Science News

Joint Hypertension 2018 Scientific Sessions

AHA Council on Hypertension | AHA Council on Kidney in Cardiovascular Disease
American Society of Hypertension

September 6–9, 2018
Hyatt Regency Chicago | Chicago, Ill.

Science from Thursday, Sept. 6


What to Expect at the Joint Hypertension Scientific Sessions 2018

Karen Griffin, MD, programming committee chair for Hypertension 2018, John Bisognano, MD, PhD, immediate past president of the American Society of Hypertension, and Jan N. Basile, MD, vice chair of clinical programming, discuss some of the highlights they have planned for the meeting this year in Chicago.


Hypertension 2018 Presidential Address

Ivor J. Benjamin, MD, president of the American Heart Association, addresses the attendees of Hypertension 2018 in Chicago.

Jie Zhang | The University of South Florida, Tampa, FL

Macula Densa SGLT1-NOS1-TGF Pathway -- A New Mechanism for Glomerular Hyperfiltration in Diabetes
Jie Zhang | The University of South Florida, Tampa, FL

  • RESULTS: The Macula Densa SGLT1-NOS1-TGF Pathway is identified as a new mechanism for glomerular hyperfiltration in diabetes: increase in tubular glucose concentration increases macula densa activity, increasing glomerular filtration rate (GFR).
  • Zhang's Abstract (opens in new window)
Bethany L Dale | Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, TN

Interleukin-21 Plays a Critical Role in Hypertension and Vascular Dysfunction
Bethany L Dale | Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, TN

David M Patrick | Vanderbilt University Medical Ctr, Nashville, TN

Proteasome Inhibition Prevents Renal Inflammation and Hypertension by Abrogation of Dendritic Cell Autoantigen Presentation
David M Patrick | Vanderbilt University Medical Ctr, Nashville, TN

Ravindra K Sharma | University of Florida, Gainesville, FL

Global ACE2 Over-Expression is Protective Against a Dysfunctional Brain-Gut-Lung Axis in Hypoxia-Induced Pulmonary Hypertension
Ravindra K Sharma | University of Florida, Gainesville, FL

  • RESULTS: Activation of the paraventricular nucleus, gut pathology and an altered gut microbiome, and sympathetic activation are all associated with hypoxia-Induced pulmonary hypertension (PH). Angiotensin converting enzyme 2 (ACE2) over-expression protects against all of these.
  • Sharma's Abstract (opens in new window)
Andrew Michael South | Wake Forest School of Medicine, Winston Salem, NC

Food Insecurity is Associated With Hypertension in Children and Adolescents Independent of Obesity
Andrew Michael South | Wake Forest School of Medicine, Winston Salem, NC

Other science highlighted Thursday:

Science from Friday, Sept. 7


Stopping the Progression of Hypertension to CHF

Jan Basile, MD, vice chair of clinical programs for the Council on Hypertension, interviews Daniel Levy, MD of the NHLBI about his presentation, "The Progression from Hypertension to Congestive Heart Failure: How Do We Stop It?"


Sex Differences in Mechanisms of Hypertension Associated with Obesity

John Bisognano, MD, PhD, vice chair for the council on Hypertension, interviews Eric Belin de Chantamele, MS, DSc about the paper he presented, "Sex Differences in Mechanisms of Hypertension Associated with Obesity."

Hypertension Early Career Oral Award Finalists

Mohammad Saleem | Vanderbilt University Medical Center, Nashville, TN

Sox6 Has Protective Role During Renal Artery StenosisSInduced Hypertension
Mohammad Saleem | Vanderbilt University Medical Center, Nashville, TN

Daniela Ravizzoni Dartora | Department of Pediatrics, University de Montréal and CHU Sainte-Justine Research Center, Montréal, QC, Canada

Cardiac Mitochondria are Impaired After Transient Neonatal High Oxygen Exposure in a Rat Model of Prematurity-Related Condition
Daniela Ravizzoni Dartora | Department of Pediatrics, University de Montréal and CHU Sainte-Justine Research Center, Montréal, QC, Canada

Andrew C Tiu | Albert Einstein Medical Center, Philadelphia, PA

WINNER Sorting Nexin 19: A Novel & Key Player in Renal Dopamine D1R Regulation
Andrew C Tiu | Albert Einstein Medical Center, Philadelphia, PA

Edem Binka | Johns Hopkins Hospital, Baltimore, MD

Impact of New Clinical Practice Guidelines on Cardiovascular Disease Risk Assessment in an Obese Pediatric Population
Edem Binka | Johns Hopkins Hospital, Baltimore, MD

Karla B Neves | University of Glasgow, Glasgow, United Kingdom

Endothelial-Derived Microparticles as Biomarkers and Mediators of Endothelial Cell Injury in VEGF Inhibitor-Treated Cancer Patients: Implications in Hypertension
Karla B Neves | University of Glasgow, Glasgow, United Kingdom

Antonio Giaimo | Yale University, New Haven, CT

Hypertensive Urgency: An Emergency Department Pipeline to Primary Care Pilot Study
Antonio Giaimo | Yale University, New Haven, CT

  • RESULTS: For patients with seriously elevated BP, collaboration between the ER and referral for primary care follow-up significantly reduces BP, offers timely care, and reduces emergency department (ED) utilization.
  • Giaimo's Abstract (opens in new window)
Other science highlighted Friday:

