Evidence-Based Practices in the Cardiac Catheterization Laboratory 2025
Published: November 20, 2025
- Guidelines on coronary revascularization recommend invasive coronary physiologic assessment to aid decision making in patients with intermediate coronary lesions (40 to 69% stenosis on visual assessment).
- There has been an evolution in the measurement of pressure gradients across a coronary lesion that has led to the development and calculation of fractional flow reserve (FFR) which has become the gold standard of functional assessment and leading to other related assessments from this. During this evolution some clinical practices have emerged based on evidence, but other traditions have continued.
- This scientific statement by experts in the field evaluates evidence-based practice (and compares with what is done based on traditions of practice) for the use of invasive epicardial physiologic assessment.