Science News

International Stroke Conference 2018

Nursing Symposium & Pre-Con Symposia: Jan. 23, 2018
Sessions: Jan. 24–26, 2018
Los Angeles Convention Center | Los Angeles, Calif.

Welcome to Science News from #ISC18

This is the place to get exclusive quick-glance summaries of featured science presentations, deep-dive interviews with cardiovascular and stroke influencers, and links to important studies published during the International Stroke Conference 2018 in Los Angeles, California.


ISC 2018 Program Highlights

John Warner, MD, president of the American Heart | American Stroke Association interviews Bruce Ovbiagele, MD, MSc and Miguel Perez-Pinzon, PhD, the chair and vice chair of the ISC 2018 Program Committee.
State-of-the-Science Stroke Nursing Symposium

Predictors of Ischemic Stroke and Stroke Mimic During Pregnancy
Chelsea Meyer | University of Utah, Salt Lake City, UT


It Takes a Village: And Other Lessons Learned from a Large Volume Comprehensive Stroke Center
Sandi G. Shaw | Memorial Hermann Hospital, Houston, TX

Post TPA Neuro Vitals, a New Approach With the Help of an Old Friend
Jason Lee | Houston Methodist Hospital, Houston, TX

Driving Down Readmissions With Dynamic Discharge Follow up Team
Alicia Richardson | Penn State Health, Hershey, PA

Blood Pressure Medications at Hospital Discharge
Amanda Lantzy | MedStar Georgetown University Hospital, Washington, DC

A Rapid Care Evaluation Transient Ischemic Attack Clinic by Nurse Practitioners
Tina Michele Dvoren-Baker | Medical University of South Carolina, Charleston, SC

Implementing Community Stroke Outreach Using Peer Educators to Improve Readiness to Act Among Local Community Members
Nataliya Omelchenko | Northwest Community Hospital, Arlington Heights, IL


ISC 2018 Presidential Address

AHA|ASA President John Warner, MD, opens the International Stroke Conference 2018 in Los Angeles with a look at some of the most recent advances in stroke care and treatment, and insight into the future.

2018 AIS Guidelines
William J. Powers, MD, writing group chair, provides an overview of the 2018 Acute Ischemic Stroke Guidelines.

The 2018 AIS Guidelines: Potential Future Impact
Karen L. Furie, MD, MPH, chair, Stroke Council, interviews William J. Powers, MD, writing group chair for the 2018 Acute Ischemic Stroke Guidelines.

2018 Acute Ischemic Stroke (AIS) Guidelines

Changing Guidelines and Care for the Better

Articles below link to Stroke, a Journal of the American Heart Association

Visit our AIS Guidelines Science News Page for a look at clinical slides, Top 10 Things to Know, links to AHA News stories and the official AHA Newsroom release, plus related science and professional resources.

Greg Albers, MD, Director of the Stanford Stroke Center, provides an overview of the results of the DEFUSE 3 trial.

Bruce C. Campbell, MBBS (Hons), PhD, provides an overview of the results of the EXTEND-IA TNK trial.

Results of the DEFUSE 3 Study
Gregory W Albers | Stanford University Medical Center, Stanford, CA

Tenecteplase Versus Alteplase Before Endovascular Thrombectomy (EXTEND-IA TNK): A Multicenter, Randomized, Controlled Trial
Bruce C Campbell | Royal Melbourne Hospital, University of Melbourne, Parkville, Australia

Magnitude of Benefit of Endovascular Thrombectomy 6-24 Hours After Onset in Acute Ischemic Stroke Patients with Clinical-Core Mismatch
Jeffrey L Saver | Geffen School of Medicine at UCLA, Los Angeles, CA


Hyperexcitability and Seizures in Primary Intraventricular Hemorrhage
Christoph Stretz | Yale School of Medicine, New Haven, CT

Secular Increases in Spontaneous Subarachnoid Hemorrhage during Pregnancy
Kaustubh Limaye | University of Iowa, Iowa City, IA

The Efficacy and Safety of Cilostazol in Subarachnoid Hemorrhage. A Meta-analysis of Randomized and Non Randomized Studies
Muhammad F Ishfaq | Department of Neurology, University of Tennessee Health Sciences Center, Memphis, TN

Soluble ST2 Predicts Delayed Cerebral Ischemia and Outcome After Subarachnoid Hemorrhage
Zoe Wolcott | Massachusetts General Hospital, Boston, MA

Time to Detect Seizures Among Hemorrhagic and Ischemic Stroke Patients Undergoing Continuous EEG (cEEG) Monitoring
Ifrah Zawar | Cleveland Clinic Foundation, Cleveland, OH

Endothelium-Targeted Deletion of MicroRNA-15a/16-1 Cluster Promotes Post-Stroke Angiogenesis and Improves Long-Term Neurological Functions
Ping Sun | University of Pittsburgh, Pittsburgh, PA

  • RESULTS: Endothelial miR-a5a/16-1 may offer a target to improve angiogenesis and long-term neurological functions after AIS.
  • Abstract for Sun



DAWN Results
Raul Nogueira, MD, analyzes implications from the DAWN trial, where clinical core mismatch patients benefited from thrombectomy up to 24 hours, but chances for good outcomes declined over time.

