Mitochondrial Genetics in Cardiovascular Health and Disease
Published: December 02, 2025
- The mitochondrial genome, inherited maternally, encodes essential components for heart energy production, and its coordination with nuclear genes is crucial for cardiovascular (CV) health.
- Variants and heteroplasmy in mitochondrial DNA increase with age and are linked to CVD, but research and therapies are limited by disease complexity and insufficient understanding.
- This statement summarizes key practices in identifying mitochondrial DNA variants, reviews current knowledge of their role in CVD disease, and identifies existing gaps in understanding.
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