Science News

Macula Densa SGLT1-NOS1-TGF Pathway -- A New Mechanism for Glomerular Hyperfiltration in Diabetes
Jie Zhang | The University of South Florida, Tampa, FL

• RESULTS: The Macula Densa SGLT1-NOS1-TGF Pathway is identified as a new mechanism for glomerular hyperfiltration in diabetes: increase in tubular glucose concentration increases macula densa activity, increasing glomerular filtration rate (GFR).
• Zhang's Abstract (opens in new window)(link opens in new window)

Interleukin-21 Plays a Critical Role in Hypertension and Vascular Dysfunction
Bethany L Dale | Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, TN

• RESULTS: Interleukin-21 may be the 'master' cytokine in the pathology of hypertension and end-organ damage.
• Dale's Abstract (opens in new window)(link opens in new window)

Proteasome Inhibition Prevents Renal Inflammation and Hypertension by Abrogation of Dendritic Cell Autoantigen Presentation
David M Patrick | Vanderbilt University Medical Ctr, Nashville, TN

• RESULTS: Proteasome inhibition is identified as a mechanism for prevention of renal inflammation and hypertension.
• Patricks's Abstract (opens in new window)(link opens in new window)

Global ACE2 Over-Expression is Protective Against a Dysfunctional Brain-Gut-Lung Axis in Hypoxia-Induced Pulmonary Hypertension
Ravindra K Sharma | University of Florida, Gainesville, FL

• RESULTS: Activation of the paraventricular nucleus, gut pathology and an altered gut microbiome, and sympathetic activation are all associated with hypoxia-Induced pulmonary hypertension (PH). Angiotensin converting enzyme 2 (ACE2) over-expression protects against all of these.
• Sharma's Abstract (opens in new window)(link opens in new window)

Food Insecurity is Associated With Hypertension in Children and Adolescents Independent of Obesity
Andrew Michael South | Wake Forest School of Medicine, Winston Salem, NC

• RESULTS: Food insecurity contributes to health disparities and is associated with hypertension in children and adolescents.
• South's Abstract (opens in new window)(link opens in new window)
• AHA News Release: Children with food insecurity at risk for high blood pressure

Sox6 Has Protective Role During Renal Artery Stenosis Induced Hypertension
Mohammad Saleem | Vanderbilt University Medical Center, Nashville, TN

• RESULTS: Novel role suggested for Sox6 in the regulation of renin expression and hypertension when renal artery stenosis is present.
• Saleem's Abstract (opens in new window)(link opens in new window)

Cardiac Mitochondria are Impaired After Transient Neonatal High Oxygen Exposure in a Rat Model of Prematurity-Related Condition
Daniela Ravizzoni Dartora | Department of Pediatrics, University de Montréal and CHU Sainte-Justine Research Center, Montréal, QC, Canada

• RESULTS: A prematurity-related model found O2-induced cardiomyopathy resulted from high neonatal oxygen exposure similar to preterm birth conditions.
• Dartora's Abstract (opens in new window)(link opens in new window)

WINNER Sorting Nexin 19: A Novel & Key Player in Renal Dopamine D1R Regulation
Andrew C Tiu | Albert Einstein Medical Center, Philadelphia, PA

• RESULTS: Sorting Nexin 19 plays a key role in renal dopamine D1R signaling and protein function.
• Tiu's Abstract (opens in new window)(link opens in new window)
• Video Interview: Christian Delles, MD, and Augusto Montezano, PhD, interview Tieu about his paper (opens in new window)(link opens in new window)

Impact of New Clinical Practice Guidelines on Cardiovascular Disease Risk Assessment in an Obese Pediatric Population
Edem Binka | Johns Hopkins Hospital, Baltimore, MD

• RESULTS: Adiposity was more predictive of left ventricular hypertrophy than HTN in this small study of 54 youth at an obesity HTN clinic.
• Binka's Abstract (opens in new window)(link opens in new window)

Endothelial-Derived Microparticles as Biomarkers and Mediators of Endothelial Cell Injury in VEGF Inhibitor-Treated Cancer Patients: Implications in Hypertension
Karla B Neves | University of Glasgow, Glasgow, United Kingdom

• RESULTS: Endothelial-derived microparticles provide clues to the mechanisms for hypertension in VEGF inhibitor-treated cancer patients.
• Neves's Abstract (opens in new window)(link opens in new window)

Hypertensive Urgency: An Emergency Department Pipeline to Primary Care Pilot Study
Antonio Giaimo | Yale University, New Haven, CT

• RESULTS: For patients with seriously elevated BP, collaboration between the ER and referral for primary care follow-up significantly reduces BP, offers timely care, and reduces emergency department (ED) utilization.
• Giaimo's Abstract (opens in new window)(link opens in new window)

Mechanism of Action of 8-Aminoguanine on Renal Excretory Function
Edwin K Jackson | University of Pittsburgh School of Medicine, Pittsburgh, PA

• RESULTS: Mechanism of action of 8-Aminoguanine on renal excretory function suggests blocking PHPase and Rac1 inhibition.
• Jackson's Abstract (opens in new window) (link opens in new window)

Sub-Perception Transdermal Vagal Stimulation in Postural Tachycardia Syndrome
André Diedrich | Vanderbilt Medical Center, Nashville, TN

• RESULTS: Supine cardio-vagal function in postural tachycardia syndrome (POTS) patients was improved by auricular transdermal vagal stimulation at a sub-perception threshold.
• Diedrich's Abstract (opens in new window)(link opens in new window)

Lifestyle Interventions Reduce the Need for Guideline-Directed Antihypertensive Medication
Alan Hinderliter | University of North Carolina, Chapel Hill, NC

• RESULTS: Lifestyle interventions in overweight or obese men and women with hypertension reduced the number who needed medications.
• Hinderliter's Abstract (opens in new window)(link opens in new window)
• AHA News Release: Lifestyle changes reduce the need for blood pressure medications

Ambulatory Blood Pressure Phenotypes and Cardiovascular Target Organ Damage in Adolescents: The SHIP AHOY Study
Elaine M Urbina | Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Joshua A Samuels | University of Texas Health Science Center at Houston, Houston TX

• RESULTS: The SHIP AHOY Study: Ambulatory blood pressure measurement added to office measurements to define a BP phenotype improved target organ damage (TOD) risk stratification.
• Urbina's Abstract (opens in new window)(link opens in new window)

Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening, and Hypertension
Jing Wu | University of Iowa, Coralville, IA

• RESULTS: The mechanisms for hypertension caused by mutations in endothelial Cullin-3 were partially explained by a vascular mechanism causing endothelial dysfunction.
• Wu's Abstract (opens in new window)(link opens in new window)

Axl+ Siglec6+ Dendritic Cells: the Role of Salt, Stretch, and Hypertension
Justin P Van Beusecum | Vanderbilt University Medical Center, Nashville, TN

• RESULTS: Axl and Sigelc6+ dendritic cells (AS DCs) may represent an immune cell subset in human hypertension.
• Van Beusecum's Abstract (opens in new window)(link opens in new window)