Science News
Council on Hypertension Scientific Sessions 2016
September 14 – 17, 2016
The Dolphin Hotel | Orlando, FL
Hypertension 2016 Resources
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Wednesday, September 14
Steve Houser, PhD, president of the American Heart | American Stroke Association welcomes attendees to Hypertension 2016 in Orlando.
Keynote Lecturer William Cushman, MD and Dan Jones, MD, discuss the results of the SPRINT trial and its implications for improving outcomes for patients with high blood pressure.
The SPRINT Trial: Does Intensive Management of High Blood Pressure Further Reduce Rates of Cardiovascular Disease and Lower Risk of Death?
William Cushman, MD | University of Tennessee College of Medicine, Memphis TN
Keynote Lecture
Assisted Reproductive Technologies Increase the Vasoconstrictor Responsiveness to Angiotensin II by an Epigenetic Mechanism
Theo A. Meister | University Hospital of Bern, Bern, Switzerland
Exercise Training Normalizes Vascular Changes in Aging Hypertension Involving microRNAs Profile and Target Genes
Tiago Fernandes | University of São Paulo, São Paulo, Brazil
Eating more fruits and vegetables cut kidney patients’ medicine expense in half(link opens in new window) (opens in new window)
People with kidney disease cut their medicine expenses in half and reduced their blood pressure by eating more fruits and vegetables compared to patients who followed a baking soda regimen or had typical care.
Thursday, September 15
2016 Arthur C Corcoran Award Lecturer Karen Griffin talks about her 20 years of research into chronic kidney disease, incorporating the results of the SPRINT trial into clinical practice and research, and her role as incoming chair for the American Heart Association Council on Hypertension.
Greg Fink, PhD, interviews Elaine Urbina, MD and Jennifer Pollock, MD about the science they presented for a recent advances session for Hypertension 2016 in Orlando.
Anna Dominiczak, MD and Paul Cohen, MD, PhD discuss the Obesity and Diabetes science that was presented for Hypertension 2016 in Orlando.
Acanthi Karumanchi, MD interviews Jens Jordan, MD and Bina Joe, PhD about the hot topic science they presented at Hypertension 2016 in Orlando.
Garry Jennings, MD interviews Nancy Brown, MD and Shehzad Basaria, MD about their research into the relationship between hormones and cardiovascular disease, which they presented at Hypertension 2016 in Orlando.
Optogenetic Activation of OVLT Neurons Stimulates Water Intake and Produces a Sympathetically-Mediated Increase in Arterial Blood Pressure
Sean D. Stocker | Penn State University College of Medicine, Hershey, PA
- Stocker's Abstract (PDF)
Expression of a Hypertension-causing Mutation in Cullin 3 (CUL3Δ9) Specifically in Smooth Muscle Causes Vascular Dysfunction and Hypertension
Larry N. Agbor | University of Iowa Carver College of Medicine, Iowa City, IA
- Agbor's Abstract (PDF)
mir-192-5p in the Kidney is Protective Against the Development of Hypertension
Maria Angeles Baker | Medical College of Wisconsin, Wauwatosa, WI
- Baker's Abstract (PDF)
Link discovered between preterm birth and risk of heart disease(link opens in new window) (opens in new window)
Study Highlight: Being born extremely early affects blood vessel cell development, and may explain why adults born pre-term are at increased risk of high blood pressure.
Preterm birth leads to smaller kidneys, higher blood pressure in adulthood(link opens in new window) (opens in new window)
Study Highlights: Being born extremely early leads to smaller kidneys and higher blood pressure in adulthood. People who were born preterm should receive regular medical follow-up aimed at preventing and treating heart disease risk factors.
Lowering blood pressure’s top number could prevent 100,000-plus deaths a year(link opens in new window) (opens in new window)
Study Highlights: Aggressively lowering systolic blood pressure to 120 mm Hg or less could prevent more than 100,000 deaths yearly. Current medical practice is generally aimed at lowering systolic blood pressures to 140 mm Hg or less among high-risk adults.
Sound therapy may balance brain signals to reduce blood pressure, migraines(link opens in new window) (opens in new window)
Study Highlights: A noninvasive neurotechnology that identifies and translates unbalanced brain electrical activity into audible tones was associated with lower blood pressure and improved heart rate variability The same technology reduced self-reported disability from migraines and associated sleep and mood disorders.
