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Featured Articles | May 2019

About the Cover

About the Cover

Section of an atherosclerotic lesion from an ApoE-/- mouse fed a Western diet for 6 weeks shows a substantial amount of lipid droplets (red) accumulating in cells not expressing either leukocyte (cyan) or smooth muscle cell markers (green) . Nuclei (blue). Scale bar, 16µm.

Editor's Pick

Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab; First-in-Human Healthy Volunteer Trial

Editor's Note:
This article reports a human, randomized, placebo-controlled phase I study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ACT017 (an antibody to platelet glycoprotein VI ) in healthy subjects.

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