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ATVB Journal Header Centered 750x266

ATVB Featured Articles
JUNE 2020

ATVB_cover_June 2020_150 px
 
About the Cover

A macrophage in coculture with aortic valve interstitial cells. The coculture was stained with DAPI (blue, nuclei), phalloidin (yellow, F-actin), and by immunofluorescence with anti-CD68 antibody (pink) to identify macrophages. (See pages e153–e165.)

Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing

 


 Announcement from our Editor-in-Chief, Dr. Alan Daugherty

ATVB is pleased to announce that we are now considering Research Letters for publication. Please visit https://www.ahajournals.org/atvb/article-types for additional information. 
Editor's Pick

Editor's Pick

ATVB_cover_June 2020_Fig 01

Twitter Logo white 30x30Galectin-3 may serve as a novel marker for a protective macrophage subset during atherosclerosis progression. Whereas, MMP-12 can cleave galectin-3 and drive pro-inflammatory macrophage polarization.

Galectin-3 identifies a subset of macrophages with a potential beneficial role in atherosclerosis
K Di Gregoli, M Somerville, R Bianco, AC Thomas, A Frankow, AC Newby, SJ George, CL Jackson and JL Johnson

Editor's Note:
This article reports that galectin-3 deficiency in apolipoprotein E -/- mice leads to altered plaque composition. This article also highlights a new mechanism where MMP12-dependent cleavage of galectin-3 promotes pro-inflammatory macrophage polarization. 

Featured Articles

 

ATVB_cover_June 2020_Fig 03

Twitter Logo white 30x30Dysregulated EP4 overexpression in vascular smooth muscle cells promotes inflammatory monocyte/macrophage infiltration and attenuates elastin/collagen fiber formation, leading to AAA exacerbation.
 

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