Addressing Current Gaps in our Understanding of Coronary Artery Disease (CAD) using American Heart Association’s (AHA) Get With The Guidelines® (GWTG) CAD Data

At the American Heart Association, equity and science are at the center of everything we do.

The American Heart Association’s (AHA) Get With The Guidelines® (GWTG) is a hospital-based quality improvement program designed to close treatment gaps. It includes modules in atrial fibrillation, coronary artery disease, heart failure, resuscitation, and stroke. This RFP will focus on GWTG CAD and HF data linked* to Social Determinants of Health Data (SDOH) as well as GWTG AFib and Resuscitation data that can be supplemented/linked* with publicly available datasets of the applicant’s choice. 

*Please note that linked datasets provided by the AHA or any linkage the applicant chooses to do (i.e. AFib, Resuscitation) is only conducted and allowed from a geographic perspective.  The datasets are not to be linked with any other patient level data sources.  

The AHA collects millions of patient records in our Quality Programs (>14 million), creating vast databases for advancing scientific research. The GWTG AFib, CAD, HF, and Resuscitation datasets contain approximately 125k, 500k, 2.4M, and 1.2M records respectively. Using the data that is collected through AHA's national GWTG programs, researchers can test hypotheses and apply for AHA research grants. 

The AHA and the Institute for Health Metrics and Evaluation at the University of Washington have recently linked SDOH to the GWTG CAD and HF data.  Specifically, the data includes but is not limited to county-specific median household income, and county and race/ethnicity specific variables such as life expectancy, all-cause mortality rate, ischemic heart disease mortality rate, all cause years life lost, ischemic heart disease years life lost, income, unemployment, home ownership, poverty, environmental exposures (PM 2.5, NO2, and ozone), average annual daily traffic, percent of households with internet access, proportion of open park land, physical activity, depression among adults, all teeth lost,  current asthma prevalence, and total number of hospitals per 1000.

AHA’s Quality Programs Research has been a highly valuable source for quality outcomes-based research, with more than 800 peer-reviewed studies published using these data. 

To access and analyze AHA GWTG data, the AHA offers a cloud-based research data analysis platform, the Precision Medicine Platform, with secure, private workspaces equipped with tools for data analysis, machine learning, and artificial intelligence. The Precision Medicine Platform is the only research interface with access to The American Heart Association’s Get With The Guidelines registry data. 

The purpose of this RFP is to leverage one of the four datasets (AFib, CAD, HF, or Resuscitation) in the Precision Medicine Platform to ask new and innovative questions regarding the role of social determinants of health in cardiovascular disease.  

Examples of research applications include but are not limited to:
i)    Does education level impact the incidence of ___ or recovery from ___?
ii)   Does median household income, poverty, income per capita, or home ownership impact the quality of care for individuals with ___?
iii)  Do environmental exposure levels impact the incident of ___?

To be eligible and invited to apply for this award, individuals must have received a travel/training grant to learn how to use the GWTG data, successfully attended the Data Science bootcamp, and received a GWTG research certification.

The applicant must be embedded in an appropriate investigative group with the mentorship, support, and relevant scientific guidance of a research mentor. Recognizing the unique challenges that clinicians, in particular, experience in balancing research and clinical activity, this award mechanism aims to be as flexible as possible to enable applicants to develop academic careers in research alongside fulfilling clinical service commitments.  The applicant and mentor should collaboratively provide a thoughtfully planned, systematic proposal aimed at clearly answering an investigative question using the GWTG dataset of choice (AFib, CAD, HF, or Resuscitation) in the Precision Medicine Platform.

Before you apply

Every applicant must be an American Heart Association professional member.

• Join or renew online when preparing an application in Proposal Central or by phone at 1-888-242-2453 or 972-349-5803.
• Membership processing takes 3 to 5 days; do not wait until the application deadline to renew or join.

Projects may include collaborators from across sectors and countries; however, the project proposal must be submitted by a project lead representing an academic or non-profit organization based in the United States.  
 
Any member of the team can serve as the project lead. Projects may include co-investigators from other collaborating organizations. We strongly recommend that organizations identify only one project lead per project. 
 
Organizations that are currently funded through other American Heart Association funding mechanisms can apply. 
 
Organizations can submit multiple proposals. 

All grantees are required to use the Precision Medicine Platform.

