigan, Ann Arbor, MI

MP102 - Loss of Notch Signaling in Pericytes Induces Arteriovenous Malformations
Taliha Nadeem, | University of Illinois at Chicago, Chicago, IL

MP103 - A Naive CD8 T Cell Expressing CD95 Intensifies Cardiovascular Disease and Atherosclerosis
Lindsey Padgett | LJI, La Jolla, CA

MP104 - Wnt Signaling Enhances Macrophage Response to IL4/13 and Promotes Resolution of Atherosclerosis
Ada Weinstock | NYU School of Medicine, New York, NY

10:05am – 11:05am

Concurrent Moderated Poster Session 2

MP105 - Single-cell Analysis of Human Atherosclerosis Identifies Clusters of Macrophages Found in Plaque Progression in Mice
Dawn Fernandez | Icahn School of Medicine at Mount Sinai, New York, NY

MP107 - Pluripotency Factor OCT4 Regulates Atheroprotective Responses in Endothelial Cells
Olga A Cherepanova | Cleveland Clinic, Cleveland, OH

MP109 - SVEP1, a Novel Human Coronary Artery Disease Locus, Induces Vascular Smooth Muscle Cell Proliferation and Phenotypic Modulation Through Notch and Integrin Signaling
Jared Elenbaas | Washington Univ in St. Louis, Saint Louis, MO

MP111 - Loss of Lmo7 in Smooth Muscle Cell Promotes Atherosclerotic Plaque Stability
Yi Xie | Yale School of Medicine, New Haven, CT

10:05am – 11:05am

Concurrent Moderated Poster Session 3

MP112 - Single Cell RNA Sequencing Reveals Heterogeneous Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm
Albert J Pedroza, | Stanford Univ, Palo Alto, CA

MP113 - MicroRNA-181b Regulates Critical Limb Ischemia in Diabetic MiceOlga A Cherepanova | Cleveland Clinic, Cleveland, OH
Henry S Cheng | Brigham and Women's Hosp, Boston, MA

MP114 - Osteoprotegerin Deficiency in Mice Increases Calcification to Accelerate Vascular Dysfunction
Belinda Di Bartolo | The Kolling Inst, St Leonards, Australia

MP111 - Loss of Lmo7 in Smooth Muscle Cell Promotes Atherosclerotic Plaque Stability
Lindsey Padgett, LJI, La Jolla, CA

MP116 - A Novel Mouse Model Capable of Recapitulating Sexual Dimorphism in the Development of Ascending Aortic Aneurysms and Dissections (aads)
Xiaoyan Qi | Univ of Florida, Gainesville, FL

MP117 - Ischemic-trained Monocytes Improve Hindlimb Ischemia Outcomes
Roberta M Lassance-soares, Univ of Miami, Miami, FL

11:00am – 12:00pm

Online Interactive Early Career Training Session
Organized in cooperation with the ATVB Early Career Committee

Round Table Discussion and Networking:

  • Getting Your First Grant: Insights from Study Section
  • Building a Successful International Research Program
  • Making Moves: Transitioning Institutions, Setting up Your Lab, Hiring
  • (Early) Career Transition Goals
11:05am – 12:20pm

Concurrent Session I A: Molecular and Cellular Mechanisms of Atherosclerosis
Dissecting the Cellular and Molecular Immune Interactions In Human Atherosclerosis - Chiara Giannarelli, MD, PhD, New York, New York
Oral Abstract Presentations

Concurrent Session I B: Molecular, Development and Cellular Biology of the Vessel Wall
Clonal Vascular Smooth Muscle Cell Expansion in Disease - Helle F. Jørgensen, PhD, Cambridge, United Kingdom
Oral Abstract presentations

Concurrent Session I C: Translational Science of Vascular Medicine: Emerging Research in Thrombosis and Homeostasis
TBD - Andrea T. Obi, MD, Ann Arbor, Michigan
Oral Abstract Presentations

12:20pm – 1:05pm

The Mentor of Women Award Event
Awardee: Murray W. Huff, PhD, FAHA, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada

