Science News from ATVB|PVD 2017

Arteriosclerosis, Thrombosis and Vascular Biology | Peripheral Vascular Disease

May 4 – 6, 2017
Hyatt Regency Minneapolis | Minneapolis, Minn.

Selected Science from Thursday, May 4

Welcome to ATVB|PVD 2017

Steven R. Houser, PhD, president of the American Heart | American Stroke Association, welcomes attendees to ATVB 2017 in Minneapolis.

Genome Editing 2017: Scientific, Clinical, and Ethical Implications

Kiran Musunuru, MD, PhD, MPH, William Lagor, PhD, and Joe Miano, PhD discuss the scientific and ethical implications of recent developments in genome editing using CRISPR-CAS9 technology and its potential role in advancing the mission of the American Heart Association.

Translational Science of Vascular Medicine

Katey Rayner, PhD, Farouc Jaffer, MD, PhD, and Emily Button discuss recent efforts to translate new device and biological interface techniques into approaches that improve clinical practice.

ATVB Journal of the American Heart Association 2017

Alan Daugherty, PhD, DSci, with a message about ATVB: Journal of the American Heart Association.

Deletion of Macrophage Low-density Lipoprotein Receptor-related Protein 1 (LRP1) Accelerates Atherosclerosis Regression by Increasing CCR7-dependent Egress of Plaque Macrophages
Paul Mueller | Oregon Health and Science University, Portland, OR

  • RESULTS: Mechanism described for acceleration of atherosclerosis regression when macrophages are deficient in Low-density Lipoprotein Receptor-related Protein 1 (LRP1).
  • Abstract

Inhibition of Nudt6 Stabilizes Advanced Atherosclerotic Plaques
Hong Jin | Karolinska Institute, Stockholm, Sweden

  • RESULTS: Atherosclerotic plaque rupture rates reduced with Nudt6 inhibition.
  • Abstract

A Novel in vivo Endothelial Hierarchy from Progenitor to Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process
Jatin Patel | The University of Queensland, Brisbane, Australia

  • RESULTS: Novel endovascular progenitor process for forming new vessels in multiple tissues described.
  • Abstract

Systemic Administration of Target-Seeking, Vessel Penetrating Recombinant Decorin Fusion Protein, Car-DCN, Reduces Severity of Abdominal Aortic Aneurysm in Mice
Yue (Steve) Shen | University of British Columbia, Vancouver, BC, Canada

  • RESULTS: Abdominal aorta wall reinforced with SAR-DCN use in early pre-clinical study of abdominal aortic aneurysm.
  • Abstract

Genetic Neutrophil Deficiency Ameliorates Cerebral Ischemia-Reperfusion Injury
Ryan A Frieler | University of Michigan, Ann Arbor, MI

  • RESULTS: Neutrophils play a role in the development of the infarction during stroke.
  • Abstract

The Effects of Resveratrol Treatment on Vascular Function in Type 2 Diabetes Mellitus
Ji-Yao Zhang | Boston University School of Medicine, Whitaker Cardiovascular Institute, Boston, MA

Crosstalk Between Phosphotidylinositol-4,5 Bisphosphonate-3 Kinase Pathway and Mitogen-Activated Protein Kinase Pathway Regulates Platelet Activation and Protein Synthesis via Phosphoinositide-Dependent Kinase-1
Bhanu Kanth Manne, University of Utah, Salt Lake City, UT

  • RESULTS: Crosstalk and signaling pathways responsible for platelet activation and thrombus formation studied.
  • Abstract

Selected Science from Friday, May 5

TMAO and Thrombosis Risk

Philip Tsao, PhD, ATVB 2017 conference chair, interviews Weifei Zhu, PhD about her recent research on the role of TMAO in platelet hyperactivity and thrombosis.

Chinese American Academy of Cardiology Symposium

Alan Daugherty, Editor-in-Chief of ATVB, interviews several members of the Chinese American Academy of Cardiology Symposium about the importance of international collaboration.

Daniel Steinberg Early Career Investigator Award in Atherosclerosis/Lipoproteins

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice
Marit Westerterp | Groningen, Netherlands

Karl Link Early Career Investigator Award in Thrombosis

Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors as Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis
Thomas Gremmel | Vienna, Austria

Werner Risau Early Career Investigator Award in Vascular Biology

An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression
Sarah De Val | Oxford, United Kingdom

Young Investigator Award Finalists

Centrosome Destabilization Through the Ubiquitin-Proteasome Pathway Regulates Proplatelet Production
Kellie R Machlus | Harvard Medical School, Boston, MA

  • RESULTS: Centrosome destabilization may trigger proplatelet formation; the Ubiquitin-Proteasome Pathway appears to be crucial.
  • Abstract

