Science News from IKDS 2015

Kawasaki disease (mucocutaneous lymph node syndrome) is a children's illness characterized by fever, rash, swelling of the hands and feet, irritation and redness of the whites of the eyes, swollen lymph glands in the neck, and irritation and inflammation of the mouth, lips and throat.

The heart may be affected in as many as one of five children who develop Kawasaki disease. Damage sometimes occurs to the blood vessels that supply the heart muscle (the coronary arteries) and to the heart muscle itself.

Welcome to IKDS 2015

Program chairs Dr. Bryan McCrindle and Dr. Anne Rowley, along with AHA president Dr. Elliott Antman, welcome you to IKDS 2015 and provide an overview of the latest science and challenges for Kawasaki Disease.

KD Across The Years

Part 1

AHA President Dr. Elliott Antman and Dr. Jane Newburger interview Dr. Tomisaku Kawasaki about the symptoms that led to his identification of the new disease that now bears his name in Part One of this exclusive interview.

 Part 2

In the second part of our interview with Dr. Kawasaki, the pathophysiology of KD, the heart, and stroke are discussed.

Tuesday's Selected Science

Tuesday's Takeaways

IKDS program chairs Anne Rowley, MD, and Brian McCrindle, MD, discuss the science presented during Tuesday’s IKDS sessions and put the findings into perspective for clinicians and researchers.

Histopathological Analysis of Sudden Death Adults with Coronary Artery Aneurysms

Kei Takahashi | Toho University Ohashi Medical Center, Tokyo, Japan
Takahashi's Presentation Slides (PDF)

Analysis of the Mechanisms of Intravenous Immunoglobulinresistant Kawasaki Disease Using iPS Cell Technology

Kazuyuki Ikeda | Kyoto Prefectural University of Medicine, Kyoto, Japan
Ikeda's Presentation Slides (PDF)

Whole Genome Sequencing of a six-member African American family with two Kawasaki disease-affected siblings identifies novel susceptibility variants

Jihoon Kim | Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, CA
Jihoon Kim's Presentation Slides (PDF)

Microbiome Analysis in Kawasaki Disease

Kristine Wylie | The Genome Institute, Washington University School of Medicine, St. Louis, MO
Wylie's Presentation Slides (PDF)

Wednesday's Selected Science

Wednesday's Takeaways

IKDS program chairs Anne Rowley, MD, and Brian McCrindle, MD discuss the science presented during Wedesday’s International Kawasaki Disease Symposium, including pathology, diagnosis and biomarkers, the immunology and immunogenetics of KD, and medical treatment of KD.

Immunology of Kawasaki Disease

Michael Portman, MD, and Sadeep Shrestha, PhD, MS, along with Brian McCrindle, MD and Anne Rowley, MD, discuss possible environmental factors in the immunology, immunopathology, and immunogenetics of Kawasaki Disease.

Novel Biomarker for Early Diagnosis of Kawasaki Diseases

Tai-Ming Ko | Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Ko's Presentation Slides (PDF)

Assessment of Kawasaki Disease Risk Scores for Predicting Coronary Artery Aneurysms at a North American Center

Mary Beth F. Son | Boston Childrens Hospital, Boston, MA
Son's Presentation Slides (PDF)

Genetics of Kawasaki Disease

Jane Burns, MD, and Professor Yoshihiro Onouchi discuss the latest science connecting genetics and Kawasaki disease in the context of translational medicine.

Gut Microflora Influences Pathology in the Kawasaki Disease Vasculitis Mouse Model

Daiko Wakita | Cedars-Sinai Medical Center, Los Angeles, CA
Wakita's Presentation Slides (PDF) 

Tenascin-C can be a Novel Prognostic Biomarker for Kawasaki Disease

Kyoko Imanaka-Yoshida | Mie University Graduate School of Medicine, Tsu, Japan
Imanaka-Yoshida's Presentation Slides (PDF)

Favorable Outcome of Patients with Kawasaki Disease Treated with Unified Protocol with Cyclosporine A as the Third Line Therapy

Hiromichi Hamada | Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, Japan
Hamada's Presentation Slides (PDF)

Thursday's Selected Science

Thursday's Takeaways

Program Chairs Anne Rowley, MD, and Brian McCrindle, MD, discuss Thursday's science presented at IKDS 15, including new imaging modalities, medical management and revascularization, the role of families and parents, lifestyle and psychosocial issues, the importance of collaborations across institutions, and tools for evaluating prognosis and outcomes.

Occult Coronary Artery Dilatation: An Unrecognized Category of Coronary Involvement

Soha Rached-d’Astous | Centre hospitalier universitaire Sainte-Justine, Division of Pediatric Cardiology, Montreal, QC, Canada
Rached-d’Astous' Presentation Slides (PDF)

Characteristics and Fate of Systemic Artery Aneurysm caused by Kawasaki disease

Shinsuke Hoshino | Shiga University of Medical Science, Shiga, Japan
Hoshino's Presentation Slides (PDF)

The Spectrum of Cardiovascular Lesions Requiring Intervention in Young Adults after Kawasaki Disease

John B. Gordon | San Diego Cardiac Center, San Diego, CA
Gordon's Presentation Slides (PDF)

IKDS 2015: Conference Highlights and Next Steps

Anne Rowley, MD, and Brian McCrindle, MD along with Jane Newburger, MD and Jane Burns, MD discuss the science presented during the 2015 International Kawasaki Disease Symposium. Highlights of the meeting’s science as well as challenges and needs for the future are shared.

Kawasaki Disease Complicated by Coronary Artery Aneurysms: Mortality and 40-year Outcomes

Cedric Manlhiot | The Hospital for Sick Children, Toronto, ON, Canada
Manlhiot's Presentation Slides (PDF)

Exercise Response in Children and Adolescents Late After Kawasaki Disease According to Early Coronary Status

Nagib Dahdah | Centre hospitalier universitaire Sainte-Justine, Division of Pediatric Cardiology, Montreal, QC, Canada
DahDah's Presentation Slides (PDF)

Transition to Adult Care

Adrienne Kovacs | University Health Network, Toronto, ON
Kovacs' Presentation Slides (PDF)