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ATVB Journal Header Centered 750x266

ATVB Featured Articles
September 2019

About the Cover

Neutrophil extracellular traps. Neutrophil (yellow) casting web-like structures (green) composed of DNA filaments coated with histones and granule proteins entrapping Helicobacter pylori bacteria (blue). Image kindly provided by Dr Volker Brinkmann, Max Planck Institute for Infection Biology, Berlin, Germany. (See pages 1724–1738.)

Editor's Pick


Turbulent Flow Promotes Cleavage of von Willebrand Factor by ADAMTS13

Editor's Note:

Studies reported in this article used a mechanical circulatory device to generate laminar, transitional, and turbulent flow and evaluated the effect of each on von Willebrand factor (vWF) cleavage.  Turbulent flow was required for excessive cleavage of vWF in an ADAMTS13-dependent manner.  Turbulent flow decreased the ability of VWF to sustain platelet adhesion.

Related Editorial

Gone with the Vane

Featured Articles

Targeted deletion of hepatocyte Abca1 increases plasma HDL reverse cholesterol transport via the LDL receptor

Hepatocyte Abca1 deletion increases plasma HDL cholesterol catabolism via the LDL receptor, increasing fecal cholesterol excretion and reducing HDL-derived liver cholesterol recycling into plasma.

HDL Cholesterol Efflux Capacity is Associated with Incident Cardiovascular Disease in the General Population-a PREVEND Cohort Case-Control Study

Prospective case-control study matching for HDL-C shows that low cholesterol efflux capacity at baseline is associated with incident CVD events in the general population independent of HDL-C or apoA-I.

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