Gene Therapy in Cardiovascular Disease: Recent Advances and Future Directions in Science

Published: November 11, 2024

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  • Many cardiovascular diseases, the leading cause of morbidity and mortality worldwide, are caused by damaging DNA variants and require lifelong treatments that mitigate but do not cure disease.
  • Gene therapies deliver exogenous genes to supplement insufficient protein levels or use gene editors to correct, delete, or modify sequences that cause monogenic disorders.
  • Educating clinicians, patients, and society is critical to understanding genetic concepts, appropriately interpreting genetic test results, and advancing gene therapies to benefit patients and reduce the burden of cardiovascular disease.