Featured Presentation: Women, Hope, and Leadership in the Time of a Pandemic
Jane E. Freedman, MD, Boston, Massachusetts

1:05pm – 1:55pm

Plenary Session II: Highlights from the ATVB Journal

ATVB Journal Report
Alan Daugherty, PhD, DSc, FAHA, University of Kentucky, Lexington, KY

Daniel Steinberg Early Career Investigator Award in Atherosclerosis/Lipoproteins
Critical Role of SREBP-1c Large-VLDL Pathway in Environment-induced Hypertriglyceridemia of apoA-V Deficiency
Hiroaki Okazaki, Tokyo, Japan

Werner Risau Early Career Investigator Award in Vascular Biology
Ponatinib Combined with Rapamycin Causes Regression of Murine Venous Malformation
Elisa Boscolo, PhD, Cincinnati, Ohio

Featured Presentation: Mechanisms of Venous Thrombosis in Cancer
Nigel Mackman, PhD, FAHA, Chapel Hill, North Carolina

2:05pm – 3:05pm

Concurrent Moderated Poster Session 4

MP 119 - BCL11B is a Newly Identified Regulator of Arterial Stiffness and Related Target Organ Damage
Francesca Seta, Boston Univ Sch of Med, Boston, MA

MP120 - Discovery of an Evolutionarily Conserved Smooth Muscle Cell-specific LncRNA CARMN
Kunzhe Dong, Augusta Univ, Augusta, GA

MP121 - A Central Role for Klf4-dependent Smooth Muscle-derived Adventitial Sca1+ Vascular Stem/Progenitor Cells in Myofibroblast Formation, Adventitial Fibrosis, and Pathogenic Artery Wall Stiffening
Sizhao Lu, Univ of Colorado Anschutz, Aurora, CO

MP122 - Diabetes-induced Dynamic Changes in RNA-chromatin Interactome Promotes Endothelial Dysfunction
Kiran Sriram, City of Hope, Duarte, CA

MP125 - Enhancing Base Excision Repair of Oxidative DNA Damage Delays Vascular Aging in Mice
Kirsty Foote, Univ of Cambridge, Cambridge, United Kingdom

2:05pm – 3:05pm

Concurrent Moderated Poster Session 5

MP127 - Platelet-specific Ablation of Mtor Regulates Platelet Aggregation and in vivo Thrombosis Through Rap1b-Mediated Integrin Alphaiibbeta3 Activation
Bhanu Kanth Manne, Univ of Utah, Salt Lake City, UT

MP128 - High Throughput Screening Assay for Identifying Small Molecules That Block gα12/αSnap Binding for Inhibition of Vwf Secretion
Misuk Bae, Univ of Illinois at Chicago, Chicago, IL

MP130 - Identification of a Specific Thrombomodulin Residue That Defines Its Conformational Selectivity for TAFI or Protein C
John Ackersviller, The Univ of Western Ontario, London, ON, Canada

3:05pm – 4:20pm

Concurrent Session II A: Lipoproteins and Lipid Metabolism: LDL and Beyond
Endothelial Cell Lipoprotein Transport and Atherosclerosis, Philip W. Shaul, MD, Dallas, Texas
Oral Abstract Presentations

Concurrent Session II B: Vascular Immunity, Inflammation and Thrombosis
Immune Cell Communication in Atherosclerosis, Esther Lutgens, MD, PhD, Amsterdam, Netherlands
Oral Abstract Presentations

Concurrent Session II C: Translational Science in Vascular Medicine: Bioengineered Stents and Conduits
Organized in cooperation with the Council on Peripheral Vascular Disease
Molecular Engineering of Angiogenenic Growth Factors, Jeffrey A. Hubbell, PhD, Chicago, Illinois
Oral Abstract Presentations

4:00pm – 5:00pm

Continued: Online Interactive Early Career Training Session
Organized in cooperation with the ATVB Early Career Committee

Round Table Discussion and Networking:

  • Getting Your First Grant: Insights from Study Section
  • Building a Successful International Research Program
  • Making Moves: Transitioning Institutions, Setting up Your Lab, Hiring
  • (Early) Career Transition Goals

