Basic Science / Genetics

Integrated Single-Cell Atlas Reveals Cross-Subtype Heterogeneity in Human Pulmonary Hypertension SAHH Deficiency Decreases Stability of Atherosclerotic Plaque and Induces VSMC Phenotype Switching via Epigenetic Upregulation of KLF4 and OCT4 CCR2+ Neutrophils Exhibit a Proinflammatory Phenotype and Contribute to Plaque Vulnerability Perk Is Dispensable for Smooth Muscle Cell Phenotype Switching in Atherosclerosis Efficacy of the Shear Stress Pattern Computed in Coronary Artery Reconstruction Models With and Without Side Branches in Predicting Plaque Progression Prelamin A in an LmnaL648R/L648R Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss Abdominal Fat Measures Are Associated With Sex-Specific Prothrombotic Changes in Middle-Aged Adults Restoring TRPV4-KCa2.3 Coupling to Treat Pulmonary Arterial Hypertension Atherosclerosis Profiling Reveals BHLHE40 as a Candidate Modulator of VSMC Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis