2024 George Lyman Duff Memorial Lecture - Alan T. Remaley, MD, PhD, FAHA

 

Dr. Remaley is the section chief of the Lipoprotein Metabolism Laboratory in the Translational Vascular Medicine Branch of the National Heart, Lung, and Blood Institute (NHLBI) in Bethesda, Maryland. He is also a senior staff member of the Department of Laboratory Medicine at the National Institutes of Health Clinical Center.

Dr. Remaley received his BS in biochemistry and chemistry from the University of Pittsburgh in 1981. In 1987, he received an MD and PhD (biochemistry) from the University of Pittsburgh and completed in 1990 a residency in clinical pathology at the University of Pennsylvania. He did a post-doctoral fellowship with Dr. Bryan Brewer at NHLBI from 1990 to 1995.

He has been the recipient of many awards for his research and has published more than 500 papers in the field of lipoprotein metabolism and cardiovascular disease. He is an inventor on multiple patents related to new therapeutic agents and diagnostic tests for cardiovascular disease.

Dr. Remaley has made important contributions to the field of high-density lipoprotein metabolism, particularly related to the mechanism of the ABCA1 transporter. He has developed an apoA-I mimetic peptide and recombinant Lecithin:Cholesterol acyl transferase into therapies, which have been tested in early stage clinical trials. More recently, he expanded his research into new diagnostics and therapeutic approaches for low-density lipoproteins and on the structure of apoB100, the main protein constituent of low-density lipoproteins.