Heart Failure

AHA's Investment 2014-2019

$15 MILLION IN RESEARCH | $3.7 MILLION TO EACH CENTER

Northwestern Infographic Circle

Mount Sinai Infographic Circle

30+ Researchers Collaboration Training Basic Population Clinical

UT Southwestern Infographic Circle

Vanderbilt Infographic Circle

By The Numbers

  • 170 publications to date with 4 additional publications currently submitted or in press
  • 2 NIH R01s, 1 NIH R21 and 1 NSF research grant directly resulting from SFRN projects to date
  • 3 Prevention PIs have gone on to receive subsequent Network awards in atrial fibrillation and children’s health
  • $50 million in total NIH funding received by Prevention PIs since the start of the Network

Notable Publications

Northwestern Logo

Associations of Dietary Cholesterol or Egg Consumption with Incident CVD and Mortality, JAMA Network, March 2019

  • Higher consumption of dietary cholesterol or eggs was significantly associated with a higher risk of CVD and all-cause mortality
  • Norrina Allen PhD, Project PI, and Victor Zhong PhD, SFRN Fellow

Mount Sinai Heart

Child Health Promotion in Underserved Communities – The FAMILIA Trial, Journal of the American College of Cardiology, April 2019

  • School-based health education is effective in conveying healthy behaviors in preschoolers from an urban, underserved, multiethnic community
  • Valentin Fuster MD PhD, Center Director/Project PI, Andrew Kasarskis PhD, Project PI, Zahi Fayad PhD, Project PI, and Rodrigo Fernandez-Jimenez MD, SFRN Fellow.

 

UT Southwestern Medical Center

Nitrosative stress drives heart failure with preserved ejection fraction, Nature, April 2019

  • Describes causes of HFpEF disease pathology by creating a pivotal new mouse model (patent pending). Understanding the mechanism of heart failure may help to prevent it and subsequent adverse events.
  • Joseph Hill MD PhD, Center Director/Project PI, and Gabriele Schiattarella MD, SFRN Fellow

 

Vanderbilt University Medical Center

Polypill for Cardiovascular Disease Prevention in an Underserved Population, New England Journal of Medicine, September 2019

 

  • Significantly larger reductions in blood pressure and LDL cholesterol compared to usual care in a socioeconomically vulnerable minority population
  • Thomas Wang MD, Project PI

 

Notable Collaborations

  • Collaboration across Northwestern and UTSW investigating the relationship between physical activity, body mass index (BMI), and risk of heart failure resulted in several publications across Prevention Centers

  • Thomas Wang, MD, FAHA (Vanderbilt PI), Norrina Allen, PhD (Northwestern PI), and Deepak Gupta (Vanderbilt collaborator) awarded NIH R01 to study tissue sodium content in the MESA study participants
  • Northwestern Prevention PIs collaborating with the Hypertension SFRN center at the University of Iowa to study the impact of maternal physical activity on atherosclerosis in offspring

  • Mount Sinai Prevention PIs have gone on to collaborate with the Go Red For Women SFRN to enhance fellowship training