Wednesday, May 6

Time (Central Daylight Time)
Event
9:00am – 9:45am

Plenary Session III: Multiomics in Cardiovascular Science

  • Multi-tissue Multi-omics Approaches to Cardiovascular Diseases, Xia Yang, PhD, Los Angeles, California
  • Combined Germline and Somatic Genetic Analysis for Atherosclerotic Cardiovascular Disease, Pradeep Natarajan, MD, MMSc, Boston, Massachusetts
10:05am – 11:05am

Concurrent Moderated Poster Session 6

MP132 - Regression of Advanced Atherosclerotic Lesions in Response to Long Term Chow Diet Feeding is Associated with Increased Il1b-dependent Endo-Mt
Santosh Karnewar, Univ of Virginia, Charlottesville, VA

MP133 - Vascular Modulation of Adipose Function: Role of Endothelial Argonaute 1
Zhen Chen, City of Hope, Duarte, CA

MP134 - T Cell Specific Ezh2 Deficiency Polarizes Cd4+ T Cells Towards an Anti-inflammatory Phenotype and Attentuates Atherosclerosis
Michael Lacy, LMU Univ Munich - DZHK, Munich, Germany

MP135 - Glucocorticoid Induced Tumour Necrosis Factor Receptor Family-related Protein Drives Atherosclerosis in Mice and is Associated with an Unstable Plaque Phenotype and Cerebrovascular Events in Humans
Laura A Bosmans, Amsterdam UMC, location AMC, Amsterdam, Netherland

MP136 - Implication of Proprotein Convertase Subtilisin/Kexin Type 9 in Human Aortic Valve Interstitial Cell Calcification
Vincenza Valerio, Ctr Cardiologico Monzino IRCCS, Milan, Italy

MP137 - Notch Signaling in Smooth Muscle Cells Promotes Cap Formation During Atherosclerosis
Carlos J Martos Rodriguez, Ctr Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

10:05am – 11:05am

Concurrent Moderated Poster Session 7

MP138 - Androgen Mediates the High Susceptibility of Male Mice to Aldosterone and High Salt-induced Abdominal Aortic Aneurysm
Zhenheng Guo, Univ of Kentucky, Lexington, KY

MP139 - Role of a Novel Cardiovascular Lipid-based Biomarker Score in Identifying Candidates for Beta Blocker Intervention
Anshul Saxena, Baptist Health South Florida, Coral Gables, FL

MP140 - Genome-wide Transcriptomics Reveals New Sex-specific Gene Expression and Pathways in Patients With an Acute Myocardial Infarction
Aaron Shulkin, Dept of Molecular, Cell and Developmental Biology, Univ of California Santa Cruz, Santa Cruz, CA

MP142 - Association Between Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study
Michael G Levin, Univ of Pennsylvania, Philadelphia, PA

11:05am – 12:20pm

Concurrent Session III A: Therapeutic Targets in Atherosclerosis
Design and Delivery of Microrna Switches to Treat Cardiovascular Diseases - Hana Totary-jain, Univ of South Florida, Tampa, FL
Oral Abstract Presentations

Concurrent Session III B: Blood Coagulation and Antithrombotic Therapy
Tissue-specific Hemostasis, Maureane Hoffman, MD, PhD, Durham, North Carolina
Oral Abstract Presentations

Concurrent Session III C: Translational Science in Vascular Medicine: Vascular Dysfunction
Organized in cooperation with the Council on Peripheral Vascular Disease
Stem Cells for Preventing Vascular Injury, Sanjay Misra, MD, Rochester, Minnesota
Rapid Fire Oral Abstract Presentations

12:20pm – 1:45pm
Plenary Session IV: Award Competition
  • Kenneth M. Brinkhous Early Career Investigator Prize in Thrombosis
  • Irvine H. Page Junior Faculty Research Award
1:45pm – 2:45pm

Concurrent Moderated Poster Session 8

MP147 - Neuropilin-1 Enhances Tgf-β1-induced Alk1/Eng-pSMAD1/5/8 Signaling in Vascular Smooth Muscle Cells: Implications for Vascular Malformations
Sreenivasulu Kilari, Mayo Clinic, Rochester, MN

