Single Pill Combination Therapy for the Management of Hypertension
Published: December 15, 2025
- Single-pill combination medications (SPCMs) improve adherence and persistence, accelerate blood pressure control and lead to more sustained blood pressure reductions compared with equivalent free-pill regimens.
- Initial treatment of hypertension with SPCMs is recommended for most patients requiring medications, including those with stage 1 hypertension.
- SPCMs combining renin-angiotensin system blockers with calcium channel blockers are the preferred first choice for most patients.
Single Pill Combination Therapy for the Management of Hypertension
Writing Group Chair Jordan B. King, PharmD, MS and Vice Chair Robert D. Brook, MD announce the publication of the paper and discuss the potential benefits of using single-pill combination therapy for managing high blood pressure.