Friday's Lectures and Award Winners

Virend K. Somers, MD, FAHA | Mayo Clinic College of Medicine, Rochester, Minnesota

Arthur C. Corcoran Memorial Lecture
Virend K. Somers, MD, FAHA | Mayo Clinic College of Medicine, Rochester, Minnesota

Jennifer C. Sullivan, PhD, FAHA | Augusta University, Augusta, Georgia

Mid-Career Award for Research Excellence
Jennifer C. Sullivan, PhD, FAHA | Augusta University, Augusta, Georgia

Amy C. Arnold, PhD, FAHA | Pennsylvania State University College of Medicine, Hershey, Pennslyvania

The Harry Goldblatt New Investigator Award
Amy C. Arnold, PhD, FAHA | Pennsylvania State University College of Medicine, Hershey, Pennslyvania

Science from Saturday, Sept. 8


The Effect of Environmental Factors on Blood Pressure

Karen Griffin, MD, program chair for Hypertension 2018, interviews Robert Brook, MD about his presentation, "How Do Environmental Factors Effect Blood Pressure?"


Implementation of the New Hypertension Guidelines

ICYMI: Karen Griffin, MD, program chair for Hypertension 2018, interviewed opening plenary speaker Brent Egan, MD about successful strategies for implementing the new hypertension guidelines.

Mechanism of Action of 8-Aminoguanine on Renal Excretory Function
Edwin K Jackson | University of Pittsburgh School of Medicine, Pittsburgh, PA

André Diedrich | Vanderbilt Medical Center, Nashville, TN

Sub-Perception Transdermal Vagal Stimulation in Postural Tachycardia Syndrome
André Diedrich | Vanderbilt Medical Center, Nashville, TN

  • RESULTS: Supine cardio-vagal function in postural tachycardia syndrome (POTS) patients was improved by auricular transdermal vagal stimulation at a sub-perception threshold.
  • Diedrich's Abstract (opens in new window)
Alan Hinderliter | University of North Carolina, Chapel Hill, NC

Lifestyle Interventions Reduce the Need for Guideline-Directed Antihypertensive Medication
Alan Hinderliter | University of North Carolina, Chapel Hill, NC

Elaine M Urbina | Cincinnati Children's Hospital Medical Center, Cincinnati, OH and Joshua A Samuels | University of Texas Health Science Center at Houston

Ambulatory Blood Pressure Phenotypes and Cardiovascular Target Organ Damage in Adolescents: The SHIP AHOY Study
Elaine M Urbina | Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Joshua A Samuels | University of Texas Health Science Center at Houston, Houston TX

  • RESULTS: The SHIP AHOY Study: Ambulatory blood pressure measurement added to office measurements to define a BP phenotype improved target organ damage (TOD) risk stratification.
  • Urbina's Abstract (opens in new window)

Other science featured Saturday:

Saturday's Lectures and Award Winners

Harriet Dustan Award Winner Barbara T. Alexander, PhD, FAHA | The University of Mississippi Medical Center, Jackson, Mississippi and Karen Griffin, MD

The Harriet Dustan Award
Barbara T. Alexander, PhD, FAHA | The University of Mississippi Medical Center, Jackson, Mississippi, pictured with Karen Griffin, MD, FAHA

The Donald Seldin Lecture: Paul A. Welling, MD, FAHA | University of Maryland School of Medicine, Baltimore, Maryland and Vivek Bhalla, MD

The Donald Seldin Lecture
Paul A. Welling, MD, FAHA | University of Maryland School of Medicine, Baltimore, Maryland, pictured with Vivek Bhalla, MD, FAHA

Science from Sunday, Sept. 9


Early Career Oral Award Winner Andrew Tiu, MD

Christian Delles, MD and Augusto Montezano, PhD, interview the 2018 Early Career Oral Award winner Andrew Tiu, MD, about his paper, "Sorting Nexin 19: A Novel and Key Player in Renal Dopamine D1R Regulation."


2018 Irvine Page Alva Bradley Lifetime Achievement Award Winner William C Cushman, MD

Joey Granger, PhD, chair of the Council on Hypertension, interviews the 2018 Irvine Page-Alva Bradley Lifetime Achievement Award winner William C. Cushman, MD, about his career in clinical research in hypertension.

Jing Wu | University of Iowa, Coralville, IA

Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening, and Hypertension
Jing Wu | University of Iowa, Coralville, IA

  • RESULTS: The mechanisms for hypertension caused by mutations in endothelial Cullin-3 were partially explained by a vascular mechanism causing endothelial dysfunction.
  • Wu's Abstract (opens in new window)
Justin P Van Beusecum | Vanderbilt University Medical Center, Nashville, TN

Axl+ Siglec6+ Dendritic Cells: the Role of Salt, Stretch, and Hypertension
Justin P Van Beusecum | Vanderbilt University Medical Center, Nashville, TN

Brent M Egan Award photo

The Marvin Moser Clinical Hypertension Award

The 2018 Moser award was presented to Brent M. Egan, MD, FAHA. He is pictured with Jan Basile, MD, and Joey Granger, PhD.

Looking at Posters 2 - Hypertension 2018