Clonal Hematopoiesis and Its Cardiovascular Implications
Published: February 10, 2026
- Clonal hematopoiesis (CH) is an age-related condition marked by somatic mutations in blood stem cells, increasing cardiovascular (CV) risk through gene-specific inflammation and other pathways.
- CH carriers have higher rates and worse outcomes of coronary artery disease, myocardial infarction, heart failure, stroke, and peripheral artery disease.
- Emerging approaches such as multidisciplinary "CHIP Clinics" and experimental anti-inflammatory therapies show promise, and integrating CH status into risk models may improve personalized CV prevention and treatment.
Supporting Materials
Recommended Reading
- Direct-to-Consumer Genetic Testing for Cardiovascular Disease
- Genetic Testing for Heritable Cardiovascular Diseases in Pediatric Patients
- Genetic Testing for Inherited Cardiovascular Diseases
- Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine
- 2019 CVD Primary Prevention Guideline