Full proposals must be submitted by Friday, May 10, 2024

CHECKLIST

A. Research Plan up to 6 pages (12-point font, single space, 1-inch margins on all sides) that includes:

1. Specific Aims - Provide a clear, concise summary of the aims of the proposed work.
   • State the hypothesis to be tested.
   • State how the work will significantly add to the current work.
2. Background and Significance
3. Preliminary Studies – may include a link to a HTML Notebook created on the Precision Medicine Platform through Jupyter Notebook or R Markdown (see below)
4. Research Design and Methods - may include a link to a HTML Notebook (see below)
5. Expected outcomes and deliverables, a timeline, and project success milestones.
6. Discuss the potential difficulties and limitations of the proposed procedures and alternative approaches to achieve the aims.

• Please review the Precision Medicine Platform section that follows for more information and expectations for use.  

• Salary and fringe benefits of the project lead, collaborating investigators, and other participating research staff or faculty.
• Project-related expenses, such as salaries of technical personnel essential to the conduct of the project, travel, and publication costs in accordance with institutional and American Heart Association policies. Please note that the American Heart Association does not fund the costs of program implementation or operations beyond what is established in an approved budget.
• Maximum of 10% institutional indirect costs may be claimed on the award.
• The awardee will be responsible for overseeing the total budget for the grant. If awarded, the project lead and the institution assume an obligation to expend grant funds for the research purposes set forth in the application and in accordance with all regulations and policies governing the grant programs of the American Heart Association.

For all other required items not listed, please refer to sections displayed in your Proposal Central application. (e.g.: funding overlap, Assurances, Research Classifications, etc.)

PEER REVIEW CRITERIA
The applications will be reviewed 1/3 on the investigators, 1/3 on the proposed project and 1/3 on the research environment and mentorship. 

1. Proposed Project

• Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, well-reasoned, feasible (as determined by preliminary data), and appropriate to the aims of the proposal?
• How does the proposed work significantly add to the work in the field of SDOH and AFib, CAD, HF, or Resuscitation? 
• Does this study move the field of research on SDOH and AFib, CAD, HF, or Resuscitation?
• If the aims of the application are achieved, how will scientific knowledge or clinical practice be advanced? 
• What will be the effect of these studies on the concepts, methods and technologies that drive this field?

2. Investigator(s)

• The peer review committee will assess the merit of each investigator based on the biosketch provided and information in the letter of support.

3. Research Environment and Mentorship

• The peer review committee will assess the strength of the research environment, relevant training that will take place during the award and the experience and expertise of the mentor.

AWARD DURATION & AMOUNT

• One-year award from date of funding. Up to $100,000 per award (including 10% indirect costs). 
• The AHA anticipates funding up to 15 awards. The AHA reserves the right to determine the final number of awardees.
• An additional Amazon Web Services (AWS) service credit (up to $10,000) for use of the American Heart Association Precision Medicine Platform may be provided for computational time, use of AWS tools and infrastructure, and storage. Credit amount will be determined based on estimated need over duration of the grant.

It is required that any data analysis for your project be conducted via the American Heart Association’s Precision Medicine Platform, powered by Amazon Web Services. Our intent is to help applicants gain confidence leveraging cloud computing for applications and projects.  

The Precision Medicine Platform provides you with a secure cloud computing workspace for you to use for the application and during the term of the award that allows researchers to code in various languages, including R and Python, and to use statistical software including but not limited to SAS and R studio. The most up-to-date machine learning and artificial intelligence software available from Amazon Web Services is also included. Researchers are also able to install their own tools.

The American Heart Association asks that the grantees also accelerate collaboration through the sharing of data and code as well as the coordination for interoperability of data to facilitate findability and sustainability. The American Heart Association fully supports the FAIR (Findable, Accessible, Interoperable and Reusable) guiding principles of data stewardship.  The Precision Medicine Platform helps to support this principle by also serving as a data marketplace and enables you to share your data and make it available to other researchers.  

The Platform is HIPAA and FedRAMP compliant. Learn more about the Platform’s Security Information.

To learn more about the Precision Medicine Platform:

• Overview
• Full list of available analytical tools 

• Any inventions, intellectual property, and patents resulting from this funding are governed by the AHA’s Patent, Intellectual Property and Technology Transfer Policy.
• The applicant/awardee and institution are responsible for compliance with all AHA research award policies and guidelines for the duration of any awards they may receive.
• Visit the Research Programs Awards Policies page for more information on this topic: American Heart Association Policies Governing All Research Awards