All news releases(link opens in new window) (opens in new window)
Hypertension Early Career Award Finalists
mTORC1 is Required for Leptin-induced Sympathetic Activation to the Kidney but Not Brown Adipose Tissue
Balyssa B. Bell | University of Iowa, Iowa City, IA
- Bell's Presentation Slides (PDF)
Selective Maternal Hepatic Silencing of Angiotensinogen in Reduced Uterine Placental Perfusion Pressure Rats Improves Blood Pressure and Fetal Weights
Mark W. Cunningham Jr., University of Mississippi Medical Center, Jackson, MS
Dendritic Cells Mediate Renal T Cell Activation in Hypertension
Nathan P. Rudemiller | Duke University, Durham, NC
- Rudemiller's Presentation Slides (PDF)
Deletion of Serum and Glucocorticoid-regulated Kinase 1 (SGK1) in T Cells Attenuates Hypertension and Renal/Vascular Dysfunction
Allison E. Norlander | Vanderbilt University, Nashville, TN
- Norlander's Presentation Slides (PDF)
WINNER
Endothelial Colony Forming Cells Dysfunction Relates to Cardiovascular Alterations in Preterm Born Adults
Mariane Bertagnolli | Sainte-Justine University Hospital Research Center, University of Montreal, Montréal, QC, Canada
- Bertagnolli's Presentation Slides (PDF)
The Role of Tumor Necrosis Factor α and Natural Killer Cells in Uterine Artery Function During Pregnancy in the Stroke Prone Spontaneously Hypertensive Rat
Heather Y. Small | University of Glasgow, Glasgow, UK
Friday, September 16
Rhian Touyz, MD, PhD interviews Ariel Gomez, MD, corecipient of the 2016 Excellence in Hypertension Award about his research into the fate of renin cells during development and disease.
Rhian Touyz, MD, PhD interviews Suzanne Oparil, MD, corecipient of the 2016 Excellence in Hypertension Award about her lecture on the role of estrogen in the cardiovascular health of women.
Joey Granger, PhD, program committee chair for Hypertension, interviews David Robertson, MD, the 2016 Irvine Page | Alva Bradley Lifetime Achievement Award Winner for hypertension research.
Rhian Touyz, MBBCh, MSC (Med), PhD interviews 2016 David Seldin Award Lecturer Jeffrey Garvin, PhD about the role of fructose in salt-sensitive hypertension.
Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease
Karen Griffin, MD, FAHA | Hines VA Hospital, Hines, IL
Arthur C. Corcoran Memorial Lecture
- Griffin's Presentation Slides (PDF)
RhoBTB1 is a Novel Gene Protecting Against Hypertension
Masashi Mukohda | University of Iowa Carver College of Medicine, Iowa City, IA
- Mukhoda's Abstract (PDF)
Dopamine D2 Receptor is Associated with Inverse Salt Sensitivity
Peng Xu | University of Virginia, Charlottesville, VA
- Xu's Abstract (PDF)
Saturday, September 17
Joey Granger, PhD, program committee chair for Hypertension 2016, interviews Tainting Yang, MD, PhD, the Lewis K. Dahl Memorial Award Lecturer about his research on the physiological function of the renal (Pro)Renin Receptor.
New Insights Into the Physiological Function of Renal (Pro)Renin Receptor
Tianxin Yang, MD, PhD, FAHA | University of Utah, Salt Lake City, UT
- Yang's Presentation Slides (PDF)
Mir-431 as a Potential Master Regulator in Angiotensin Ii-induced Vascular Injury
Kugeng Huo | Lady Davis Institute of the Jewish General Hospital, Montreal, QC, Canada
Relative Contributions of Arterial Stiffness and Hypertension to CVD Risk: The Framingham Heart Study
Teemu J. Niiranen | The Framingham Heart Study, Framingham, Massachusetts
Alms1 (Alstrom Syndrome 1), a Novel Gene Involved in Blood Pressure Regulation, Renal Na Handling and Thick Ascending Limb (TAL) Function
Ankita Bachhawat Jaykumar | Wayne State University/Henry Ford Hospital, Detroit, MI
The Effect of a Practice-based Multi-component Intervention That Includes Health Coaching on Medication Adherence and Blood Pressure Control in Rural Primary Care
Doyle M. Cummings | East Carolina University, Greenville, NC
The Novel Quick, Accurate and Sensitive Measurement of Plasma Aldosterone and Active Renin Concentrations Will Be Beneficial for Diagnosing Primary Aldosteronism and for Drug Selection
Fumitoshi Satoh | Division of Clinical Hypertension, Endocrinology & Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan
Modulation of Salt and Mineralocorticoid Sensitivity of Blood Pressure by the Circadian Clock Protein Per1
Kristen Solocinski | University of Florida, Gainesville, FL
Obesity Accelerates the Deterioration of Renal Function in Developmental Programming of Hypertension. Role of Angiotensin Ii and Oxidative Stress
F. Javier Salazar Sr. | University of Murcia, Murcia, Spain
- Salazar's Abstract (PDF)
Influence of Race and Obesity on the Renin-Angiotensin-Aldosterone System in Adolescents Born Preterm
Andrew M. South | Wake Forest School of Medicine, Winston-Salem, NC
- South's Abstract (PDF)
A Fructose-enriched Diet Stimulates Superoxide Production in Juxtaglomerular Cells and Prevents High-salt Induced Inhibition of Plasma Renin Activity (PRA)
Mariela Mendez | Henry Ford Hospital, Detroit, MI