MP148 - Quantitative Trait Loci Mapped for TCF21 Binding, Chromatin Accessibility and Chromosomal Looping in Coronary Artery Smooth Muscle Cells Reveal Molecular Mechanisms of Coronary Disease Loci
Quanyi Zhao, Stanford Univ, Stanford, CA

MP149 - Inhibitor of Differentiation 3 Promotes Angiogenesis in Response to Hind Limb Ischemia by Attenuating Skeletal Muscle B-1b Cell and IgM Accumulation
Victoria Osinski, Univ of Virginia, Charlottesville, VA

MP151 - Post-prandial Lipemia Acutely Changes Epigenetic Regulation of Inflammatory Genes Over 4 Hr
Huichun Xu, Univ of Maryland Sch of Med, Baltimore, MD

1:45pm – 2:45pm

Concurrent Moderated Poster Session 9

MP152 - Satellite Cell Expression of Rage is Important for Collateral Vessel Formation
Laura M Hansen, Emory Univ, Atlanta, GA

MP153 - Critical Role of the Cytosolic Dna Sensor Cgas in Aortic Degeneration, Dissection, and Rupture
Wei Luo, Baylor Coll of Med, Houston, TX

MP156 - A Novel Mouse Arteriovenous Fistula Model Recapitulates Central Venous Stenosis
Ryosuke Taniguchi, Dept of Surgery, Yale Univ Sch of Med, New Haven, CT

MP157 - Neuropilin-1 Expressing Monocytes/macrophages: Key Regulators of Revascularisation in the Ischaemic Limb
Jun Cho, Academic Dept of Vascular Surgery, Sch of Cardiovascular Med & Sciences, St Thomas' Hosp, King's Coll London, London, United Kingdom

MP158 - Inducible Depletion of Calpain-2 in Fibrogenic Mesenchymal Cells Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm Formation in Hypercholesterolemic Mice
Michihiro Okuyama, Univ of Kentucky, Lexington, KY

2:45pm – 4:00pm

Concurrent Session IV A: Metabolic Disorders and Atherosclerosis
High Dimensional Analysis of Monocyte Heterogeneity in Atherosclerosis, Catherine C. (Lynn) Hedrick, PhD, La Jolla, California
Oral Abstract Presentations

Concurrent Session IV B: Platelet Production, Signaling and Function
Platelets: The Crossroad of Immunity and Thrombosis, Milka Koupenova, PhD, Worcester, Massachusetts
Oral Abstract Presentations

Concurrent Session IV C: Translational Aspects of Aortic Aneurysm Disease
What Diabetes is Teaching us About Abdominal Aortic Aneurysm Disease, Ronald L. Dalman, MD, Stanford, California
Oral Abstract Presentations

4:00pm – 5:00pm

Online Early Career Session
Organized in cooperation with the ATVB Early Career Committee

Mental Health Awareness Seminar

  • Managing Burn-out – especially for early stages of your career
  • Imposter Syndrome
  • Perspectives on Failure – being flexible, anticipating failure, perspective shifting
  • Social Skills – reading others, ending conversations, reading body language
  • COVID-related mental health issues – how to deal with isolation, anxiety about the future, managing in a virtual world, how to deal with being alone during the lockdown
  • Dealing with Depression – underlying disorder, warning signs, combating depression

Thursday, May 7

TIME (Central Daylight Time)
EVENT
10:30am – 11:35am

Plenary Session V: Invited Lecture Series

  • Jeffrey M. Hoeg Arteriosclerosis, Thrombosis and Vascular Biology Award for Basic Science and Clinical Research Lecture
    Cardiovascular Calcification: From Extracellular Vesicles to Systems Biology, Elena Aikawa, MD, PhD, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

  • Keynote Lecture
    Exploring Resilience to Cardiovascular Insults, Louisa Iruela-Arispe, PhD, Chicago, Illinois

  • Distinguished Lecture
    Network Medicine, Systems Pharmacology, and Cardiovascular Drug Development, Joseph Loscalzo, MD, PhD, Boston, Massachusetts

Closing Remarks/Conference Adjourns