Neutrophil-Derived S100a8 and S100a9 Promotes Reticulated Thrombocytosis and Atherogenesis in Diabetes
Prabhakara R Nagareddy | University of Alabama at Birmingham, Birmingham, AL

  • RESULTS: Mechanisms of platelet production in hyperglycemia involve regulation by neutrophil-derived S100A8/A9.
  • Abstract

Myeloid Klf2 Regulates Arterial and Venous Thrombosis
Lalitha Nayak | Case Western Reserve University, Cleveland, OH

  • RESULTS: Mechanisms for neutrophil KLF2 regulation of thrombosis described.
  • Abstract

Platelet Fragmentation During the Hemostatic Response and its Prevention by a P2Y12 Antagonist
Maurizio Tomaiuolo | University of Pennsylvania, Philadelphia, PA

Transcriptional Networks Specifying Homeostatic and Pro-Inflammatory Programs of Gene Expression in Human Aortic Endothelial Cells
Casey E Romanoski | University of Arizona, Tucson, AZ

Control of Macrophage Cholesterol Efflux and Atherogenesis by the Noncoding RNA MeXis
Tamer Sallam | David Geffen School of Medicine at UCLA, Los Angeles, CA

  • RESULTS: MeXis identified as 'transcriptional gatekeeper' in regulating macrophage responses to elevated cholesterol.
  • Abstract

Cholesterol Efflux Pathways Suppress Inflammasome Activation in Mice and Humans
Marit Westerterp | University of Groningen, Groningen, Netherlands

Failure of Protective Autoimmunity in Mouse and Human Atherosclerosis
Dennis Wolf | La Jolla Institute for Allergy and Immunology, La Jolla, CA

  • RESULTS: Transformation of atherosclerosis-protective immune cells into pathogenic cells may suggest therapeutic targets.
  • Abstract

FXR1 Regulates Inflammatory MRNA Stability and VSMC Proliferation by Modulation of HuR Activity
Allison Herman | Lewis Katz School of Medicine, Philadelphia, PA

  • RESULTS: IL-19 decreases vascular inflammation by inducing FXR1, and by reducing HuR activity.
  • Abstract

Disruption of PCSK9 Using a Targeted Base Editing Strategy
Alexandra C. Chadwick | University of Pennsylvania, Philadelphia, PA

  • RESULTS: Base-editing results for PCSK9 disruption. New genome-editing science may prove to be a strategy for lipid management.
  • Abstract

High Density Lipoprotein Mediated Protection of Macrophages Against Apoptosis Requires Scavenger Receptor Class B Type 1 Activity and Sphingosine-1-Phosphate
Kevin Chathely | McMaster University, Hamilton, ON, Canada

  • RESULTS: Possible mechanisms of HDL protection against macrophage apoptosis may reveal treatment targets to slow atherosclerosis progression.
  • Abstract

Effects of Muscle Stretching on Flow-Mediated Dilation of Popliteal Artery in Patients With Peripheral Artery Disease
Kazuki Hotta | Florida State University College of Medicine, Tallahassee, FL

Selected Science from Saturday, May 6

Circulating Non coding RNAs and Atherothrombotic Disease

Muredach Reilly, PhD, interviews Jane Freedman, the ATVB 2017 Keynote Lecturer, about her research into the role of circulating, non-coding RNAs in atherothrombotic disease.

ATVB Committee on Diversity

Steve Lentz, MD, PhD, Mahdi Garelnabi, PhD, MSC, Alison Kohan, Phd, and Pamela Miller, PhD, RN discuss some of the goals of the new ATVB Diversity Committee, which will serve as a pilot program for the American Heart Association.

Klaus Ley, Distinguished Lecturer ATVB|PVD 2017

Klaus Ley, MD, ATVB/PVD 2017 Distinguished Lecturer, talks about his research into the potential for exploiting protective autoimmunity to develop a vaccine against atherosclerosis and the importance of the American Heart Association to scientific research efforts.

ATVB|PVD 2017: What We Learned

Philip Tsao, PhD, chair of ATVB/PVD 2017 and Nancy Webb, PhD, vice chair, review some of the top science that was presented during ATVB /PVD 2017 in Minneapolis.

Global and Liver Specific Bmal1 Deficient Mice Regulate Intestinal Lipid Absorption
Xiaoyue Pan | Winthrop University Hospital, Mineola, NY

  • RESULTS: Global and liver-specific Bmal1 appears to regulate intestinal lipid absorption.
  • Abstract

Cinnamon Extract Inhibit Lipids and Inflammation by Modulation of Transcription Factors: in vivo Model
Vijaya Juturu | OmniActive Health Technologies Inc, Morristown, NJ

  • RESULTS: Animal study suggests polyphenols in cinnamon extract may reduce CVD risk factors including inflammation, hyperlipidemia, and oxidative stress.
  • Abstract