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ATVB Journal Header Centered 750x266

ATVB Featured Articles
October 2019

ATVB_cover_October 2019_630 pxAbout the Cover

The ascending aorta of a mouse deficient in the protease ADAMTS5 with an increase in aggrecan, (green) a proteoglycan substrate of ADAMTS5. Altered aggrecan proteolytic profiles correlate with ascending aortic anomalies in Adamts5–/– mice. Smooth muscle cells appear blue (a smooth muscle actin). Nuclei are stained with propidium iodine (red). (See pages 2067-2081)

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313077

Editor's Pick

ATVB_October 2019 Fig 01.jpg

ApoE receptor-2 deficiency accelerates smooth muscle cell senescence via cytokinesis impairment and promotes fibrotic neointima after vascular injury

Editor's Note:
This article reports that apoE receptor 2 modulates vascular pathologies through distinct mechanisms from apoE. The authors used genetic mouse models and a carotid endothelial denudation procedure, and demonstrated that deficiency of apoE receptor 2 accelerated premature cell senescence and vascular pathologies.

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313194

Featured Articles

ATVB_October 2019 Fig 02.jpg

 Targeted deletion of hepatocyte Abca1 increases plasma HDL reverse cholesterol transport via the LDL receptor

Lipoprotein lipase exerts distinct effects on macrophage phenotype in each tissue depot in vivo, an observation that cannot be easily modeled in vitro.

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312389

 ATVB_October 2019 Fig 03.jpg

Direct amplification of tissue factor:factor VIIa procoagulant activity by bile acids drives intrahepatic coagulation

Patients with liver disease develop complex changes in hemostasis. New study documents bile acid activation of TF:FVIIa procoagulant activity as potential mechanism driving pathologic intrahepatic coagulation activity.

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313215

 

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