Methodologic Standards for Follow-Up Extension in Cardiovascular Trials
Updated: August 03, 2026
- Extension follow-up studies address long-term questions beyond the parent trial and require clear choices about outcomes, duration, and analysis.
- Their validity depends on cohort retention, consistency with the randomized population, and stable endpoint and analytic methods across trial phases.
- Successful long-term follow-up depends on early planning, external data linkage, and durable operational support.