COMPASS - Rivaroxaban + aspirin for preventing stroke
Mukul A. Sharma, MD, MSc summarizes the results of the COMPASS trial, which showed rivaroxaban with aspirin halved the incidence of secondary stroke in patients with stable atherosclerotic disease.

COMPASS - Direct Aspiration vs. Stent Retrieval

J Mocco, MD, summarizes results of the COMPASS trial, which showed direct aspiration was non inferior to stent retrieval as a first approach to acute ischemic stroke treatment.

Time to Endovascular Treatment and Outcomes in the DAWN Trial
Raul G Nogueira | Emory University School of Medicine, Atlanta, GA

First Stroke Reduced 44 Percent by Well Tolerated Medications. Stroke Outcomes From the Heart Outcomes Prevention Evaluation 3 Study
Jackie Bosch | McMaster University, Hamilton, ON, Canada

A Comparison of Direct Aspiration vs. Stent Retriever as a First Approach ("COMPASS"): A Randomized Trial
J Mocco | Mount Sinai Hospital, New York, NY

ARISE II Trial Result
Osama Zaidat | Mercy Health St. Vincent Hospital, Toledo, OH

  • RESULTS: Novel stent-retriever (EmboTrap®) showed superiority to current FDA devices for recanalization and reperfusion rates in AIS patients. High rates of clinical outcomes at 3 months: Two-thirds of patients had functional independence
  • Abstract for Zaidat
  • Presentation Slides (PDF) for Zaidat

Subgroup Analyses of the DEFUSE 3 Study
Maarten G Lansberg, Stanford University, Stanford, CA

The Effect of Rivaroxaban with Aspirin on Stroke Outcomes in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial
Mukul Sharma | Population Health Research Institute, McMaster University, Hamilton, ON, Canada

Ticagrelor with Aspirin on Platelet Reactivity in Minor Stroke or Transient Ischemic Attack (PRINCE Trial)-Final Analysis
Yilong Wang | Beijing Tiantan Hospital, Beijing, China

Exome Sequence Study on Extreme MRI Markers of Cerebral Small Vessel Disease
Aniket Mishra | University of Bordeaux, Bordeaux, France

Alteplase for the Treatment of Acute Ischemic Stroke in Patients with Low NIHSS and Not Clearly-Disabling Deficits: Primary Results of the PRISMS Trial
Pooja Khatri | University of Cincinnati, Cincinnati, OH

Two-year Safety and Clinical Outcomes in Chronic Ischemic Stroke Patients After Implantation of Modified Bone Marrow-derived Mesenchymal Stem Cells (sb623): A Phase 1/2a Study
Gary K Steinberg | Stanford University, Stanford, CA

Short Chain Fatty Acids Mediate the Beneficial Effects of Young Microbiome on Recovery in Aged Mice after Ischemic Stroke
Juneyoung Lee | McGovern Medical School, UTHealth at Houston, Houston, TX

  • RESULTS: Young microbiome metabolites aided post-stroke recovery in aged mice. More studies needed to understand the mechanisms.
  • Abstract for J. Lee


ISC 2018: What We Learned

Bruce Ovbiagele, MD, MSc, chair, 2018 ISC program committee, Peter Panagos, MD, vice chair, Stroke Council, and Miguel Perez-Pinzon, MD, vice chair, 2018 ISC program committee review the highlights of the meeting.

Neurovascular Disease is the Second Leading Cause of Death in the United States (US): A Modern Disease Burden Analysis
Frances Fan | UCLA Medical Center, Los Angeles, CA

Duration of Heightened Stroke Risk after Acute Myocardial Infarction
Alexander E. Merkler | Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY

Preeclampsia and Early Stroke Incidence in the California Teachers Study
Eliza C. Miller | Columbia University, New York, NY

Sex Differences in the Effect of Hypertension on Stroke Risk in the REasons for Geographic and Racial Differences in Stroke Study
Tracy E. Madsen | Alpert Medical School of Brown University, Providence, RI

Exosomal Micrornas From Ischemic Cerebral Endothelial Cells and Neural Stem Cells Regulate Coupling of Neurogenesis and Angiogenesis
Xianshuang Liu | Henry Ford Hospital, Detroit, MI

Pharyngeal Electrical Stimulation for Early Decannulation in Tracheotomised Stroke Patients with Dysphagia (PHAST-TRAC): A Randomised, Single-blind, Pivotal, Superiority Trial
Philip M Bath | University of Nottingham, Nottingham, United Kingdom

DEFUSE 3 Angiographic Results Correlated with Clinical and Imaging Outcomes
Michael P Marks, Stanford Hospital, Stanford, CA


Final Results of the RHAPSODY Trial
Patrick Lyden | Cedars-Sinai Medical Center, Los Angeles, CA

  • RESULTS: A continuous reassessment method was successfully used in the dose-finding step for the neuroprotectant, 3K3A-APC, for AIS patients treated with IV rt-PA, thrombectomy or both. A phase 2 trial will follow for confirmation.
  • Data Summary (PDF) for Lyden
  • Abstract for Lyden